Category Archives: Human Longevity

President Moon Jae-in expresses appreciation for Samsung Biologics` 1.7 trillion won and Celltrion`s 500 billion won investments in biologics industry, promises 1.7 trillion won national budget for biohealth industry in 2021, at a memorandum of understanding ceremony held at Yonsei University Global Campus in Songdo, Incehon, on Wednesday. (Yonhap)

Samsung Biologics will pour 1.7 trillion won ($1.54 billion) into its new Plant 4, and Celltrion 500 billion won to its Global Life Science Research Lab and Plant 3. The Government also pledged 1.7 trillion won budget in 2021 for bio health industry, which is a 30 percent increased budget compared to last years, reflecting the growing interest from the Korean government to build up the national ecosystem for biologics industry. By 2023, the total amount of private investments for biohealth industry will amount to 10 trillion won, the Korean government projected.

President Moon Jae-in personally attended the memorandum of understanding ceremony Wednesday at Yonsei University Global Campus in Songdo to encourage and promise governmental support in the private companies endeavors.

Also among the attendees were Finance Minister Hong Nam-ki, who doubles as deputy prime minister for economic affairs, Industry Minister Sung Yoon-mo, Science Minister Choi Ki-young, Health Minister Park Neung-hoo and Drugs Minister Kim Gang-lib, as well as Incheon Mayor Park Nam-choon. Heads of parts and equipment companies Junghyun Plant and Wiatek and students in biologics and relevant fields were also included.

Koreas action plan for a more robust bio industry ecosystem is to inject 1.7 trillion won from the budget in 2021, up 30 percent from that assigned a year prior, and to foster specialized future experts and collaboration with small and medium-sized companies.

In the world market, the biologics industry is notching an annual average growth rate of 4 percent, higher than makers of ships at 2.9 percent and automakers at 1.5 percent, according to the government agencies.

Taking this into consideration, the biohealth players in Korea are seeking to create synergy by building an ecosystem for biologics in Songdo.

There are now over 60 bio-related companies in Songdo, including both Korean and global firms. These firms employ some 7,000 workers.

By 2023, about 10 trillion won of investment is expected to be made in the city by some 40 health care and venture capital firms, resulting in an annual 20 percent growth of manufacturing capacity and the additional employment of approximately 9,300.

The government envisions growing a workforce of some 47,000 in biologics by 2025 in a joint effort with the industry and academia. To that end, at Yonsei University Global Campus a center to foster biologics processing experts will be established.

In the big picture of nationwide efforts to grow the biologics industry, regional bio clusters of Songdo in Incheon, Wonju in Gangwon Province, Osong in North Chungcheong Province and Daegu will increase collaboration.

The governmental budget of 1.7 trillion won will prioritize pharmaceuticals, medical devices and digital health care, in that order.

Samsung Biologics groundbreaking ceremony for Plant 4 takes place Wednesday in Songdo, Incheon. (Samsung Biologics)

Projected to begin partial manufacturing from 2022 and full operations in 2023, Plant 4 will have capacity of 256,000 liters. This surpasses the record of Samsung Biologics Plant 3 as the largest biologics manufacturing plant in the world with 180,000 liters.

The Super Plant alone will sprawl across 238,000 square meters, nearing the combined land size of Samsung Biologics Plants 1, 2 and 3 combined, at 240,000 square meters.

The company will inject 1.74 trillion won to build the massive plant, and employ an additional workforce of 1,850.

Once Plant 4 is complete, Samsung Biologics will purchase another slab of land in Songdo to start a second campus of its facilities, Samsung Biologics CEO Kim Tae-han said at the ceremony.

Celltrions proposed Global Life Science Research Center (Celltrion)

The antibody maker is not stopping there -- Celltrion Chairman Seo Jung-jin said at Wednesdays event that the company is mulling Plant 4 in the near future, with aims to expand its total production output to 600,000 liters as fast as the company can manage.

If executed, this plan would triple Celltrions current manufacturing capacity of 190,000 liters in a single generation. According to Seo, Celltrion is mulling facilities of 200,000 liters in Songdo, with the rest located overseas.

Global Life Science Research Center will complete construction by July 2022 and accommodate 2,500 additional researchers. Plant 3 will have its groundbreaking in 2021 and finish building by May 2023.

How we compete against multinational companies with more than a century of history is through advanced technology and our fighter spirit, Seo said.

Celltrion will carry out in stages investments of 40 trillion won through 2030.

Celltrion began in 2002 as a six-person startup. This year, it is on track to place No. 30-35 among some 300,000 biologics companies in terms of operating profit.

With Samsung Biologics and Celltrions investments, Korea as a nation will have the capacity to manufacture 910,000 liters of biologics a year. Songdo as a city will have the worlds biggest manufacturing output of biologics substances.

The reason we must combine forces in the bio industry is clear, because it is something we can be good at, said President Moon Jae-in at the ceremony.

The answer to humanitys wishes to live long healthily lies in the bio industry, Moon said. And so long as human longevity continues to lengthen, the bio industry will always be a future growth driver.

Just a few years ago, biologics was an area with a great hurdle. When the free trade agreement between the US and Korea was signed, we expected bio to suffer among the worst blows, Moon said.

But now the Republic of Korea is rewriting history for the bio industry. For now, we only account for 2 percent of the world bio market. But armed with global No. 2 capability to manufacture biopharmaceuticals, we now have the growing confidence that we can achieve greater goals, Moon said.

Heading forward, Koreas Industry, Science and Health ministries would work to combine electronics, chemicals, energy, manufacturing, data, networks, artificial intelligence and semiconductors with biotechnologies.

This is anticipated to bring forth innovative research on human-augmented robots, cerebral computer interfaces, eco-friendly plastics, functional fibers, renewable green energy and breakthroughs in manufacturing models leveraging microorganisms.

Big data with biotech will enable customized personal treatments, while communications will enable real-time patient monitoring. Artificial intelligence will help conduct research more quickly, with semiconductors and software technologies aiding in early diagnoses.

By Lim Jeong-yeo (kaylalim@heraldcorp.com)

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Korea plans up to W10tr investment for biohealth by 2023 - The Korea Herald

Example of a tissue stem cell (left) holding on to its immortal DNA strands after dividing to produce a maturing tissue cell (right).

BOSTON (PRWEB) November 18, 2020

What does it mean for multiplying cells in the body to be immortal? The cell DNA is being replicated over and over again while being divided equally between new cells produced by cell divisions. All the new cell components produced by the DNA code are mixing with the old cell components and being divided between the new cells. So, every cell is a new cell. There is nothing really immortal about any of them. Right?

Not quite. Stem cells responsible for renewing other mature body cells are different. For a long time, tissue cell scientists had a somewhat nebulous idea that stem cells had a special longevity in organs and tissues that they were immortal cells, lasting for as long as the human lifespan. However, no one had a molecular concept for this idea of stem cell immortality until John Cairns, a pioneer of DNA replication, started thinking about DNA mutations and cancer in the 1970s.

Cairns predicted that stem cells did something unique with their DNA code. He said they held on to one strand of every one of their many chromosomes and never shared those DNA strands with the tissue cells they renewed. Cairns called these immortal DNA strands. Cairns argued that immortal DNA strands must exist to explain how immortal stem cells avoid higher cancer rates.

Asymmetrex director James Sherley calls the immortal strand hypothesis the Carpenters Rule for stem cells. Good carpenters avoid creeping measurement errors by using a ruler or the same piece of wood to measure duplicates. Too many DNA duplication errors in cells make them cancerous. Cairns proposed that stem cells were smart carpenters, keeping and using the same DNA strands for making their many replicate copies over the human lifespan.

Prior to Asymmetrexs new report, published in a special issue of the peer-reviewed journal Symmetry, there were many publications on the presence of immortal DNA strands in stem cells of other species, including molds, plants, insects, and mice. Low levels of immortal DNA strands were also reported for human cancer cells.

The new report from Asymmetrex describes the presence of immortal DNA strands in human liver stem cells. The SACK-Xs 12(3) stem cells used in the study were developed more than a decade earlier using Asymmetrexs patented SACK tissue stem cell expansion technology. SACK-Xs 12(3) human liver stem cells are distributed for research by Kerafast. They are the first and only commercial human tissue stem cell product supplied with their stem cell-specific dosage, certified by Asymmetrex.

The new report brings an important closure for an ingenious scientific deduction by a remarkable scientist, John Cairns, recently deceased. Now that normal human tissue stem cells are confirmed to have immortal DNA strands, scientists can get on with the business of leveraging this knowledge to a better understanding of tissue stem cells for improving human health.

About Asymmetrex

Asymmetrex, LLC is a Massachusetts life sciences company with a focus on developing technologies to advance stem cell medicine. The companys U.S. and U.K. patent portfolio contains biotechnologies that solve the two main technical problems production and quantification that have stood in the way of effective use of human adult tissue stem cells for regenerative medicine and drug development. Asymmetrex markets the first technology for determination of the dose and quality of tissue stem cell preparations for use in stem cell transplantation therapies and pre-clinical drug evaluations. Asymmetrex is a member company of the Advanced Regenerative Manufacturing Institute BioFabUSA and the Massachusetts Biotechnology Council.

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Asymmetrex Publishes the First Report of Immortal DNA Strands in Human Stem Cells - PR Web

The International Space Station has been continuously occupied for two decades, and the astronauts and cosmonauts aboard have taken more than 3.5 million photographs of our home planet from space. Credit: NASA

After 20 years of continuous human presence, the International Space Station (ISS) has provided 241 visitors with an extraordinary view of Earth from outer space one they have shared with the rest of the world.

Astronaut photography, formally called Crew Earth Observations (CEO), has resulted in more than 3.5 million photographs of the ever-changing blue planet. But camera-wielding astronauts are not the only ones looking down at Earth from their perch in the sky. An impressive suite of Earth Science instruments have also visited the station to capture vast amounts of data about our planet.

However, space aboard the station itself is limited, and the spots are highly coveted. Instruments go through a rigorous approval process and cycle through every couple of years, turning the station into a virtual swiss-army knife of interchangeable remote sensing tools. An especially comprehensive suite of Earth observing instruments are currently aboard the station, with two more approved and several more proposing to become future ISS instruments.

These instruments complement one another to provide a more complete picture of Earth systems, according to William Stefanov, branch chief for the Exploration Science Office at NASAs Johnson Space Center, and principal investigator for the Crew Earth Observations Facility on the International Space Station. Thats why its serendipitously great that all of these instruments are on the International Space Station and functioning simultaneously, Stefanov said.

The ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) is located on the Japanese Experiment Module on the International Space Station. Credit: NASA

ECOSTRESS

The human crew came in especially handy for the Ecosystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) instrument, which records the temperature of plants on Earths surface by measuring the heat they give off. The instrument required the addition of Wi-Fi modules to transmit its data to the station, which in turn required astronauts to conduct a spacewalk to install them.

Since then, ECOSTRESS has provided new insights into the relationship between plant temperatures and water usage. It can identify plant stress down to an individual farmers field, when intervention and water management may still be possible to save crops.

Principal investigator Simon Hook says scientists have only just begun to scratch the surface of how the instrument can be used based on its frequent and high-resolution temperature measurements. There is work underway to use the temperature data to observe wildfires, droughts, volcanoes, and heat waves, or even to identify heat patterns within urban cities.

GEDI

From fields to forests, another plant-focused instrument is the Global Ecosystem Dynamics Investigation(GEDI). Using lidara method of bouncing a laser off the planet and measuring how long it takes the signal to returnGEDI is creating a record of the three-dimensional structure worlds tropical and temperate forests so that Earths tree canopies can be mapped and tracked over time.

The vertical structure of forests, which is essentially the height of the trees and how their leaves and branches are arranged vertically, can help determine how much carbon storage is lost from deforestation or gained from growing forests. GEDI principal investigator Ralph Dubayah, professor of Geographical Sciences at the University of Maryland, College Park, says this is the biggest uncertainty we have about the global carbon cycle, and why there is so much attention put on understanding how deforestation and tree growth contribute to atmospheric carbon dioxide concentrations. GEDI is a collaborative effort between NASA and UMD.

Measurements from the Global Ecosystem Dynamics Investigation (GEDI) show that tree canopy peaks in the middle of the African continent what we know as the Congo Basin. Credit: University of Maryland

To supply its high-power laser, GEDI takes advantage of the massive solar panels on the station. Right now on the International Space Station we have an amazing confluence of instruments that together are able to observe ecosystem function, structure and plant composition, Dubayah said. And it was entirely made possible because we have this incredible science platform in the ISS.

LIS

Being high above the clouds also makes the station a good platform for observing the weather. NASAs Lightning Imaging Sensor (LIS) records the time, energy output and locations of lightning events around the world in the lower atmosphere. It can provide information on when storms are growing or decaying, thereby helping to improve weather forecasting models and aircraft/spacecraft safety precautions.

It complements the Geostationary Lightning Mapper (GLM) aboard the Geostationary Operational Environmental Satellite (GOES-16), which is a collaboration between NASA, the National Atmospheric and Oceanic Administration (NOAA) and industry partners, and the European Space Agencys (ESA) monitoring of thunderstorms and upper atmosphere lightning events through the Atmosphere Space Interaction Monitor (ASIM) instrument which is on the ISS.

The data from ASIM and LIS are both able to capture the impacts of dust storms, pollution, fires, and volcanic eruptions on cloud formation and electrification. This is just one example of how ESA, and other international agencies including the German Aerospace Center(DLR) andthe Japan Aerospace Exploration Agency (JAXA), are also helping advance a global understanding of our planet through ISS-instruments with Earth observations of their own.

OCO-3

Several instruments currently aboard the station are not the first of their kind. As the name might suggest, the Orbiting Carbon Observatory-3(OCO-3) is a third iteration instrument for long-term monitoring of atmospheric carbon dioxide distributions around the globe, complementing long-term ground-based observations. It provides insights into regional carbon sources and sinks and monitors changes in the carbon cycle linked to human activity.

Together with GEDI and ECOSTRESS, OCO-3 contributes to a more complete picture of terrestrial ecosystems. While its predecessor, the OCO-2 satellite, followed a polar orbit, OCO-3s path aboard the station offers a denser data set for areas with large carbon fluxes, including Earths most biologically diverse regions like the Amazon rainforest.

The orbit also allows measurements at different times of day, which especially benefits ECOSTRESS and OCO-3 as plants and their contribution to the carbon cycle fluctuate with time of day due to variations in sun, temperature and water availability.

SAGE III

Like OCO-3, the Stratospheric Aerosol and Gas Experiment (SAGE) III, is a third-generation instrument. The successive SAGE instruments have provided an ongoing record of Earths upper atmospheric water vapor, aerosol and ozone which make up the protective sunscreen layer for the planet.

The stratospheric aerosol and gas experiment (SAGE) IIIs line of sight from the international space station provides a view of the aerosols and gases present in Earths atmosphere by taking advantage of the sunlight traveling through a slice of the atmosphere. Credit: NASA

When sunlight passes through the upper atmosphere, its unique mixture of particulates and gases create the picturesque colors of spectacular sunsets and sunrises. To replicate a sunset or sunrise view from the space station, SAGE III looks at Earth from a side angle, capturing a similar view of the atmosphere on its edge as someone watching the sunset from the ground. But from its vantage point of space, SAGE III can view the entirety of these atmospheric layers according to project scientist Dave Flittner, and sees 15 sunrises and sunsets every day.

Science manager Marilee Roell says the longevity of these observations has been crucial to monitoring and maintaining the protective ozone layer in the upper atmosphere. SAGE II closely monitored the past ozone decline from common aerosols in hair sprays and fire retardants that degraded the layer, and its data informed the Montreal Protocol Treaty, which phased out the use of these damaging chemicals.

Its one of the biggest success stories of science informing policy, said Roell. And not only is this a premier science instrument, but its also on the International Space Stationa crewed platform. We are kind of getting the best of both science and getting to be a part of the human spaceflight program in a peripheral way.

TSIS-1

Additional atmospheric measurements of the sun come from the Total and Spectral Solar Irradiance Sensor(TSIS-1) which is actually made of two instruments: the Total Irradiance Monitor (TIM) and Spectral Irradiance Monitor (SIM).

TSIS-1 continues the work of NASAs Solar Radiation and Climate Experiment satellitebymeasuring the amount of sunlight that reaches Earth, and how it is distributed in wavelength.

These measurements of solar energy, along with model-based calculations of its absorption and reflection by Earths atmosphere and surface, provide insights into the suns influence on climate, the ozone layer, atmospheric circulation, and ecosystems. The data are critical inputs for modeling of Earths climate and atmospheric systems.

COMING SOON: EMIT & CLARREO-PF

There is still more to learn about Earth, and new instruments which can further contribute to our understanding like the Climate Absolute Radiance and Refractivity Observatory (CLARREO) Pathfinder and the Earth Surface Mineral Dust Source Investigation (EMIT) are already scheduled to reach the station within the next couple of years.

The CLARREO Pathfinder will measure sunlight reflected off Earth, and take direct measurements of the Sun, with unparalleled accuracy. The data can then help calibrate other sensors starting in 2021. EMIT is scheduled to launch the following year in 2022 to map dust-source regions on Earths surface and assess the impact of dust on the warming and cooling of the atmosphere.

Its been really satisfying to see the range of things we have had on the space station, said Stefanov. From imaging systems to lasers and radars, and more recently hyperspectral instruments Stefanov believes that the limit to what they can do in the future is really only limited by what scientists and engineers are able to design and the number of instrument ports available.

There will be opportunities for new sensors to go up to the station, he said. And I think it will continue to develop as a very useful remote sensing platform for Earth observations going forward.

See more here:
20 Years of Observing Earth From the Space Station An Extraordinary View From Outer Space - SciTechDaily

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Global AI Medicine Software Market Analysis of Key Players, Type, Application, Demand and Consumption By 2026 - Stock Market Vista

Specific dietary changes, like including natural supplements, can help in enhancing sexual energy in women. Aphrodisiacs are the foods, drinks, or drugs that help increase female libido. Cannabis is another such natural aphrodisiac that can help increase womens libido. Cannabis can also help in reducing the pain during penetration experienced by some women.

According to a study, women who ate cannabis experienced two times higher sex drives, with satisfactory orgasms than those with irregular cannabis usage. Cannabis interacts with endocannabinoids in the body, which help regulate sexual function. Women can use cannabis as an aphrodisiac in many ways. Earlier, people used to take it in the form of a beverage, but today, there are many different consumption methods. Women can also use cannabis as lubricants, helping in reducing pain during sex.

Mental health disorders affect both men and women, but theyre more severe in women. Various factors like career, family responsibility, and abuse are significant causes of mental issues in women. The most common mental illness in women is depression, bipolar disorder, and schizophrenia, often challenging to diagnose.

According to an article, cannabis has antidepressant traits that help decrease anxiety and depression in women. The depletion of serotonin in the brain leads to depression. However, taking cannabis in low doses helps release serotonin, which causes anti-depressant effects. This can help in alleviating stress and anxiety, as well as assisting in doing day-to-day activities.

These are some of the benefits of cannabis for women. Research states that one should always use cannabis from low doses to reap the right health benefits. Buy cannabis products from reputed shops that will provide authentic cannabis products. Make sure to check the THC and CBD content in the product to understand the dosage. You may need to think twice if you have any medical condition or are taking any medication. If you fall into either of these groups, make sure to consult a health professional before starting cannabis.

Denson, T. F., & Earleywine, M. (2006). Decreased depression in marijuana users.Addictive behaviors,31(4), 738742. https://doi.org/10.1016/j.addbeh.2005.05.052

Lynn, B. K., Lpez, J. D., Miller, C., Thompson, J., & Campian, E. C. (2019). The Relationship between Marijuana Use Prior to Sex and Sexual Function in Women.Sexual medicine,7(2), 192197. https://doi.org/10.1016/j.esxm.2019.01.003

Olh, A., Tth, B. I., Borbr, I., Sugawara, K., et al. (2014). Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. The Journal of clinical investigation,124(9), 37133724. https://doi.org/10.1172/JCI64628

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4 Reasons To Use Cannabis For Treating Women's Health Issues - Longevity LIVE

New Market Research Report: on Adrenomyeloneuropathy Treatment Market size | Segment by Applications (Hospitals, Clinics, Ambulatory Surgical Centers and Others), by Type (Steroid Replacement Therapy and Stem Cell Transplant), Regional Outlook Opportunity, Market Demand, Latest Trends, Adrenomyeloneuropathy Treatment Industry Share & Revenue by Manufacturers, Leading Companies Profiles, Analysis, Growth Forecast 2025. Analyzes current market size and upcoming Few years' growths of this industry.

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Global Adrenomyeloneuropathy Treatment Market Size, Share, Trends, CAGR by Technology, Key Players, Regions, Cost, Revenue and Forecast 2020 to 2025 -...