Category Archives: Human Longevity

New Jersey, United States,-Verified Market Research recently released a new report titled Precision Medicine Software MarketSize Report, Growth and Forecast 2021-2028, Breakdown Data by Company, Key Regions, Types and Applications. The report has been compiled using primary and secondary research methodology that will provide a precise and precise understanding of the Precision Medicine Software market. Analysts used a top-down and bottom-up approach to assess the segments and properly assess their impact on the Precision Medicine Software market. The report offers a market overview which briefly describes the market situation and major segments. It also mentions the best players represented in the Precision Medicine Software market.

The 2021 report offers an in-depth analysis of each sector of this Precision Medicine Software industry. Fill in historical Precision Medicine Software data according to customer requirements. It offers Precision Medicine Software market research globally and locally. The detailed segment and manufacturer information of Precision Medicine Software helps guide future benefits and make important decisions for the growth of Precision Medicine Software.

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The report covers extensive analysis of the key market players in the market, along with their business overview, expansion plans, and strategies. The key players studied in the report include:

2bPrecise LLC, Syapse PierianDx Fabric Genomics, SOPHiA GENETICS SA, N-of-One Foundation Medicine Human Longevity Sunquest Information Systems Inc., Translational Software, Inc.

Precision Medicine Software Market Segmentation

Precision Medicine Software Market, By Delivery Type

On-Premise Cloud-Based

Precision Medicine Software Market, By Application

Rare Diseases Oncology Pharmacogenomics Others

Precision Medicine Software Market, By End-User

Pharmaceutical and Biotechnology Companies Healthcare Providers Research Centers and Academic Institutes Others

In the next chapters, the research report reveals the development of the Precision Medicine Software market segments. Analysts have segmented the market on the basis of product, application, end-users, and geography. Each segment of the Precision Medicine Software market has been studied with in-depth insight. Analysts have evaluated the changing nature of the market segments, growing investments in manufacturing activities, and product innovation that are likely to impact them. In terms of geography, the report studies the changing political environment, social upliftment, and other government initiatives that are expected to contribute to the regional markets.

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Precision Medicine Software Market Report Scope

Geographic Segment Covered in the Report:

North America (USA and Canada) Europe (UK, Germany, France and the rest of Europe) Asia Pacific (China, Japan, India, and the rest of the Asia Pacific region) Latin America (Brazil, Mexico, and the rest of Latin America) Middle East and Africa (GCC and rest of the Middle East and Africa)

Key questions answered in the report:

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Precision Medicine Software Market Size 2021 Global Analysis, Trends, Forecast up to 2028 - The Market Writeuo - The Market Writeuo

In 2019, Guinness World Recordsawarded the "world's oldest animal on land" to a certain creature located in South Atlantic. The award was given to Jonathan, an enormous tortoise that had been living on the island of St. Helena for almost two centuries now.

Guinness World Records selected Jonathan as the winner of the title due to the tortoise being born during Queen Victoria's era way back in the 1830s. Jonathan was 80 years old when the famous ship Titanic sank, and by the time it got the world record, the tortoise was at its 187 years of age.

(Photo: Brady Knoll from Pexels)

Jonathan is an example of a creature under the family of turtles that had been recorded with staggering longevity. According to Florida SouthWestern State College biology expert and turtle ecologist Jordan Donini in a Live Sciencereport, sea turtles have a life span of 50 to 100 years, while box turtles are more enduring and can live beyond a century. Donini added that the maximum life span of most sea turtle species is still uncovered.

Turtles have the best longevity among the animal kingdom due to numerous biological and evolutionary explanations. In the Live Science interview, Arkansas State University reptile expert and physiology professor Lori Neuman-Lee said that in terms of evolution, the turtles have simply adapted to the common food chain activity that was being conducted for many years.

Some animals like snakes and raccoons are fond of turtle eggs, and the only way to escape this chain is for the turtles to pass down their genes. Along with procreation, turtles learned how to live longer than they do and breed consecutively.

The turtles' longevity in biological explanation, on the other hand, is much more complicated than their straightforward evolutionary history. According to Neuman-Lee, turtles are also composed of telomeres, a genetic material that houses genomes by acting as a protective cap on DNA's end strands or chromosomes.

ALSO READ: Congenital Heart Disease and Autism in Children Possibly Caused by Sperm Mutation in Older Men

The function of telomeres is to protect the chromosomes in case of cell division. However, these protective caps get smaller and degrade over time, creating an effect on the chromosomes and eventually halting DNA replication. What is devastating about this genetic process is that when DNA stops replicating, tumors and cell anomalies develop.

Telomeres in turtles, however, have a lower rate of decay. Compared to the protective caps in human chromosomes, the telomeres of turtles do not shorten quickly and can deflect any significant changes brought by a negative effect during DNA replication.

The turtles are not yet fully examined, and other factors that could explain their longevity are still a puzzle for experts. However, some scientific theories have been formulated regarding the turtle's long life. Through the series of experiments and observations, the scientists are able to build a hypothesis that will possibly help us understand the longevity of turtles in the future.

Among the investigations on the near-immortality feature of turtles is the recently published article in the journal arXiv, titled "Concurrent Evolution of Anti-Aging Gene Duplications and Cellular Phenotypes in Long-Lived Turtles."

RELATED ARTICLE: Plant-Animal Mutualism: Coevolution of Fruit Bats and Pepper Plants Linked to Biological Scent Sensory Ability

Check out more news and information on Biologyin Science Times.

Original post:
Turtles Can Live From the Victorian Era up to Present; Reason Behind the Longevity of Turtles Explained - Science Times

If you require a lot of motivation to get yourself to exercise, take comfort in this fact: You're not actually lazy. At least that's according to Harvard biologist Daniel Lieberman, Ph.D., author of Exercised: Why Something We Never Evolved to Do Is Healthy and Rewarding. He says you're totally normal and behaving the way that human beings naturally evolved to behave.

"We evolved to be physically active, but exercise is a special kind of physical activity," he explained to The Harvard Gazette. "It's voluntary physical activity for the sake of health and fitness. Until recently, nobody did that. In fact, it would be a kind of a crazy thing to do because if you're a very active hunter-gatherer, for example, or a subsistence farmer, it wouldn't make sense to spend any extra energy going for a needless five-mile jog in the morning. It doesn't help you."

Fast forward to 2021, and you need exerciseand you need to fight your instincts not to. So the first order of business is to be kinder to yourself, and know that you're inherently hardwired to avoid it. The next thing to do? Follow these simple tricks for convincing yourself to hit the gym. Trust us: Your body will thank you later. And for more great exercise advice, don't miss the Secret Side Effects of Lifting Weights for the First Time, Says Science.

Ticking off many achievable targets keeps people motivated, says Mark Davis, a researcher at the University of Bristol, in England. In a study of 78 adults, Davis gave half the subjects a modest fitness goal (walk 2,500 steps daily) and the others an ambitious goal (10,000 steps). Result: The participants with the easier target were 27 percent more likely to keep exercising. And if you love to walk, make sure you know about The Secret Cult Walking Shoe That Walkers Everywhere Are Totally Obsessed With.

"Your training partner needs to be someone who will hold you accountable," says Jack Raglin, Ph.D., a professor of kinesiology at Indiana University. An old study by Raglin found that 92 percent of couples who went to the gym together continued to do so after a year. By contrast, couples who worked out separately had a 50 percent dropout rate. And for more amazing exercise advice, don't miss the Unexpected Side Effects of Working Out in the Morning, Say Experts.

"Eliminating boredom is one of the most important factors for maintaining the longevity of a fitness program," says Chris Jordan, C.S.C.S. A study of 61 people at the University of Florida found that people who varied their workouts were 15 percent more likely to exercise regularly than those who stuck to one workout.

The music will help you exercise longer and more intensely without even realizing it. Anew study just released by the University of Edinburgh reports that when it comes to going for a run or jog, music helps you overcome mental adversity so much more easily. Read more about this study here.

Research conducted at Springfield College in Massachusetts found that people who cooled down for 5 minutes at the end of a bike workout rated it easier than when they did a workout of equal intensity that didn't include a cool down. It suggests that if the last thing you do is pleasant, you're more apt to repeat your workout. And if you're inspired to lift now, make sure you're aware of The Single Greatest Weightlifting Move for Shedding Pounds, Says Science.

Read more from the original source:
Secret Tricks for Convincing Yourself to Exercise, Say Experts | Eat This Not That - Eat This, Not That

Longevity and Anti-Senescence Therapy Market Growth 20202027 is the latest updated report announced by Oneup Business Insights which is a complete research study on the market, which attempts to provide a clear picture of the key factors that shape this market.

This marketplace additionally analyzes the marketplace status, share, demand, boom rate, destiny trends, marketplace drivers, opportunities, and challenges, dangers and access barriers, income channels, and vendors with the assistance of SWOT evaluation and Porters Five Forces Analysis. In this bit of the research the organizations chief outlines, monetary outlines, and field-tested strategies are introduced.

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The Study Is A Source of Reliable Data On:

Market trends and dynamics supply and demand

Market sizing, growth & estimates considering current trends/opportunities/challenges

Competitive landscape

Technological breakthroughs

Value chain and stakeholder analysis

Top Key Vendors of Longevity and Anti-Senescence Therapy Market Report:

Acorda Therapeutics, Calico Life Sciences, Human Longevity Inc., Insilico Medicine, Oisin Biotechnology, Proteostasis Therapeutics Inc., Recursion Pharmaceuticals, Restorbio, Senex Biotechnology, Senolytic Therapeutics, and Sierra Sciences LLC

Segmentation of Longevity and Anti-Senescence Therapy Market:

Product Type Coverage

Hemolytic Drug Therapy

Gene Therapy

Immunotherapy

Other Stem Cell Therapies

Application Coverage

Hospital

Medical Service Institution

Drug and Device Sales

Regions covered in the Longevity and Anti-Senescence Therapy market report are:

North America

Europe

Asia Pacific

Latin America

The Middle East and Africa

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Table of Contents: Longevity and Anti-Senescence Therapy Market:

Chapter 1: Overview of Longevity and Anti-Senescence Therapy Market

Chapter 2: Global Longevity and Anti-Senescence Therapy Market Status and Forecast by Regions

Chapter 3: Global Longevity and Anti-Senescence Therapy Market Status and Forecast by Types

Chapter 4: Global Longevity and Anti-Senescence Therapy Market Status and Forecast by Downstream Industry

Chapter 5: Longevity and Anti-Senescence Therapy Market Driving Factor Analysis

Chapter 6: Longevity and Anti-Senescence Therapy Market Competition Status by Major Manufacturers

Chapter 7: Major Manufacturers Introduction and Longevity and Anti-Senescence Therapy Market Data

Chapter 8: Upstream and Downstream Longevity and Anti-Senescence Therapy Market Analysis

Chapter 9: Cost and Gross Margin Analysis of Longevity and Anti-Senescence Therapy market

Chapter 10: Marketing Status Analysis of Longevity and Anti-Senescence Therapy market

Chapter 11: Longevity and Anti-Senescence Therapy Market Report Conclusion

Chapter 12: Longevity and Anti-Senescence Therapy Market Research Methodology and Reference

Research Objectives of this report:

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Longevity and Anti-Senescence Therapy Market 2021 Size, Status and Global Outlook Acorda Therapeutics, Calico Life Sciences, Human Longevity Inc.,...

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A new report from the Global Coalition on Aging (GCOA) and the Infectious Diseases Society of America (IDSA), a first of its kind known as the AMR Preparedness Index, provides an evaluation and roadmap for the 11 largest global economies and their efforts to tackle rising cases of antimicrobial resistance.

While recognition of the threat has risen, according to the organizations, there has been a broad failure to match public promises and actual actions to avert a crisis. The U.K. and the United States have fared best along with Brazil, Canada, China, France, Germany, India, Italy, Japan, and South Korea. Case studies were presented from Australia, Kenya, Russia, Saudi Arabia, and Sweden as well.

Increasing resistance to life-saving antimicrobials, together with our broken innovation pipeline, threatens to erode the very foundation of modern medicine and, with it, erase one of the principal achievements of the 20th century the miracle of human longevity, Michael Hodin, CEO of the GCOA, said. As the United Nations (UN) and World Health Organization (WHO) Decade of Healthy Ageing brings greater attention and energy to our remarkable demographic achievement and the COVID-19 experience make clear the compounded risk to older adults from infectious disease, we must fully acknowledge the threat that AMR poses to the very prospect of healthy and active aging. Without true action to effectively address AMR, tens of millions of lives both young and old will be cut short, and so many others will be diminished as a result of care foregone over concerns about now untreatable infection.

It is estimated that 700,000 people die each year from drug-resistant infections, and those figures are expected to grow as the problem worsens. Resistance is increasing to existing drugs, increasing the risk of even routine medical care.

If unaddressed, the continued rise of AMR is expected to lead to as many as 10 million deaths per year, disability and lower quality of life for millions more, and $100 trillion in lost GDP by 2050, the organizations said in a statement.

Countries were ranked based on seven categories. The results led the GCOA and IDSA to recommend several means of bolstering government action, as well, including:

The COVID-19 pandemic has made painfully clear to all the far-reaching impact of untreatable infectious diseases across societies and economies, Dr. Barbara Alexander, IDSA president, said. As we enter the next stage of the pandemic and with global momentum for AMR action building among G7 countries in the UK with the launch of the subscription pilot, and most recently, with the reintroduction of the PASTEUR Act in the US Congress the 2021 AMR Preparedness Index comes at a pivotal moment. We are pleased to partner with the Global Coalition on Aging to create this vital tool that will help governments around the world reinforce their words with actions.

Read the original:
First AMR Preparedness Index finds UK, US top charts amid first world failures to address antimicrobial resistance threat - Homeland Preparedness News

Jul 3rd 2021

CAIRD COLLECTIVE, LUNA

Editors note: This year What If?, our annual collection of scenarios, considers the future of health. Each of these stories is ction, but grounded in historical fact, current speculation and real science. They do not present a unied narrative but are set in dierent possible futures

THEY CAN, at times, look somewhat sinister, their faces oddly small for their heads, their white ear tufts jutting out almost aggressively. Their ability to throw themselves at people across seemingly unfeasible distances can be unsettling, and their buzzing and shrieking takes a lot of getting used to, as does their smell. But the members of the Caird collective will not hear a word spoken against the marmosets with whom they share their spaces at the Moons South Pole. As they sit in their insulated caves hoovering moondust out of the animals tails, few of the Cairders can imagine their life on the rim of Shackleton crater without themand none wants to. The marmosets of the Moon are the first and best example of what has turned out to be a fundamental fact of space flight: that the further humans get from Earth, the more they benefit from the companionship of other Earthly animals.

The marmosets were originally brought to the Moon as unwilling participants in a vital research project. Marmosets are lighteven under Earth gravityand reasonably easy to care for, but they have placentas much more like those of humans than any other animal their size, and reasonably short gestation periods. That made them ideal for looking at a fundamental question: can humans have healthy pregnancies in the low gravity of the Moon, where things weigh only one-sixth what they do on Earth?

In the 2020s and 2030s, the years of what the novelist Wil McCarthy called the Rich Mans Sky, questions of obstetrics and gynaecology received remarkably little attention. For many, the idea of staying in space long enough for such things to matter made little sensespace stations in Earth orbit and bases on the Moon were places for fixed-length work contracts and research sojourns, or for tourism. Babies were no more of an issue than they were in isolated 20th-century Antarctic research outposts.

There were, as it happens, a few babies born in Antarctica even back then, when its ice cover was all but intact. The Argentine and Chilean governments both saw the creation of natives on the continent as a way to establish sovereignty and arranged births to that end. But there was no reason to think that Antarctica was inimical to pregnancy and infancy. The long-term health effects of low gravity and microgravitywhich for those in orbit include brittle bones, muscle wasting and eye diseasewere something else. Adults could counter some of these effects with treadmills and tension cords. But as the title of an early paper on the subject succinctly put it, The fetus cannot exercise like an astronaut.

Even those, like Elon Musk, who talked of permanent settlements on Mars spent little time working on the question. It was left to a small team of scientists in the Japanese modules of the Artemis base founded in 2029 by America and its allies to explore the question experimentally with the help of marmosets, gene-splicing technology, intra-uterine monitoring devices and a giant centrifuge.

They had some success. Like human fetuses, marmoset fetuses spend most of their gestation with a density equal to that of the amniotic fluid around them, a neutral buoyancy that leaves them indifferent to local gravity; only relatively late on do differences due to gravity start to crop up. After a few years of trial and error, and some dainty gene-editing to rebalance the rate at which bones grow when not stressed through use, the researchers developed a regime involving hormone treatments for the mothers and regular late-pregnancy sessions in their custom-made room-sized centrifuge, known as the marmo-go-round. This reliably produced pups with strong-enough bones and muscles and little by way of deformity, though their tails were impressively long even by marmoset standards.

Unfortunately, in 2038 that research was interrupted by the geopolitical meltdown of the wolf-and-wimp war and then by the 26 months of the Great Grounding. With all powered flight within or through the Earths atmosphere prohibited, the various Moon bases seemed doomed even after they agreed to pool their resources to create what became known as the Polynational James Caird Collective. With all the groups biotech know-how turned to increasing food production and nutrient recycling, the marmosets were at first ignored and then freed to roam within the bases. Their effect on morale was instantaneous and profound.

The importance of companion animals to the mental health of people engaged in a homeless lifestyle was well documented in pre-war societies. It has been suggested that the effect of the marmosets on the Caird collective was similar; cut off from Earth, the humans were more homeless than any group of people had ever been before. Caring for, playing with and grooming marmosets also became a basis for bonding between humans, many of whom had not known each other before the Grounding, and some of whose countries had been adversaries in the war. By the time the mysterious entity responsible for the Great Grounding finally abandoned its control of the Earths air-traffic-control and missile-defence systems, allowing traffic with the Moon to resume, the marmosets had become an indispensable part of the settlers new identity and society. Few believe that a lack of companion animals was, in itself, the reason that the Mars base failed during the Grounding. But it surely did not help.

The bond between the Moons larger and smaller primates persisted even as the rigours of separation came to an end. Almost all Cairders still dislike spending any significant time deprived of marmoset company. They cuddle them and relish their low-gravity acrobatics. In a joking way that seems, at some level, not to be a joke, they treat the abnormally long tails of the Moon-born marmosets as a sign of providence, holding the tail-fur to be particularly good at picking up moondust. The dust, which can cause lung disease, infiltrates their habitats despite all the airlock precautions; its suppression is a constant battle. Whether hoovering it out of tails which accumulate it in the manner of a feather duster is in fact more effective than the settlements electrostatic air-filtration systems is open to question. But it is clearly more therapeutic. And the marmosets enjoy the attention.

The oldest Earth-born marmoset, New Mrs Chippy (who is, despite his name, male) enjoys an honorary seat on the collectives council. He has now reached the age of 31 with no obvious signs of ageing other than a pelt almost as white as his ear tufts. This is seen as a good omen for human longevity among those Cairders who refuse to countenance a return to Earth. In Japan, by contrast, laboratory marmosets rarely make it past their 21st birthday.

The most salient biological, as opposed to sociological, novelty among Moon-born marmosets is a very high prevalence of adolescent-onset blindness. The constellation of eyesight problems known as Spaceflight Associated Neuro-ocular Syndrome (SANS) has been studied since early this century. In adult humans SANS normally develops only during long stays in the microgravity conditions of space stations; it is rare and mild among humans on the Moon. But in marmosets born in low gravity it develops swiftly and severely at the onset of puberty and leads to almost complete loss of vision.

There is as yet no agreed explanation for this pathology. Some researchers believe it is not in fact gravity-related but the result of an off-target effect of the gene editing which realigned the calcium pathways used in bone growth, but it is hard to square this with the similarity to SANS as experienced by genotypical adult humans. Others think its onset could be avoided if newborn pups were required to spend more, or all, of their time in the simulated Earth-normal gravity of the centrifuge. But it has proved hard to test this hypothesis. Infants that have spent any time at all in lunar gravity are greatly distressed by the rigours of the centrifuge and will not suckle when put into it. And Cairders are unanimous in their opposition to anything that causes marmosets distress.

The blind marmosets are not badly off. Their sibling groups and human companions provide what little practical support they need. And they are happier than sighted marmosets to travel in the pouches which many Cairders have incorporated into the suits they use for working on the lunar surface. Sighted marmosets are clearly disturbed by the harsh monochrome landscape, even when emotionally supported with the amplified sound of their companions heartbeat.

Sudden-onset SANS leaves the question of whether human children can be born and raised on the Moon unanswered. It is sometimes suggested that a blind woman happy with the idea of a child who might also be blind could choose to join the collective and explore the issue. But bringing a child to term would require a centrifuge capable of holding a grown human, rather than a 250-gram marmoset. There is no appetite among Cairders for devoting resources to such a project, and their juche ethic of self-sufficiency will not let them accept funding for such experiments from Earth. Thus how well humans may eventually be able to breed on alien worlds remains unknown, even today.

That they will take animal companions with them, though, now seems certain. And some of those companions will surely have shocking-white ear tufts, odd little faces and very long tails.

Full contents of this What If?Freedom to tinker, October 2029: What if biohackers injected themselves with mRNA?The other epidemic, June 2025: What if America tackled its opioid crisis?A tale of two cities, June 2041: What if a deadly heat wave hit India?You are what you eat, January 2035: What if everyones nutrition was personalised?iHealthy, September 2028: What if smartphones become personal health assistants?Mrs Chippys benediction, February 2055: What if marmosets lived on the Moon?*Novel treatments, August 2050: What if dementia was preventable and treatable?Rage against the machine, December 2036: What if an AI wins the Nobel prize for medicine?Germ of an idea: What if germ theory had caught on sooner?

This article appeared in the What If? section of the print edition under the headline "Mrs Chippys benediction"

Originally posted here:
What if marmosets lived on the Moon? - The Economist