Category Archives: Anti-Aging Medicine

Penny Foskaris, a well-respected and prominent functional nutritionist in Los Angeles, California, has joined the prestigious Haute Beauty network.

LOS ANGELES, Aug. 28, 2020 /PRNewswire-PRWeb/ --Penny Foskaris is a Functional Nutritionist, American Association of Diabetes Educators Paraprofessional Level 1 and a Certified Health Coach. She is also on the Community Leadership Board with the American Diabetes Association and is a member of The American Academy of Anti-Aging Medicine.

Penny has been seen on NBC, CBS and Fox cooking healthy delicious recipes while teaching the importance of healthy eating. She has helped hundreds of people find the importance of following a balanced diet by eating whole foods through the years.

She has spoken in front of hundreds of people teaching the importance of proper nutrition and eating a balanced diet. She created The Fast Foods Diet Cookbook to make it easy to make meals that are healthy and equally delicious.

Visit Penny Foskaris's Haute Beauty Profile at: https://hauteliving.com/hautebeauty/member/penny-foskaris/

Visit Penny Foskaris's website at: https://www.foskariswellness.com/

ABOUT HAUTE BEAUTY:

Haute Beauty offers readers access to an invite-only, prominent collective of leading doctors and industry-leading aesthetic surgeons located in their area. Haute Beauty is affiliated with the luxury lifestyle publication Haute Living. As a section of Haute Living magazine, Haute Beauty covers the latest advancements in beauty and wellness, providing readers with expert advice on aesthetic and reconstructive treatments through its network of acclaimed surgeons.

To learn more about Haute Beauty, visit https://hauteliving.com/hautebeauty/

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Renowned Functional Nutritionist Expert Penny Foskaris Partners with the Exclusive Haute Beauty Network - Yahoo Finance

If youve been holding off on restocking your medicine cabinet shelves or your makeup bag, now is the moment. The Nordstrom Anniversary Sale ends this Saturday, August 30 and while some of the star products sold out during the early access phase, there are still plenty of worthy steals to be found.

While Sephora, Ulta, Dermstore and others all run annual sales, none of them can hold a candle to the deep discounts on top beauty products found during the Nordstrom Anniversary Sale. The department stores annual sale is one of the only beauty sales to mark down a slew of best-sellers as well as brand-new products, meaning its the perfect time to snag latest-technology beauty devices as well as stock up on products you use frequently.

There are plenty of haircare and make-up products to add to your shopping cart (see highlights from Oribe, Briogeo, Becca and Charlotte Tilbury below), and the skincare selection should not be missed. Look for minis from ultra-luxe brands like La Mer and Doctor Barbara Sturm, or round out your skincare regimen with best-sellers from Kate Somerville, and Kiehls.

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While some scrubs can strip the skins protective barrier, this formula from Kate Somerville combines lactic acid with honey and vitamin E to polish without drying. Its gentle enough for most skin types and is formulated without sulfates or phthalates. You only need a pea size amount each time, so this 5 oz bottle will last you well through the fall and winter.

British makeup darling Charlotte Tilbury's best selling gilded eyeshadows are now available in a three piece set: two cream-to-sheen eyeshadows and one volume-enhancing mascara come together to make the perfect soft golden eye. The darker shade, called Star Gold, has a rich coppery hue which looks great as all-over color or smudged into the crease of your lid, while the lighter Golden Eclipse adds a lovely wash of light shimmer.

Bouncy curls and loose waves at home have never been easier than with this technologically advanced curling iron, which recognizes each section of your hair in order to use the correct amount of heat. (In the market for a straightener instead? This GHD styler is designed with a similar technology and is also on sale.)

This gentle liquid cleanser is a great one-size-fits all option: it whisks away makeup and grime without upsetting the pH balance of your skin. Sensitive and dry types will love the soothing addition of apricot kernel oil, vitamin E, and avocado oil, too. Plus, its a concentrated formula, so this jumbo size will last for months.

Briogeos quenching clean hair care line is a favorite amongst folks with curly, kinky, or frizzy locks or anyone with color-treated hair that could use some extra TLC. This kit includes a full size 8 fl oz tub of the popular Don't Despair, Repair! Conditioning Mask, as well as a full size Farewell Frizz Rosarco Milk Leave-In Conditioning Spray. It also includes a travel size Scalp Revival Charcoal + Coconut Oil Micro-Exfoliating Scalp Scrub Shampoo, which is a weekly treatment that combats product build up or itchy, flaky scalp build up.

Lash serums are having a moment: with former extension fanatics taking a break during Covid and the idea of applying mascara (and taking it off) day in and out seeming a little tedious, the allure of plumped up natural lashes has never been stronger. This serum from NeuLash relies on hydrating sodium hyaluronate, amino acids, and peptides to lengthen and strengthen.

As much as La Mer has a reputation for excellence, it can be hard to not balk at the steep price tags. This set of soothing and moisturizing minis gives you both the opportunity to find your cant live without product from the storied French brand and provides a pretty discount. The gold standard Crme de La Mer is included of course, alongside a fast-absorbing treatment lotion, which relies on the brands proprietary Miracle Broth to hydrate and tone. Also included is the regenerative Renewal Oil and a highlighter, called the Hydrating Illuminator, which gives skin a lit-from-within glow.

This translucent setting powder extends the life of your makeup without any dryness or powdery texture, thanks to its lush, mist-like feeling on skin (the formula is made up of 50% water and glycerin to add moisture). While its nearly translucent, it does come in two flattering shades the original, a pale peachy tone, and the golden bronze, a deep caramel color.

Nordstrom

This is the perfect set for those days when youre trying to stretch your shampoo but you still need to hop on Zoom meeting after Zoom meeting. The Gold Lust Dry Shampoo absorbs oil without adding grit or residue, while the Dry Texturizing Spray adds shape.

British makeup artist Charlotte Tilbury is known for her soft, sultry, vaseline-lensed beauty looks so its no surprise that her best selling Pillow Talk lipstick would end up being the enhanced nude for thousands of women (including Gwenyth Paltrow and Kate Moss.) The light, pinkish mauve lipstick has a creamy consistency that plumps and moisturizes, with a buildable hue. This kit comes with the original lipstick as well as a liner and gloss in the same shade, for creating every possible rendition of pillowy, pink lips.

Living Proofs Perfect Day hair care line is a cult favorite for a reason it delivers manageable and moisturized hair without phthalates, silicone, or oils. This three piece set is a great option for anyone with low maintenance hair who just wants an effective straightforward routine and big enough bottles that they wont have to refill anytime soon. For $99, you get a 24 oz set of shampoo and conditioner, plus a dry shampoo to stretch styles.

If youve wondered about Dr. Barbara Sturms beloved skincare line but had sticker shock each time, this starter trio is the way to go. At $215, its still pricey but each of the anti-aging serums are meant to be applied just a few drops at a time (and, they work best in unison.) Start with the Super Anti-Aging Serum, a calming, regenerative mix of anti-inflammatory purslane and antioxidant rich skullcap. Then, dab on the Hyaluronic Serum to quench skin. And finally, pat on the Night Serum, which also relies on hyaluronic acid, this time mixed with plankton extract to reduce fine lines and senna alata to repair skin.

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The 12 Beauty Products Not To Miss From The Nordstrom Anniversary Sale - Forbes

HONG KONG, CHINA - 2020/08/28: French multinational Chanel clothing and beauty products brand store ... [+] seen in Hong Kong. (Photo by Budrul Chukrut/SOPA Images/LightRocket via Getty Images)

Millennials have taken the bull by the horn they are redefining norms and challenging the status quo. Traditions that looked like bus-stops, have now been challenged and transformed by the innovative ideas from millennials.

They unarguably represent the future of the world in many ways and are the new decision-makers, affecting the way companies produce and innovate. Though born between the 1980s and 1990s, the influence of millennials or Generation Y as they are called in some quarters, transcends their age grade. Millennials are determining fashion trends and affecting the way their predecessors do things and approach life.

Millennials grew up right in the face of the internet and mobile technologies. Backed by this, their understanding and definition of luxury differ in many ways to age-long traditions. Companies must now repackage and refocus her processes and models to meet the realities of the present age as influenced by millennials.

Today, the luxury fashion industry is undergoing large-scale changes. The reason being is because consumer behavior has been forced to adapt to the rise of the global leader; technology. In fact, the impact of modified technology has affected most business especially in these uncertain times.

As we roll into the second half of a very challenging year, we notice that old buying patterns have made significant changes to a simpler yet, complex environment. Many luxury vendors who I report on have been trying to stay focused and willing to update their digital technology methods.

LOS ANGELES, CALIFORNIA - FEBRUARY 07: Tom Ford Model attends the Tom Ford AW/20 Fashion Show at ... [+] Milk Studios on February 07, 2020 in Los Angeles, California. (Photo by David Crotty/Patrick McMullan via Getty Images)

Challenging the Status-quo

Not only are millennials influencing the activities of luxury brands, but their preferences in terms of buying is also affecting the sales strategy and focus of brands. According to a report by McKinsey&Company, Online sales of personal luxury goods apparel, footwear, accessories, jewellery and watches, leather goods, and beauty and perfume account for 8 percent of the 254 billion global luxury market, or about 20 billion.

The report indicates the companys expectation that online luxury sales would triple by 2025 - meaning that nearly one-fifth of personal luxury sales will take place online. The footprint of millennials is written all over this new trend if they are not ordering an item(s) for themselves, they are ordering for someone else or influencing someone to do so. Indeed, millennials are redefining buying behaviour for luxury items.

Age-long traditions for luxury items like fashion wears, smartphones, design furniture, cars and the likes, were characterized by luxuriously decorated showrooms and stores, but the millennial lives on the internet. As a result of this, brands are investing more energies into product photography and in building their online appeal.

Setting the pace through digital technology

Millennials are not determining the trends and pace of innovation through digital technology alone, they are also leading the way by creating digital technology-powered solutions. These solutions are shattering the norms and setting the pace in various aspects of luxury.

PARIS, FRANCE - JANUARY 18: A model walks the runway during the Hermes Menswear Fall/Winter ... [+] 2020-2021 show as part of Paris Fashion Week on January 18, 2020 in Paris, France. (Photo by Peter White/Getty Images)

Millennials are not determining the trends and pace of innovation through digital technology alone, they are also leading the way by creating digital technology-powered solutions. These solutions are shattering the norms and setting the pace in various aspects of luxury.

Millennials and financing

According to a Forbes report, the global luxury market is predicted to top 1.3 trillion ($1.5 trillion) by 2025, with experiential luxury growing about 5%, far faster than personal luxury at 3%, with accessories and cosmetics expected to gain the most from 2018-2025. The report holds that millennials represent only about 32% of spending in the personal luxury market, but expects this number to increase to 50% by 2025.

For this to happen, millennials would need to have greater financial access. Over the past decade, the world has seen millennials rise to become millionaires and billionaires through legitimate means. Much of this rise is on the heels of digital technology-powered solutions.

There are unarguably more innovative ideas, some of which are yet to see the light of day. Business reality shows targeted at bringing new ideas to the limelight are filled with entries from millennials. Most of these millennials lack the financial resources to birth their ideas.

To tackle this financing problem, Cash-U finance was set up to provide quick, easy and low-interest loans to people. Cash-Us procedure simplifies the online receipt of money and takes only a few minutes to process.

According to Evgeny Yezhov, founder of MFO Cash-U Finance, In every application that we process, our automated scoring system Cash-U Finance runs through up to 10,000 parameters within 20 seconds, all within regulatory compliance. It takes into account not only credit data and the income level of the applicant but also the movement of funds in their accounts, the nature of expenses and settlements with organizations Access to finance has never been this easy and it is all part of the giant strides by millennials in breaking age-long traditions.

Isabel Alysa on set with Cardi B, making sure she glows

Millennials and medicals

With digital technology, everything is easier. Through the help of digital technology, there is little need for physical meetings. If you needed to see a doctor, you can book for an appointment and have the consulting session using your mobile devices.

Even the way that people stay healthy, fit and achieve flawless aging has changed. The infusion of digital technology into the practice of medicine has led to life-changing innovations that are making medicare both affordable and effective. Once again, millennials are at the forefront of this, leading to medical practices that are created to match their preferences.

Isabel Alysa

Millennials are also not leaving the responsibility for what they want to coincidence, they are stepping forward to lead the change they want to see. One of such millennials is Celebrity Tan Artist Isabel Alysa, who owns Dolce Glow and is the private tanning professional to people like Kim Kardashian, Miley Cyrus, Cardi B and J Lo. Her brand offers luxury treatments for millennials with product offerings that include spray tanning courses, private tanning service, and a proprietary spray tan solution. Alysa explains, Its not just about going digital and customizing our products to match a new and different approach to luxury, its about connecting with people on a personal basis. Reinforcing peoples confidence, individuality and learning is what really resonates these days. So combine the three and you have a modern and approachable brand that is bound to captivate. Isabel has utilized zoom to digitally train people worldwide on her spray tanning techniques, touching people all the way in Kuwait, France, and Guatemala.

MILAN, ITALY - JANUARY 16: Models pose at Ralph Lauren Purple Label Presentation as part of Milan ... [+] Men's Fashion Week FW16 on January 16, 2016 in Milan, Italy. (Photo by Stefania D'Alessandro/Getty Images)

Sandra Bledsoe is another example. Together with her brand, Revenge MD, Sandra Bledsoe hopes to inspire women and men alike to transform and improve their confidence. Sandra believes that successfully looking your best is the ultimate revenge. To help people achieve this, Revenge MD offers services that are centred around anti-aging and medical wellness from licensed trained professionals. These services include weight loss, hormone balance solutions, botox, fillers and PDO thread lifts.

LONDON, ENGLAND - NOVEMBER 21: a general view at the men's grooming event for the opening of the ... [+] first TOM FORD global beauty store in Covent Garden on November 21, 2017 in London, England. (Photo by David M. Benett/Dave Benett/Getty Images for Tom Ford )

However, despite the massive opportunities that digital technology presents, millennials still encounter challenges with job hunting and product management interviews. Product Gym exists to help people solve this problem and transition into software product manager jobs. Though many millennials possess relevant tech skills, the reality is that the job market is filled with tons of unemployed millennials. Whether it is a career in software or product management, product gyms are redefining the future of product management and empowering people to land the jobs of their dreams.

Millennials are leaving no stone unturned in their quest to make the world a better, safer and easier place to live in. Enabled by digital technology and the many possibilities it presents, age-long traditions of luxury are being challenged for good. These changes would no doubt set the tone for Generation Z.

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How Millenials Are Changing Age-Long Traditions Of Luxury With Digital Technology - Forbes

On April 15, 2002, the FDA approved a temporary treatment for wrinkles that would revolutionize aging. All of a sudden, you could waltz into a derms office and get your frown lines ironed out faster than it would take to iron an actual shirt. It was called botulinum toxin,Botox for short.

Eighteen years later, a few units of Botox every three months has become the norm for millions around the world (more than seven million yearly in the U.S. alone). Now, if someone had told your grandparents, or even your parents, 20 years ago that people would be getting their foreheads frozen to look younger, they likely would have scoffed at the idea. So just imagine what other wild fixes could be coming to a medi-spa near you.

Its exciting to think about how the next 10 years will look, says Dr. Rohan Bissoondath, medical director of Calgarys Preventous Cosmetic Medicine clinic. With lifespan increasing, people are routinely going to be living into their hundreds, so we want to look great as well. From magic pills to creams that mimic injections, we take a look at the incredible innovations on the horizon.

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The way science is progressing, facelifts are set to become obsolete, says Dr. Lisa Kellett of Torontos DLK on Avenue. I think that the gold standard will eventually be finding ways to regenerate and kick-start our own collagen instead of doing a facelift. Kellett is already trying out cutting-edge technology to accomplish this, such as a laser that delivers growth factors right in the dermis to regenerate tissue. Its pretty snazzy stuff, but she anticipates even greater advances in coming years. I think well be able to use stem cells in conjunction with technology to regenerate collagenI think thats what well be doing one day.

Botox in a cream? This has been in the pipeline for a while, says Bissoondath. The challenge is getting the molecules to penetrate the skin so that they can act on the muscle. Maybe on crows feet because its a thinner area, thinner muscles; that may be an area where we see some utility for it, but its still out there. Topical Botox had some success in trials, but scientists still have kinks to work out. In the meantime, a Botox cream might be beneficial even if it doesnt reach muscles, says Bissoondath. I see the potential for having it in a cream and applying it to the whole face, not necessarily affecting facial expressions, but giving an improved glow and better skin quality.

If you want to smooth, you get Botox. If you want to brighten, you get IPL. If you want to tighten, you get Thermage. But what if there was a treatment that did it all? I think thats the future of aging, says Kellett, who is just about to launch such a treatment at her clinic. Marketed as the next generation of laser and light-based platform technology, Ethera is a multiple modality device that can tackle everything from dark spots and skin laxity to textural issues and wrinkles. It means that when patients come in, theyre not just doing one thing, says the doc. Instead, in the same appointment, shes able to address a variety of concerns with a single machine.

Okay, this is very cool. Something I think is possible is a pill to replace exercise, says Bissoondath, who adds that this could be developed in the not so distant future. With the advances were making in understanding the functions of our body down to the cellular level and intracellular level, and understanding how our mitochondria actually ages, were looking at ways now where we can manipulate that from a pill perspective. The pill wouldnt deliver all the benefits of physical activity, such as the positive impact on our mood, but it would replicate its effects on our body. It wont take the place of walking around outside and soaking up natureit cant do the mental part of it. But as far as the physiologic, biochemical part of it, were really understanding that better and making big strides. Its exciting.

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Best Anti Aging Advances to ComeHow We'll Soon Be Looking Younger - The Kit

DUBLIN, Aug. 21, 2020 /PRNewswire/ -- The "Squalene Market by Source Type (Animal Source (Shark Liver Oil), Vegetable Source (Olive Oil, Palm Oil, Amaranth Oil), Biosynthetic (GM Yeast]), End-use Industry (Cosmetics, Food, and Pharmaceuticals), and Region - Global Forecast to 2025" report has been added to ResearchAndMarkets.com's offering.

The global squalene market was worth USD 140 million in 2019 and is projected to reach USD 184.4 million by 2025, growing at a CAGR of 7.3% between 2020 and 2025.

The growth in the cosmetics and pharmaceutical industry is expected to drive the squalene market.

The squalene market is driven mainly by increasing sales of cosmetics and pharmaceuticals. The growing cosmetics industry in emerging markets such as Brazil, China, and India; increasing consumer awareness of the usage of high-quality cosmetic products; and willingness to pay premium prices are driving the cosmetics industry at the global level.

The growth in the pharmaceutical industry will be a major driver for the demand for squalene in the future. Increasing R&D in the oncology segment along with increasing spending on oncology medicine is expected to drive the market for squalene in the coming years. Additionally, the rising awareness about the beneficial properties of squalene such as anti-oxidation, anti-aging, strengthening of the immune system, and UV protection is driving the growth of the market.

Biosynthetic expected to be the fastest-growing segment of the squalene market, in terms of value, between 2020 and 2025.

The biosynthetic segment is expected to witness the highest growth in terms of value during the forecast period. With skepticism about the shark liver oil sourced from sharks and low concentration of squalene in vegetable sources, the supply is fluctuating, keeping the prices volatile.

As several limitations are introduced for shark fishing, the supply of squalene has been majorly affected. While in the vegetable sources, squalene content is very low. Therefore tons of olives and amaranth are required to produce a small quantity of squalene.

Collectively, these reasons have led to high squalene retail prices. Hence, sugarcane and other sugar-containing bio-materials have been identified as a source for producing squalene. This biosynthetic squalene is available at relatively lower prices; thus, the market for biosynthetic squalene is expected to grow at a high rate during the forecast period.

The cosmetics industry is estimated to account for the largest share of the overall squalene market, in terms of value, between 2020 and 2025.

Cosmetics is the largest end-use industry of squalene due to its increasing usage in skincare products manufacturing. The demand for natural cosmetics with good quality has been the main driver for the growth of the market. The various beneficial properties and the natural occurrence of squalene is another factor responsible for the growth of this market. APAC primarily drives the growth of squalene containing products. The rising consumer awareness of using high-quality products and willingness to pay a premium price for the products are the major factors driving the demand.

A strong foothold of cosmetics manufacturers in France to drive the demand for squalene in Europe.

Europe's squalene market is estimated to be the largest during the forecast period. Due to the strong foothold of the key cosmetics product manufacturers and high demand for premium beauty products. The demand for high-quality products from cosmetics, food supplements, and pharmaceutical end-use industries is driving the squalene market in the region. The market witnessed a shift from animal-sourced squalene to vegetable-sourced squalene in the past years. The trend is anticipated to remain the same in the forecast period.

France accounted for the largest share in the region, followed by Germany, the U.K., Italy, and Spain. The high-spending power of consumers and the increasing demand for luxury products will continue to drive the squalene market in the region during the forecast period.

Research Coverage

This report segments the market for squalene based on source type, end-use industry, and region, and provides estimations for the overall market size across various regions. A detailed analysis of key industry players has been conducted to provide insights into their business overviews, products & services, key strategies, associated with the market for squalene.

The key players profiled in the report include as Sophim (France), New Zealand GreenHealth Limited (New Zealand), Kishimoto Special Liver Oil Co. Ltd. (Japan), Amyris (US), Ekiz Olive Oil & Soap Inc. (Turkey), SeaDragon Marine Oils Limited (New Zealand), Nucelis LLC (US), Arista Industries Inc. (US), Empresa Figueirense de Pesca, Lda (Portugal), and Arbee BiomarineExtracts Pvt. Ltd. (India).

Key Topics Covered

1 Introduction

2 Research Methodology

3 Executive Summary3.1 Squalene Market: Realistic, Pessimistic, Optimistic, and Non-COVID-19 Scenario3.1.1 Non-COVID-19 Scenario3.1.2 Optimistic Scenario3.1.3 Pessimistic Scenario3.1.4 Realistic Scenario

4 Premium Insights4.1 Significant Opportunities in the Squalene Market4.2 Squalene Market, by Region4.3 Europe: Squalene Market, by End-use Industry and Country4.4 Squalene Market, by End-use Industry4.5 Squalene Market Attractiveness4.6 Squalene Market, by Source Type and Region

5 Market Overview5.1 Introduction5.2 Market Dynamics5.2.1 Drivers5.2.1.1 Beneficial Properties of Squalene for Human Health5.2.1.2 Growth in Pharmaceutical and Cosmetic Industries5.2.2 Restraints5.2.2.1 Consumer Skepticism About Animal-Sourced Products and Limitations on Shark Fishing5.2.2.2 Volatile Supply of Raw Materials5.2.3 Opportunities5.2.3.1 New Renewable Sources for Squalene Production5.3 Porter's Five Forces Analysis5.4 Economic Pandemic due to COVID-195.4.1 Impact of COVID-19 on the Cosmetics Industry5.4.1.1 Impact on Customers' Output and Strategies to Resume/Improve Production5.4.1.2 Customers' Most Affected Regions5.4.1.3 Analyst Viewpoint on Growth Outlook and New Market Opportunities

6 Squalene Market, by Source Type6.1 Introduction6.2 Animal Source6.3 Vegetable Source6.4 Biosynthetic

7 Squalene Market, by End-use Industry7.1 Introduction7.2 Cosmetic7.3 Food7.4 Pharmaceutical7.5 Others

8 Squalene Market, by Region8.1 Introduction8.2 Europe8.3 APAC8.4 North America8.5 Middle East & Africa8.6 South America

9 Competitive Landscape9.1 Introduction9.2 Competitive Leadership Mapping, Tier 1 Companies9.2.1 Visionary Leaders9.2.2 Innovators9.2.3 Emerging Companies9.3 Strength of Product Portfolio9.4 Business Strategy Excellence9.5 Competitive Leadership Mapping (Small and Medium-Sized Enterprises)9.5.1 Progressive Companies9.5.2 Responsive Companies9.5.3 Dynamic Companies9.5.4 Starting Blocks9.6 Strength of Product Portfolio9.7 Business Strategy Excellence9.8 Market Share Analysis9.8.1 Kishimoto Special Liver Oil Co. Ltd.9.8.2 Sophim9.9 Competitive Scenario9.9.1 New Product Launch9.9.2 Expansion

10 Company Profiles10.1 Seadragon Marine Oils Limited10.2 Amyris10.3 Arbee Biomarine Extracts Pvt. Ltd.10.4 Sophim10.5 Kishimoto Special Liver Oil Co. Ltd.10.6 Empresa Figueirense de Pesca, LDA10.7 Nucelis LLC10.8 Arista Industries10.9 Ekiz Olive Oil & Soap Inc.10.10 New Zealand Green Health Ltd.10.11 Other Key Players10.11.1 RLR Squalene10.11.2 Cabomer Inc.10.11.3 Blueline Foods Pvt. Ltd.10.11.4 Coastal Aquatic Proteins10.11.5 Globalab10.11.6 Squalop10.11.7 CN Lab Nutrition10.11.8 Isho Genki International

For more information about this report visit https://www.researchandmarkets.com/r/70tati

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

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Research and Markets Laura Wood, Senior Manager [emailprotected]

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$184.4M Squalene Market by Source Type, Vegetable Source, Biosynthetic, End-use Industry and Region - Global Forecast to 2025 - PRNewswire

Genes that play an important role in allowing SARS-CoV-2 to invade heart cells become more active with age, according to research published today in the Journal of Molecular and Cellular Cardiology. The findings could help explain why age is major risk factor for dying from COVID-19, with people over 70 years at greatest risk, and why the disease can cause heart complications in severe cases, including heart failure and inflammation of the heart.

"When this novel coronavirus first emerged, we expected it to be primarily a respiratory illness, as the virus usually takes hold first in the lungs," said Professor Anthony Davenport from the Department of Medicine. "But as the pandemic has progressed, we've seen more and more COVID-19 patients - particularly older patients - affected by heart problems. This suggests that the virus is capable of invading and damaging heart cells and that something changes as we age to make this possible."

Professor Davenport led an international team of researchers from the University of Cambridge, Maastricht University, KU Leuven and Karolinska Institute to investigate the link between COVID-19 and heart failure. The researchers examined cells known as cardiomyocytes to see how susceptible they were to infection by the coronavirus. Cardiomyocytes make up the heart muscle and are able to contract and relax, enabling the heart to pump blood around the body. Damage to these cells can affect the ability of the heart muscles to perform, leading to heart failure.

To cause damage, the virus must first enter the cell. SARS-CoV-2 is a coronavirus - spherical in shape with 'spike' proteins on its surface, which it uses to gain entry. The spike protein binds to ACE2, a protein receptor found on the surface of certain cells. The virus is also able to hijack other proteins and enzymes, including TMPRSS2 and Cathepsins B and L to gain entry.

The researchers compared cardiomyocytes from five young (19-25 year old) males and five older (63-78 year old) males and found that the genes that give the body instructions to make these proteins were all significantly more active in cardiomyocytes from the older males. This suggests that there is likely to be an increase in the corresponding proteins in aged cardiomyocytes.

"As we age, the cells of our heart muscles produce more of the proteins needed by the coronavirus to break into our cells," said Dr Emma Robinson from Maastricht University and KU Leuven. "This makes these cells more vulnerable to damage by the virus and could be one reason why age is a major risk factor in patients infected with SARS-CoV-2."

Some of the proteins encoded by the genes can be inhibited by existing medicines. For example, the anti-inflammatory drug camostat inhibits TMPRSS2 and has been shown to block SARS-CoV-2 entry in cells grown in the laboratory. The study also suggests new targets for medicines that could be developed such as compounds blocking binding of the virus to ACE2 that may be beneficial in protecting the heart.

"The more we learn about the virus and its ability to hijack our cells, the better placed we are to block it, either with existing drugs or by developing new treatments," said Professor Davenport.

Reference:Robinson, E. L., Alkass, K., Bergmann, O., Maguire, J. J., Roderick, H. L., & Davenport, A. P. (2020). Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes. Journal of Molecular and Cellular Cardiology. doi:10.1016/j.yjmcc.2020.08.009

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

The text in this work is licensed under a Creative Commons Attribution 4.0 International License.

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Aging Heart Cells Offer Clues to Susceptibility of Older People to Severe COVID-19 - Technology Networks