Bioinformatics and Bioengineering - Todd McDevitt, Georgia Institute of Technology - NSF
Stem cell biomanufacturing is the conduit for fundamental scientific discoveries about stem cell biology to be translated into biomedical diagnostics and therapies. Robust new approaches to control the expansion and differentiation of stem cells in a scalable manner are required for cell production purposes. In addition, non-destructive means of assaying cell fate are needed to introduce feedback control processes and ensure the safety and efficacy of stem cell-derived products. These objectives are being met by the research currently being carried out by Stem Cell Biomanufacturing IGERT trainees at Georgia Tech who are preparing to become the scientific leaders of this rapidly emerging field that exists at the crossroads of stem cell biology, bioengineering and bioprocessing. Specific research efforts include the development of biomaterials approaches for the culture and delivery of stem cells, computational modeling of stem cell fate decisions, label-free non-destructive cell sorting technologies and "real-time" gene expression analysis. Overall, these projects represent the next generation of technologies to be integrated into the biomanufacturing pipeline for the production and ultimately translation of stem cells for biomedical applications.
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Bioinformatics and Bioengineering - Todd McDevitt, Georgia Institute of Technology - NSF - Video
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