Category Archives: Chemistry

MAHWAH, N.J., March 23, 2012 /PRNewswire/ -- HepatoChem, Inc, a chemistry-based technology platform company with a primary focus on metabolite production from bioactive small molecules, and an investment holding of Heartland Bridge Capital, Inc. (OTCBB: HLBC.OB - News), announced that it will present at the Early-Stage Life Sciences Technology Conference VIII at the Merck Research Laboratories in Boston, MA, on April 12, 2012.

The Early-Stage Life Sciences Technology Conference will showcase 20 life sciences technologies developed at the universities, research institutions, and hospitals of Massachusetts and recently formed Massachusetts companies to an audience of angel investors, venture capitalists and corporate investors. http://www.mattcenter.org/lsconf2012/

HepatoChem recently moved to its new laboratory in Beverly, MA. This is an important step for HepatoChem, which is committed to offering unique metabolite production services. This laboratory is part of the NorthShore Biotech Innoventure.

About HepatoChem, Inc

HepatoChem is a chemistry-based technology platform company with a primary focus on metabolite production from bioactive small molecules. Founded by Marc Bazin, previously with Pfizer, Inc., and Prof. John T. Groves, the Hugh Stott Taylor Chair of Chemistry at Princeton University, HepatoChem is dedicated to developing technologies that help pharmaceutical companies improve the quality of drug development pipelines. HepatoChem offers a unique and powerful solution to resolve the traditional lack of rapid and efficient metabolite access in drug discovery. http://www.hepatochem.com

About Heartland Bridge Capital, Inc.

Heartland Bridge Capital, Inc. (OTCBB:HLBC.OB - News) is a public company that, in addition to managing its own operating entities, participates in emerging companies run by exceptionally talented entrepreneurs and operating executives who are dedicated to creating positive change in our world. HLBC functions as an owner, product developer, and investor focused primarily on providing equity, acquisition debt, or bridge financing to emerging high-growth companies and entrepreneurs in the areas of clean energy, waste management, and life sciences. http://www.heartlandbridgecapital.com.

To request an investor packet, or to receive updates on Heartland Bridge Capital register online at http://www.wallstreetnewscast.com/request/hlbc.html

Safe Harbor Notice

Certain statements contained herein are "forward-looking statements" (as defined in the Private Securities Litigation Reform Act of 1995). Heartland Bridge Capital, Inc. cautions that statements made in this news release relating to the investment in HepatoChem, and potential investment in and the business direction of the Company, constitute forward-looking statements and makes no guarantee of future performance. Forward-looking statements are based on estimates and opinions of management at the time statements are made. These statements may address issues that involve significant risks, uncertainties, estimates, and assumptions made by management. Actual results could differ materially from current projections or implied results. Heartland Bridge Capital, Inc. undertakes no obligation to revise these statements following the date of this news release.

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HepatoChem to Present at Early-Stage Life Sciences Technology Conference VIII

Tweaking Samples for High-Speed Chemistry

A nanoprinting technique can be used to modify millions of samples.

A new way to print, and modify, nanoscale molecular samples could mean faster drug discovery and scientific experimentation. Combinatorial chemistryexposing a huge array of slightly different molecules to samples in parallelis an extremely fast way to screen drug molecules, or to test the way certain molecules affect biological cells.

Researchers at the International Institute for Nanotechnology at Northwestern University, in Chicago, led by director Chad Mirkin, have devised a way to rapidly prepare the smallest type of combinatorial chemistry array. They tested the approach by exposing stem cells to different-sized samples of fibronectin, a protein that plays an important role in cell adhesion, growth, and differentiation. The researchers used a nanoprinting technique previously developed by Mirkin's group, called polymer pen lithography, that delivers samples to a substrate in parallel via the tips of millions of pyramid-shaped "pens."

The innovation was to tilt the array slightly as these molecules were deposited, so that the pyramids closest to the surface make more contact and leave more material, while those farthest away leave less. Mirkin and colleagues found that, by tilting an array just 0.01 degrees, they could create 25 million fibronectin deposits of different size and structure.

When they applied stem cells to the array, they found that the size of the fibronectin molecules controlled the differentiation of these cells. "In the experiment, we only adjusted the size," says Mirkin, whose group published their results in Proceedings of the National Academy of Science earlier this month

It may eventually be possible to change other features of samples, such as composition or shape, using the same technique. These are common features explored by drug companies, Mirkin says.

"The technique they developed is extremely powerful with the generation of a large number of features in parallel," says Bing Yan, director of the High-Throughput Analytical Chemistry Facility at St Jude's Children's Research Hospital in Memphis, Tennessee, who was not involved with the research. "The number alone is very impressive."

Along with drug testing, Yan says the approach could be used to test the reactivity of catalysts and the properties of new materials.

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Tweaking Samples for High-Speed Chemistry

Dr. Keven Miller, Assistant Professor of Chemistry at Murray State University, addressed a talk on Adventures in Ionic Liquids: From Reactions to Solvents to Macromolecular Architectures to students, faculty, and members of the UT Martins Student Members of the American Chemical Society (SMACS) last Thursday.

Dr. Miller says, Ionic liquids are salts that exist in the liquids state. Typical salts (like sodium chloride - table salt) are highly crystalline and require extremely high temperatures to melt. Ionic liquids are poorly coordinated and the melting point is below 100 degrees Celcius, so they are not fully crystalline. Although ionic liquids have been around for nearly a century, the term ionic liquid has been accepted only within the last 15-20 years. Ionic liquids are used in a number of industrial processes such as acid scavenging and cellulose processing. More recently (last 10-15 years) ILs (ionic liquids) have been used more as greener replacements for volatile organic solvents in common organic reactions. Ionic liquids have negligible volatility, flammability and a lower toxicity profile. Some ionic liquids have even been shown to be biodegradable.

Dr. Miller goes on to name the four main classes of ionic liquids cations. They include ammonium, imidazolium, pyridinium, and phosphinium. Anions are not mentioned because they can vary widely.

Dr. Miller then explained the Michael Addition. The Michael Addition is a versatile, efficient method of forming new carbon-carbon bonds. According to Dr. Miller, base catalysts such as carbonate and bicarbonate can range from weak, to moderate, the amine group, to strong, the amides and hydrides groups.

The reactions are done in volatile toxic solvents. Dr. Millers interest on this topic of Michael Addition is how fast the reactions work and if a reaction will even occur. In model ionic liquids, changing the cation will effect the cation-anion interactions because the larger bulky anions tend to result weaker cation-anion interactions but improved organic solubility.

Dr. Miller tested the Michael Addition and found out it was successful. The reactions occurred faster than expected.

The reason for this enhanced rate is unclear but could be due to a number of different factors, says Dr. Miller.

Michael Additions proceeds well in ionic liquid solvents. Future studies for Dr. Miller in response to the Michael Addition is to pursue other anions with phosphonium cations.

Research interests include the applications of ionic liquids in organic and polymer/materials chemistry.

Senior Engineering major Jareth Embrey had this to say about Dr. Millers talk: Most people think research presentations are about a finished product, but this was really insightful for a work still in progress.

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Chemistry professor to speak on ionic liquids

DUBLIN--(BUSINESS WIRE)--

Dublin - Research and Markets (http://www.researchandmarkets.com/research/b81e8458/supramolecular_pol) has announced the addition of John Wiley and Sons Ltd's new book "Supramolecular Polymer Chemistry" to their offering.

Presenting the work of pioneering experts in this exciting field of supramolecular polymer chemistry, this monograph covers an extensive range of applications, including drug delivery and catalysis. It focuses on new structures and phenomena of cyclodextrin-based supramolecular polymers and many other compound classes. While providing a deeper insight in macromolecular recognition and the mechanisms of living systems, this book also introduces fascinating novel phenomena beyond natural systems.

Key Topics Covered:

- Multiple Hydrogen-Bonded Supramolecular Polymers

- Cyclodextrin-Based Supramolecular Polymers

- Supra-Macromolecular Chemistry: Toward Design of New Organic Materials from Supramolecular Standpoints

- Polymerization with Ditopic Cavitand Monomers

- Polymers Containing Covalently Bonded and Supramolecularly Attached Cyclodextrins as Side Groups

- Antibody Dendrimers and DNA Catenanes

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Research and Markets: Supramolecular Polymer Chemistry

DUBLIN--(BUSINESS WIRE)--

Dublin - Research and Markets (http://www.researchandmarkets.com/research/67961fb7/metal_chemistry_of) has announced the addition of John Wiley and Sons Ltd's new book "Metal Chemistry of Porphyrinoids" to their offering.

The examination of porphyrins and phthalocyanines and their metal complexes remains a pillar of the chemical sciences spanning fundamental chemistry and applications to biological chemistry and design of advanced materials. While the chemistry of the metalloporphyrins and metallophthalocyanines has been extensively explored, the metal chemistry of many of the analogs and isomers of the porphyrin macrocycle has only recently matured into a significant field.

With recent significant advances in the organic chemistry of aromatic polypyrrolic macrocycles, leading to the easy availability of porphyrin analogs and isomers, research into the metal chemistry of these compounds is allowing a deeper understanding of their role in biochemistry and the development of new molecules with exciting applications in medicine, catalysis, materials science, and sensors.

Metal Chemistry of Porphyrinoids summarizes these recent synthetic developments, particularly in respect of metallation strategies for freebase porphyrinoids, as well as progress towards applications in areas such as sensor and optical materials, catalysis and medicine. This reference summarizes those developments as well as progress towards a variety of applications which mirror the many uses of normal porphyrins and phthalocyanines.

Key Topics Covered:

- Chapter 1 Introduction

- Chapter 2 Metallation strategies for the porphryinoids

- Chapter 3 Isomeric porphyrins

- Chapter 4 Ring modified porphyrins

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Research and Markets: Metal Chemistry of Porphyrinoids

LONDON--(BUSINESS WIRE)--

Due to a number of factors like new and more stringent regulations; advances in diagnostic technologies, system engineering, automation, and IT; as well as intensifying competition, the clinical chemistry and immunodiagnostics markets are undergoing significant changes. Some segments, such as routine chemistry, start resembling commodity markets, where product positioning and cost per test are more critical than underlying technology. All these upcoming transformations in the marketplace are expected to provide amazing opportunities for a variety of new instruments and reagent systems, as well as auxiliary products, like specimen preparation devices, controls, calibrators.

New research report The 2012 European Clinical Chemistry and Immunodiagnostics Markets: France, Germany, Italy, Spain, UK - Emerging Opportunities and Business Expansion Strategies developed by Venture Planning Group (VPG) explores future marketing and technological trends in five major Europeancountries (France, Germany, Italy, Spain and the UK) and Japan; provides estimates of the specimen, test and sales volumes, as well as major suppliers' sales and market shares; compares features of leading analyzers; profiles top market players; and identifies specific product and marketing opportunities facing suppliers during the next five years.

Companies mentioned in the report include: Abbott Laboratories, AdnaGen, Ambrilia, AMDL, Beckman Coulter, Biomedical Diagnostics, BioMerieux, Bio-Rad, Canag Diagnostics, Dako, DiaSorin, Eiken, Fujirebio, Instrumentation Laboratory, J&J, Kyowa Medex, Matritech, Roche, Siemens, Sysmex, Thermo Fisher, Trinity Biotech, Tosoh, Wako, and Wallac.

Report Details:

Title: The 2012 European Clinical Chemistry and Immunodiagnostics Markets: France, Germany, Italy, Spain, UK - Emerging Opportunities and Business Expansion Strategies Published: March, 2012 Pages: 900 Price: US$ 18,500

http://marketpublishers.com/report/medicine_pharmaceuticals_biotechnology/drugs_biotechnology/2012_european_clinical_chemistry_n_immunodiagnostics_markets_france_germany_italy_spain_uk_emerging_opportunities_n_business_expansion_strategies.html

Report Contents:

INTRODUCTION

WORLDWIDE MARKET AND TECHNOLOGY OVERVIEW A. Major Routine Chemistry Tests 1. Albumin 2. Alkaline Phosphatase 3. ALT/SGPT 4. Ammonia 5. Amylase 6. AST/SGOT 7. Bilirubin 8. Blood Gases 9. Blood Urea Nitrogen (BUN) 10. Calcium 11. Cholesterol 12. Cholinesterase 13. Creatinine 14. Electrolytes a. Carbon Dioxide/Bicarbonate b. Chloride c. Potassium d. Sodium 15. Fructosamine 16. Gamma-Glutamyl Transpeptidase (GGT) 17. Glucose 18. High Density Lipoprotein (HDL) 19. Iron 20. Lactate Dehydrogenase (LDH) 21. Magnesium 22. Phosphorus 23. Protein 24. Triglycerides

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Europe Clinical Chemistry & Immunodiagnostics Markets Discussed in New Report Published at MarketPublishers.com