Category Archives: Neurology

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Research and Markets: The Animated Pocket Dictionary of Neurology & Psychiatry - A Must-Have Resource

Free event connecting local patients, families and caregivers with important resources to win the battle against brain disease

WHAT: Brain Health Fair WHERE: New Orleans Ernest N. Morial Convention Center (MCCNO), Exhibit Hall B WHEN: Saturday, April 21, 2012; 9:30 a.m.-3:30 p.m. HOW: FREE Registration Now Open at http://www.BrainHealthFair.com

DETAILS: On Saturday, April 21, the American Academy of Neurology Foundation will host the Brain Health Fair, a free, day-long family event connecting patients, families and caregivers affected by a neurologic disorder with important resources to battle brain disease. Free registration is now open for everyone at http://www.BrainHealthFair.com. This event is scheduled for the opening day of the 64th Annual Meeting of the American Academy of Neurology, which will bring more than 10,000 healthcare professionals to New Orleans April 21-28.

Attendees of the Brain Health Fair will have the opportunity to learn from more than 30 exhibitors and neurologists from around the world about the latest research advances in Alzheimers disease, autism, brain injuries, epilepsy, headaches, multiple sclerosis, Parkinsons disease, stroke and other types of brain disease. The exhibitors will offer tips on topics such as how to prevent diabetes and stroke, how to spot a concussion, support groups, activities for kids and teens and free giveaways and resources.

List of exhibitors includes: American Academy of Neurology (AAN), AAN Patient Education Resources Booth, Agency for Toxic Substances and Disease Registry, Allergan, Inc., Amerigroup Louisiana Healthcare, AxelaCare Health Solutions, Benign Essential Blepharospasm Research Foundation, Inc., Brain Injury Association of Louisiana, Cadwell Laboratories, Inc., Critical Patient Care/Balanceback, Culicchia Neurological Clinic, Dance for PD, Centers for Disease Control and Prevention Division of Injury Response, DiscoverMI.org, Electrical Geodesics, Inc. (EGI), Epilepsy Foundation Louisiana, ForMemory, Inc., Building Hope in Early Onset Cognitive Challenges, Genentech, Genzyme A Sanofi company, Glut1 Deficiency Foundation, International Essential Tremor Foundation (IETF), MedMerits, Inc., Multiple Sclerosis Foundation, National Ataxia Foundation, National MS Society, Louisiana chapter, National Parkinson Foundation, National Spasmodic Torticollis Association, Nicolet CareFusion, Office of Public Health, Parkinson's Action Network, Parkinson's Disease Foundation, Pfizer Inc., Society of Nuclear Medicine, The Secret Gardens Tour, The Sturge-Weber Foundation, UCB, Inc.

The event is sponsored by Genzyme Corporation, a Sanofi company, Neurology Now magazine, PSAV Presentation Services, Peoples Health, Teva Neuroscience, Inc. and in-kind donations from Dance for Parkinsons Disease, the Centers for Disease Control and the National Institute of Neurological Disorders and Stroke.

The AAN, an association of more than 25,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. This years Annual Meeting, including the Brain Health Fair, is expected to generate more than $11 million in economic impact.

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American Academy of Neurology Foundation Hosting FREE Brain Health Fair on April 21

Supplementation with an antioxidant-rich combination of vitamin E, vitamin C and alpha-lipoic acid (ALA) is not associated with changes in important markers for Alzheimers disease, finds new research.

The randomized controlled trial published in JAMAs Archives of Neurology reports thatthe vitamin E, C and ALA combination had no significant effect on cerebrospinal fluid biomarkers related to Alzheimer disease.

Led by Dr Douglas Galasko, of the University of California, San Diego, USA, the research team examined changes in cerebrospinal fluid (CSF) biomarkers related to Alzheimer disease and oxidative stress, cognition and function finding that the combination of the omega-3 fatty acid ALA and vitamins C and E did not affects key biomarkers for Alzheimers disease.

They added that the combination resulted in a lowering of CSF F2-isoprostane levels suggesting a reduction of oxidative stress in the brain. However, Galasko and his colleagues said supplementation also led to faster cognitive declines as assessed by the Mini-Mental State Examination (MMSE).

"It is unclear whether the relatively small reduction in CSF F2-isoprostane level seen in this study may lead to clinical benefits in Alzheimers disease, commented Galasko and his colleagues.

The more rapid MMSE score decline raises a caution and indicates that cognitive performance would need to be assessed if a longer-term clinical trial of this antioxidant combination is considered," they concluded.

Commenting on the study, Dr Harry Rice, vp regulatory & scientific affairs for the omega-3 trade group GOED, told NutraIngredients that he contended such conclusions.

Rice argued that the absence of any cognitive benefits in the current study does not exclude the possibility that supplementation with antioxidants prior to the onset of Alzheimer Disease could provide a neuroprotective benefit such as delaying the onset of symptoms, or slowing the progression of the disease.

Study details

The researchers studied the effects of the combined supplements in 78 patients from the Alzheimer's Disease Cooperative Study (ADCS) Antioxidant Biomarker study. The participants were divided into one of three groups: 800 IU/per day of vitamin E (-tocopherol) plus 500 mg/per day of vitamin C plus 900 mg/per day of -lipoic acid (E/C/ALA); 400 mg of coenzyme Q (CoQ) three times a day; or placebo.

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Clinical trial fails to find antioxidant Alzheimer’s benefit

Public release date: 21-Mar-2012 [ | E-mail | Share ]

Contact: Rachel Seroka rseroka@aan.com 651-695-2738 American Academy of Neurology

ST. PAUL, Minn. A new study suggests that older people may have an increased risk of problems with memory and thinking abilities after being in the hospital, according to research published in the March 21, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology.

"Our study is timely as the United States population continues to rapidly age and researchers try to identify factors that could reduce memory and thinking problems in the elderly," said study author Robert S. Wilson, PhD, of Rush University Medical Center in Chicago. "Understanding a possible link to something as common as hospital stays is extremely important."

The study involved 1,870 people over the age of 65 who lived in Chicago and were interviewed every three years for up to 12 years to test their memory and thinking skills. Of those, 1,335 people, or 71 percent, were hospitalized at least once during the study.

On average, elderly people's scores on tests of memory and thinking skills decline slightly as they age. In the study, researchers found that people's overall scores declined twice as fast after a first hospital stay, compared either to their previous rate before the hospital stay or to people who were not admitted to the hospital. On specific tests, the rate of decline after the first hospital stay was more than three times faster on a long-term memory test and 1.5 times faster on a complex attention test. The results stayed the same even after considering factors such as severe illness, longer hospital stay and older age.

"Further research may help to develop strategies to prevent medical problems in older people that lead to hospital stays. It could also lead to changes in hospital inpatient and discharge policies," said Wilson.

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The study was supported by the National Institutes of Health and the National Institute on Aging.

To learn more about dementia, visit http://www.aan.com/patients.

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Memory problems may increase after being hospitalized

19-03-2012 13:19 lyremilan.blogspot.ca These videos are designed for medical students studying for the USMLE step 1. Feel free to comment and suggest what you would like to see in the future, and I will do my best to fulfill those requests.

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USMLE NEUROLOGY INTRODUCTION - Video

Featured Article Academic Journal Main Category: Alzheimer's / Dementia Also Included In: Nutrition / Diet;Neurology / Neuroscience Article Date: 20 Mar 2012 - 3:00 PDT

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First author Dr Douglas R. Galasko, from the Department of Neuroscience at the University of California San Diego, and colleagues describe how they tested for the effects of a combination of vitamin E, vitamin C and alpha-lipoic acid (E/C/ALA) on levels of CSF biomarkers.

Alzheimer's disease is characterized by an abundance of beta-amyloid protein plaques that clog up the spaces between brain cells and tau-based neurofibrillary tangles that clog up the insides of brain cells. Certain proteins in spinal fluid relate to this amyloid and tau pathology and serve as reliable biomarkers for the disease.

Metabolic reactions in the body produce free radicals that interact with other molecules to cause oxidative damage to proteins, membranes and genes. This influences the aging process and is also linked to disease, including cancer and Alzheimer's. In fact, oxidative damage in the brain is widespread among people with Alzheimer's disease.

The body defends against oxidative damage by producing antioxidants to mop up free radicals. Genes, environment and lifestyle (eg diet, smoking, exercise) determine how well it does this.

Increasing intake of antioxidants can boost the body's ability to defend itself against oxidative damage, and Galasko and colleagues write that some observational studies have suggested that a diet rich in antioxidants can reduce the risk of Alzheimer's disease, but randomized clinical trials have shown mixed results.

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Alzheimer's Biomarkers Unaffected By Antioxidants