Pills that promise to boost the metabolism-regulating enzyme NAD+ are increasingly popular, and show some potential promise in a few very small studies of people that have been done over the past few years.
NAD+ is an important enzyme in our bodies that helps us create energy. NAD+ levels decline as we age, so there's some suspicion that boosting them might help preserve a more youthful state of being and protect aging DNA.
Two supplements, nicotinamide mononucleotide, or NMN, and nicotinamide riboside, or NR, supposedly help us produce more NAD+ and they have a lot of hype around them. Kourtney Kardashian called NAD+ "our genetic key to longevity" in a recent Instagram post touting some of her favorite supplements.
But the science hasn't really borne out yet whether artificially boosting NAD+ precursors like NMN and NR has real benefits for people.
The bulk of the research on NAD+ has been done in mice and Petri dishes in the lab, and it's still unclear what taking supplements like NMN and NR can do for people in the long run. Almost all of the human studies so far have been funded by companies that are either already selling NMN and NR supplements, or have a vested interest in profiting from anti-aging, so more independent research is needed.
In October of 2022, the US Food and Drug Administration said that because NMN is being investigated as a drug, it "may not be marketed as or in a dietary supplement." Because of this, some NMN sellers have subsequently been kicked off Amazon.
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