Category Archives: Neurology

What happened to "Grand Rounds" medblog carnival?

It's sad to see the demise of "Grand Rounds" medblog carnival. The weekly summary of the best medical blog posts has been published since 2004, with only few breaks. There have not been any editions for more than a month, and no new ones are scheduled. A new initiative by Health Care SoMedia Review could replace some of it http://goo.gl/73RpE

This blog post is a part of a project to recreate a weekly review, or blog carnival, of the best medical blog posts. Feel free to send your suggestions to my email at clinicalcases@gmail.com. The “Best of Medical Blogs - weekly review, blog carnival” will be published on Tuesdays, just like the old Grand Rounds. The last organizers of the Grand Rounds blog carnival. @DrVal and @NickGenes, are aware of this project.

How Doctors Manage Their Social Media Profiles

Personal vs. Professional: How Doctors Manage Their Social Media Profiles is a blog post by Matt Wood of the University of Chicago Medicine blog http://goo.gl/JNyu1. Matt has published a series of great blog posts recently about physicians’ use social media. The doctors at University of Chicago are clearly the leaders in social media use in a city with a rich history of great medical centers such as UChicago Medicine, Northwestern, Childrens’ Memorial, Rush, Loyola and Northshore. Matt tries to find out what makes the UChicago doctors more comfortable using social media that their peers at other institutions: http://goo.gl/JNyu1

Consumers use social media to make medical decisions

Consumer Expectations for Healthcare Social Media - this is a succinct summary by Ed Bennett, “a maker of lists” of healtchare oragnizations that use social media http://goo.gl/REXqV

Digital Strategies for Healthcare Organisations - a good overview by the Australian blog IV line http://goo.gl/PZtWl

Doctors’ salaries

Dr. Mandrola quotes an experienced colleague on doctors' salaries: “We are all happy with what we make. What upsets us most is seeing what others make.” Since then, I try not to dwell on what others make. http://goo.gl/WBnJq

Healthcare social media is a “moral obligation” for doctors

Healthcare social media is a 'moral obligation', says Farris Timimi, M.D., medical director for the Mayo Clinic Center for Social Media, quoted by “Fierce Health IT” . Social media needs to be grown and nurtured for patients. "Our patients are there. Our moral obligation is to meet them where they're at and give them the information they need so they can seek recovery," Dr. Timimi said. "You've got to be ready for it. You build it for the patients; not for yourself. "This is not marketing," he added. "This is the right thing to do." http://goo.gl/BHzKf

Social media is no more a moral obligation for doctors than it is to appear on TV and radio shows, and to write newspaper columns. It is great if you have the time and aptitude to do it, but the most important things is to focus on what matters most - providing correct diagnosis and best possible treatment to your patients.

Comments from Twitter:

Westby Fisher, MD @doctorwes: Best of Medical Blogs - weekly review, RIP blog carnival bit.ly/KsBSLJ

Laika (Jacqueline) @laikas: After the demise of THE Grand Rounds @DrVes starts his own weekly blog review bit.ly/Iqgcmx Gr8 initiative; but still miss the OLD GR

WB Medical Education @WBmeded: Hope to check out some of these later, looks interesting RT @DrVes: Best of Medical Blogs: weekly review, blog carnival goo.gl/fb/d870P

Mike Cadogan @sandnsurf: Another great way to control the information overload with the Best of Medical Blogs - weekly review bit.ly/K1stxo

Source:
http://feeds.feedburner.com/CasesBlog

"What is the minimal webmaster competence for running a medical blog?", asked a relatively new blogger recently. My suggestions are listed below.

Keep it simple, and free

If your blog content is great and compelling, you don't need much HTML, CSS, etc. knowledge. Knowing HTML doesn't hurt, of course, but it's not essential.

Keep it simple, and free. Many doctors are wrongly advised to spend time and money on custom installations of WordPress, hosting, and social media consultatants when all they need is a free Google/Blogger blog with a custom domain name.

"Blogging is teaching, whether it’s yourself or others, and that’s the best feeling in the world" 

Speaking from personal experience, my blogs reached more than 8 million page views and I've never used outside help for blog launch or maintenance. I don't think my blog content is that great or original apart from a few mind map diagrams, mnemonics and social media how-to articles - it's just my personal digital netbook that I share with the world.

I typically publish one post per day during the week at CasesBlog and AllergyNotes. They are scheduled 2-3 months in advance, and publish automatically, unless I edit them the day before they are due for posting.

"Blogging is teaching, whether it’s yourself or others, and that’s the best feeling in the world" http://goo.gl/hCpF8

Comments from Google Plus:

Ahmad Gandour, Jan 25, 2012: This is a great advice i will consider starting a blog in the near future .you really post interesting post i check your post every day in the morning while i am checking journal watch and BEJM news letter thanks for these great post .?

Ves Dimov, M.D., Jan 25, 2012: Thank you for your interest. I typically publish one post per day during the week at CasesBlog and AllergyNotes. They are scheduled 2-3 months in advance, and publish automatically, unless I edit them the day before they are due for posting.?

Ahmad Gandour, Jan 25, 2012: Thanks for the info i booked marked the both pages i am going to check it every day?

Ves Dimov, M.D., Jan 25, 2012: You can subscribe to the RSS feeds - this way there is no need to visit the website every day - the new post gets delivered to your RSS reader (Google Reader) or email.?

Ahmad Gandour, Jan 25, 2012: Done :)?

Jill Celeste, Jan 25, 2012: Blogger is the perfect tool for a doctor. Great post!?

Source:
http://feeds.feedburner.com/CasesBlog

01-05-2012 12:04 Daryl A. Bosco, PhD, assistant professor of neurology at the University of Massachusetts Medical School and a protein chemist investigating the causes of ALS (Lou Gehrig's Disease), talks about research at UMMS that identifies the toxic proteins that cause the disease and how that work indicates new therapeutic directions for ALS research, including RNA interference, immunotherapy and the search for small molecules that might target the rogue proteins.

See original here:
Daryl Bosco, PhD: Assistant Professor of Neurology - Video

Public release date: 2-May-2012 [ | E-mail | Share ]

Contact: Rachel Seroka rseroka@aan.com 651-695-2738 American Academy of Neurology

MINNEAPOLIS A new study suggests that eating foods that contain omega-3 fatty acids, such as fish, chicken, salad dressing and nuts, may be associated with lower blood levels of a protein related to Alzheimer's disease and memory problems. The research is published in the May 2, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology.

"While it's not easy to measure the level of beta-amyloid deposits in the brain in this type of study, it is relatively easy to measure the levels of beta-amyloid in the blood, which, to a certain degree, relates to the level in the brain," said study author Nikolaos Scarmeas, MD, MS, with Columbia University Medical Center in New York and a member of the American Academy of Neurology.

For the study, 1,219 people older than age 65, free of dementia, provided information about their diet for an average of 1.2 years before their blood was tested for the beta-amyloid. Researchers looked specifically at 10 nutrients, including saturated fatty acids, omega-3 and omega-6 polyunsaturated fatty acids, mono-unsaturated fatty acid, vitamin E, vitamin C, beta-carotene, vitamin B12, folate and vitamin D.

The study found that the more omega-3 fatty acids a person took in, the lower their blood beta-amyloid levels. Consuming one gram of omega-3 per day (equal to approximately half a fillet of salmon per week) more than the average omega-3 consumed by people in the study is associated with 20 to 30 percent lower blood beta-amyloid levels.

Other nutrients were not associated with plasma beta-amyloid levels. The results stayed the same after adjusting for age, education, gender, ethnicity, amount of calories consumed and whether a participant had the APOE gene, a risk factor for Alzheimer's disease.

"Determining through further research whether omega-3 fatty acids or other nutrients relate to spinal fluid or brain beta-amyloid levels or levels of other Alzheimer's disease related proteins can strengthen our confidence on beneficial effects of parts of our diet in preventing dementia," said Scarmeas.

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The study was supported by the National Institute on Aging.

More here:
Eating fish, chicken, nuts may lower risk of Alzheimer's disease

Editor's Choice Main Category: Epilepsy Also Included In: Neurology / Neuroscience;Pediatrics / Children's Health Article Date: 02 May 2012 - 13:00 PDT

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The device could potentially collect clinically useful data from epilepsy patients during their daily routines instead of having to visit the hospital for observation. If the early results are confirmed, the device would even be able to alert patients to seek immediate medical attention when their seizures are severe enough.

Professor of media arts and sciences at MIT, Rosalind Picard, and her team originally designed the sensors to measure the emotional states of children with autism given that their outward behavior can be different to that what they actual feel. The sensor measures the skin's electrical conductance, which indicates the state of the sympathetic nervous system that controls the human fight-or-flight response.

The study, conducted at the Children's Hospital in Boston, revealed that the higher a patient's skin conductance is during a seizure, the longer it took for the patient's brain to resume neural oscillations, i.e. brain waves that are measured by EEGs.

According to at least one clinical study, there is a correlation between the duration of brain-wave suppression after seizures and the number of sudden unexplained deaths in epilepsy (SUDEP) that can occur hours after a seizure. In the U.S. alone, thousands of people die from SUDEP.

At present, epileptic patients may use various criteria, one of them being the duration of the seizure, to establish whether a seizure is severe enough to seek immediate medical attention.

However, Picard says:

See more here:
New Wristband For Epileptic Seizures Shows Promise

MELBOURNE, AUSTRALIA--(Marketwire -05/01/12)- Prana Biotechnology (PRAN - News) (PBT.AX - News) today commented on the publication of new data of relevance to the current clinical trial, testing Prana's PBT2 as a treatment for Huntington disease.

The authors of the publication are led by Professor Diana Rosas of the Center for Neuroimaging of Aging and Neurodegenerative disease at Massachusetts General Hospital (MGH) in Boston. The paper, titled "Alterations in Brain Transition Metals in HD," published in the Archives of Neurology* describes how the rise in levels of Iron in the brains of people carrying the mutant gene which causes Huntington disease, correlates with the severity of symptoms and also predicts the time of disease onset. The article concluded that "an important and early role of altered metal homeostasis is suggested in the pathogenesis of Huntington disease" and this points to "metals as potential therapeutic targets." Selected patients in the current Reach2HD trial, testing PBT2, will be monitored using the imaging technology described in the publication.

According to Professor Rudy Tanzi, Prana's Chief Scientific Advisor and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University, "The new findings serve to further support the role of brain metal imbalances in the pathology of neurodegenerative diseases such as Alzheimer's disease and Huntington disease. It is becoming increasingly clear that PBT2 and Prana's other metal chaperone drugs could have broad utility as powerful modifiers of disease progress in a growing number of neurodegenerative diseases caused by misfolded proteins."

Ira Shoulson MD, Professor of Neurology, Pharmacology and Human Science at Georgetown University (Washington DC) and the Chair of the Executive Committee of the Huntington Study Group, said, "The data from the Harvard group are very encouraging and timely. The Reach2HD trial is underway and intended to characterize the safety and dosing parameters of PBT2, an experimental drug aimed at restoring function to neurons damaged by the pathological interaction between the mutant Huntingtin protein and transition metals. PBT2 has signaled some cognitive benefit in patients with Alzheimer disease that may also involve a pathological interaction between a protein and transition metals."

Huntington disease is a complex and severely debilitating genetic, neurodegenerative disease, for which there is no cure. It is caused by an abnormally high number of repeats of a DNA sequence (CAG) which encodes for the amino acid glutamine. The disease often affects young adults and, whilst associated with severe physical movement symptoms, progressively impacts the mind and emotions as well. The disease causes incapacitation and death about 15-25 years after onset. The disease affects 30,000 people in the US and about 70,000 worldwide.

There are no drugs either available or in development that have established clinical evidence for treating the cognitive decline associated with Huntington disease. In this study, Prana aims to demonstrate cognitive improvements as already demonstrated in a Phase IIa study in mild Alzheimer's patients treated with PBT2. The study will also investigate safety, functional, behavioural and motor benefits in this Huntington patient population.

PBT2 is concurrently being tested in a Phase II trial in Alzheimer's disease.

Key points from the publication

Using an advanced non-invasive MRI Imaging technique with pre-symptomatic and symptomatic patients, the authors show that:

The authors found that the MRI data correlated well with the levels and anatomical distribution of iron in postmortem brain tissue.

The rest is here:
Prana Comments on Archives of Neurology Publication Which Highlights Critical Role of Brain Metals in Huntington ...