Category Archives: Pharmacogenomics

- The increasing prevalence of cancer and rising R&D activities in the cancer immunotherapy field is driving the demand for the market.

- Market Size USD 78.04 billion in 2019, Market Growth - CAGR of 10.1%, Market trends Growing health awareness and effectiveness of treatment

VANCOUVER, B.C, Sept. 17, 2020 /PRNewswire/ --The globalCancer Immunotherapy Marketis expected to reach USD 153.03 Billion by 2027, according to a new report by Emergen Research. The cancer immunotherapy market is growing at a substantial pace owing to the growing acceptance and inclination of the patients towards the newly invented advanced treatments over the conventional ones. In order to substantialize the severe and chronic diseases like cancer, every year, the cancer research centers invest a handful of the amount in their R&D, which fuels up the market growth by a large margin.

Key factors responsible for driving the growth of the cancer immunotherapy market include technological advancements in therapy, rising incidences of cancer, increasing R&D activities for the treatment of cancer, and the improving effectiveness of cancer immunotherapy for the treatment of a wide range of diseases, such as lung cancer, breast cancer, and skin cancer, among others. Factors that could significantly limit market growth is the high price of the slow and long-term procedure, expensive treatment and R&D, and stringent government regulations. Moreover, product approvals and high cost of treatment are expected to act as a restraining factor on the growth of the global market in the near future.

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For the purpose of this report, Emergen Research has segmented the Global Cancer Immunotherapy Market on the basis of technology, application, end-use, and region:

Technology Outlook (Revenue, USD Billion; 2017-2027)

Application Outlook (Revenue, USD Billion; 2017-2027)

End-Use Outlook (Revenue, USD Billion; 2017-2027)

Regional Outlook (Revenue, USD Billion; 2017-2027)

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Cancer Immunotherapy Market Estimated to be Worth USD 153.03 Billion by 2027 | CAGR of 10.1%: Emergen Research - PR Newswire UK

The Global Medical Simulator Market size is projected to reach USD XX Mn by 2023 from USD XX Mn in 2018, at a CAGR of 13.8% during the forecast period.

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Medical Simulator Market 2020 Will Emerge Globally And Grow upto 13.8% of CAGR by 2023 - The Daily Chronicle

A worker conducts testing during the 2014 Ebola outbreak in Liberia. Credit: John Saindon/Centers for Disease Control and Prevention. CC BY 2.0.

Once a COVID-19 vaccine is approved for public use, officials around the world will face the monumental challenge of vaccinating billions of people, a logistical operation rife with thorny ethical questions. What if instead of orchestrating complicated and resource-intensive campaigns to vaccinate humans against emerging infectious diseases like COVID-19, we could instead stop the zoonotic diseases that sometimes leap from animals to people at their source? A small, but growing number of scientists think its possible to exploit the self-propagating properties of viruses and use them to spread immunity instead of disease. Can we beat viruses like SARS-CoV-2, the novel coronavirus, at their own game?

A virus that confers immunity throughout an animal population as it spreads in the wild could theoretically stop a zoonotic spillover event from happening, snuffing out the spark that could ignite the next pandemic. If the wild rats that host the deadly Lassa virus, for example, are vaccinated, the risks of a future outbreak among humans could be reduced. For at least 20 years, scientists have been experimenting with such self-spreading vaccines, work that continues to this day, and which has gained the attention of the US military.

For obvious reasons, public and scientific interest in vaccines is incredibly high, including in self-spreading vaccines, as they could be effective against zoonotic threats. The biologists Scott Nuismer and James Bull generated fresh media attention to self-spreading vaccines over the summer after publishing an article in the journal Nature Ecology & Evolution. But the subsequent reporting on the topic gives short shrift to the potentially significant downsides to releasing self-spreading vaccines into the environment.

Self-spreading vaccines could indeed entail serious risks, and the prospect of using them raises challenging questions.

Who decides, for instance, where and when a vaccine should be released? Once released, scientists will no longer be in control of the virus. It could mutate, as viruses naturally do. It may jump species. It will cross borders. There will be unexpected outcomes and unintended consequences. There always are.

While it may turn out to be technically feasible to fight emerging infectious diseases like COVID-19, AIDS, Ebola, and Zika with self-spreading viruses, and while the benefits may be significant, how does one weigh those benefits against what may be even greater risks?

How they work. Self-spreading vaccines are essentially genetically engineered viruses designed to move through populations in the same way as infectious diseases, but rather than causing disease, they confer protection. Built on the chassis of a benign virus, the vaccines have genetic material from a pathogen added to them that stimulates the creation of antibodies or white blood cells in infected hosts.

These vaccines could be particularly useful, some scientists say, for wildlife populations where direct vaccination is difficult due to issues like inaccessible habitats, poor infrastructure, high costs, or lack of resources. The idea, essentially, is to vaccinate a small proportion of a population through direct inoculation. These so-called founders will then passively spread the vaccine to other animals they encounter either by touch, sex, nursing, or breathing the same air. Gradually, these interactions could build up population-level immunity.

Self-spreading vaccines have some of their roots in efforts to reduce pest populations. Australian researchers described a virally spread immunocontraception, which hijacked the immune systems of infected animalsin this case a non-native mouse species in Australiaand prevented them from fertilizing offspring. The earliest self-spreading vaccine efforts targeted two highly lethal infectious diseases in the European rabbit population (myxoma virus and rabbit hemorrhagic disease virus). In 2001, Spanish researchers field-tested a vaccine in a wild rabbit population living on Isla del Aire, a small Spanish island just off Menorca. The vaccine spread to more than half the 300 rabbits on the island, and the trial was deemed a success.

In 2015, another team of researchers speculated on the development of a self-spreading vaccine for the Ebola virus that could be used on wild great apes like chimpanzees. Since then, scientists have come to see a wide array of animalsfrom wildlife such as bats, birds, and foxes to domesticated animals like dogs, pigs, and sheepas amenable to self-spreading vaccines.

So far, researchers have not developed experimental self-spreading vaccines for humans; there is no clear evidence that anybody is actively working on the technology. Nuismer and Bull argue, rather, that self-spreading vaccines present a revolutionary approach to control emerging infectious diseases before they even spill over from animals into the human population.

Zoonotic spillover is certainly a pressing problem; alongside SARS-CoV-2, HIV, Ebola virus, and the Zika virus, there are over a thousand other new viruses with zoonotic potential that have been detected in wild animals over the last decade. Prevention is better than a cure, Nuismer and Bull say in a New Scientist article. In their Nature Ecology & Evolution article, they claim they are poised to begin developing self-disseminating vaccines to target a wide range of human pathogens in animals.

Outside of an experiment, scientists would face massive technical and practical hurdles in identifying the most appropriate targets for intervention and ensuring immunity is maintained in the wildlife populations. Despite these substantial challenges, the potential security implications of self-spreading vaccines are even more serious.

The principal security concern is that of dual-use. In essence, this means that the same research that is used to develop self-spreading vaccines to prevent disease, could also be used to deliberately cause harm. You could, for instance, engineer triggers into a virus that cause immune system failures in infected people or animals, a bit like HIV does naturally. Or you could create triggers in a virus that cause a harmful autoimmune response, where the body starts attacking its own healthy cells and tissues.

The bioweapon question. While researchers may intend to make self-spreading vaccines, others could repurpose their science and develop biological weapons. Such a self-spreading weapon may prove uncontrollable and irreversible.

We dont have to dig very deep for a historical example of weaponized biology. As the apartheid-era South African biowarfare program shows, social, political, and scientific pressures can lead to the misuse of biological innovation.

Codenamed Project Coast, South Africas program was primarily focused on covert assassination weapons for use against individuals deemed a threat to the racist apartheid government. In addition to producing contraptions to inject poisons, Project Coast researchers developed techniques to lace sugar cubes with salmonella and cigarettes with Bacillus anthracis.

While there have been many biowarfare programs, including several that were far more elaborate and sophisticated, the South African program is particularly relevant in thinking through malicious uses of self-spreading vaccines. One of Project Coasts research projects aimed at developing a human anti-fertility vaccine.

The idea took hold during a time of widespread concern over worldwide population explosion. Schalk Van Rensburg, who oversaw fertility-related work at a Project Coast laboratory, told South Africas post-apartheid Truth and Reconciliation Commission, a forum for examining the sordid history of the era and laying the foundation for future peace and tolerance, that he thought the project was in line with the World Health Organizations attempts to curb rising global birth rates. He believed it could bring his lab international acclaim and funding. According to Van Rensburg, Wouter Basson, the director of the biowarfare program, said the military needed an anti-fertility vaccine so that female soldiers would not fall pregnant.

While some of the scientists involved in the project denied awareness of ulterior intentions or even that their fertility work was part of a military endeavor, Van Rensburg and Daniel Goosen, a lab director, told the Truth and Reconciliation Commission that the real intention behind the project was to selectively administer the contraceptive in secret to unwitting Black South African women.

In the end, the anti-fertility vaccine was not produced before Project Coast was officially closed down in 1995, 12 years after it was initiated. An early version was tested in baboons, but never in humans. South Africa isnt the only country to try and forcibly sterilize parts of its population. European countries, including Sweden and Switzerland, sterilized members of the Roma minority in the early half of the 20th century and some, like Slovakia, continued even beyond that. More recently, analysts have alleged that the Chinese government is sterilizing women in Xinjiang, a province with a large population of Uighur Muslims.

It doesnt take a massive leap of the imagination to see how the aims of South Africas anti-fertility vaccine project would have benefited from research into self-spreading vaccines, particularly if you combine it with current developments in pharmacogenomics, drug development, and personalized medicine. Taken together, these strands of research could help enable ultra-targeted biological warfare.

An expanding potential for abuse. The Biological Weapons Convention, the treaty that bans biological weapons, is nearly 50 years old. Negotiated and agreed to in the depths of the Cold War, the convention suffers from outdated modes of operation. There are also significant compliance assessment challenges. The convention certainly didnt stop South Africa from pursuing Project Coast in the early 1980s.

Self-spreading vaccine research is a small but growing field. At the moment, about 10 institutions are doing significant work in the area. These laboratories are primarily located in the United States, but some are in Europe and Australia, as well. As the field expands, so does the potential for abuse.

So far research has primarily been bankrolled by US government science and health funders like the National Science Foundation, the National Institutes of Health, and the Department of Health and Human Services. Private organizations like the Gates Foundation and academic institutions have also financed projects. Recently, the Defense Advanced Research Projects Agency (DARPA), sometimes thought of as the US militarys research and development wing, has gotten involved in the research. The University of California, Davis, for example, is working on a DARPA administered project called Prediction of Spillover Potential and Interventional En Masse Animal Vaccination to Prevent Emerging Pathogen Threats in Current and Future Zones of US Military Operation. According to a pamphlet, the project is creating the worlds first prototype of a self-disseminating vaccine designed to induce a high level of herd immunity (wildlife population level protection) against Lassa virus and Ebola.

Military investment in biological innovation for defensive or protective purposes is permissible under the Biological Weapons Convention, but it can still send the wrong signals. It could cause countries to doubt one anothers intentions and lead to tit-for-tat investment in potentially risky research, including in self-spreading vaccines. The result of research gone awry or biowarfare could be catastrophic for health and the environment.

At a time when the norm against chemical weapons is degrading, underscored most recently by the poisoning of Russian opposition leader Alexei Navalny with the nerve agent Novichoka crime for which many European officials blame Russiathe international community simply cant afford to have the same thing happen to the norm against the use of biological weapons. It would completely defy the spirit of the treaty if it seemed like states would even want to pursue high-risk dual use activities in biology.

Early, open, good-faith conversations about scientific aims and advances that cause particular dual-use concerns, as self-spreading vaccines do, are essential to exploring the broader stakes of certain technical trajectories. The University of California, Davis program is pursuing ways to incorporate an off switch to safely control the technology. And DARPA says any field experimentation related to the project would follow biosafety protocols. But these pledges wont suffice. Our ambition must be to make a collective decision about the technical pathways we are willing, or not willing, to take as a society.

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Scientists are working on vaccines that spread like a disease. What could possibly go wrong? - Bulletin of the Atomic Scientists

This transcript has been edited for clarity.

I'm David Kerr, professor of cancer medicine at the University of Oxford. One of my abiding interests has been to apply my old training in clinical pharmacology to how I deliver cancer medicine. I've been a cancer doc for 30 years and one of the recent roads I've traveled has been trying to incorporate pharmacogenetics into my clinical decision pathway. I'm a gastrointestinal oncologist; I treat patients predominantly with colorectal, gastric, and pancreatic cancers. Therefore, the fluoropyrimidines 5-fluorouracil (5-FU) and capecitabine are a central part of my therapeutic armamentarium.

I've talked before about the relevance of the pharmacogenomics of fluoropyrimidines and dihydropyrimidine dehydrogenase (DPD). This is a rate-limiting catabolic enzyme which is responsible for breaking down and destroying fluoropyrimidines. Therefore, it's terribly important. If we find genetic variance which reduces the activity of the enzyme, you get a concomitant increase in the plasma concentration of the 5-FU, and consequently much worse toxicity even to the point of death in some situations or extremely bad toxicity. This is compounded by the fact that 5-FU has nonlinear pharmacokinetics; that means for a small increase in dose you can get a very large increase in plasma concentration. It's a very complicated kinetic situation to be in.

We've instituted DPD testing in our institute in Oxford, I think successfully, and we're seeing a very significant change in reduction in the number of patients being admitted to wards with severe toxicity. I think DPD tests are very good at predicting life-threatening myelosuppression and risk of death, but they're not so good at fluoropyrimidine-induced diarrhea and mucositis.

One thing that interests me, and this is perhaps a more philosophical than scientific question, is how widely do we cast the ethnic net when we build a pharmacogenetic test? I do a lot of work in China. The single nucleotide polymorphisms (SNPs) we've discovered, based on our Western databases, don't apply as readily to our patients who are citizens of Eastern Asian countries.

I have many friends in the Middle East, having worked in Qatar, and I have very strong associations with colleagues in Saudi Arabia and the Middle East. We know that the Arab genome looks significantly different. Also, I work in sub-Saharan Africa, and the SNPs we see in DPD again have different frequencies and prevalences in the African population.

All of us live within a multiethnic society. Although patients in my hospital are predominantly Caucasian, it still seems to me important that we incorporate SNPs, which allow us to detect the possibility of these variants if we're seeing patients from Africa or from other ethnic groups. Rather than focusing and narrowing down in a very small SNP set, as is sometimes recommended, I would rather we had an expanded SNP set, especially in the time of next-generation sequencing when it's relatively easy to expand the SNP signature algorithm to include these different ethnic groups.

We have had a couple of Eastern African patients where, if we had not done the wider SNP that we helped to develop, we would have missed the possibility of being able to dose-reduce somebody who would undoubtedly have had life-threatening toxicity if we'd gone ahead with conventional treatment.

Why is that a philosophical question? So far, pharmacogenomics has been predominantly driven from the West in Caucasian populations. With precision medicine, of course, we understand that we can shape, change, or alter the SNP panel to suit one's local population an Arab SNP test, a Chinese SNP test, and so on. But if we live in a multiethnic society in which we serve a population of patients of many different ethnicities, shouldn't we have a pan test to cover the spectrum of these so that if we do have patients coming from different ethnic backgrounds, a single test with the appropriately wide SNP signature would serve all rather than some? Something to think about.

I would be very interested in your comments and I'd be very happy to engage in discussion about this. For the time being, Medscapers, over and out.

David J. Kerr, CBE, MD, DSc, is a professor of cancer medicine at the University of Oxford. He is recognized internationally for his work in the research and treatment of colorectal cancer and has founded three university spin-out companies: COBRA Therapeutics, Celleron Therapeutics, and Oxford Cancer Biomarkers. In 2002, he was appointed Commander of the British Empire by Queen Elizabeth II.

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It's Time to Cast a Wider Net With DPD Testing - Medscape

The research report on Pharmacogenomics Market gives todays industry data and upcoming developments, allowing you to know the products and quit customers using sales rise and profitability of the market. The record gives a detailed analysis of key drivers, leading market key players, key segments, and regions. These understandings provided in the record would advantage market players to formulate strategies for the destiny and benefit a robust role within the worldwide market.

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Major Companies Covered in Research Report:

Bayer AGBecton, Dickinson and CompanyAffymetrix, Inc.F. Hoffmann-La Roche AGQIAGENAbbott Laboratories, Inc.Bio-Rad Laboratories, Inc.Thermo Fisher Scientific Inc.Illumina, Inc.AstraZeneca PLC

Regional segmentation of the Pharmacogenomics market:

The report also provides the latest market dynamics, industry news like mergers, acquisitions, and investments. The report can help to realize the market and strategize for business expansion accordingly. In the scheme analysis, it gives insights from marketing channel and market positioning to probable growth strategies, providing comprehensive analysis for new entrants or exists competitors in the Pharmacogenomics industry.

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This detailed market study is centered on data obtained from multiple sources and is analyzed using various tools. These tools are engaged to achieve insights on the potential assessment of the industry, facilitating the market strategists with the latest development opportunities. Moreover, these tools also deliver a comprehensive analysis of each application/product segment in the global Pharmacogenomics Market.

Pharmacogenomics Market Segment considering Production, Revenue (Value), Price Trend by Type:

DNA SequencingMicroarray, Polymerase Chain ReactionElectrophoresisMass SpectrometryOthers

Pharmacogenomics Market Segment by Consumption Growth Rate and Market Share by Application:

Drug DiscoveryTailored TreatmentOncologyPain ManagementOther Therapeutic Applications

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Global Pharmacogenomics Market Overview With Detailed Analysis, Competitive Landscape, Emerging Trends , Future Prospects during 2020-2027 - Scientect

Analysis of the Global Pharmacogenomic (PGx) Testing Market

A recent market research report on the Pharmacogenomic (PGx) Testing market published by Fact.MR is an in-depth assessment of the current landscape of the market. Further, the report sheds light on the different segments of the Pharmacogenomic (PGx) Testing market and provides a thorough understanding of the growth potential of each market segment over the forecast period (20XX-20XX).

According to the analysts at Fact.MR, the Pharmacogenomic (PGx) Testing market is evenly poised to register a CAGR growth of ~XX% during the assessment and surpass a value of ~US$ XX by the end of 2029. The report analyzes the micro and macro-economic factors that are likely to impact the growth of the Pharmacogenomic (PGx) Testing market in the upcoming years.

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Segmentation of the Pharmacogenomic (PGx) Testing Market

The presented report dissects the Pharmacogenomic (PGx) Testing market into different segments and ponders over the current and future prospects of each segment. The report depicts the year-on-year growth of each segment and touches upon the different factors that are likely to influence the growth of each market segment.

Competitive landscape

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COVID-19 Analysis

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Pharmacogenomic (PGx) Testing Market to Witness Comprehensive Growth by 2018 to 2028 - The Daily Chronicle