Category Archives: Human Reproduction

STUDY QUESTION What are the obstetric and neonatal outcomes of deliveries after oocyte donation (OD) in women with Turner syndrome (TS)? SUMMARY ANSWER Pregnancies among women with TS carry a substantial risk, particularly for hypertensive disorders. Potentially life-threatening complications occurred … Continue reading →

STUDY QUESTION Are there any differences in the location and distance to the internal cervical ostium of the implantation site of the intrauterine gestation sacs, early pregnancy symptoms and pregnancy outcome at 12 weeks gestation between women with and without … Continue reading →

STUDY QUESTION What is the relative importance of the six dimensions of quality of care according to different stakeholders and can a quality indicator set address all six quality dimensions and incorporate the views from professionals working in different disciplines … Continue reading →

STUDY QUESTION Does preconceptionally started low-dose aspirin prevent hypertensive pregnancy complications and preterm delivery in IVF patients? SUMMARY ANSWER The current data do not support the use of preconceptionally started low-dose aspirin treatment for the prevention of hypertensive pregnancy complications … Continue reading →

STUDY QUESTION What are the anatomic variants (and their frequencies) of double uterus, obstructed hemivagina and ipsilateral renal agenesis? SUMMARY ANSWER Most cases examined (72.4%) were of the classic anatomic variant of the Herlyn-Werner-Wunderlich syndrome (with didelphys uterus, obstructed hemivagina … Continue reading →

STUDY QUESTION Is fertility preservation feasible after the onset of puberty in adolescents with Klinefelter syndrome (KS)? SUMMARY ANSWER Fertility preservation counseling should be an integral part of the care of XXY adolescents. Frozen ejaculated or testicular spermatozoa and even … Continue reading →

STUDY QUESTION What are the diagnostic benefits of using ultrasound in patients with a clinical suspicion of acute salpingitis and signs of pelvic inflammatory disease (PID)? SUMMARY ANSWER In patients with a clinical suspicion of acute salpingitis, the absence of … Continue reading →

STUDY QUESTION Does vasectomy impact microRNA (miRNA) expression in the epididymis and seminal microvesicles (SMVs) in a non-reversible manner? SUMMARY ANSWER The miRNA signature in the epididymis and SMVs is altered by vasectomy and only partially restored after vasovasostomy surgery. … Continue reading →

STUDY QUESTION Is there a global consensus on the management of endometriosis that considers the views of women with endometriosis? SUMMARY ANSWER It was possible to produce an international consensus statement on the current management of endometriosis through engagement of … Continue reading →

This Task Force document revisits the debate about the ethics of sex selection for non-medical reasons in the light of relevant new technological developments. First, as a result of improvement of the Microsort® flow cytometry method, there is now a … Continue reading →

STUDY QUESTIONS What are the symptoms of uterine perforation caused by modern copper intrauterine devices (Cu-IUDs) and the levonorgestrel-releasing intrauterine system (LNG-IUS); how is perforation detected and what are the findings in abdominal surgery? SUMMARY ANSWER Symptoms are mostly mild … Continue reading →

Source:http://humrep.oxfordjournals.org/cgi/content/short/28/6/1446?rss=1

STUDY QUESTION Does heparin ablate the advantageous effects of cyclic adenosine mono-phosphate (cAMP) modulators during pre-in vitro maturation (IVM) and have a deleterious effect in standard oocyte IVM? SUMMARY ANSWER Heparin interrupts energy metabolism and meiotic progression and adversely affects … Continue reading →

Source:http://humrep.oxfordjournals.org/cgi/content/short/28/6/1445?rss=1

STUDY QUESTION Does the human embryo growth rate affect the outcome of vitrified–warmed blastocyst transfer? SUMMARY ANSWER Following vitrification, the incidence of abnormal spindle morphology was increased and the implantation competence was decreased in growth-retarded embryos compared with normally developing … Continue reading →

STUDY QUESTION Is the attachment of biofunctionalized polysilicon barcodes to the outer surface of the zona pellucida an effective approach for the direct tagging and identification of cultured embryos? SUMMARY ANSWER The results achieved provide a proof of concept for … Continue reading →

STUDY QUESTION What are women’s experiences with tailored use of combined oral contraceptive pills (COCPs)? SUMMARY ANSWER Some women reported very positive experiences with tailored use of COCPs, others did not like the unpredictability about when they would bleed and … Continue reading →

STUDY QUESTION Does embryo biopsy inherent to preimplantation genetic screening (PGS) affect neurological, cognitive and behavioural development of 4-year-old children? SUMMARY ANSWER PGS does not seem to affect neurological, cognitive and behavioural development of 4-year-old singletons; however, our data suggest … Continue reading →

STUDY QUESTION Does prolonged exposure of the endometrium to hCG, as experienced after ovulation induction in an assisted reproduction technology (ART) cycle, affect functional measures of endometrial receptivity? SUMMARY ANSWER Prolonged endometrial hCG exposure detrimentally affects the manner in which … Continue reading →

STUDY QUESTION What are the effects of the eotaxin group of chemokines (CCL11, CCL24 and CCL26) on extravillous trophoblast (EVT) functions important during uterine decidual vessel remodelling? SUMMARY ANSWER CCL11, CCL24 and CCL26 can regulate EVT migration, invasion and adhesion, … Continue reading →

STUDY QUESTION Does surgical and low-dose progestin treatment differentially affect endometriosis-associated severe deep dyspareunia in terms of sexual functioning, psychological status and health-related quality of life? SUMMARY ANSWER Surgery and progestin treatment achieved essentially similar benefits at 12-month follow-up, but … Continue reading →

STUDY QUESTION Do different concentrations of FSH in the assisted reproductive technology (ART) procedure in vitro or in vivo affect the developmental competence of oocytes, the embryos and the offspring conceived from these embryos? SUMMARY ANSWER Improper FSH treatment (200 … Continue reading →

STUDY QUESTION Is it feasible to identify factors that significantly affect the clinical outcome of IVF-ICSI cycles and use them to reliably design a predictor of implantation? SUMMARY ANSWER The Bayesian network (BN) identified top-history embryos, female age and the … Continue reading →

STUDY QUESTION Is lactoferrin (LF) (detected in oviductal secretion) able to bind to oocytes and sperm and modulate gamete interaction? SUMMARY ANSWER LF binds to zona pellucida (ZP) and spermatozoa (depending upon the capacitation stage and acrosome status) and inhibits … Continue reading →