Category Archives: Neurology

Patients with a rare type of Alzheimer's disease do not show the memory loss characteristic of the condition even over the long term, new research suggests. They also show some differences in neuropathology to typical Alzheimer's patients, raising hopes of discovering novel mechanisms that might protect against memory loss in typical forms of the disease.

Dr Marsel Mesulam

"We are discovering that Alzheimer's disease has more than one form. While the typical Alzheimer's patient will have impaired memory, patients with primary progressive aphasia linked to Alzheimer's disease are quite different. They have problems with language they know what they want to say but can't find the words but their memory is intact," lead author Marsel Mesulam, MD, told Medscape Medical News.

"We have found that these patients still show the same levels of neurofibrillary tangles which destroy neurons in the memory part of the brain as typical Alzheimer's patients, but in patients with primary progressive aphasia Alzheimer's the nondominant side of this part of the brain showed less atrophy," added Mesulam, who is director of the Mesulam Center for Cognitive Neurology and Alzheimer's Disease at Northwestern University Feinberg School of Medicine, Chicago, Illinois. "It appears that these patients are more resilient to the effects of the neurofibrillary tangles."

The researchers also found that two biomarkers that are established risk factors in typical Alzheimer's disease do not appear to be risk factors for the primary progressive aphasia (PPA) form of the condition.

"These observations suggest that there are mechanisms that may protect the brain from Alzheimer's-type damage. Studying these patients with this primary progressive aphasia form of Alzheimer's may give us clues as to where to look for these mechanisms that may lead to new treatments for the memory loss associated with typical Alzheimer's disease," Mesulam commented.

The study was published online in the January 13 issue of Neurology.

PPA is diagnosed when language impairment emerges on a background of preserved memory and behavior, with about 40% of cases representing atypical manifestations of Alzheimer's disease, the researchers explain.

"While we knew that the memories of people with primary progressive aphasia were not affected at first, we did not know if they maintained their memory functioning over years," Mesulam noted.

The current study aimed to investigate whether the memory preservation in PPA linked to Alzheimer's is a consistent core feature or a transient finding confined to initial presentation, and to explore the underlying pathology of the condition.

The researchers searched their database to identify patients with PPA with autopsy or biomarker evidence of Alzheimer's, who also had at least two consecutive visits during which language and memory assessment had been obtained with the same tests.

The study included 17 patients with the PPA-type Alzheimer's disease. They were compared with 14 patients who had typical Alzheimer's disease with memory loss.

The authors point out that characterization of memory in patients with PPA is challenging because most tests use word lists, and thus patients may fail the test because of their language impairments. To address this issue, they included patients with PPA who had had memory tests involving recalling pictures of common objects.

Patients with typical Alzheimer's disease underwent similar tests but used a list of common words.

A second round of tests was conducted in the primary progressive aphasia group an average of 2.4 years later and in the typical Alzheimer's group an average of 1.7 years later.

Brain scans were also available for the patients with PPA, as well as postmortem evaluations for eight of the PPA cases and all the typical Alzheimer's cases.

Results showed that patients with PPA had no decline in their memory skills when they took the tests a second time. At that point, they had been showing symptoms of the disorder for an average of 6 years. In contrast, their language skills declined significantly during the same period. For typical Alzheimer's patients, verbal memory and language skills declined with equal severity during the study.

Postmortem results showed that the two groups had comparable degrees of Alzheimer's pathology in the medial temporal lobe the main area of the brain affected in dementia.

However, MRI scans showed that patients with PPA had an asymmetrical atrophy of the dominant (left) hemisphere with sparing of the right sided medial temporal lobe, indicating a lack of neurodegeneration in the nondominant hemisphere, despite the presence of Alzheimer's pathology.

It was also found that the patients with PPA had significantly lower prevalence of two factors strongly linked to Alzheimer's TDP-43 pathology and APOE 4 positivity than the typical Alzheimer's patients.

The authors conclude that: "Primary progressive aphasia Alzheimer's syndrome offers unique opportunities for exploring the biological foundations of these phenomena that interactively modulate the impact of Alzheimer's neuropathology on cognitive function."

In an accompanying editorial, Seyed Ahmad Sajjadi, MD, University of California, Irvine; Sharon Ash, PhD, University of Pennsylvania, Philadelphia; and Stefano Cappa, MD, University School for Advanced Studies, Pavia, Italy, say these findings have important implications, "as ultimately, preservation of cognition is the holy grail of research in this area."

They point out that the current observations imply "an uncoupling of neurodegeneration and pathology" in patients with PPA-type Alzheimer's, adding that "it seems reasonable to conclude that neurodegeneration, and not mere presence of pathology, is what correlates with clinical presentation in these patients."

The editorialists note that the study has some limitations: the sample size is relatively small; not all patients with PPA-type Alzheimer's underwent autopsy; MRI was only available for the aphasia group; and the two groups had different memory tests for comparison of their recognition memory.

But they conclude that this study "provides important insights about the potential reasons for differential vulnerability of the neural substrate of memory in those with different clinical presentations of Alzheimers pathology."

The study was supported by the National Institute on Deafness and Communication Disorders, the National Institute of Neurological Disorders and Stroke, the National Institute on Aging, the Davee Foundation, and the Jeanine Jones Fund.

Neurol. Published online January 13, 2021. Abstract, Editorial

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Type of Alzheimer's With Intact Memory Offers New Research Paths - Medscape

TORONTO, Jan. 19, 2021 (GLOBE NEWSWIRE) -- Newscope Capital Corporation (CSE: PHRM) (OTCQB: PHRRF), who through its wholly-owned subsidiary, PharmaTher Inc. (PharmaTher), is a specialty life sciences company focused on the research and development of psychedelic pharmaceuticals, is pleased to announce that PharmaTher has entered into an Exclusive Worldwide License Agreement (the Agreement) with the National Health Research Institutes (NHRI) for the development and commercialization of a patented combination formulation of FDA-approved ketamine and betaine (KETABET) as a potential next-generation ketamine treatment for mental health, neurological and pain disorders.

KETABET has shown in clinical research to enhance the antidepressant effect while having the potential to significantly reduce the known negative side effects of ketamine.1 Side effects such as hallucinations, confusion, memory loss and abuse liability compromise the compliance and potential therapeutic value of ketamine.

Through a proprietary microneedle (MN) patch, KETABET aims to empower patients to dose their medication remotely, safely and conveniently rather than being under supervision by a healthcare provider at a certified medical office. KETABET MN patch has the potential to incorporate anti-tampering and anti-abuse features because of the combined presence of ketamine and betaine and the delivery format of the product that would parallel the approach used for the tamper-resistant transdermal fentanyl patch.

PharmaTher will seek FDA approval to conduct a Phase II clinical study for KETABET targeting the more than 300 million people who suffer from major depressive disorder and 100 million people who are resistant to available treatments worldwide.

We believe KETABET has the potential to change the way mental health, neurological and pain disorders will be treated for the hundreds of millions of people globally who are suffering from these debilitating conditions, said Fabio Chianelli, CEO of PharmaTher. We are pursuing the clinical development of KETABET to overcome the current limitations of ketamine and to unlock the known potential therapeutic value of ketamine for FDA approval.

Currently, pharmaceutical companies are developing new types of antidepressants. Approved antidepressants have significant limitations, including delayed response rates and unwanted side effects causing poor patient compliance and low remission rates.

Ketamine was approved by the FDA in 1970 and is clinically used for analgesia, sedation, and anesthetic induction.

Ketamine is emerging as a viable treatment option for depression. Recent clinical studies have shown that low dose ketamine produces a rapid-acting and sustained antidepressant effect in major depressive disorder2, bipolar depression3, depression with suicidal ideation4 and post-traumatic stress disorder5. Despite this, the potential for abuse and misuse of ketamine and the adverse mental effects of ketamine use such as dissociative, hallucinogenic, and amnesic effects6 leads to its limited clinical use and discontinuation.

The FDA granted Fast Track and Breakthrough Therapy designations for SPRAVATO (esketamine) nasal spray. In March 2019, the FDA approved SPRAVATO, in conjunction with an oral antidepressant, for treatment-resistant depression to Janssen Pharmaceuticals, Inc. According to the FDA, because of the risk of serious adverse outcomes resulting from sedation and dissociation caused by Spravato administration, and the potential for abuse and misuse of the drug, it is only available through a restricted distribution system, under a Risk Evaluation and Mitigation Strategy.7 The estimated annual cost per patient for SPRAVATO could cost up to $49 thousand with limited reimbursement, whereas intravenous ketamine could cost up to $5,000 per patient annually without any reimbursement. Both require numerous administration sessions in a certified medical office under medical supervision by a health care provider.

COMPASS Pathways plc is developing COMP360 psilocybin therapy to be administered in conjunction with psychological support for treatment-resistant depression. In 2019, Compass Pathways plc completed a Phase I clinical trial and is currently evaluating COMP360 in a Phase IIb trial. The therapy protocol for COMP360, which would last approximately six to eight hours, includes the presence of a therapist and assisting therapist throughout the treatment session.8

PharmaTher aims to develop KETABET in a proprietary microneedle patch for FDA approval in certain mental health, neurological and pain disorders and provide the patient with a potentially convenient, safe and effective ketamine treatment through the combination of two FDA-approved drugs, ketamine and betaine.

Betaine anhydrous (CYSTADANE) was approved by the FDA in 1996 for the treatment of homocystinuria to decrease elevated homocysteine blood concentrations.

There is growing evidence that betaine plays a critical role in regulating brain functions and has an antidepressant-like effect.9 Betaine has been reported to prevent seizures in rodents10, to improve symptoms of Rett syndrome11, and to delay the onset of neurologic impairment due to vitamin B12 deficiency12 clinically. Furthermore, betaine attenuates memory deficits induced by homocysteine.13

Based on preclinical studies that supported the granted patent and patent applications of KETABET, the combination of ketamine and betaine produced more robust antidepressant-like responses than their individual effects and that the combination blocked the psychotomimetic effects of ketamine.1 This suggests that betaine can be considered as an add-on therapy to ketamine or as a fixed-dose combination therapy for treatment-resistant depression, treatment-resistant bipolar disorder, post-traumatic stress disorder, obsessive-compulsive disorder and chronic pain.

Under the terms of the Agreement, PharmaTher gained exclusive worldwide development and commercial rights to an intellectual property portfolio consisting of a granted patent (Taiwan patent: I648049) and patent applications (International Publication Number: WO2017205666A1) titled, Method and composition for decreasing the psychotomimetic side effect and addictive disorder of ketamine in the U.S., Europe, Japan, Canada, Israel and China.

Consistent with industry standards, PharmaTher paid a one-time fee for entering into the Agreement, and all other future payments will be based on clinical trial and revenue milestones reached by PharmaTher.

About The National Health Research Institutes

The National Health Research Institutes (NHRI) is a non-profit foundation established in 1995 by the government of Taiwan. Being an autonomous research organization under the supervision of the Department of Health, the NHRI is dedicated to the enhancement of medical research and the improvement of health care in this country. Scientists at the NHRI conduct mission-oriented medical research and investigate many aspects of the basic biomedical sciences, as well as specific diseases. These range from the common problems such as aging, cancer, infectious diseases, mental disorders, occupational diseases, to health policy. For more information about the NHRI visit http://www.nhri.edu.tw.

About PharmaTher Inc.

PharmaTher Inc., a wholly-owned subsidiary of Newscope Capital Corporation (CSE: PHRM) (OTCQB: PHRRF), is a specialty life sciences company focused on the research and development of psychedelic pharmaceuticals, such as ketamine and psilocybin, for FDA approval to treat mental health, neurological and pain disorders.

Learn more at:PharmaTher.comand follow us on Twitter,LinkedIn andFacebook.

For more information, please contact:

Fabio ChianelliChief Executive OfficerPharmaTher Inc.Tel: 1-888-846-3171Email: info@pharmather.comWebsite: http://www.pharmather.com

Neither the Canadian Securities Exchange nor its Regulation Services Provider have reviewed or accept responsibility for the adequacy or accuracy of this release.

Cautionary Statement

This press release contains forward-looking information within the meaning of applicable Canadian securities legislation. These statements relate to future events or future performance. The use of any of the words could, intend, expect, believe, will, projected, estimated, potential and similar expressions and statements relating to matters that are not historical facts are intended to identify forward-looking information and are based on theNewscope Capital Corporations (the Company)current belief or assumptions as to the outcome and timing of such future events. Forward-looking information in this press release includes information with respect to development and commercialization of a patented combination formulation of FDA-approved ketamine and betaine (KETABET) as a potential next-generation ketamine treatment for mental health, neurological and pain disorders, KETABET aims to empower patients to dose their medication remotely, safely and conveniently rather than being under supervision by a healthcare provider at a certified medical office, KETABET MN patch has the potential to incorporate anti-tampering and anti-abuse features, seek FDA approval to conduct a Phase II clinical study, intellectual property portfolio,psychedelic pharmaceuticals,psilocybin andketamine programs and product developments.Forward-looking information is based on reasonable assumptions that have been made by the Company at the date of the information and is subject to known and unknown risks, uncertainties, and other factors that may cause actual results or events to differ materially from those anticipated in the forward-looking information. Given these risks, uncertainties and assumptions, you should not unduly rely on these forward-looking statements. The forward-looking information contained in this press release is made as of the date hereof, and Company is not obligated to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, except as required by applicable securities laws. The foregoing statements expressly qualify any forward-looking information contained herein. Factors that could cause actual results to differ materially from those anticipated in these forward-looking statements are described under the caption Risk Factors in Companys managements discussion and analysis for the period of August 30, 2020 (MD&A), dated October 1, 2020, which is available on the Companys profile atwww.sedar.com.

This news release does not constitute an offer to sell or the solicitation of an offer to buy, and shall not constitute an offer, solicitation or sale in any state, province, territory or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state, province, territory or jurisdiction.

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PharmaTher Signs Exclusive Worldwide License Agreement for Patented Ketamine Formulation Targeting Mental Health, Neurological and Pain Disorders -...

Recovering from trauma can often be difficult and slow going. What works for one person may not help someone else at all.

This is because people respond to trauma differently, and the effects of trauma can be complicated.

Trauma can cause physiological, neurological, and emotional effects some short-lived and others much longer lasting. When the effects of trauma dont go away or disrupt daily life, you may be experiencing post-traumatic stress disorder (PTSD).

Heres whats known about the treatment options for PTSD and what research tells us about the effectiveness of these treatments.

When you experience a traumatic event, your hypothalamic, pituitary, and adrenal systems release a surge of hormones to prepare you to fight, flee, or freeze.

In response, your heart rate speeds up, your breathing quickens, and your muscles tense. Your field of vision may narrow, your short-term memory may seem to go blank, and you might feel a sense of panic.

Even after the traumatic event ends, these symptoms can come and go for days or weeks.

You may have panic attacks or nightmares in response to similar sights, sounds, and smells even when theres no actual danger present.

In some cases, these symptoms persist for years. When symptoms continue for more than a month, you may be diagnosed with PTSD.

Around 10 to 20 percent of people who experience a trauma will develop PTSD symptoms afterward.

PTSD has been the focus of quite a lot of research. Several medications and therapeutic approaches have been shown effective in treatment.

Lets look at each of these treatment options in more detail:

Some forms of psychotherapy also known as talk therapy are effective treatments for PTSD.

Most of them are based on cognitive behavioral therapy (CBT), a kind of talk therapy that aims to identify and correct unhealthy and unrealistic thought patterns.

Cognitive processing therapy (CPT) is based on the idea that immediately following a trauma, you were probably not able to fully process what happened to you.

In trying to understand the event and how it affected you, you might later come to conclusions that arent healthy.

You might, for example, decide that its not safe to trust anyone, or you might believe that youre to blame for what happened.

CPT aims to identify those incorrect conclusions and restructure them in healthier ways. This kind of therapy usually takes place in around 12 sessions, during which you and your therapist work together to process what happened through talking or writing about the experience.

Like CPT, prolonged exposure therapy addresses the tendency to adopt unhealthy thinking patterns in the aftermath of a traumatic event.

For example, as a result of trauma, you may have developed a fear response thats out of proportion to the dangers you face.

To change your fear response, prolonged exposure therapy begins with some education about PTSD symptoms. Your therapist will equip you with skills to calm down and cope when you face something frightening.

Once youve learned self-calming techniques, you and your therapist will create a hierarchy of fears.

Youll start with things you find slightly scary and progress to more intense fears possibly those related to the trauma you experienced. You wont progress to the next level on your hierarchy until you and your therapist are satisfied you can handle each one.

Over several months of treatment, you and your therapist will work together to help you face your fears, allowing you to practice new coping skills.

Youll learn that your thoughts and memories related to the trauma arent actually dangerous and dont need to be avoided.

Many of the long-term effects of PTSD are neurological. For that reason, treatments that focus on the brain and nervous system have been found to be particularly effective at restoring function and reducing symptoms.

Eye movement desensitization and reprocessing (EMDR) is a therapy that uses repetitive eye movements to interrupt and re-pattern some of the trauma-related memories you have.

After talking about your history, you and your therapist will select a memory that you find particularly difficult.

While you bring the details of that memory to mind, your therapist will guide you through a series of side-to-side eye movements. As you learn to process the memory and related feelings it brings up, youll gradually be able to reframe that memory in a more positive light.

A 2018 review of research found that when provided by an experienced therapist, EMDR has the ability to reduce many symptoms of PTSD, including anxiety, depression, fatigue, and paranoid thought patterns.

Its a low-cost therapy, has few if any side effects, and is recommended by the World Health Organization (WHO) for treatment of PTSD.

Tapping is one element of a treatment approach called clinical emotional freedom technique (EFT).

Its similar to acupressure, a kind of massage treatment that uses physical pressure on certain sensitive points of the skin to relieve pain and muscle tension.

In a series of 4 to 10 sessions, a trained therapist can teach you how to tap certain rhythms on your hands, head, face, and collarbones while you actively reframe your memories of a traumatic event.

Tapping is often used along with cognitive and exposure therapies.

Studies have found that EFT therapies can reduce PTSD symptoms especially anxiety, depression, and pain.

EFT therapies may also decrease the amount of cortisol (a stress hormone) in your body.

Although you can eventually use tapping on your own, its important to work with a trained, licensed therapist as youre learning the techniques.

The short answer is a lot. A good starting place is to recognize the skills that enabled you to survive the trauma, even if those skills dont necessarily serve you well today.

You can also explore the many resources that have been developed to help trauma survivors recover from PTSD and regain their mental and physical health.

The National Center for PTSD provides a number of resources, including:

One of the most effective ways to process trauma is by writing.

Research has shown that writing about the traumatic event in several short sessions may help reduce symptoms of PTSD significantly.

In fact, some research has shown that combining writing with other therapies may help shorten your treatment time.

You dont necessarily have to write about the traumatic event on its own. Writing about your life as a whole, including traumatic events, may also help reduce PTSD symptoms.

An older study suggests that writing may also help lower blood pressure, improve anxiety and depression symptoms, and help with behavioral problems in children with PTSD.

Recent studies have shown that meditation and yoga are helpful complementary therapies for people with PTSD.

While yoga or meditation may not provide complete relief from symptoms, researchers recommend them as additions to therapy and medication.

Yoga may help you regulate your breathing, increase your awareness of your body, and respond to changing emotions.

Meditation may help you redirect your attention to the present moment, giving you a greater sense of control over intrusive memories.

To find a therapist who can help you with PTSD, consider the following strategies:

And finally, give yourself permission to change therapists.

The first therapist you visit might not turn out to be a good fit. Its OK to consider your initial visits as a kind of interview process to find the therapist thats right for you.

Most insurance plans offer some coverage for mental health services, although deductible amounts and copays will vary from policy to policy.

Original Medicare, Medicare Advantage plans, and Medicaid also provide mental health benefits.

If you dont have health insurance and youre looking for affordable PTSD treatment, try looking for a therapist who has a sliding-scale fee structure.

This search tool may be useful. The Open Path Psychotherapy Collective is another good option.

And if you need low-cost or free therapy, a community mental health center near you is an excellent starting point.

Trauma can cause physiological, neurological, and emotional effects. If the effects of trauma last longer than a month, or cause disruptions in your normal way of functioning, you may have PTSD.

The gold standard for treating PTSD symptoms is psychotherapy, particularly cognitive behavioral therapy, cognitive processing therapy, and prolonged exposure therapy.

EMDR and EFT have also shown promise in helping people recover from PTSD.

The effects of trauma are real and can have a powerful effect on the quality of your life, long after the event is over. But with time and the right treatment, there are ways to lessen the negative effects and restore your health and well-being.

See the article here:
PTSD Treatment: What Are the Most Effective Therapy Options? - Healthline

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In a paper published today in Nature Communications, Dr. Marco Capogrosso, assistant professor in the Department of Neurological Surgery at the University of Pittsburgh School of Medicine, proposed a new technology to improve arm and hand movements in individuals with arm paralysis due to spinal cord injury, stroke or other movement disorders.

In collaboration with colleagues in Switzerland, Capogrosso and his team combined physics simulations with experiments in macaque monkeys and humans to demonstrate that epidural electrical stimulation of specific regions in the spinal cord can be used to activate arm and hand muscles.

This work is very important for clinical applications, said Capogrosso, senior author of the paper, who is also part of the Pitt Rehab Neural Engineering Labs. To design effective therapies for paralysis, we need to selectively engage hand and arm muscles by providing the surviving neural circuits with appropriate electrical signals. In practice, this means that we need to know where to implant electrodes and how to design them and our work provides guidance to that.

Epidural stimulation is a neurotechnology that is used to treat pain caused by damage or injury to the nerves in thousands of patients every year. For this procedure, a surgeon implants a small neurostimulation device consisting of thin electrode wires over the spinal cords protective coating. When the device is turned on, it can send electric signals to the damaged nerve fibers and stimulate them, restoring the spinal circuits and dampening the feeling of pain after the injury.

However, modern spinal cord stimulators are not intended to target the cervical neural circuits necessary for arm and hand movement. Therefore, the scientists proposed and tested a modified design of multi-electrode spinal implants that were fitted to monkeys spinal cord dimensions.

To determine the optimal placement of electrodes in the cervical spinal cord where neural circuits that control arm movements are located researchers used insights from in silico, or computer, experiments and reproduced them in monkeys. Combining computer simulation with animal studies allowed researchers to reduce the number of animals needed to collect meaningful data as part of an effort called the Three Rs (Replacement, Reduction, Refinement) that strives to minimize the use of animals in research. And, because the monkeys cervical spine is anatomically and functionally similar to the humans, scientists were able to approximate the arm and hand movement in people very closely.

I think our graduate students Nathan Greiner, Beatrice Barra and the other members of the team did great work in building up from basic science concepts to design this practical technology while minimizing the number of animals used in this research, added Capogrosso.

However, there is still significant work to do to optimize this technology for use in people.

Capogrosso moved to Pittsburgh in January 2020 and joined the Department of Neurological Surgery to use the impressive resources of UPMC to bring this technology to patients as soon as possible. Thanks to collaborations with neurosurgeons such as Dr. Peter Gerszten, Capogrosso hopes to start testing the implant in patients soon.

Using the tools developed by other researchers, such as Dr. Fang-Cheng Yeh at the Department of Neurological Surgery and Dr. Elvira Pirondini at the Department of Physical Medicine and Rehabilitation, they will use precise MRI imaging to target electrode implantation in humans and reproduce the results obtained in monkeys.

Hopefully, well see the first results in humans in 2021, Capogrosso said.

See the article here:
New Technology Promises to Restore Movement in Paralyzed Arms - UPMC

This article was originally published here

Nervenarzt. 2021 Jan 18. doi: 10.1007/s00115-020-01058-w. Online ahead of print.

ABSTRACT

Neurological diseases are the most common cause of disability worldwide. In addition to physical limitations, they often lead to cognitive deficits that make active participation in professional and social life difficult. Due to physical and cognitive deficits, it is often difficult for neurological patients to gain access to specialized knowledge or to receive specialized treatment and is associated with greatly increased effort. Neurological diseases account for 11.6% of global disability-adjusted life years (DALYs, a measure for quantifying disease burden) and 16.5% of deaths, and remain the leading cause of DALYs and the second leading cause of death worldwide. Neurorehabilitation encompasses the goal of reintegrating patients with neurological dysfunctions into everyday life. The ongoing situation in the context of the COVID-19 pandemic poses new challenges for the healthcare system. Social distancing and quarantine have deprived many people with neurological disorders of access to routine medical care. The corona pandemic is a catalyst for the widespread use of telemedicine in the field of neurology and neurorehabilitation. Projects such as the Brunei project of the Nordwest Krankenhaus Frankfurt as well as an MS clinic in Canada show that highly specialized medicine and neurorehabilitation can be delivered to remote areas or in the living room of patients or any doctors office. Telemedical, telerehabilitative and teletherapeutic applications offer the opportunity to supplement and optimize existing care structures and with modern technology to make a new and contemporary interpretation of old-fashioned medical and therapeutic home visits.

PMID:33459797 | DOI:10.1007/s00115-020-01058-w

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Telerehabilitation: from the virtual world to reality-Medicine in the twenty-first century : Video-assisted treatment in times of COVID-19 - DocWire...

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Covid-19 Impact on Neurological Biomarkers Market Size, Share, Trends and Forecast 2021-2026: Abbott, QIAGEN, Thermo Fisher Scientific - KSU | The...