Category Archives: Nanomedicine

PARIS & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Regulatory News:

NANOBIOTIX (Paris:NANO) (Euronext: NANO Nasdaq: NBTX the Company), a clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced the closing of an additional 1,095,000 American Depositary Shares (ADSs) pursuant to the full exercise of the underwriters option to purchase additional ADSs in connection with the Companys initial public offering on the Nasdaq Global Select Market.

The 1,095,000 additional ADSs were sold at $13.50 per ADS, the same public offering price as in the initial public offering. Consequently, the total number of ordinary shares issued amounts to 8,395,000, including 6,540,000 in the form of ADSs, and the total net proceeds (including the sale of the additional ADSs pursuant to the exercise of the underwriters option), after deducting underwriting commissions and estimated offering expenses payable by Nanobiotix, from the initial public offering were approximately $100.4 million (82.8 million)1. The Company believes that the total net proceeds, together with its cash and cash equivalents, will be sufficient to fund its operations through the middle of the second quarter of 2023.

Nanobiotix's ordinary shares are listed on the regulated market of Euronext in Paris under the ticker symbol "NANO". Nanobiotixs ADSs began trading on the Nasdaq Global Select Market on December 11, 2020 under the ticker symbol "NBTX".

Jefferies LLC acted as global coordinator and joint book-running manager for the global offering, and Evercore Group, L.L.C. and UBS Securities LLC acted as joint book-running managers for the U.S. offering. Gilbert Dupont acted as manager for the European offering.

The initial public offering was made only by means of a prospectus. A copy of the prospectus relating to the initial public offering was filed with the U.S. Securities and Exchange Commission and may be obtained from Jefferies LLC, 520 Madison Avenue New York, NY 10022, or by telephone at 877-547-6340 or 877-821-7388, or by email at Prospectus_Department@Jefferies.com; or from Evercore Group L.L.C., Attention: Equity Capital Markets, 55 East 52nd Street, 35th Floor, New York, New York 10055, or by telephone at 888-474-0200, or by email at ecm.prospectus@evercore.com; or from UBS Securities LLC, Attention: Prospectus Department, 1285 Avenue of the Americas, New York, New York 10019, or by telephone at 888-827-7275, or by email at ol-prospectusrequest@ubs.com.

Allocation of the Share Capital

The following table presents the expected allocation of the Company's share capital following the initial public offering, to the Companys knowledge:

Situation before the capital increase (on anon-diluted basis)

Situation after the capital increase (on a non-diluted basis and including the exercise ofthe underwriters option to purchaseadditional ADSs )

Shareholders

Number ofshares

% of sharecapital

% of votingrights

Number ofshares(1)

% of sharecapital

% of votingrights

Institutional Investors

8,428,377

32.37%

31.17%

11,509,459

33.43%

32.48%

Amiral Gestion

1,418,179

5.45%

5.25%

1,479,619

4.30%

4.18%

Baillie Gifford

409,836

1.57%

1.52%

2,109,836

6.13%

5.95%

Qatar Holding

0

0%

0%

1,850,000

5.37%

5.22%

Invus

330,000

1.27%

1.22%

2,032,478

5.90%

5.74%

Retail

13,734,003

52.75%

50.80%

13,734,003

39.89%

38.76%

Management

962,613

3.70%

6.06%

962,613

2.80%

4.62%

including Laurent Levy

809,060

3.11%

5.10%

809,060

2.35%

3.90%

Employees (excl.management)

450,211

1.73%

2.87%

450,211

1.31%

2.19%

Family offices and others

298,388

1.15%

1.10%

298,388

0.87%

0.84%

Liquidity Contract

5,515

0.02%

0.02%

5,515

0.02%

0.02%

Total

26,037,122

100.00%

100.00%

34,432,122

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Nanobiotix Announces Closing of Underwriters' Option to Purchase Additional ADSs - Business Wire

Virtual 3D Nanorobots Market: Global Size, Trends, Competitive, Historical & Forecast Analysis, 2020-2025Increasing prevalence of chronic diseases and rising adoption of technologically advanced medical equipments drive the growth of global virtual 3D nanorobots Market.

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Scope of Global Virtual 3D Nanorobots Market Report-

Nanorobots are nano electromechanical systems designed to perform a specific task with precision at nano scale dimensions. It will be mainly used for the treatment in field of nanomedicine. An interesting utilization of nanorobots may be their attachment to transmigrating inflammatory cells or WBC, to reach inflamed tissues and assist in their healing process. It can also used for biomedical instrumentation, early diagnosis and targeted drug delivery for cancer, pharmacokinetics, surgery, monitoring of diabetes and health care. Virtual 3D nanorobots are expected to provide personalized treatments with improved efficacy and reduced side effects that are not available today. Virtual 3D nanorobots can be used to treat genetic diseases by comparing the molecular structures of both DNA and proteins found in the cell to known or desired reference structures. Some of its potential applications are; early diagnosis and targeted drug delivery for cancer biomedical instrumentation, pharmacokinetics, monitoring of diabetes, surgery and others. Another possible application can be the capability to locate atherosclerotic lesions in stenosed blood vessels, particularly in the coronary circulation, and treat them either mechanically, chemically or pharmacologically.

Virtual 3D nanorobots marketreport is segmented on the basis of type, application, distribution channel and region & country level. Based upon type, global virtual 3D nanorobots market is classified into microbivore nanorobots, respirocyte nanorobots, clottocyte nanorobots. Based upon application, global virtual 3D nanorobots market is divided into dentistry, emerging drug delivery, brain aneurysm, cancer detection, gene therapy, nanomedicine, biomedical, healthcare and others.

The regions covered in this Virtual 3D Nanorobots Market report are North America, Europe, Asia-Pacific and Rest of the World. On the basis of country level, the market of Virtual 3D Nanorobots is sub divided into U.S., Mexico, Canada, U.K., France, Germany, Italy, China, Japan, India, South East Asia, Middle East Asia (UAE, Saudi Arabia, Egypt) GCC, Africa, etc.

Some major key players for Global Virtual 3D Nanorobots Market Gingko Bioworks, Synthace, Zymergen Inc., Advanced Diamond Technologies and Advanced Nano Products Co. Limited and others.

Increasing Prevalence of Chronic Diseases and Rising Adoption of Technologically Advanced Medical Equipments Drive the Growth of Global Virtual 3D Nanorobots Market

Nanorobots are expected to provide new treatments for the patients suffering from different diseases. Latest developments in the field of biomolecular computing have demonstrated the feasibility of processing logic tasks by bio-computers. The major factor driving the growth of global virtual 3D nanorobots market is increasing adoption of technologically advanced products in healthcare coupled with the rising government initiatives in this field. In addition, increasing prevalence of chronic diseases, improving healthcare infrastructure and technological advancements to develop more innovative, better and effective medical treatments are also anticipated to foster the market growth within the forecast period. In recent years, the potential of nanotechnology motivated many governments to devote significant resources to this new field. The U.S. National Science Foundation launched a program in Scientific Visualization in part to harness supercomputers in picturing the nanoworld. Firms such as; IBM, PARC, Hewlett Packard, Bell Laboratories, and Intel Corp. and others are collaborating to produce new nano products.

Cancer can be successfully treated with current stages of medical technologies and therapy tools. One of the important aspect to achieve a successful treatment for cancer patients is the development of efficient targeted drug delivery to decrease the side effects from chemotherapy. Nanorobots can help on such extremely important aspects of cancer therapy owing to the properties of nanorobots to navigate as blood borne devices. Nanorobots with embedded chemical biosensors can be used to perform detection of tumour cells in early stages of development inside the patients body. Thus all these advantages of nanorobots are expected to boost the market growth.

However, lack of trained professional may hamper the market growth. In spite of that, increasing advancements in the field can provide various opportunities for the further growth of the market. The use of nanorobots may advance biomedical intervention with minimally invasive surgeries and help patients who need constant body functions monitoring, or ever improve treatments efficiency through early diagnosis of possible serious diseases.

North America is Expected to Dominate the Global Virtual 3D Nanorobots Market

The global virtual 3D nanorobots market is segmented into North America, Europe, Asia-Pacific Latin America and Middle East & Africa. North America is expected to dominate the global virtual 3D nanorobots market within the forecast period attributed to the highly developed healthcare infrastructure and increasing adoption of new technologies in healthcare in this region. In addition, increasing government initiative in this field are also supplementing the growth of virtual 3D nanorobots market in this region. Asia Pacific is anticipated to witness a significant growth in global Virtual 3D Nanorobots market owing to emerging economies and growing awareness about nanorobotics in healthcare. In addition, improving healthcare infrastructure due to the favourable government initiatives regarding health are also expected to foster the growth of virtual 3D nanorobots market in this region within the forecast period.

Key Benefits for Market Report

Virtual 3D Nanorobots MarketSegmentation:-

By Type: Respirocyte Nanorobots, Microbivore Nanorobots, Clottocyte Nanorobots

By Application:-Dentistry, Gene therapy, Brain Aneurysm, Emerging Drug Delivery, Cancer detection, NanoMedicine, Biomedical, Healthcare, Others

By Regional & Country Analysis

North America, US, Mexico, Chily, Canada, Europe, UK, France, Germany, Italy, Asia Pacific, China, South Korea, Japan, India, Southeast Asia, Latin America, Brazil, The Middle East and Africa, GCC, Africa, Rest of Middle East and Africa

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US Virtual 3D Nanorobots Market 2020: Deep Analysis of Current Trends and Future Demand by Top Key Players are Gingko Bioworks, Synthace, Zymergen...

ProfessorTimo Laaksonen, who divides his time between the University of Helsinki and Tampere University, has received a grant of roughly 2 million from the European Research Council (ERC). Laaksonens research focuses on releasing pharmaceutical agents in a controlled way in the body using blue or ultraviolet light.

Employing light in drug release is not a new invention as such. With the help of red light, for instance, the membrane of a liposome transporting a nano-sized drug can be made more permeable, releasing the drug. However, blue light provides a more extensive set of tools compared to red light.

Blue and UV light have more energy, powerful enough, for example, to break up chemical bonds in a certain type of drug carrier and detach the drug molecules bound to the carriers surface, Laaksonen explains.

Earlier, the use of UV light has been hindered by the fact that, even at its best, it travels less than a hundred micrometres in the tissue, or the breadth of a single average hair. Red light advances much further. That UV light can damage the body adds another complication, while red light is markedly safer.

Laaksonen is now focusing on how to safely target blue or UV light to the site where the drug should be released. There are two options: either photons could be locally upconverted to a higher energy level inside the body, or a variety of drug implants activated by light could be used.

In practice, photoactivation could potentially be used to release drugs, for example, at the precise moment when another dose is needed. It could be a certain time every morning, or we could continually adjust the release rate to suit the patient.

Timo Laaksonen heads research groups at both the Faculty of Pharmacy, University of Helsinki and the Faculty of Engineering and Natural Sciences, Tampere University. The pharmacy component of the project is carried out in Helsinki and the photochemical component in Tampere. The University of Helsinki will receive 60% of the ERC grant and Tampere University 40%.

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Significant EU funding awarded to nanomedicine research Blue light used to release pharmaceutical agents at the target - India Education Diary

SALT LAKE CITY, Dec. 10, 2020 (GLOBE NEWSWIRE) -- Clene Nanomedicine, Inc., a clinical-stage biopharmaceutical company, today announced the presentation of blinded interim results from the Phase 2 RESCUE-ALS clinical trial investigating the effects of its lead clinical candidate, CNM-Au8, for the treatment of amyotrophic lateral sclerosis (ALS). CNM-Au8 is an aqueous suspension of clean-surfaced, faceted gold nanocrystals with catalytic activity that has been shown to enhance the metabolic energetic capacity of motor neurons while simultaneouslyreducing oxidative stress.

As of the data cutoff (October 27, 2020), the trial was fully enrolled with a preliminary blinded assessment of the studys primary endpoint, the motor neuron number index-4 [MUNIX(4)] score, showing that more than 40% of enrolled patients with completed week 12 data experienced improvements in motor neuron function assessed by MUNIX. When compared to baseline values, the average MUNIX(4) score of the overall trial population (including both active CNM-Au8 and placebo) experienced an absolute increase in mean MUNIX(4) values. This increase exceeded the expectations of the statistical modeling on which the study was based, which predicted a linear decline in average MUNIX(4) score from study onset (Neuwirth et al. JNNP 2015). These data, while blinded, suggest that CNM-Au8 may have neuro-reparative potential in ALS patients. Clene expects to report the complete, unblinded results from the RESCUE-ALS study in 2H 2021.

Although blinded to treatment assignment, these data are encouraging. We believe Clenes breakthrough approach with the application of physics to biology via direct electron interactions within cellular systems at the nano-scale may hold the potential to revolutionize the treatment of neurodegenerative diseases such as ALS and other motor neuron diseases, said Robert Glanzman, MD, FAAN, Chief Medical Officer of Clene.

Rob Etherington, President and CEO of Clene added, This blinded interim analysis suggests that CNM-Au8 is working mechanistically to address a foundational challenge common to many neurodegenerative diseases, namely that stressed or failing neurons need additional energy for their survival, repair, and improved function. Emerging MUNIX data potentially indicate preservation of motor units, which is promising. We eagerly anticipate final results and are encouraged that these blinded interim results may provide hope for ALS patients and their families as they search for new therapies to treat this devastating disease.

The presentation (CLT-23) titled, RESCUE-ALS Trial, A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of CNM-Au8 to Slow Disease Progression in Amyotrophic Lateral Sclerosis Patients: Design and Interim Blinded Results, is available as a live e-Poster on December 10th at 12:10 12:50 pm EST at the Virtual 31st International Symposium on ALS/MND, held online (https://symposium.mndassociation.org/virtual-2020/).

About RESCUE-ALSRESCUE-ALS is a Phase 2 multi-center, randomized, double-blind, parallel group, placebo-controlled study examining the efficacy, safety, pharmacokinetics and pharmacodynamics of CNM-Au8 in participants who are newly symptomatic with ALS (within 24-months of screening or 12-months from diagnosis). Enrolled subjects will be randomized 1:1 to receive either active treatment with CNM-Au8 (30 mg) or placebo in addition to their current standard of care. Participants will receive their randomized treatment over 36 consecutive weeks during the treatment period. The objective of this study is to assess the impact of improving neuronal bioenergetics, reducing reactive oxygen species and promoting protein homeostasis with CNM-Au8 to slow disease progression in patients with ALS. In the trial, efficacy is assessed as the average change in motor neuron unit number index (MUNIX) estimated by electromyography for the abductor digiti minimi (ADM), abductor pollicis brevis (APB), biceps brachii (BB), and tibialis anterior (TA) (muscles of the hand, arm, and leg). The trial was fully enrolled with 44 participants as of the reported 27-October-2020 data cut. Baseline characteristics include [mean (SD)], MUNIX(4) score: 93.7 (45.8); FVC % predicted: 80.8 (16.3); ALSFRS-R: 38.6 (6.1); ALSSQOL-20: 3.3 (1.3), mean time from diagnosis: 4.7 (4.6) months; riluzole background treatment, 92%.

About CNM-Au8CNM-Au8 is a concentrated, aqueous suspension of clean-surfaced faceted gold nanocrystals that act catalytically to support important intracellular biological reactions. CNM-Au8 consists solely of pure gold nanoparticles, composed of clean-surfaced, faceted, geometrical crystals held in suspension in sodium bicarbonate buffered, pharmaceutical grade water. CNM-Au8 has demonstrated safety in Phase 1 studies in healthy volunteers and has shown both remyelination and neuroprotective effects in multiple preclinical (animal) models. Preclinical data, both published in peer-reviewed journals and presented at scientific congresses, demonstrate that treatment of neuronal cultures with CNM-Au8 improves survival of neurons, protects neurite networks, decreases intracellular levels of reactive oxygen species and improves mitochondrial capacity in response to cellular stresses induced by multiple disease-relevant neurotoxins. Oral treatment with CNM-Au8 improved functional behaviors in rodent models of ALS, multiple sclerosis, and Parkinsons disease versus vehicle (placebo). CNM-Au8 is currently being tested in a Phase 2 clinical study for the treatment of chronic optic neuropathy in patients with MS in addition to Phase 2 and Phase 3 clinical studies for disease progression in patients with ALS.

About ALSALS is a universally fatal neurodegenerative disorder that results in loss of motor neurons in the cerebral cortex, brain stem, and spinal cord. ALS, also known as Lou Gehrig's disease, leads to the death of the neurons controlling voluntary muscles resulting in weakness, muscle atrophy, and progressive paralysis. ALS affects more than 15,000 patients in the United States and is the most prevalent adult-onset progressive motor neuron disease.

About CleneClene is a clinical-stage biopharmaceutical company focused on the development of unique therapeutics for neurodegenerative diseases. Clene has innovated a novel nanotechnology drug platform for the development of a new class of orally administered neurotherapeutic drugs. Clene has also advanced into the clinic an aqueous solution of ionic zinc and silver for anti-viral and anti-microbial uses. Founded in 2013, the company is based in Salt Lake City, Utah with R&D and manufacturing operations located in North East, Maryland. For more information, please visit http://www.clene.com.

Forward-Looking StatementsThis press release contains, and certain oral statements made by representatives of Tottenham, Clene, and their respective affiliates, from time to time may contain, "forward-looking statements" within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Tottenham's and Clene's actual results may differ from their expectations, estimates and projections and consequently, you should not rely on these forward-looking statements as predictions of future events. Words such as "expect," "estimate," "project," "budget," "forecast," "anticipate," "intend," "plan," "may," "will," "could," "should," "believes," "predicts," "potential," "might" and "continues," and similar expressions are intended to identify such forward-looking statements. These forward-looking statements include, without limitation, Tottenham's and Clene's expectations with respect to future performance and anticipated financial impacts of the business combination, the satisfaction of the closing conditions to the business combination and the timing of the completion of the business combination. These forward-looking statements involve significant risks and uncertainties that could cause actual results to differ materially from expected results. Most of these factors are outside the control of Tottenham or Clene and are difficult to predict. Factors that may cause such differences include, but are not limited to: (1) the occurrence of any event, change or other circumstances that could give rise to the termination of the Merger Agreement relating to the proposed business combination; (2) the outcome of any legal proceedings that may be instituted against Tottenham or Clene following the announcement of the Merger Agreement and the transactions contemplated therein; (3) the inability to complete the business combination, including due to failure to obtain approval of the shareholders of Tottenham or other conditions to closing in the Merger Agreement; (4) delays in obtaining or the inability to obtain necessary regulatory approvals (including approval from regulators, as applicable) required to complete the transactions contemplated by the Merger Agreement; (5) the occurrence of any event, change or other circumstance that could give rise to the termination of the Merger Agreement or could otherwise cause the transaction to fail to close; (6) the inability to obtain or maintain the listing of the post-acquisition company's ordinary shares on NASDAQ following the business combination; (7) the risk that the business combination disrupts current plans and operations as a result of the announcement and consummation of the business combination; (8) the ability to recognize the anticipated benefits of the business combination, which may be affected by, among other things, competition, the ability of the combined company to grow and manage growth profitably and retain its key employees; (9) costs related to the business combination; (10) changes in applicable laws or regulations; (11) the possibility that Clene or the combined company may be adversely affected by other economic, business, and/or competitive factors; and (12) other risks and uncertainties to be identified in the Form S-4 filed by Chelsea Worldwide (when available) relating to the business combination, including those under "Risk Factors" therein, and in other filings with the Securities and Exchange Commission (SEC) made by Tottenham and Clene. Tottenham and Clene caution that the foregoing list of factors is neither exclusive nor exhaustive. Tottenham and Clene caution readers not to place undue reliance upon any forward-looking statements, which speak only as of the date made. Neither Tottenham or Clene undertakes or accepts any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements to reflect any change in its expectations or any change in events, conditions or circumstances on which any such statement is based, subject to applicable law. The information contained in any website referenced herein is not, and shall not be deemed to be, part of or incorporated into this press release.

Media ContactAndrew MielachLifeSci Communications(646) 876-5868amielach@lifescicomms.com

Investor ContactBruce MackleLifeSci Advisors, LLC(929) 469-3859bmackle@lifesciadvisors.com

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Clene Nanomedicine Presents Blinded Interim Results from RESCUE-ALS Phase 2 Study at the 31st International Symposium on ALS/MNDResults provide...

PARIS & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Regulatory News:

NANOBIOTIX (Euronext: NANO ISIN : FR0011341205 the Company), a clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, announced today that trading of its ordinary shares on the regulated market of Euronext in Paris (Euronext Paris) will be temporarily halted, at the Companys request, from the opening of the market at 9:00 AM CET. This trading halt takes place in the context of the initial public offering of the Company on the Nasdaq Global Select Market, in order to allow for the confirmation of allocations to investors and for the commencement of trading of the Companys American Depositary Shares (ADSs) on the Nasdaq Global Select Market.

This suspension will be effective until a new communication is released by the Company. Trading on the regulated market of Euronext Paris is expected to resume today, December 11, 2020, at approximately 4:00 pm (CET), which is the earliest time ADSs are expected to begin trading on the Nasdaq Global Select Market (10:00 am (EST)) under the ticker symbol NBTX.

About NANOBIOTIX

Incorporated in 2003, Nanobiotix is a leading, clinical-stage nanomedicine company pioneering new approaches to significantly change patient outcomes by bringing nanophysics to the heart of the cell.

The Nanobiotix philosophy is rooted in designing pioneering, physical-based approaches to bring highly effective and generalized solutions to address unmet medical needs and challenges.

Nanobiotixs novel, proprietary lead technology, NBTXR3, aims to expand radiotherapy benefits for millions of cancer patients. Nanobiotixs Immuno-Oncology program has the potential to bring a new dimension to cancer immunotherapies.

Nanobiotix is listed on the regulated market of Euronext in Paris (Euronext: NANO / ISIN: FR0011341205; Bloomberg: NANO: FP). Its headquarters are in Paris, France. Nanobiotix has a subsidiary, Curadigm, located in France and the United States, as well as a US affiliate in Cambridge, MA, and European affiliates in France, Spain and Germany.

Disclaimer

This press release contains certain forward-looking statements concerning Nanobiotix and its business, including its prospects and product candidate development. Such forward-looking statements are based on assumptions that Nanobiotix considers to be reasonable. However, there can be no assurance that the estimates contained in such forward-looking statements will be verified, which estimates are subject to numerous risks including the risks set forth in the universal registration document of Nanobiotix registered with the AMF under number R.20-010 on May 12, 2020 and in its amendment filed with the AMF under number D.20-0339-A01 on November 20, 2020 (copies of which are available on http://www.nanobiotix.com) and to the development of economic conditions, financial markets and the markets in which Nanobiotix operates. The forward-looking statements contained in this press release are also subject to risks not yet known to Nanobiotix or not currently considered material by Nanobiotix. The occurrence of all or part of such risks could cause actual results, financial conditions, performance or achievements of Nanobiotix to be materially different from such forward-looking statements.

This press release has been prepared in both French and English. In the event of any differences between the two texts, the French language version shall supersede.

This press release does not constitute an offer to sell nor a solicitation of an offer to buy, nor shall there be any sale of ordinary shares or ADSs of Nanobiotix in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

The distribution of this document may, in certain jurisdictions, be restricted by local legislations. Persons into whose possession this document comes are required to inform themselves about and to observe any such potential local restrictions.

A French listing prospectus comprising (i) the 2019 universal registration document filed with the AMF under number R.20-010 on May 12, 2020, as completed by a first amendment to such universal registration document filed with the AMF under number D.0339-A01 on November 20, 2020 and a second amendment to such universal registration document, which will be filed with the AMF on December 11, 2020, and (ii) a Securities Note (Note dopration), including a summary of the prospectus, will be submitted to the approval by the AMF and will be published on the AMFs website at http://www.amf-france.org. Following the filing of the second amendment to the universal registration document with the AMF, copies of Companys 2019 universal registration document, as amended, will be available free of charge at the Companys head office located at 60 rue de Wattignies, 75012 Paris.

European Economic Area

In relation to each Member State of the European Economic Area (each, a Member State) no offer to the public of ordinary shares and ADSs may be made in that Member State other than:

- to any legal entity which is a qualified investor as defined in the Prospectus Regulation;

- to fewer than 150 natural or legal persons (other than a qualified investor as defined in the Prospectus Regulation); or

- in any other circumstances falling within Article 1(4) of the Prospectus Regulation,

provided that no such offer of ordinary shares and ADSs shall require us or any Underwriter to publish a prospectus pursuant to Article 3 of the Prospectus Regulation or supplement a prospectus pursuant to Article 23 of the Prospectus Regulation and each person who initially acquires any shares or to whom any offer is made will be deemed to have represented, acknowledged and agreed to and with each of the Underwriters and the Company that it is a qualified investor as defined in the Prospectus Regulation.

For the purposes of this provision, the expression an offer to the public in relation to any ordinary shares and ADSs in any Member State means the communication in any form and by any means of sufficient information on the terms of the offer and any ordinary shares and ADSs to be offered so as to enable an investor to decide to purchase any ordinary shares and ADSs, and the expression Prospectus Regulation means Regulation (EU) 2017/1129 (as amended).

France

The ADSs and the ordinary shares have not been and will not be offered or sold to the public in the Republic of France, and no offering of this prospectus or any marketing materials relating to the ADSs and the ordinary shares may be made available or distributed in any way that would constitute, directly or indirectly, an offer to the public in the Republic of France (except for public offerings defined in Article L.411-2 1 of the French Code montaire et financier).

The ordinary shares in the form of ADSs may only be offered or sold in France pursuant to article L. 411-2 1 of the French Code montaire et financier to qualified investors (as such term is defined in Article 2(e) of Regulation (EU) n 2017/1129 dated 14 June 2017, as amended) acting for their own account, and in accordance with articles L. 411-1, L. 411-2 and D. 411-2 to D.411-4, D.744-1 and D. 754-1 and D. 764-1 of the French Code montaire et financier.

This announcement is not an advertisement and not a prospectus within the meaning of the Prospectus Regulation.

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NANOBIOTIX Announces Temporary Trading Halt of Its Ordinary Shares on Euronext Paris - Business Wire

The "Nanomedicine Global Market Insights 2020, Analysis and Forecast to 2025, by Manufacturers, Regions, Technology, Application" report has been added to ResearchAndMarkets.com's offering.

This report describes the global market size of Nanomedicine from 2015 to 2019 and its CAGR from 2015 to 2019, and also forecasts its market size to the end of 2025 and its CAGR from 2020 to 2025. For the geography segment, regional supply, demand, major players, price is presented from 2015 to 2025.

For the competitor segment, the report includes global key players of Nanomedicine as well as some small players.

The information for each competitor includes:

Company Profile

Main Business Information

SWOT Analysis

Sales, Revenue, Price and Gross Margin

Market Share

Applications Segment:

Cancer Detection

Monitoring Therapy

Disease Detection

Companies Covered:

Abbott Laboratories

Cepheid

Philips

GE Healthcare

Siemens

Gen-Proberporated

MDxHealth SA

EpiGenomics AG

Roche Diagnostics

Sequenom

Manhattan Scientifics

Key Topics Covered:

Chapter 1 Executive Summary

Chapter 2 Abbreviation and Acronyms

Chapter 3 Preface

3.1 Research Scope

3.2 Research Sources

3.2.1 Data Sources

3.2.2 Assumptions

3.3 Research Method

Chapter 4 Market Landscape

4.1 Market Overview

4.2 Classification/Types

4.3 Application/End-users

Chapter 5 Market Trend Analysis

5.1 Introduction

5.2 Drivers

5.3 Restraints

5.4 Opportunities

5.5 Threats

Chapter 6 Industry Chain Analysis

6.1 Upstream/Suppliers Analysis

6.2 Nanomedicine Analysis

6.2.1 Technology Analysis

6.2.2 Cost Analysis

6.2.3 Market Channel Analysis

6.3 Downstream Buyers/End-users

Chapter 7 Latest Market Dynamics

7.1 Latest News

7.2 Merger and Acquisition

7.3 Planned/Future Project

7.4 Policy Dynamics

Chapter 8 Trading Analysis

8.1 Export of Nanomedicine by Region

8.2 Import of Nanomedicine by Region

8.3 Balance of Trade

Chapter 9 Historical and Forecast Nanomedicine Market in North America (2015-2025)

9.1 Nanomedicine Market Size

9.2 Nanomedicine Demand by End Use

Story continues

9.3 Competition by Players/Suppliers

9.4 Type Segmentation and Price

9.5 Key Countries Analysis

9.5.1 US

9.5.2 Canada

9.5.3 Mexico

Chapter 10 Historical and Forecast Nanomedicine Market in South America (2015-2025)

10.1 Nanomedicine Market Size

10.2 Nanomedicine Demand by End Use

10.3 Competition by Players/Suppliers

10.4 Type Segmentation and Price

10.5 Key Countries Analysis

10.5.1 Brazil

10.5.2 Argentina

10.5.3 Chile

10.5.4 Peru

Chapter 11 Historical and Forecast Nanomedicine Market in Asia & Pacific (2015-2025)

11.1 Nanomedicine Market Size

11.2 Nanomedicine Demand by End Use

11.3 Competition by Players/Suppliers

11.4 Type Segmentation and Price

11.5 Key Countries Analysis

11.5.1 China

11.5.2 India

11.5.3 Japan

11.5.4 South Korea

11.5.5 Asean

11.5.6 Australia

Chapter 12 Historical and Forecast Nanomedicine Market in Europe (2015-2025)

12.1 Nanomedicine Market Size

12.2 Nanomedicine Demand by End Use

12.3 Competition by Players/Suppliers

12.4 Type Segmentation and Price

12.5 Key Countries Analysis

12.5.1 Germany

12.5.2 France

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Global Nanomedicine Market Analysis and Forecast to 2025 by Cancer Detection, Monitoring Therapy & Disease Detection - ResearchAndMarkets.com -...