Category Archives: Chemistry

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/256cfr/solidphase) has announced the addition of John Wiley and Sons Ltd's new book "Solid-Phase Organic Syntheses. Solid-Phase Palladium Chemistry" to their offering.

This series informs researchers of major accomplishments in solid-phase organic synthesis and provides actual experimental details and specific references. With this series, a reader will be able to sharpen hands-on skills by following the experimental procedures and refining understanding of the science by studying the chosen reactions. More importantly, this series guides readers in designing novel compound libraries, and may also inspire future breakthroughs.

This second volume focuses on palladium chemistry in solid-phase synthesis, and discusses: palladium catalysts and reactions, procedures for preparation and utilization, ligands, and linker reactions.

Key Topics Covered:

1. An Introduction to Solid-Phase Palladium Chemistry

2. Pd-Catalysed Solid-Phase Decoration of the 2(1H)-Pyrazinone Scaffold

3. One-Step Palladium and Phenylsilane Activated Amidation of Solid Supported Ally Esters

4. Solid-Phase Reactions of Polymer-Bound Arenesulfonates with Aryl Grignard Reagents

5. Fluorous Synthesis of 3-Aminoimidazo[1,2-A]-Pyridine/Pyrazine Library

See the article here:
Research and Markets: Solid-Phase Organic Syntheses. Solid-Phase Palladium Chemistry

LOVELAND, Colo., Oct. 2, 2012 /PRNewswire/ -- Heska Corporation (NASDAQ:HSKA; "Heska"), a leading provider of advanced diagnostic and specialty products to veterinarians, announced today the expansion of its diagnostic blood analyzer suite. With proven dry chemistry technology and faster time to results, Heska introduces the new Element DC Veterinary Chemistry Analyzer. The Element DC will be manufactured by FUJIFILM Corporation. Heska believes blood chemistry represents the largest in-clinic testing market.

"Heska has enhanced our diagnostic line-up with a faster, more efficient point-of-care analyzer," commented Michael McGinley, President and Chief Operating Officer of Heska. "Among other notable features, the Element DC provides high-efficiency throughput, and an enhanced user interface, yielding faster answers for clients and patients. Consistent with ourcommitment to offer the latest technology in fundamental areas of veterinary medicine, Heska is thrilled to offer this latest generation chemistry analyzer."

Ideally suited for progressive veterinary practitioners who value speed and accuracy, the new Element DC is now available.

About HeskaHeska Corporation (HSKA) sells advanced veterinary diagnostic and specialty products. Heska's state-of-the-art offerings to its customers include diagnostic and monitoring instruments and supplies, allergy testing and treatment, as well as single use point-of-care tests, vaccines and pharmaceuticals. The company's core focus is on the canine and feline markets where it strives to provide high value products and unparalleled customer support to veterinarians. For further information on Heska and its products, visit the company's website at http://www.heska.com.

Forward-Looking StatementsThis announcement contains forward-looking statements regarding Heska's future financial and operating results. These statements are based on current expectations and are subject to a number of risks and uncertainties. There are uncertainties regarding Heska's ability to successfully commercialize new products; uncertainties regarding the in-field performance of any new product, including the Element DC; competition, including new products competitors may introduce in the future; uncertainties related to Heska's market estimates; uncertainties regarding Heska's ability to gain market share in an economic manner; and the risks set forth in Heska's filings and future filings with the Securities and Exchange Commission, including those set forth in Heska's Quarterly Report on Form 10-Q for the three months ended June 30, 2012.

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Heska Corporation Announces New Chemistry Analyzer

This is another approximate transcript of a part of the conversation I had with Chemjobber that became a podcast. This segment (from about 29:55 to 52:00) includes our discussion of what a just punishment might look like for PI Patrick Harran for his part in the Sheri Sangji case. From there, our discussion shifted to the question of how to make the culture of academic chemistry safer:

Chemjobber: One of the things that I guess Ill ask is whether you think well get justice out of this legal process in the Sheri Sangji case.

Janet: I think about this, I grapple with this, and about half the time when I do, I end up thinking that punishment and figuring out the appropriate punishment for Patrick Harran doesnt even make my top-five list of things that should come out of all this. I kind of feel like a decent person should feel really, really bad about what happened, and should devote his life forward from here to making the conditions that enabled the accident that killed Sheri Sangji go away. But, you know, maybe hes not a decent person. Who the heck can tell? And certainly, once you put things in the context where you have a legal team defending you against criminal charges that tends to obscure the question of whether youre a decent person or not, because suddenly youve got lawyers acting on your behalf in all sorts of ways that dont look decent at all.

Chemjobber: Right.

Janet: I think the bigger question in my mind is how does the community respond? How does the chemistry department at UCLA, how does the larger community of academic chemistry, how do Patrick Harrans colleagues at UCLA and elsewhere respond to all of this? I know that there are some people who say, Look, he really fell down on the job safety-wise, and in terms of creating an environment for people working on his behalf, and someone died, and he should do jail time. I dont actually know if putting him in jail changes the conditions on the outside, and Ive said that I think, in some ways, tucking him away in jail for however many months makes it easier for the people who are still running academic labs while hes incarcerated to say, OK, the problem is taken care of. The bad actor is out of the pool. Not a problem, rather than looking at what it is about the culture of academic chemistry that has us devoting so little of our time and energy to making sure were doing this safely. So, if it were up to me, if I were the Queen of Just Punishment in the world of academic chemistry, Ive said his job from here on out should be to be Safety in the Research Culture Guy. Thats what he gets to work on. He doesnt get to go forward and conduct new research on some chemical question like none of this ever happened. Because something happened. Something bad happened, and the reason something bad happened, I think, is because of a culture in academic chemistry where it was acceptable for a PI not to pay attention to safety considerations until something bad happened. And thats got to change.

Chemjobber: I think it will change. I should point out here that if your proposed punishment were enacted, it would be quite a punishment, because he wouldnt get to choose what he worked on anymore, and that, to a great extent, is the joy of academic research, that its self-directed and that there is lots and lots of freedom. I dont get to choose the research problems I work on, because I do it for money. My choices are more or less made by somebody else.

Janet: But they pay you.

Chemjobber: But they pay me.

Janet: I think Id even be OK saying maybe Harran gets to do 50% of his research on self-directed research topics. But the other 50% is he has to go be an evangelist for changing how we approach the question of safety in academic research.

Chemjobber: Right.

The rest is here:
Community responsibility for a safety culture in academic chemistry.

WALTHAM The last time the Celtics [team stats] made a preseason trip to Europe, they won the championship. Theyre hoping history repeats, as they departed for a week-long trip to Istanbul and Milan last night.

The 2007 trip to London and Rome gave the newly formed core of Paul Pierce [stats], Kevin Garnett and Ray Allen an opportunity to develop the chemistry that helped the team win the title. The Celtics underwent a makeover this offseason Allen departed for Miami and a number of players were added and the hope is this trip yields a similar bond.

Obviously we want to work on team chemistry, Garnett said. We want to get better every time we step on the floor. From a basketball standpoint, obviously were still getting to know each other. But its bigger than that. I think the trip to Turkey will be more social. The trip to Milan will be more for the chemistry.

Coach Doc Rivers had a practical explanation for why the players grow closer on foreign trips.

The craziest thing is that their cellphones didnt work so they actually had to talk to each other on the bus, Rivers said of the 2007 trip. I thought that was nice in this new cellphone-whatever generation this is.

The well-traveled Rivers has never been to Istanbul or Milan, and was looking forward to walking around the cities. As far as the trips effect on preparation for the season, Rivers isnt as enthusiastic.

This is a little different. We scheduled the Rome trip in response to all the moves we made and we really wanted that trip to happen, Rivers said. I dont know if this one I can say I wanted it, but its something now with all the moves Im looking forward to it. I think whenever you go on a road trip, even during the season, its never a bad thing.

Rivers is more concerned with the basketball work than tourism.

Were not going to change, Rivers said. Were going to do our job. All the other stuff is secondary for me, hopefully for them, too. But this is our camp and thats the way that I view it going into it.

Rivers sees early signs of strong team chemistry, crediting Garnett for getting new players acclimated.

Link:
Chemistry test during Euro trip

FRANKFURT, Germany, October 1, 2012 /PRNewswire/ --

Roche researchers expected to benefit from increased discoverability of in-house chemistry content,integrated and unified with externally validated content,directly retrievable in Reaxys

Elsevier today announced the integration of Roche propriety reaction information within Reaxys, which will run on Roche's infrastructure and inside the Roche firewall to provide high performance and security. Roche chemistry information will be securely searchable and discoverable by Roche scientists through the Reaxys user interface. The incorporation and discoverability of Roche proprietary information in Reaxys is anticipated to significantly improve Roche scientists' productivity.

With this development Roche researchers will be able to launch a single search in Reaxys across integrated internal data and experimental data published in journals and patents, with results unified and organised in a context directly relevant to the researcher workflow. The announcement comes after many months of collaboration between teams from Roche and Reaxys.

"We have been seeking to improve the discoverability of our in-house proprietary content, while at the same time avoiding investing in and maintaining an entirely new internally or externally developed system," explained Sven-Olaf Vogt, Global Head Scientific Information Management at Roche. "Working with the Reaxys team was a logical choice given the widespread adoption of Reaxys at Roche and the knowledge of the Reaxys team in chemistry content."

Mark van Mierle, Managing Director of Elsevier's Pharma and Biotech Group, added, "Our collaboration with Roche shows how we can work together with customers to serve scientist needs. Researchers want seamless, unified data streams, delivered through highly intuitive workflow tools. Our work with Roche responds directly to those needs and enables researchers to innovate more effectively by accessing data they need, through a world-leading interface."

About Reaxys

Reaxys is a workflow solution for research chemists. Offering a wealth of experimentally validated information, Reaxys combines reaction and substance data in organic, organometallic, inorganic and physical chemistry with synthesis planning. Researchers can get the information they need in a single overview, from source publications carefully selected for their importance and relevance to research chemists. Elsevier continues to engage with the chemistry community to ensure that Reaxys continues to reflect how chemists think and work. https://www.reaxys.com/info/

Reaxys and the Reaxys trademark are owned and protected by Reed Elsevier Properties SA and used under license.

About Elsevier

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Elsevier and Roche Collaborate To Integrate Proprietary Chemistry Data In Reaxys®

Ron Washington tells a story that sheds light on why the Rangers, two-time reigning American League champions, are so much more than the popular image of a marauding band of bash brothers, pounding the opposition into submission.

A players' manager of the highest order, respected for the freedoms and trust he grants his athletes, Washington has his rules and regulations.

Above all, this man, who was content teaching infielders and flashing signs from the third-base coach's station, is fastidious about fundamentals, about playing the game the right way and making no excuses. He will not compromise there.

When one of his players gets mentally lazy -- no matter the rank -- the nice-guy manager will vent. On this particular occasion, he was on his way to the offending athlete's locker after the game to hammer home a point.

"Before I got there," Washington said, "I saw Adrian [Beltre] in his face, letting him have it. I turned and went back to my office. That's what you want on your team, and that's what we have. These guys run their clubhouse. We have strong leaders on this team."

The Rangers are rawhide-tough. Balancing the voices of authority, such as Beltre and Michael Young, is the light, fun-loving touch of Elvis Andrus, who can create a party atmosphere in a heartbeat.

To sustain winning chemistry over a long season, you need that positive energy along with the physical and emotional commitment. In spite of the rueful way the 2011 season ended, the Rangers still have it. It's impossible to miss.

Supremely confident, they are destined to reach their promised land, at last, in 2012. They have the resources -- pitching, power, defense, speed -- and the mental toughness. Having achieved so much these past three seasons, the final hurdle awaits.

It's time to win the World Series.

Everyone knows how close they came last season when the Cardinals staged their comeback of the ages. Game 6 of the 2011 Fall Classic is the stuff of legend -- at the Rangers' expense. Game 7 became an extension of the implausible way Game 6 played out.

Original post:
Rangers have resources, chemistry to win it all