Category Archives: Stem Cell Therapy

Global Animal Stem Cell Therapy Market Study Focuses On Market Growth Insights, Latest Developments, Industrial Analysis, And Future Trends

The research report on globalAnimal Stem Cell Therapy marketpublished byMarket Research Storecovers all the market details for the forecast period. Primarily, the report considers some essential factors that accounts for the growth and development of the market. The Animal Stem Cell Therapy market report sheds light on the major interferences and challenges. The document provides a clear picture of the future market scope and competitive market scenarios for gaining complete knowledge about the market growth rate during the forecast period. Furthermore, the report studies the vital growth aspects such as growth stimulators, market valuation, regional segmentation, and market competitiveness among the key players.

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Some of the major players analyzed in the report includeANIMAL CELL THERAPIES, Celavet, Animacel, VETSTEM BIOPHARMA, Cell Therapy Sciences, Magellan Stem Cells, Cells Power Japan, Animal Care Stem, Aratana Therapeutics, VetCell Therapeutics, MediVet Biologic, U.S. Stem Cell, J-ARM.

The latest research report on the Animal Stem Cell Therapy market provides a complete analysis of the market sphere and various market segmentation. The research report clearly portrays the substantial growth that the Animal Stem Cell Therapy market is expected to attain during the forecast period. The study also compiles and details all concerning market size, market growth rate, growth drivers, and key market trends. A complete examination of the important growth influencers of the Animal Stem Cell Therapy industry in the next few years is also represented in the report.

Global manufacturing companies launch new products once in a few months and Marketresearchstore listed down information on the outcomes of the Animal Stem Cell Therapy Market:

Dogs, Horses, Others

There are categories based on the types of the products of the Animal Stem Cell Therapy Market. The product demand information given by the customer application and the report has data on it as well:

Veterinary Hospitals, Research Organizations

The global Animal Stem Cell Therapy market report also encompasses the regional analysis including North America (Canada, U.S., Rest of North America), Europe (UK, France, Italy, Germany, Spain, Rest of Europe), Asia Pacific (Japan, India, China, Southeast Asia, Rest of Asia Pacific), Latin America (Argentina, Brazil, Rest of Latin America), Middle East and Africa (South Africa, Rest of Middle East & Africa) to offer the complete regional development status. Additionally, the report also provides necessary recommendations and suggestions for the Animal Stem Cell Therapy market players in order to attain a competitive edge in various regions.

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Major factors covered in the research report:

The report provides all the vital and accurate figures required to gain better understanding of the market revenue, share, and volume. Market overview, competitive landscape, costing analysis, consumption rate, export/import details, and market strategies. A complete detail of the growth rate over the forecast period is depicted in the Animal Stem Cell Therapy market report. All the aspects including market regional development status and market competitiveness are also presented in the statistical format. Other essential data including challenges, opportunities, risks, latest developments, and future scope of the market are accurately covered in the report. The report covers key business strategies, growth stimulators, and statistical data that will help market players take crucial business decisions.

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Global Animal Stem Cell Therapy Market To Witness Huge Gains Over 2020-2026 - NeighborWebSJ

Fort Collins, Colorado: Reports Globe has published the latest study on Animal Stem Cell Therapy Market Report Analysis by Size with Future Outlook, Key Players SWOT Analysis and Forecast to 2026. It uses exploratory techniques such as qualitative and quantitative analysis to identify and present data on the target market. Successful sales strategies have been mentioned that will help you do business in record time and multiply customers.

This report is presented clearly and concisely to help you better understand the structure and dynamics of the market. The trends and recent developments in the Animal Stem Cell Therapy market were analyzed. The opportunities that lead to the growth of the market were analyzed and presented. Focusing on the global market, the report provides answers to the key questions stakeholders are facing today around the world. Information on market size raises the problem of increasing competitiveness and hampering market-leading sectors and market growth.

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Some of the Important and Key Players of the Global Animal Stem Cell Therapy Market:

Animal Stem Cell Therapy market research report provides detailed information on the following aspects: Industry Size, Market Share, Growth, Segmentation, Manufacturers and Advancement, Key Trends, Market Drivers, Challenges, Standardization, Deployment Models, Opportunities, Strategies, Future Roadmaps and Annual Forecasts to 2027, etc. The report will help you also in understanding the dynamic structure of the Animal Stem Cell Therapy market by identifying and analyzing market segments. The Global Animal Stem Cell Therapy 2021 Industry Research Report has given the expected compound annual growth rate (CAGR) as a% of value for a given period of time and clearly helps the user make their decision based on the futuristic chart of the key players on the global Animal Stem Cell Therapy market. The report introduces some of the major players in the global Animal Stem Cell Therapy market and offers insightful information about the Animal Stem Cell Therapy industry such as Business Overview, Animal Stem Cell Therapy Market Product Segmentation, Revenue Segmentation, and the Latest Information. Developments.

Additionally, the Animal Stem Cell Therapy market report includes a comprehensive strategic review as well as summarized studies of the growth, key factors, and market opportunity by which to evaluate the Animal Stem Cell Therapy market and other important market related details on Animal Stem Cell Therapy. The investigation of the research report also helps uncover accurate industry statistics depicting the ultimate model of the global Animal Stem Cell Therapy market, including various types, applications, market growth structures, and opportunities. In addition, the study of the market research report provides an investigation and analysis of the past and current performance of the regional market that includes regions by department and subdivision. This regional analysis studies various key market parameters such as Animal Stem Cell Therapy market growth rate in each region, production volume and capacity, market demand and supply, and return on investment (RoI).

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Some of the key questions answered in the report include-

1. What is the overall structure of the market?2. What was the historical value and what is the forecasted value of the market?3. What are the key product level trends in the market?4. What are the market level trends in the market?5. Which of the market players are leading and what are their key differential strategies to retain their stronghold?6. Which are the most lucrative regions in the market space?

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Global Animal Stem Cell Therapy market is segmented based by type, application and region.

Animal Stem Cell Therapy Market Segmentation, By Type

Animal Stem Cell Therapy Market Segmentation, By Application

The prime objective of this report is to help the user understand the market in terms of its definition, segmentation, market potential, influential trends, and the challenges that the market is facing. Deep researches and analysis were done during the preparation of the report. The readers will find this report very helpful in understanding the market in depth. The data and the information regarding the market are taken from reliable sources such as websites, annual reports of the companies, journals, and others and were checked and validated by the industry experts. The facts and data are represented in the report using diagrams, graphs, pie charts, and other pictorial representations. This enhances the visual representation and also helps in understanding the facts much better.

Global Animal Stem Cell Therapymarket Key Report Highlights:

This in-depth research documentation offers an illustrative overview of the entire market outlook with details on scope, executive summary, and market segments The report also includes sections on the competitive spectrum, highlighting major players, with a detailed assessment of supply chain management, competition dynamics, and growth objectives. Other crucial details on Porters Five Forces assessment, SWOT analysis, and data triangulation methods have also been included in the report. Other relevant details on production patterns, growth rate, market share of each of the segments have also been pinned in the report. The report also houses crucial analytical details on revenue share and sales projections, besides volumetric estimations of each of the product segments have also been highlighted in the report to encourage unfaltering market decisions and sustainable revenue streams in the global Animal Stem Cell Therapy market.A dedicated chapter on COVID-19 analysis has therefore been included in this versatile report to encourage future-ready business discretion aligning with post-COVID-19 market environment.

Major Points from Table of Content:

1. Executive Summary2. Assumptions and Acronyms Used3. Research Methodology4. Animal Stem Cell Therapy Market Overview5. Animal Stem Cell Therapy Supply Chain Analysis6. Animal Stem Cell Therapy Pricing Analysis7. Global Animal Stem Cell Therapy Market Analysis and Forecast by Type8. Global Animal Stem Cell Therapy Market Analysis and Forecast by Application9. Global Animal Stem Cell Therapy Market Analysis and Forecast by Sales Channel10. Global Animal Stem Cell Therapy Market Analysis and Forecast by Region11. North America Animal Stem Cell Therapy Market Analysis and Forecast12. Latin America Animal Stem Cell Therapy Market Analysis and Forecast13. Europe Animal Stem Cell Therapy Market Analysis and Forecast14. Asia Pacific Animal Stem Cell Therapy Market Analysis and Forecast15. Middle East & Africa Animal Stem Cell Therapy Market Analysis and Forecast16. Competition Landscape

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Animal Stem Cell Therapy Market Size By Analysis, Key Vendors, Regions, Type and Application, and Forecasts to 2027 - NeighborWebSJ

This article was originally published here

Hum Gene Ther. 2021 Jan 15. doi: 10.1089/hum.2020.275. Online ahead of print.

ABSTRACT

Wound healing has been greatly challenging in different acute and chronic skin injuries. Among them, non-revascularizable critical limb ischemic ulcers, venous leg ulcers, and diabetic lower limb or extremity ulcers are well-known refractory skin injuries that are difficult to treat. Partly differentiated progenitor cell-based graft transplantation or direct injection of autologous stem cells might promote the wound healing process. Studies aiming to comprehensively analyze the effects of cell therapy on skin wound healing could provide clinical evidence for skin injury treatment. Different databases were searched for full-text publications about the comparison between cell therapy and regular therapy. Heterogeneity was detected by the I2 method, and a fixed-effect model was applied for data pooling if heterogeneity was absent. Publication bias was analyzed using a funnel plot, and 10 studies were finally included in this study. After a long-term follow-up, fewer patients underwent major amputation in the cell therapy group, compared with the standard therapy group, and those in the cell therapy group were characterized with smaller ulcer area. Moreover, there was a significant difference in the wound healing rate between the intervention and control groups. However, pain caused by skin wounds was hardly mitigated by cell therapy in patients with critical limb ischemia. In this study, cell therapy proved effective in decreasing the size of ulcer and improving wound closure rate. Additionally, major amputation rate was decreased in the cell therapy group. However, the symptoms of pain were hardly alleviated by cell therapy in patients with cutaneous ulcers caused by peripheral artery disease-related critical limb ischemia.

PMID:33446038 | DOI:10.1089/hum.2020.275

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Comprehensive analysis of cell therapy on chronic skin wound healing: a meta-analysis - DocWire News

This contemporary, modern market research compilation is a systematic overview of the overall market status and structure prevalent in global Canine Stem Cell Therapy market and their rampant implications upon holistic growth trajectory and further probabilities in the near future. The report is based on extensive primary and secondary research initiatives and the insights thus achieved have been stacked systematically aided by several graphs, tables and charts to encourage seamless comprehension. The report sheds ample light into both past and current developments to infer futuristic probabilities. Relevant understanding on market prognosis, trends, policy updates and current development statistics have all been highlighted in thorough detail for quick deductions and subsequent investment discretion by Orbis Pharma Reports.

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Major Company Profiles operating in the Canine Stem Cell Therapy Market:

Stem Cell VetRegeneus LtdMedregoAratana TherapeuticsVetStem BiopharmaMagellan Stem CellsOkyanosCell Therapy SciencesMediVet BiologicMajor Types CoveredAllogeneic Stem CellsAutologous Stem Cells

By the product type, the market is primarily split into

Allogeneic Stem CellsAutologous Stem Cells

By the application, this report covers the following segments

Veterinary HospitalsVeterinary ClinicsVeterinary Research Institutes

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Regional Overview:This versatile research report presentation on global Canine Stem Cell Therapy market, presented by Orbis Pharma Reports has maintained highest parameters of research practices to unravel crucial details. Holistic geographical diversifications have been carefully analyzed and prominent growth centers have been categorically flagged to maintain uniform growth trends.Besides entailing region-specific details, country-wise detailing have also been included to encourage rapid decision making. For maximum reader discretion and subsequent investment decisions, this report on global Canine Stem Cell Therapy market as assessed by Orbis Pharma Reports reveals Germany, France, Italy, UK as ideal growth hotspots, followed by American growth hubs such as Mexico, Brazil, US and Canada. MEA countries and APAC nations have also been thoroughly scanned to understand growth patterns, competition intensity as well as vendor activities across these growth points.

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Decoding Segment Specifications:The report by Orbis Pharma Reports on global Canine Stem Cell Therapy market encourages complete stratification of the market in terms of segments to understand growth patterns. All prominent segments highlighted in the report have been assessed based on set parameters such as capital diversion, inventory management as well as utility diversification, besides exploring supply chain developments to understand segment potential in growth progression. Each of the segment identified has been assessed on the basis of various market parameters to explore growth projections and likelihood. The report is based on complete SWOT and PESTEL assessment, followed by PORTERs Five Forces assessment and evaluation of all DROT factors. These details are highly crucial to encourage appropriate investment decisions on the part of inquisitive readers and aspirational investors.Orbis Pharma Reports also sketches the prevalent competition landscape, isolating frontline players as well as their growth proficient business decisions. Based on these business decisions, this report helps investors to deliver lucrative business decisions.

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Canine Stem Cell Therapy Industry Market 2021 by Company, Regions, Type and Application, Forecast to 2027:Stem Cell Vet, Regeneus Ltd, Medrego,...

Dublin, Jan. 05, 2021 (GLOBE NEWSWIRE) -- The "Stem Cell Therapy Global Market Report 2020-30: COVID-19 Growth and Change" report has been added to ResearchAndMarkets.com's offering.

Stem Cell Therapy Global Market Report 2020-30: COVID-19 Growth and Change provides the strategists, marketers and senior management with the critical information they need to assess the global stem cell therapy market.

Major players in the stem cell therapy market are Anterogen, JCR Pharmaceuticals, Medipost, Osiris Therapeutics, Pharmicell, Astellas Pharma, Cellectis, Celyad, Novadip Biosciences and Gamida Cell.

The global stem cell therapy market is expected to decline from $8.73 billion in 2019 to $8.62 billion in 2020 at a compound annual growth rate (CAGR) of -1.24%. The decline is mainly due to the COVID-19 outbreak that has led to restrictive containment measures involving social distancing, remote working, and the closure of industries and other commercial activities resulting in operational challenges. The market is then expected to recover and reach $14.76 billion in 2023 at a CAGR of 19.62%.

The stem cell therapy market consists of the sales of stem cell therapy and related services by entities (organizations, sole traders, and partnerships) that provide stem cell therapy. Stem cell therapy, also known as regenerative medicine, promotes the repair response of diseased patient, dysfunctional or injured tissue using stem cells or their derivatives. Only goods and services traded between entities or sold to end consumers are included.

The stem cell therapy market covered in this report is segmented by type into allogeneic stem cell therapy; autologous stem cell therapy. It is also segmented by cell source into adult stem cells; induced pluripotent stem cells; embryonic stem cells, by application into musculoskeletal disorders; wounds and injuries; cancer; autoimmune disorders; others, and by end-user into hospitals; clinics.

In September 2019, Vertex Pharmaceuticals Inc, a US-based biopharmaceutical company, announced its decision to acquire Semma Therapeutics, a private biotechnology company, for $950 million. The acquisition is expected to align with Vertex's strategy of investing in scientific innovation that creates transformative medicine for patients with serious diseases. Semma Therapeutics is a US-based company that is involved in using stem cell therapy for diabetes treatment.

The high cost of stem cell therapy is expected to limit the growth of the stem cell therapy market. The pressure to contain costs and demonstrate value is widespread. Political uncertainty and persistent economic stress in numerous countries are calling into question the sustainability of public health care funding. In less wealthy countries, the lack of cost-effective therapies for chronic diseases has impacted the health conditions of the population and has led to a low average life expectancy. According to the DVCSTEM, the average cost of stem cell therapy in the USA is between $20,000 to $25,000, in Mexico, it is $33,000, in Central America, it is $30,000, and in Asia, it is $50,000, thus restraining the growth of the market.

The companies in the stem cell therapy market are increasingly investing in strategic partnerships. The strategic partnership is a mutually beneficial agreement between two companies that do not compete directly with each other. For instance, in September 2018, CRISPR Therapeutics, a biotechnology company that develops transformative medicine using the gene-editing platform for serious diseases, and ViaCyte, a California-based regenerative medicine company, collaborated for the development and commercialization of allogeneic stem cell therapies for diabetes treatment.

The rising prevalence of chronic diseases contributed to the growth of the stem cell therapy market. Long working hours, limited physical activity, and unhealthy eating and drinking habits contribute to the prevalence of chronic diseases among people, thus driving the need for stem cell therapy. According to a United Nations article, by 2030, the proportion of global deaths due to chronic diseases is expected to increase to 70% of total deaths. The global burden of chronic diseases is expected to reach about 60%. The rising prevalence of chronic diseases is expected to drive the stem cell therapy market.

Key Topics Covered:

1. Executive Summary

2. Stem Cell Therapy Market Characteristics

3. Stem Cell Therapy Market Size And Growth 3.1. Global Stem Cell Therapy Historic Market, 2015 - 2019, $ Billion 3.1.1. Drivers Of The Market 3.1.2. Restraints On The Market 3.2. Global Stem Cell Therapy Forecast Market, 2019 - 2023F, 2025F, 2030F, $ Billion 3.2.1. Drivers Of The Market 3.2.2. Restraints On the Market

4. Stem Cell Therapy Market Segmentation 4.1. Global Stem Cell Therapy Market, Segmentation By Type, Historic and Forecast, 2015-2019, 2023F, 2025F, 2030F, $ Billion

Story continues

4.2. Global Stem Cell Therapy Market, Segmentation By Cell Source, Historic and Forecast, 2015-2019, 2023F, 2025F, 2030F, $ Billion

4.3. Global Stem Cell Therapy Market, Segmentation By Application, Historic and Forecast, 2015-2019, 2023F, 2025F, 2030F, $ Billion

4.4. Global Stem Cell Therapy Market, Segmentation By End-User, Historic and Forecast, 2015-2019, 2023F, 2025F, 2030F, $ Billion

5. Stem Cell Therapy Market Regional And Country Analysis

Companies Mentioned

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Global Stem Cell Therapy Market Report 2020: Market to Recover and Reach $14.76 Billion in 2023 at a CAGR of 19.62% - Forecast to 2030 - Yahoo Finance

Despite the introduction of CAR T-cell therapy to the mantle cell lymphoma (MCL) armamentarium, induction therapy followed by stem cell transplant has maintained a role, said James Gerson, MD, who added that he continues to recommend transplant for patients, since they are still eligible for CAR T-cell therapy upon relapse on transplant.

I tell patients that we have very long-term data that a consolidative transplant for those who are eligible leads to a prolonged remission, Gerson explained. If a patient can be in remission for 10 years, maybe 10 years from now we will have something that is even better and more tolerable than CAR T-cell therapy.

In July 2020, the FDA approved brexucabtagene autoleucel (Tecartus) for the treatment of adult patients with relapsed/refractory MCL. The indication was based on findings from the phase 2 ZUMA-2 trial where brexucabtagene autoleucel, given as a single infusion, induced an 87% objective response rate and a 62% complete response rate in this patient population.

Unlike in diffuse large B-cell lymphoma where more restrictions [with CAR T-cell therapy] exist, any patient with MCL who had 1 prior therapy and relapsed can go straight to CAR T-cell therapy, Gerson said. We can use BTK inhibitors to bridge them, but we dont have to. There are a lot of possibilities.

Though not yet planned, further studies evaluating CAR T-cell therapy in the frontline setting for patients with high-risk MCL may be worth exploring, said Gerson.

In an interview with OncLive during a 2020 Institutional Perspectives in Cancer webinar on hematologic malignancies, Gerson, an assistant professor of clinical medicine at Penn Medicine, discussed navigating treatment selection amid the approval of CAR T-cell therapy in MCL and the role of transplant after induction therapy.

OncLive:What induction regimens do you consider for your patients with MCL and how do you select between possible options?

Gerson: For young, fit patients, there is really no right answer for induction therapy because [treatment selection] is based on phase 2, nonrandomized data. Typically, induction therapy involves high-dose chemotherapy. Im actually very intrigued by a recent publication from the French group that looked at obinutuzumab [Gazyva] with DHAP [dexamethasone, cytarabine, and cisplatin; O-DHAP] as frontline therapy for young patients prior to consolidative transplant.

Ive used a lot of R-DHAP [rituximab (Rituxan) plus DHAP], but I havent used this O-DHAP. I think there is rationale to be excited about that option. Even though it is a phase 2 trial, it should [yield] reasonable data to take to insurance and get approval for. Again, it is not something Ive given, but Im very compelled by it and it is something I will try in the coming months.

Then, [we] usually follow [induction therapy] with a stem cell transplant for patients who are eligible.

In the relapsed setting, second-line BTK inhibition is pretty much the standard of care now. There is no right answer between [ibrutinib (Imbruvica) and acalabrutinib (Calquence)]. Anecdotally and by some limited published data, ibrutinib seems to have a higher occurrence of adverse effects [AEs]. Acalabrutinib is a little bit different but seems to be more tolerable in the long run. I tend to tell patients that and then they tend to want the medication that probably has fewer AEs. A lot of us end up choosing acalabrutinib, but from an efficacy standpoint, we have no comparative data. The curves are pretty similar when we look between the 2 trials.

In the era of cellular therapy, what is the role of transplant in MCL?

The challenge, of course, is that with the FDA approval of brexucabtagene autoleucel and CAR T-cell therapy coming into MCL, it is hard to know if we should still be transplanting patients. No one knows the answer because it is obviously not something that has been explored. The only thing that is known is that patients who have been transplanted can still go forward with [CAR T-cell] therapy and respond quite well. Therefore, it is not that getting a transplant means a patient cannot get CAR T-cell therapy in the future.

[With that], I usually tell my patients not to skip transplant because of the approval of brexucabtagene autoleucel in the relapsed/refractory setting. That said, it is an individualized choice. Certainly, some patients might make that choice not to undergo a transplant now that CAR T-cell therapy is available to them should they relapse. Still, in my practice, I will still offer transplant to a patient who is young and fit as a consolidative measure after induction therapy.

Do you see CAR T-cell therapy gaining a more significant role in MCL? Will it eventually moveinto the frontline setting?

Right now, the label given to brexucabtagene autoleucel was very open, [encompassing] any relapsed/refractory patient [with MCL]. That is great not only for patients but for practicing physicians.

[Bringing CAR T-cell therapy to] the frontline setting will likely be investigated in the future, especially for high-risk patients with high MIPI [Mantle Cell Lymphoma International Prognostic Index] scores,TP53mutations, blastoid variant MCL, or pleomorphic variant MCL. [These features] tend to [confer] worse outcomes. There are areas where using [CAR T-cell therapy] in the frontline setting is worth looking into.

It is completely up to the company whether they want to pursue it. Otherwise, it is going to be left to investigator-initiated trials, which are going to be difficult because of the cost associated with CAR T-cell therapy. Some centers may pursue using homegrown CAR T-cell therapy where the cost is much lower for some of these high-risk patients, but I hope the company will pursue such trials in the frontline setting.

What other regimens are potentially on the horizon in MCL and how could they best fit into the paradigm?

There are a lot of similarities between chronic lymphocytic leukemia [CLL] and MCL. A similar triplet strategy to ibrutinib, obinutuzumab, and venetoclax [(Venclexta) in CLL] is being looked at in frontline and relapsed/refractory MCL. That is incredibly exciting and could very well supplant typical [cytarabine]-based induction and transplant. We will need long-term follow-up, so we probably wont know for many years.

Thankfully, with minimal residual disease [MRD], we will possibly be able to know much sooner, because if we can get a large percentage of patients into an MRD-negative state, that is a proxy for outcome. Again, we wont know for probably about 10 years before we get that long-term follow-up, but we will have a good enough idea if we [should] use MRD as a surrogate end point.

Reference

Wang M, Munoz J, Goy A, et al. KTE-X19 CAR T-cell therapy in relapsed or refractory mantle-cell lymphoma. N Eng J Med. 2020;382(14):1331-1342. doi:10.1056/NEJMoa1914347

See the rest here:
MCL Landscape Adapts to Changes After CAR T-Cell Therapy Approval - OncLive