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Can Europe afford the next generation of medicines? – POLITICO Europe

On the face of it, medical science has delivered at just the right time.

Europes population is growing older: by 2100 nearly a third of people will be aged 65 or over. A major challenge for this century is how to keep people healthy.

At the same time, the last decade has seen personalized medicines come within reach. Cell and gene therapies tailored to individual patients can cure diseases, from fixing misfiring biology to training the immune system to kill cancer cells.

But with price tags of up to 3 million per treatment,healthsystems simply arent designed to absorb these kinds of hits.

The question now is whether Europe will be able to square the circle and take full advantage of the new therapies. Or will budget constraints keep these medical advances out of reach?

To date, the European Commission has authorized 25 cell and gene therapies for use in Europe.

These therapies involve careful manipulation and growth of human cells to be given often as one-off treatments and in some cases cures for debilitating and often deadly rare diseases and certain types of cancer. Novartis Kymriah, a CAR-T therapy that delivers genes into the body to tell the immune system to attack and kill blood cancer cells, is one such example.

These medicines are often tailor-made for a single patient, making them extremely expensive.

Novartis Zolgensma, a gene therapy for children with spinal muscular atrophy, had a U.S. list price of $2.1 million for a one-off dose when it was approved in May 2019 (it was approved in the EU in May 2020). Since then, it has lost the title of the worlds most expensive therapy to CSL Behrings hemophilia B gene therapy Hemgenix, a one-off infusion that costs $3.5 million a dose.

Big upfront costs in building the first manufacturing facilities for these types of therapies play a role in high prices, said Matthew Durdy, chief executive of the Cell and Gene Therapy Catapult, an independent nonprofit that brings together academia, industry, health services and government to deliver these products in the U.K.

But these costs will come down, he said, just as they do with every new technology, from mobile phones to laptops. For that to happen, health systems must start using the therapies. Without a market, competitors will not follow, and without competition, prices wont drop.

But thats easier said than done.

Finding a price that is both affordable to health care payers and profitable for companies is a major and significant challenge, said Tim Hunt, chief executive of the Alliance for Regenerative Medicine (ARM), which represents developers of these therapies.

And its one which has pushed companies to shutter some EU operations and investors to hold back, he said. Seven of the 25 cell and gene therapies approved in Europe have already been withdrawn by drugmakers from EU markets.

Since 2018, the EU cell and gene therapy market has grown just 11 percent, compared with 43 percent in the U.S. and 531 percent in China.

Consequently, EU patients are losing out on the next generation of treatments, Hunt said.

One way to bring things back on track is delivering data that shows a particular therapy works and justifies those initial high costs. But this data can be hard to come by.

Thats because it takes years to prove that a drug prevents a progressive disease, for example. And in rare conditions, there are only a handful of patients to test out new therapies, limiting the evidence.

Therefore, to approve these therapies, Europe has been steadily lowering the bar for clinical evidence, said Lydie Meheus, managing director at the not-for-profit research organization the Anticancer Fund.

While this authorizes more therapies, lack of data creates significant problems for payers asking health systems to take big financial risks when resources are especially stretched, staff are on strike and services are still grappling with pandemic backlogs.

We really need to rebalance the scale when it comes to the evidence generation of these types of products, said Yannis Natsis, chief executive of the European Social Insurance Platform (ESIP). Limited data and high prices are a huge challenge for payers, he said.

One hope lies in Europes 2021 Health Technology Assessment (HTA) regulation.

From 2025, all cell and gene therapies will undergo a single EU assessment of the value they add to patients and health systems, hopefully ending the need for 27 duplicate reviews. This recommendation will be used by payers in each country in their pricing talks with developers.

Companies will also meet jointly with the European Medicines Agency and Europes HTA coordinating group to thrash out the best clinical trial designs that deliver data, not only on safety and efficacy but also on added value.

And the technology is rapidly progressing. While the majority of cell and gene therapies involve taking a patient sample and tailor-making a treatment, in time the aim is to deliver more products that are developed without the need of a patient sample.

A lot of companies are trying to focus more on in vivo gene therapies [where the genetic changes happen inside the body as opposed to in a lab] and off-the-shelf cell therapies that use donor materials, said Stephen Majors, head of communications at ARM.

This will lessen the production costs, curtailing the need for the intensive process of removing a patients cells, sending them elsewhere to be modified, and using cold chain storage infrastructure, he said.

And if the longer-term data bears fruit on curative benefits, payers may be more willing to pay. Some are already adapting payment models to spread the costs over several years.

To Durdy, at the U.K. catapult, these types of therapies will save money in the long run. Spending for example $2 million to $3 million on curing a hemophilia patient will prevent up to $12 million in lifetime care costs for that patient, he said.

He imagined that, in the future, payers would think along the following lines: Its going to blow my budget this year. But if all of these therapeutics come through, Im going to transform the way I do health care.

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Can Europe afford the next generation of medicines? - POLITICO Europe

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The Center for Breakthrough Medicines is Building the World’s Largest Cell and Gene Therapy Contract Development and Manufacturing Organization (CDMO)…

The Center for Breakthrough Medicines has Signed a Long-Term Lease for 680,000 square feet at The Discovery Labs King of Prussia and Plans to Hire 2,000 PhD Scientists, Manufacturing Experts, Lab Technicians and Support Staff

The New Facility Will Relieve the Cell and Gene Therapy Industry's Production Constraints, Providing Patients Better Access to Treatments

The Discovery Labs Will be Home to THE COLONY Creating an International Magnet for Scientists to Co-create with Members of The Philadelphia Life Sciences Community

KING OF PRUSSIA, Pa., Jan. 22, 2020 /PRNewswire/--The Discovery Labs and Deerfield Management Company have formed The Center for Breakthrough Medicines, a Contract Development and Manufacturing Organization (CDMO) and specialty investment company, to alleviate the critical lack of capacity that is preventing patients from accessing critically needed cell and gene therapies. The CDMO is occupying over 40 percent of The Discovery Labs' 1.6 million square foot biotech, healthcare and life sciences campus in King of Prussia, PA.

(PRNewsfoto/The Discovery Labs)

The CDMO provides preclinical through commercial manufacturing of cell and gene therapies and component raw materials. It offers process development, plasmid DNA,viral vectors, cell banking, cell processing, and support testing capabilities all under one roof. The immense $1.1 billion facility will provide instant capacity as the largest known single source for accelerating the delivery and affordability of lifesaving and life-changing therapies from the bench to the patient's bedside.

The Company has initiated a substantial hiring effort targeting the best and brightest of the life sciences community including, experts in CGMP manufacturing. The Company expects to hire over 2,000 team members within the next 30 months.

The CDMO has retained Nucleus Careers, a cloud-based specialty life sciences human capital recruiting and retention management expert, to buildout the entire team. Nucleus has proprietary recruiting and retention software designed for large scale human capital buildouts of high growth companies.

In addition to developing the world's largest single-point cell and gene therapy manufacturing facility, The Discovery Labs is establishing THE COLONY which will provide custom built discovery labs, breakthrough funding, sponsored research agreements, housing and relocation for the world's leading iconic experts in cell and gene therapy.

THE COLONY will seek to work hand in hand with scientists from both academic and pharmaceutical institutions to unlock and expedite groundbreaking therapies.

Marco A. Chacn, Ph.D., Founder of Paragon Bioservices and Chairman of The Discovery Labs states, "musicians, artists, members of religious communities and great thinkers throughout time have formed colonies where freedom of thought and expression combined with unlimited dreams and potential have resulted in the world's greatest accomplishments." Dr. Chacn went on to say, "the goal of THE COLONY is to unshackle the potential of the world's greatest scientific minds."

The ability for the industry's greatest scientists to cohabitate, collaborate, cooperate, and communicate via technology and in person will create an exponential therapeutic "X FACTOR." THE COLONY seeks to unlock institutional barriers prohibiting the world's greatest scientists from moving at a pace necessary in today's ever-changing therapeutic revolution. THE COLONY will partner with the institutions where the scientists currently work by providing equity, license fees, and revenue sharing.

Story continues

"The Center for Breakthrough Medicines will be serving companies from the earliest stages through commercialization. Its exceptional scale and offering will quickly relieve the production bottleneck for advanced therapies by reducing the time, complexity, and cost of commercializing vitally needed gene and cell therapies," noted Audrey Greenberg, Board Member and Executive Managing Director for The Discovery Labs.

The addition of this end-to-end manufacturing capability is expected to significantly enhance the offerings of The Discovery Labs in an area that has become one of the largest life sciences hubs in the world. Renovations are underway to construct a total of 86 plasmid, viral vector production, universal cell processing, CGMP testing, process development and cell banking suites. The viral vector and cell processing suites will be fully compliant with both U.S. Food and Drug Administration and European Medicines Agency standards. All suites will offer the flexibility to meet client-specific workflows and will be able to adapt quickly to meet demand. The Company is in the process of reserving capacity now for late 2020.

"Today brilliant scientists are advancing an unprecedented number of gene and cell therapy drug candidates. The real tragedy, however, is a scarcity of manufacturing know-how, which is complex and expensive," said Alex Karnal, Partner and Managing Director of Deerfield Management and a Board Member of the Discovery Labs. "With its visionary business model, it is hoped that The Center for Breakthrough Medicines will help realize the promise of cell and gene therapies in time to treat the many patients who need them."

The Discovery Labs provides a central campus where the world's greatest scientists can collaborate on new therapeutic discoveries to eradicate diseases affecting small and large segments of the global population. The Center for Breakthrough Medicines will work with these leaders, life sciences companies, large pharmaceutical companies, and academic and government institutions.

This new manufacturing capability is a transformational addition to The Discovery Labs market offering and dovetails with The Discovery Labs biotech incubator, Unite IQ. Unite IQ offers immediate space to emerging life sciences companies and scientists giving them the ability to grow from startup to enterprise company on one campus. The incubator and accelerator space at Unite IQ provides a comprehensive home for startups with every resource needed to initiate business operations. Unite IQ tenants are expected to utilize the discovery, development, testing, and manufacturing capabilities of the Center for Breakthrough Medicines with seamless forward integration of processes and analytics, and seamless tech transfer from research lab to large scale production

The Emerging Field of Cell and Gene Therapy in Pennsylvania

The demand for clinical and commercial manufacturing capacity is acute and expected to remain that way. The current shortfall in manufacturing for cell and gene therapies is severely underserved with few approved products. There are currently approximately 1,100 advanced therapies in the pipeline pending FDA approval. This will greatly increase highly skilled manufacturing demand. Dr. Peter Marks, Director of the FDA Center for Biologics Evaluation and Research, states, "what keeps me up at night is will we be able to manufacture these on a scale that will allow us to bring the benefit of these therapies to patients?"He further added that "if we can help see cost of goods and ability to manufacture reproducibly improve, I think that'll be a big thing."All of this adds up to a supply constrained market that The Center for Breakthrough Medicines aims to help address.

With the potential to treat and even cure disabling, and deadly diseases, gene and cell therapies are ushering in a new era of medicine. These therapies may eventually be able to cure genetic conditions, such as cystic fibrosis, hemophilia A, and a range of cancers. The Philadelphia area has become the epicenter for the flourishing field of gene and cell therapy. Research from CBRE currently ranks the market among the top biotech clusters for medical research and health services. The cluster has become known worldwide as "Cellicon Valley"for its leadership in research and development of this rapidly evolving field. The Discovery Lab's suburban Philadelphia location offers a talent rich environment due to the area's preponderance of large pharmaceutical companies and the Philadelphia region's position boasting the top 10 universities and primary school systems in nation.

Over the past three years, multiple Philadelphia companies have received approvals for major breakthroughs in cell and gene therapy. In 2017, the U.S. FDA approved the first-ever CAR-T cell therapy, Novartis's Kymriah, which originated at the University of Pennsylvania. Shortly thereafter, the FDA gave landmark approval for the first-ever gene therapy to treat a genetic blindness condition to Spark Therapeutics, a start-up founded by researchers at Children's Hospital of Philadelphia. These discoveries and others in the pipeline are attracting billions of dollars of venture capital. The Greater Philadelphia Region set a recent record in venture capital financing.

The Discovery Labs Center for Breakthrough Medicines joins more than 25 healthcare, life sciences and tech-enabled companies that already call The Discovery Labs King of Prussia home.

Brian O'Neill, Founder of The Discovery Labs Center for Breakthrough Medicines, and Tony Khoury, Board Member of The Discovery Labs and Engineer at Project Pharma, will be speaking at the 2020 PhacilitateWorld Stem Cell Summit discussing The Future of Gene Therapy Manufacturing at 4 p.m. today at the Hyatt Regency in Miami, Florida.

Contact Audrey Greenberg at agreenberg@thediscoverylabs.com for more information about development services, manufacturing capacity, incubator space or leasing information at the property.

About The Discovery LabsPart of MLP Ventures, The Discovery Labs is a global provider of world-class cGMP manufacturing, turnkey laboratory solutions, critical materials and office space that support therapeutic products and services to the biotechnology and pharmaceutical industry so that groundbreaking medicines get to the patients that need them. The location in eastern King of Prussia is a prototype for a global rollout of The Discovery Labs, providing Big Pharma, emerging life sciences, consumer and technology companies flexible, end-to-end technical real estate and business infrastructure for the customer's entire lifecycle from discovery to delivery, including manufacturing capacity. It is the first fully integrated environment that merges technology and life sciences under one roof to drive innovation.

About Deerfield Management

Deerfield is a healthcare investment management firm committed to advancing healthcare through investment, information and philanthropy.

Media Contact:Tony DeFazio, DeFazio Communications(o) 484-534-3306 (c) 484-410-1354tony@defaziocommunications.com

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SOURCE The Discovery Labs

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The Center for Breakthrough Medicines is Building the World's Largest Cell and Gene Therapy Contract Development and Manufacturing Organization (CDMO)...

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Apotheosis of the Dissected Plate; Cult of the Dead; Morbid Curiousity; Classes Galore: Morbid Anatomy Presents This Week and Beyond

I am delighted to announce a few recently added Morbid Anatomy events taking place this May and June. This Friday, May 17, I urge you not to miss London-based artist Chiara Ambrosio's talk on the enigmatic and fascinating Neapolitan "cult of the dead;" (more here). I am also excited to announce a brand new lecture by Morbid Anatomy favorite Michael Sappol of The National Library of Medicine who will be giving an illustrated lecture on Thursday, May 23rd entitled "The Apotheosis of the Dissected Plate: Spectacles of Layering and Transparency in 19th- and 20th-Century Anatomy" (see image above, "The Human Ear in Anatomical Transparencies, Elmsford, NY, 1946, Courtesy National Library of Medicine, photo by Mark Kessell.)

Following this, on Thursday, June 13, we will host Denny Daniel of The Museum of Interesting Things for a demonstration antique quack medical devices from his collection, while on Thursday, June 6 we will have an illustrated lecture with professor Eric G Wilson about the history and science of "morbid curiosity" (June 6). We also have a newly added Bat Dome Workshop (Sunday, June 16) as well as a variety of classes in taxidermy, Victorian mourning hair art, anthropomorphic insect shadow boxes, and Dance of Death linocuts, Also, for UK-based readers, don't miss our special 2-month series of events, workshops, special backstage tours, screenings and spectacles surveying the interstices of art and medicine, death and culture (June 2 - July 25) in London.

Full details for all follow. Hope to see you at one or more of these terrific events!
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The Neapolitan Cult of the Dead: An Illustrated Lecture with Chiara Ambrosio
 Date: Friday, May 17
Time: 8:00 PM
Admission: $8
Presented by Morbid Anatomy

Naples is a unique city in which the sacred and the profane, Catholicism and paganism, beauty and decay blend and contrast in intriguing ways. No practice illustrates this tangle of ideas better than what is known as "The Neapolitan Cult of the Dead" in which devout Catholics--generally poor women--adopt anonymous skulls found in charnel houses and clean, care for, and sometimes house them, offering up prayers and offerings to shorten that soul's time in purgatory before reaching paradise, where, it is hoped, it will assist its earthbound caretaker with special favors. The macabre artifacts of this cult can be seen in the Cimitero delle Fontanelle (see above) and the crypt of the church of Saint Mary of Purgatory.In tonight's illustrated lecture, Italian artist and filmmaker Chiara Ambrosio will elucidate this curious and fascinating "Neapolitan Cult of the Dead" and situate it within a the rich death culture and storied history of Naples.

Chiara Ambrosio is a visual artist working with video and animation. Her work has included collaborations with performance artists, composers, musicians and writers, and has been shown in a number of venues including national and international film festivals, galleries and site specific events. She also runs The Light & Shadow Salon is a place for artists, writers and audience to meet and share ideas about the past, present and future of the moving image in all its forms.
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Quail - Bird Taxidermy with Rogue Taxidermist Katie Innamorato
Date: Saturday, May 18th
Time: 12 - 6.30
Admission: $250
***Maximum class size: 8 Students; Must RSVP to katie.innamorato [at] gmail.com
This class is part of The Morbid Anatomy Art Academy

This class will introduce students to basic small bird taxidermy processes. As with other classes, this is only open to 6-8 students to allow for a more intimate one on one environment. Each student will be provided with their own quail which they will skin, flesh, and prep for mounting. Students will learn how to mount a bird using its skull and learn how to preserve the skin and pose it. Legalities of working with birds and bird parts will also be discussed. A copy of the MBTA will be brought to class and passed around to students.

Rogue taxidermist Katie Innamorato has a BFA in sculpture from SUNY New Paltz, has been featured on the hit TV show "Oddities," and has had her work featured at La Luz de Jesus gallery in Los Angeles, California. She is self and professionally taught, and has won multiple first place ribbons and awards at the Garden State Taxidermy Association Competition. Her work is focussed on displaying the cyclical connection between life and death and growth and decomposition. Katie is a member of the Minnesota Association of Rogue Taxidermists, and with all M.A.R.T. members she adheres to strict ethical guidelines when acquiring specimens and uses roadkill, scrap, and donated skins to create mounts.

Her website and blogs-
http://www.afterlifeanatomy.com
http://www.afterlifeanatomy.tumblr.com
http://www.facebook.com/afterlifeanatomy
http://www.etsy.com/shop/afterlifeanatomy

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Anthropomorphic Mouse Taxidermy Class with Divya Anantharaman
Date: Saturday, May 18
Time: 1-5 PM
Admission: $110
***Please note: This class will be held offsite at Acme Studio : 63 N. 3rd Street, Williamsburg, Brooklyn
Advance Tickets Required; Click here to purchase
Email divya.does.taxidermy at gmail dot com with questions or to be put on wait list
Class limit: 10
This class is part of the Morbid Anatomy Art Academy

Anthropomorphic taxidermy--in which taxidermied animals are posed into human attitudes and poses--was an artform made famous by Victorian taxidermist and museologist Walter Potter. In this class, students will learn to create--from start to finish--anthropomorphic mice inspired by the charming and imaginative work of Mr. Potter and his ilk. With the creative use of props and some artful styling, you will find that your mouse can take nearly whatever form you desire, from a bespectacled, whiskey swilling, top hat tipping mouse to a rodent mermaid queen of the burlesque world.

In this class, Divya Anantharaman--who learned her craft under the tutelage of famed Observatory instructor Sue Jeiven--will teach students everything involved in the production of a fully finished mount, including initial preparation, hygiene and sanitary measures, fleshing, tail stripping, and dry preservation. Once properly preserved, the mice will be posed and outfitted as the student desires. Although a broad selection of props and accessories will be provided by the instructor, students are also strongly encouraged to bring their own accessories and bases; all other materials will supplied. Each student will leave class with a fully finished piece, and the knowledge to create their own pieces in the future.

Also, some technical notes:

  • We use NO harsh or dangerous chemicals.
  • Everyone will be provided with gloves.
  • All animals are disease free.
  • Although there will not be a lot of blood or gore, a strong constitution is necessary; taxidermy is not for everyone
  • All animals were already dead, nothing was killed for this class.
  • Please do not bring any dead animals with you to the class.

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Dance of Death by Hans Holbein: A Linocut Workshop with Classically Trained Artist Lado Pochkua 
Dates: Tuesdays May 20, May 27 and June 4
Time: 7 - 10 PM
Admission: $60
***MUST RSVP to morbidanatomylibrary [at] gmail.com
This class is part of The Morbid Anatomy Art Academy

The "dance of death" or "danse macabre" was a "medieval allegorical concept of the all-conquering and equalizing power of death, expressed in the drama, poetry, music, and visual arts of western Europe, mainly in the late Middle Ages. It is a literary or pictorial representation of a procession or dance of both living and dead figures, the living arranged in order of their rank, from pope and emperor to child, clerk, and hermit, and the dead leading them to the grave." (Encyclopedia Britannica). One of the best known expressions of this genre are a series of forty-two wood cuts by Hans Holbien published in 1538 under the title "Dance of Death."

In this class, students will learn the techniques of woodcuts and linocuts by creating a copy of one of Hans Holbein’s prints from the Dance of Death series. The class will follow the entire process from beginning to end: drafting a copy of the image, either a fragment or whole; transfer of the image to a linoleum block; cutting the image; printing the image on paper. Students will leave class with their own finished Dance of Death linocut and the skills to produce their own pieces in the future.

  • Lesson 1: creating a copy of either a fragment or full image from the series on paper. The copy can either be freehand and stylized, or students can use a grid to copy more exactly.
  • Lesson 2: transfer the drawing to linoleum.
  • Lesson 3: correction of image, and beginning to cut the image.
  • Lesson 4: finalizing the cut image.
  • Lesson 5: Printing the image. Students will be able to use several colors and backgrounds to create the final image.

REQUIRED MATERIALS

  • A block of linoleum: Blick Battleship Gray Linoleum, mounted or unmounted (details here)

OR

  • Speedball Speedy-carve blocks, pink only (details here) Size: 9x12 or 8x10.

AND

  • Linocutter set: Blick Lino Cutter Set (details here)Water soluble printing inks
  • Printing paper
  • Tracing paper
  • Pencils
  • Black markers (fine point)

ABOUT THE INSTRUCTOR
Lado Pochkhua was born in Sukhumi, Georgia in 1970. He received his MFA in Painting and Printmaking from Tbilisi State Art Academy in Georgia in 2001. He currently divides his time between New York and Tbilisi, Georgia.

Image: Image: “Melior est mors quam vita” to the aged woman who crawls gravewards with her bone rosary while Death makes music in the van." From Hans Holbein's "Dance of Death."

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The Apotheosis of the Dissected Plate: Spectacles of Layering and Transparency in 19th- and 20th-Century Anatomy
Presented by Michael Sappol, National Library of Medicine
Date: Thursday, May 23
Time: 8:00 PM
Admission: $8
Presented by Morbid Anatomy

This is a story about “topographical anatomy”— a tradition of slicing and sawing rather than cutting and carving — and its procedures for converting bodies from three dimensions to two dimensions and back again. In topographical cross-section anatomy, the frozen or mummified body was cut into successive layers that were then transcribed and reproduced as pages of a book or a sequence of prints or slides (sometimes with the original slices preserved as a sequence of specimens for the anatomical museum). The topographical method influenced, and was in turn influenced by, flap anatomy (the technique of cutting out printed anatomical parts on paper or cardboard and assembling the parts into a layered representation of the human body). In the 20th century, medical illustrators and publishers developed a new technique of three-dimensional anatomical layering: the anatomical transparency — an epistemological/heuristic device which in the postmodern era has come to enchant artists as well as anatomists. I will argue that these anatomical productions — artworks, but also, exhibitions, toys, gimmicks, and other objects of consumer desire — are meaningful to us because the oscillation between the dis-assembly and re-assembly of bodies as images and image-objects, rehearses our own ambivalent relation to the anatomical body. It also rehearses (perhaps more mysteriously) our ambivalent relation to the planearity of anatomical images which serve as an effigy of self and other, and to the Flatland universe of planearity in which we imaginatively dwell. This talk features astonishing photographs by Mark Kessell.

Michael Sappol is a historian in the History of Medicine Division of the National Library of Medicine (National Institutes of Health), Bethesda, MD. His scholarly work focuses on the body; the history of anatomy; the history of death; the history of medical illustration and display; and the history of medical film. He is the author of A Traffic of Dead Bodies (2002) and Dream Anatomy (2006), and editor of Hidden Treasure (Blast, 2012). PDFs of his selected works can be read or downloaded here. He currently lives in Washington, DC.

Mark Kessell, an Australian medical doctor and professional artist  based in New York City, focuses on the art and science of our species and its biology. His next exhibition, “Perfect Specimens”, a life cycle of Homo sapiens, opens at Last Rites Gallery, a renowned center of the tattoo-and-bod-mod subculture, in August 2013.

Image: Transparency. Artist: Gladys McHugh. McHugh, Polyak et al., The Human Ear in Anatomical Transparencies (Elmsford, NY, 1946). Courtesy National Library of Medicine. Photo: Mark Kessell.
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Date: Sunday, June 2
Time: 12-4 PM
Admission: $75
***Must pre-order tickets here: http://victorianmourningjewelry.bpt.me
This class is part of The Morbid Anatomy Art Academy
Hair jewelry was an enormously popular form of commemorative art that began in the late 17th century and reached its zenith during the Victorian Era. Hair, either of someone living or deceased, was encased in metal lockets or woven to enshrine the human relic of a loved one. This class will explore a modern take on the genre.
The technique of "palette working" or arranging hair in artful swoops and curls will be explored and a variety of ribbons, beads, wire and imagery of mourning iconography will be supplied for potential inclusion. A living or deceased person or pet may be commemorated in this manner.
Students are requested to bring with them to class their own hair, fur, or feathers; all other necessary materials will be supplied. Hair can be self-cut, sourced from barber shops or hair salons (who are usually happy to provide you with swept up hair), from beauty supply shops (hair is sold as extensions), or from wig suppliers. Students will leave class with their own piece of hair jewelry and the knowledge to create future projects.

Karen Bachmann
 is a fine jeweler with over 25 years experience, including several years on staff as a master jeweler at Tiffany and Co. She is a Professor in the Jewelry Design Dept at Fashion Institute of Technology as well as the School of Art and Design at Pratt Institute. She has recently completed her MA in Art History at SUNY Purchase with a thesis entitled Hairy Secrets:... In her downtime she enjoys collecting biological specimens, amateur taxidermy and punk rock. 
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Morbid Curiosity, or Everyone Loves a Good Train Wreck: Why We Can't Look Away
An Illustrated Lecture and Book Signing with author Eric G. Wilson
Date: Thursday, June 6
Time: 8:00
Admission: $5
Produced by Morbid Anatomy

"Why can’t we look away? Whether we admit it or not, we’re fascinated by evil. Dark fantasies, morbid curiosities, Schadenfreude: As conventional wisdom has it, these are the symptoms of our wicked side, and we succumb to them at our own peril. But we’re still compelled to look whenever we pass a grisly accident on the highway, and there’s no slaking our thirst for gory entertainments like horror movies and police procedurals. What makes these spectacles so irresistible? Author Eric G. Wilson attempts to discover the source of our morbid fascinations, drawing on the findings of biologists, sociologists, psychologists, anthropologists, philosophers, theologians, and artists. A professor of English with a penchant for Poe as well as a lifelong student of the macabre, Wilson believes there’s something nourishing in darkness. He believes that to repress death is to lose the feeling of life, and that a closeness to death discloses our most fertile energies.

Eric G Wilson is Thomas H. Pritchard Professor of English at Wake Forest University and author of several books that explore the power of life's darker sides, including Everyone Loves a Good Train Wreck: Why We Can't Look Away; Against Happiness: In Praise of Melancholy; and The Mercy of Eternity: A Memoir of Depression and Grace. 

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"It Hurts When I Do This" An illustrated History of Quack Medicine through the Artifacts of The Museum of Interesting Things  
Antique Medical Device Demonstration with Denny Daniel, The Museum of Interesting Things
Date: Thursday, June 13
Time: 8:00 PM
Admission: $8
Presented by Morbid Anatomy

In the handful of centuries documented by mankind, medicine evolved through discovery and practice, with each era experimenting with the technology of its time in a quest to understand the human machine, suppress pain, and vanquish disease and, perhaps, death itself. Some of the techniques employed by our relentless ancestors now seem rather odd, inappropriate or, sometimes, just... brutal.

Tonight, join us for a night of bizarre health machinery hosted by Denny Daniel, proud collector and owner of The Museum of Interesting Things. Daniel will trace the evolution--or, sometimes, lack thereof!-- of medical devices advances via an interactive demonstration of objects from his own collection ranging from magnetic quack medical devices to prosthetics, glass eyes and civil war and early 20th century surgical tools, dental devices including tooth keys and 19th century foot pump dental drills, pill molds, and medicines that worked (or didn’t)!

Come see and feel actual items from the 1800’s and 1900’s. We will cure you of your ailments.

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Bat in Glass Dome Workshop
Part of DIY Wunderkammer Series: With Wilder Duncan (formerly of Evolution Shop, Soho) and Laetitia Barbier, head librarian at The Morbid Anatomy Library
With Wilder Duncan (formerly of Evolution Store, Soho) and Laetitia Barbier, head librarian at The Morbid Anatomy Library
Date: Sunday, June 16
Time: 1 – 6 PM
Admission: $200
In this class, students will learn how to create an osteological preparation of a bat in the fashion of 19th century zoological displays. A bat skeleton, a glass dome, branches, glue, tools, and all necessary materials will be provided for each student, but one should feel welcome to bring small feathers, stones, dried flowers, dead insects, natural elements, or any other materials s/he might wish to include in his/her composition. Students will leave the class with a visually striking, fully articulated, “lifelike” bat skeleton posed in a 10” tall glass dome. This piece can, in conjunction with the other creations in the DIY Wunderkammer workshop series, act as the beginning of a genuine collection of curiosities!
This class is part of the DIY Wunderkammer workshop series, curated by Laetitia Barbier and Wilder Duncan for Morbid Anatomy as a creative and pluridisciplinary exploration of the Curiosity Cabinet. The classes will focus on teaching ancient methods of specimen preparation that link science with art: students will create compositions involving natural elements and, according to their taste, will compose a traditional Victorian environment or a modern display. More on the series can be found here.
Wilder Duncan is an artist whose work puts a modern-day spin on the genre of Vanitas still life. Although formally trained as a realist painter at Wesleyan University, he has had a lifelong passion for, and interest in, natural history. Self-taught rogue taxidermist and professional specimen preparator, Wilder worked for several years at The Evolution Store creating, repairing, and restoring objects of natural historical interest such as taxidermy, fossils, seashells, minerals, insects, tribal sculptures, and articulated skeletons both animal and human. Wilder continues to do work for private collectors, giving a new life to old mounts, and new smiles to toothless skulls.
Laetitia Barbier is the head librarian at The Morbid Anatomy Library. She is working on a master's thesis for the Paris Sorbonne on painter Joe Coleman. She writes for Atlas Obscura and Morbid Anatomy.
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Squirrel Taxidermy and the Ancient Technique of Wrapped Body with Rogue Taxidermist Katie Innamorato
Date: Sunday, June 23
Time: 12 - 6.30
Admission: $275
***Maximum class size: 8 Students; Must RSVP to katie.innamorato [at] gmail.com
This class is part of The Morbid Anatomy Art Academy

This class will introduce students to basic taxidermy processes. As with other classes, this is only open to 8 students to allow for a more intimate one on one environment. Each student will be provided with their own squirrel which they will skin, flesh, and prep for mounting. Students will be taught how to wrap bodies for the animals using the carcasses for reference. Wrapping is an old school traditional taxidermy process that many taxidermists do not bother with today. Pre-sculpted head forms will be available for students, but if they are feeling more adventurous they can carve their own! Students will be able to pose their squirrels however they want and are encouraged to bring in any props they may want to dress the animal up in, and items to secure their mounts on. Animal remains will be collected at the end of class and either the students can take them with them, or the instructor will dispose of them.

Rogue taxidermist Katie Innamorato has a BFA in sculpture from SUNY New Paltz, has been featured on the hit TV show "Oddities," and has had her work featured at La Luz de Jesus gallery in Los Angeles, California. She is self and professionally taught, and has won multiple first place ribbons and awards at the Garden State Taxidermy Association Competition. Her work is focussed on displaying the cyclical connection between life and death and growth and decomposition. Katie is a member of the Minnesota Association of Rogue Taxidermists, and with all M.A.R.T. members she adheres to strict ethical guidelines when acquiring specimens and uses roadkill, scrap, and donated skins to create mounts.

Her website and blogs-
http://www.afterlifeanatomy.com
http://www.afterlifeanatomy.tumblr.com
http://www.facebook.com/afterlifeanatomy
http://www.etsy.com/shop/afterlifeanatomy

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Morbid Anatomy Presents at London's Last Tuesday Society this June and July
A series of London-based events, workshops, special tours, screenings and spectacles surveying the interstices of art and medicine, death and culture curated by Observatory's Morbid Anatomy
Date: June 2 - July 25
Time: Variable, but most lectures begin at 7 PM
Location: The Last Tuesday Society at 11 Mare Street, London, E8 4RP map here) unless otherwise specified

The series will feature Morbid Anatomy's signature mix of museum professionals, professors, librarians, artists, rogue scholars, and autodidacts--many flown in direct from Morbid Anatomy's base in Brooklyn, New York--to elucidate on a wide array of topics including (but not limited to!) The Neapolitan Cult of the Dead; "human zoos;" "speaking reliquaries;" why music drives women mad; eccentric folk medicine collections; Santa Muerte (or "Saint Death); dissection and masturbation; dissection and magic; Victorian memorial hair jewelry; the "hot nurse" in popular fiction; The Danse Macabre; "a cinematic survey of The Vampires of London;" and anatomical waxworks and death.

There will be also two special backstage tours: one of the legendary Blythe House, home of the vast and incredible collection of Henry Wellcome and the other of the Natural History Museum's zoological collection, featuring the famously gorgeous Blaschka invertebrate glass model collection; a special magic lantern show featuring "the weirdest, most inappropriate and completely baffling examples of lantern imagery" conjured by collector and scholar Professor Heard, author of Phantasmagoria- The Secret Life of the Magic Lantern; a screening of rare short films from the BFI National Archive documenting folk music, dance, customs and sport; and workshops in the creation of Victorian hair work, lifelike wax wounds, and bat skeletons in glass domes.

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Wax Wound Workshop with medical artist Eleanor Crook
Sunday, June 2, 2013 at 1:00 - 5:00 PM
More here

Let acclaimed sculptor Eleanor Crook guide you in creating your very own wax wound. Crook has lent her experience to professionals ranging from forensic law enforcement officers to plastic surgeons, so is well placed to help you make a horrendously lifelike scar, boil or blister.
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Art, Wax, Death and Anatomy : Illustrated lecture with art historian Roberta Ballestriero
Monday, June 3, 2013 at 7:00pm
More here

Wax modelling, or ceroplastics, is of ancient origin but was revived in 14th century Italy with the cult of Catholic votive objects, or ex votos.  Art Historian Roberta Ballestriero will discuss the art and history of wax modeling sacred and profane; she will also showcase many of its greatest masterworks.
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Music Driving Women Mad: The History of Medical Fears of its Effects on Female Bodies and Minds: Illustrated lecture with Dr. James Kennaway
Tuesday, June 4, 2013 at 7:00pm
More here

Over the past few centuries, countless physicians and writers have asserted that music could cause very serious medical problems for the 'weaker sex'. Not only could it bring on symptoms of nervousness and hysteria, it could also cause infertility, nymphomania and even something called 'melosexualism'. This talk will give an outline of this strange debate, using the raciest stories to be found in gynaecological textb
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Solitary vice? Sex and Dissection in Georgian London With Dr Simon Chaplin
Wednesday, June 5, 2013 at 7:00pm
More here

In this lavishly illustrated lecture, Simon Chaplin explores the sexual undertones of the anatomy schools of Georgian London, in which students dissected grave-robbed bodies in the back-rooms of their teachers' houses, while their masters explored new strategies for presenting their work to polite audiences through museums and lectures.
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Heartthrobs of the Human Zoo: Ethnographic Exhibitions and Captive Celebrities of Turn of the Century America: An Illustrated Lecture with Betsy Bradley
Thursday, June 6, 2013 at 7:00pm
More here

From ransomed Congolese pygmies to winsome Eskimo babies, the American world's fairs and patriotic expositions  present history with a number of troubling ethnographic celebrities, and their stories offer a rare glimpse inside the psychology and culture of imperial America at the turn of a new century.
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The Astounding Collection of Henry Wellcome: Blythe House Backstage Tour with Selina Hurley, Assistant Curator of Medicine, The Science Museum
Friday, June 7, 2013 at 3:00pm
More here

Henry Wellcome (1853 - 1936)----early pharmaceutical magnate and man behind the Wellcome Trust, Collection, and Library--was the William Randolph Hearst of the medical collecting world. That collection, possibly the finest medical collection in the world, now resides in Blythe House, kept in trust by The Science Museum on permanent loan from the Wellcome Trust. Today, a lucky fifteen people will get a rare chance to see this collection, featuring many artifacts of which have never before been on public view, in this backstage tour led Selina Hurley, Assistant Curator of Medicine at The Science Museum.
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Neapolitan Cult of the Dead with Chiara Ambrosio
Monday, June 10, 2013 at 7:00pm
More here

In tonight's illustrated lecture, Italian artist and filmmaker Chiara Ambrosio will elucidate this curious and fascinating "Neapolitan Cult of the Dead" and situate it within a the rich death culture and storied history of Naples.
  
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A Vile Vaudeville of Gothic Attractions: Illustrated lecture by Mervyn Heard, author of Phantasmagoria- The Secret Life of the Magic Lantern
Tuesday, June 11, 2013 at 7:00pm
More here

An illustrated talk in which writer and showman 'Professor' Mervyn Heard waxes scattergun- sentimental over some of the more bizarre, live theatrical experiences of the 18th, 19th and early 20th century - from the various ghastly manifestations of the phantasmagoria to performing hangmen, self-crucifiers and starving brides.

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Professor Heard's Most Extraordinary Magic Lantern Show with Mervyn Heard
Wednesday, June 12, 2013 at 7:00pm
More here

Professor Heard is well known to patrons of the Last Tuesday Lecture programme for his sell-out magic lantern entertainments. In this latest assault on the eye he summons up some of the weirdest, most inappropriate and completely baffling examples of lantern imagery, lantern stories and optical effects by special request of Morbid Anatomy.

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"Speaking Reliquaries" and Christian Death Rituals: Part One of "Hairy Secrets" Series With Karen Bachmann
Thursday, June 13, 2013 at 7:00pm
More here

3-part series on human relics and Victorian mourning jewelry--master jeweler and art historian Karen Bachmann will focus on what are termed "speaking" reliquaries: the often elaborate containers which house the preserved body parts--or relics--of saints and martyrs with shapes which reflect that of the body-part contained within.

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Hair Art Workshop Class: The Victorian Art of Hair Jewellery With Karen Bachmann
Friday, June 14, 2013 at 1:00pm
More here

Hair jewellery was an enormously popular form of commemorative art that began in the late 17th century and reached its zenith during the Victorian Era. Hair, either of someone living or deceased, was encased in metal lockers or woven to enshrine the human relic of a loved one. This class will explore a modern take on the genre.

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The History of the Memento Mori and Death's Head Iconography: Part Two of "Hairy Secrets" Series Illustrated lecture with Art Historian and Master Jeweler Karen Bachmann
Friday, June 14, 2013 at 7:00pm
More here

In tonight's lecture--the second in a 3-part series on human relics and Victorian mourning jewelry--master jeweler and art historian Karen Bachmann will explore the development of the memento mori,objects whose very raison d'être is to remind the beholder that they, too, will die.

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Hair Art Workshop Class: The Victorian Art of Hair Jewellery With Karen Bachmann
Saturday, June 15, 2013 at 1:00pm (More here)
Sunday, June 16, 2013 at 1:00pm (More here)

Hair jewellery was an enormously popular form of commemorative art that began in the late 17th century and reached its zenith during the Victorian Era. Hair, either of someone living or deceased, was encased in metal lockers or woven to enshrine the human relic of a loved one. This class will explore a modern take on the genre.

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The Victorian Love Affair with Death and the Art of Mourning Hair Jewelry: Illustrated lecture with Art Historian and Master Jeweler Karen Bachmann
Monday, June 17, 2013 at 7:00pm
More here

The Victorians had a love affair with death which they expressed in a variety of ways, both intensely sentimental and macabre. Tonight's lecture-the last in a 3-part series on human relics and Victorian mourning jewelry-will take as its focus the apex of the phenomenon of hair jewelry fashion in the Victorian Era as an expression of this passion.

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Dissection and Magic with Constanza Isaza Martinez
Tuesday, June 18, 2013 at 7:00pm
More here

This lecture examines images of human corpses in Early Modern European art in relation to two specific themes: the practice of 'witchcraft' or 'magic'; and the emergent medical profession, particularly anatomical dissection.
  
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Future Death. Future Dead Bodies. Future Cemeteries Illustrated lecture by Dr. John Troyer, Deputy Director of the Centre for Death and Society at the University of Bath
Thursday, June 20, 2013 at 7:00pm
More here

Dr. John Troyer, from the Centre for Death & Society, University of Bath, will discuss three kinds of postmortem futures: Future Death, Future Dead Bodies, and Future Cemeteries. Central to these Futures is the human corpse and its use in new forms of body disposal technology, digital technology platforms, and definitions of death.

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‘She Healed Their Bodies With Her White Hot Passions’: The Role of the Nurse in Romantic Fiction with Natasha McEnroe Illustrated lecture Natasha McEnroe, Director of the Florence Nightingale Museum
Sunday, June 23, 2013 at 7:00pm
https://www.facebook.com/events/478987722156193/

Victorian portrayals of the nurse show either a drunken and dishonest old woman or an angelic and devoted being, which changes to a 20th-century caricature just as pervasive - that of the 'sexy nurse'. In this talk, Natasha McEnroe will explore the links between the enforced intimacy of the sickroom and the handling of bodies for more recreational reasons.

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Face lift or face reconstruction? Redesigning the Museum Vrolik, Amsterdam's anatomical museum An illustrated lecture with Dr. Laurens de Rooy, curator of the Museum Vrolik in Amsterdam
Monday, June 24, 2013 at 7:00pm
More here

Counting more than five thousand preparations and specimens, the Museum Vrolikianum, the private collection of father Gerard and his son Willem Vrolik was an amazing object of interest one hundred and fifty years ago. In the 1840s and 50s this museum, established in Gerard's stately mansion on the river Amstel, grew into a famous collection that attracted admiring scientists from both the Netherlands and abroad. In this talk, Museum Vrolik curator Dr Laurens de Rooy will take you on a guided tour of the new museum, and give an overview of all the other aspects of the 'new' Museum Vrolik.

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The Walking Dead in 1803: An Illustrated Lecture with Phil Loring, Curator of Psychology at the Science Museum in London
Tuesday, June 25, 2013 at 7:00pm
More here

A visiting Italian startled Londoners at the turn of the 19th century by making decapitated animals and executed men open their eyes and move around, as if on the verge of being restored to life. This was not magic but the power of electricity from the newly invented Galvanic trough, or battery. This talk will discuss a variety of historical instruments from the Science Museum's collections that figured in these re-animation experiments, including the apparatus used by Galvani himself in his laboratory in Bologna.
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The Influencing Machine: James Tilly Matthews and the Air Loom with Mike Jay
Wednesday, June 26, 2013 at 7:00pm
More here

Confined in Bedlam in 1797 as an incurable lunatic, James Tilly Matthews' case is one of the most bizarre in the annals of psychiatry. He was the first person to insist that his mind was being controlled by a machine: the Air Loom, a terrifying secret weapon whose mesmeric rays and mysterious gases were brainwashing politicians and plunging Europe into revolution, terror and war. But Matthews' case was even stranger than his doctors realised: many of the incredible conspiracies in which he claimed to be involved were entirely real.

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A Waxen France: Madame Tussaud’s Representations of the French: Illustrated Lecture by Pamela Pilbeam Emeritus Professor of French History, Royal Holloway, University of London and author of Madame Tussaud and the History of Waxworks
Thursday, June 27, 2013 at 7:00pm
More here

Madame Tussaud's presentation of French politics and history did much to inform and influence the popular perception of France among the British. This lecture will explore that view and how it changed during the nineteenth century.

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Backstage Tour of the Zoological Collection of the Natural History Museum with Miranda Lowe
Friday, June 28, 2013 at 3:00pm
More here

Today, ten lucky people will get to join Miranda Lowe, Collections Manager of the Aquatic Invertebrates Division, for a special backstage tour of The Natural History Museum of London. The tour will showcase the zoological spirit collections in the Darwin Centre, some of Darwin's barnacles and the famed collection of glass marine invertebrate models crafted by Leopold and Rudolf Blaschka in the 19th and early 20th century.
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Bat in Glass Dome Workshop: Part of DIY Wunderkammer Series With Wilder Duncan (formerly of Evolution Store, Soho) and Laetitia Barbier, head librarian at The Morbid Anatomy Library
Saturday, June 29, 2013 at 1:00pm (more here)
Sunday, June 30, 2013 at 1:00pm (more here)

In this class, students will learn how to create an osteological preparation of a bat in the fashion of 19th century zoological displays. A bat skeleton, a glass dome, branches, glue, tools, and all necessary materials will be provided for each student.  The classes will focus on teaching ancient methods of specimen preparation that link science with art: students will create compositions involving natural elements and, according to their taste, will compose a traditional Victorian environment or a modern display.
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The Coming of Age of the Danse Macabre on the Verge of the Industrial Age with Alexander L. Bieri Illustrated lecture with Alexander L. Bieri
Tuesday, July 9, 2013 at 7:00pm
More here

The lecture not only discusses Schellenberg's danse macabre in detail, but also gives an insight into the current fascination with vanitas and its depictions, especially focusing on the artistic exploitation of the theme and takes into consideration the history of anatomical dissection and preparation.
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"Viva la Muerte: The Mushrooming Cult of Saint Death" Illustrated lecture and book signing with Andrew Chesnut
Wednesday, July 10, 2013 at 7:00pm
More here

The worship of Santa Muerte, a psuedo Catholic saint which takes the form of a personified and clothed lady death, is on the rise and increasingly controversial in Mexico and the United States. Literally translating to "Holy Death" or "Saint Death," the worship of Santa Muerte-like Day of the Dead-is a popular form of religious expression rooted in a rich syncretism of the beliefs of the native Latin Americans and the colonizing Spanish Catholics.
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From Blue Beads to Hair Sandwiches: Edward Lovett and London's Folk Medicine: An Illustrated lecture with Ross MacFarlane, Research Engagement Officer in the Wellcome Library
Monday, July 15, 2013 at 7:00pm
More here

During his life Edward Lovett (1852-1933) amassed one of the largest collections of objects pertaining to 'folk medicine' in the British Isles.  Lovett particularly focused his attention on objects derived from contemporary, working class Londoners, believing that the amulets, charms and mascots he collected - and which were still being used in 20th century London - were 'survivals' of antiquated, rural practices.
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The Vampires of London: A Cinematic Survey with William Fowler (BFI) and Mark Pilkington (Strange Attractor)
Thursday, July 18, 2013 at 7:00pm
More here

This heavily illustrated presentation and film clip selection explores London's Highgate Cemetery as a locus of horror in the 1960s and 1970s cinema, from mondo and exploitation to classic Hammer horror.
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"Here's a Health to the Barley Mow: a Century of Folk Customs and Ancient Rural Games" Screenings of Short Films from the BFI Folk Film Archives with William Fowler
Wednesday, July 24, 2013 at 7:00pm
More here

Tonight, the British Film Institute's William Fowler will present a number of rare and beautiful short films from the BFI National Archive and Regional Film Archives showing some of our rich traditions of folk music, dance, customs and sport. Highlights include the alcoholic folk musical Here's a Health to the Barley Mow (1955), Doc Rowe's speedy sword dancing film and the Padstow Mayday celebration Oss Oss Wee Oss (Alan Lomax/Peter Kennedy 1953).
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Of Satyrs, Horses and Camels: Natural History in the Imaginative Mode: illustrated lecture by Daniel Margócsy, Hunter College, New York
Thursday, July 25, 2013 at 7:00pm
More here

From its beginnings, science was (and still is) an imaginative and speculative enterprise, just like the arts. This talk traces the exchange of visual information between the major artists of the Renaissance and the leading natural historians of the scientific revolution. It shows how painters' and printmakers' fictitious images of unicorns, camels and monkfish came to populate the botanical and zoological encyclopedias of early modern Europe.

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You can find out more about all events here.

Source:
http://morbidanatomy.blogspot.com/2013/05/apotheosis-of-dissected-platemorbid.html

Posted in Anatomy | Comments Off on Apotheosis of the Dissected Plate; Cult of the Dead; Morbid Curiousity; Classes Galore: Morbid Anatomy Presents This Week and Beyond

This year’s winner of the Dream Chemistry Award competition is organic chemist Mark Levin with his vision for … – EurekAlert

image:

From the left: the organizers of the competition Prof. Pavel Jungwirth (IOCB Prague) and Prof. Robert Hoyst (IChF PAS) and the winner of the 2023 Dream Chemistry Award Dr. Mark Levin (University of Chicago)

Credit: Photo: Tom Bello / IOCB Prague

The Dream Chemistry Award, a unique competition that does not count scientific articles in prestigious journals or affiliations with renowned universities, knows its winner for this year. Its contestants are young scientists within seven years of having received their doctorate. To be true to its name, it rewards ideas so novel that their realization is akin to fulfilling a bold human dream. The 2023 award has been given to Mark Levin from the University of Chicago, whose aim is to simplify the design of pharmaceutically active substances.

Co-organized by the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences and the Institute of Physical Chemistry of the Polish Academy of Sciences, the Dream Chemistry Award reaches out to researchers that are at the beginning of their careers and are trying to solve fundamental problems in chemistry or related fields. To achieve this goal, they propose innovative solutions to problems with a global impact. It is the general benefit that can come from these projects which is crucial for success in this competition.

This year, the challenge was tackled the best by Dr Mark Levin with his dream about the targeted editing of the skeletons of aromatic molecules. His vision is that molecular designers will be better able to synthesize new functional molecules directly, preferably avoiding dead ends. This would give the world substances with properties that are perfectly suited to specific roles, which is especially important for modern medicinal chemistry. The reason is that this field is currently facing a multitude of problems, for example concerning the effectiveness of medicines.

It is a real breakthrough that can fundamentally transform the way new molecules are discovered, even though this will require a collaborative effort from many research groups around the world, says Mark Levin, adding that It can revolutionize the science of synthesis.

Contestants are nominated for the competition by their reputable senior colleagues from scientific institutions around the world. Young researchers that accept the nomination and prepare a competition submission get evaluated by an international scientific committee. One of its members as well as organizer of the Czech branch of the competition, Prof.Pavel Jungwirth from IOCB Prague, describes: This year's Dream Chemistry Award event presented five scientifically strong finalists, and the jury and audience heard five great lectures. It is difficult to choose a winner from among such brilliant candidates, but this is what the jury is for.

I enjoyed all the lectures. They were of really high quality, agrees the representative of the Polish side, Prof.Robert Hoyst, adding: These people are exceptional, and it is a great honour to be part of such a competition. Although, come to think of it, for us this is not a mere competition; we are talking about the Dream Chemistry Award a festival of science.

Also visiting Prague this year are young recipients of the award from previous years: Karl Brozek, Jessica Kramer and Yujia Qing, who shone in the competition four years ago. Since then, the postdoctoral researcher and then youngest finalist has become an associate professor in organic chemistry at Oxford (UK) and leader of her own research group. How did her success in the Dream Chemistry Award help her? Yujia answers: Receiving this award in the field of chemical biology helped me start my own research programme. I was particularly inspired by the scientific discussion that accompanied the competition. I received a lot of feedback. I also really appreciate the support given by the Dream Chemistry Awards committee. A letter of recommendation from one of its members undoubtedly helped me land my current faculty position.

She is not giving up on her dream of sequencing all life, molecule by molecule, with which she impressed the evaluators in 2019, although she admits that she will have to take a different path than she originally envisaged. I will celebrate every step forward and stay open to all the surprises that science can bring to me, Yujia Qing looks to the future.

The main accolade, the Dream Chemistry Award, comes with an original glass statuette and a prize of 10,000. The remaining finalists have received the TOP5 Prize and a financial reward of 1,000. The top five include: Aisha Bismillah from the University of York in the UK (accelerating the development of shape-shifting molecules and their use in medicine), Moran Frenkel-Pinter from the Hebrew University of Jerusalem (studying primordial peptides as mixtures to find connections between today's biochemistry and the chemical principles from prebiotic times that led to the origin of life on Earth), Francesca Grisoni from the Eindhoven University of Technology (revolutionizing the next generation of artificial intelligence based on principles of chemical intuition) and Barak Hirshberg from Tel Aviv University (designing molecular crystals with customized properties using machine learning algorithms).

The Dream Chemistry Award (www.dreamchemistryaward.org) was founded ten years ago by Prof.Robert Hoyst from the Institute of Physical Chemistry of the Polish Academy of Sciences in Warsaw (IChF PAS). In 2017, the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) joined as the second organizing institution, and since then the competition has been held annually, alternating between Prague and Warsaw.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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This year's winner of the Dream Chemistry Award competition is organic chemist Mark Levin with his vision for ... - EurekAlert

Posted in Chemistry | Comments Off on This year’s winner of the Dream Chemistry Award competition is organic chemist Mark Levin with his vision for … – EurekAlert

New International Partnership to Tackle Public Health Challenges – University of Arizona

The University of Arizona Mel and Enid Zuckerman College of Public Health and the University of Limerick School of Medicines Master of Science Public Health program in Ireland have entered into an International Memorandum of Agreement to enhance cooperation in research and academics.

The partnership will focus on areas of mutual interest through research collaboration, faculty, scholar and student exchanges, direct enrollment and study abroad programs.

In August 2021, Gabriela Valdez, PhD, director of global education and assistant professor in the Zuckerman College of Public Health, and Niamh Cummins, PhD, lecturer in the School of Medicine at the University of Limerick, began crafting an agreement. The strategic goal of the partnership is to advance public health education, research and practice to address the health needs of diverse populations in both countries.

We are pleased to partner with the University of Limerick, especially as we both see the benefits of applied public health education, said Iman Hakim, MD, PhD, dean of the Zuckerman College of Public Health. I want to thank Dr. Valdez and Dr. Cummins for all the work they did to bring our institutions together for the greater good of public health.

The initial collaboration will focus on exchanges of faculty and scholars for short- and long-term visits. The programs plan to collaborate on research, including developing formal research funding proposals.

Megan Bounds, a second-year graduate student in the Zuckerman College of Public Health, was the first student to participate in a research program at the University of Limerick this summer as part of the partnership. Bounds said she is passionate about incorporating public health into medicine and hopes to attend medical school in the future.

My time in Ireland was life-changing, Bounds said. I appreciated the University of Limericks help involving me in many opportunities on campus and around Ireland. They truly took an interest in and enhanced my experience abroad, taking into account my long-term interests and goals.

Those experiences included working at the University of Limerick hospital, meeting with graduate entry medical students and touring the universitys medical facility.

Overall, the Irish people were some of the most kind and welcoming people I have ever met, she added.

In alignment with the partnership, the School of Medicine at the University of Limerick now offers an annualFulbright Scholarship opportunityto a U.S. student, including graduates from the Zuckerman College of Public Health.The Fulbright scholarship will allow one student to complete a fully funded masters in public health at the University of Limerick, which offers a student-centered learning model with an emphasis on community and collaborative learning. The program aims to move from a traditional public health teaching model to a more applied approach to public health education.

The Fulbright scholarship covers the costs of tuition and a student stipend for a 12-month period. The deadline to apply isOct. 11. For more information, visit the Fulbright website. To apply, visit the University of Limerick website or emailmph@ul.ie.

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New International Partnership to Tackle Public Health Challenges - University of Arizona

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Novartis and the pan-Canadian Pharmaceutical Alliance (pCPA) conclude negotiations for Luxturna, a gene therapy for previously untreatable inherited…

DORVAL, QC, Sept. 20, 2022 /CNW/ - Novartis Pharmaceuticals Canada Inc. and the panCanadian Pharmaceutical Alliance (pCPA) have successfully concluded negotiations for Luxturna (voretigene neparvovec),a one-time gene therapy for the treatment of adult and pediatric patients with vision loss due to inherited retinal dystrophy caused by confirmed biallelic RPE65 mutations.

Novartis Pharmaceuticals Canada Logo (CNW Group/Novartis Pharmaceuticals Canada Inc.)

Inherited retinal dystrophies (IRDs) are a major cause of early onset blindness2. RPE65-mediated IRDs are rare, serious, and progressive conditions that ultimately lead to severe visual impairment and blindness. Prior to the approval of Luxturna, there were no available pharmacological treatment options for this form of inherited blindness2.

"We are thrilled to have positively completed these negotiations for Luxturna,oneof two pioneering targeted gene therapies Novartis has introduced in Canada forpatients and families devastated by rare,debilitating orlife-threatening genetic diseases. For all Canadians who urgently need treatment with this innovative therapy, this is an important step to achieve access," said Andrea Marazzi, Country President, Novartis Canada. "We will continue to work collaboratively with provincial and territorial jurisdictions so that patients whose vision is impaired as a result of a mutation in both copies of the RPE65 gene can have access to Luxturnathrough public drug plans as quickly as possible."

"This type of inherited eye disease affects childrenand youngadults and creates a significant impact on the entire family," said Doug Earle, President & CEO of Fighting Blindness Canada.

"For the majority, it can lead to completeblindness as cells in the retina, the light sensitive tissue of the eye, gradually stop working, work less effectively, or die2. Having access to a treatment that can help restore sight, can be life-altering for a child or young adult and their family. We encourage the provinces to recognize the hope Luxturnarepresents and prioritize access as there are no approved alternative treatments available for these Canadians."

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AboutRPE65mutation-associated inherited retinal dystrophyMutations in both copies of theRPE65gene affect approximately 1 in 200,000 people and can lead to blindness3,4. Early in the disease patients can suffer from night blindness (nyctalopia), loss of light sensitivity, loss of peripheral vision, loss of sharpness or clarity of vision, impaired dark adaptation and repetitive uncontrolled movements of the eye (nystagmus)4. Patients with mutations in both copies of theRPE65gene may be diagnosed, for instance, with subtypes of either retinitis pigmentosa or Leber congenital amaurosis5.

About Novartis in Gene Therapy and Rare DiseaseNovartis is at the forefront of cell and gene therapies designed to halt diseases in their tracks or reverse their progress rather than simply manage symptoms. The company is collaborating on the cell and gene therapy frontier to bring this major leap in personalized medicine to patients with a variety of diseases, including genetic disorders and certain deadly cancers. Cell and gene therapies are grounded in careful research that builds on decades of scientific progress. Following key approvals of cell and gene therapies by health authorities, new treatments are being tested in clinical trials around the world.

About Novartis in CanadaNovartis Pharmaceuticals Canada Inc., a leader in the healthcare field, is committed to the discovery, development and marketing of innovative products to improve the well-being of all Canadians. Over the last 5 years, our average annual research and development investment in Canada was $47 million. Located in Dorval, Quebec, Novartis Pharmaceuticals Canada Inc. employs approximately 1,000 people in Canada and is an affiliate of Novartis AG, which provides innovative healthcare solutions that address the evolving needs of patients and societies. The company prides itself on its commitment to diversity and to nurturing an inclusive and inspiring environment. Novartis is recognized as a Great Place to Work, ranked among the Top 50 Best Workplaces in the country and is proudly named on the 2021 Best Workplaces for Women in Canada and Best Workplace for Mental Wellness lists. For further information, please consultwww.novartis.ca.

About NovartisNovartis is reimagining medicine to improve and extend people's lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. In our quest to find new medicines, we consistently rank among the world's top companies investing in research and development. Novartis products reach more than 800 million people globally and we are finding innovative ways to expand access to our latest treatments. About 108,000 people of more than 140 nationalities work at Novartis around the world. Find out more atwww.novartis.com.

Luxturna is a registered trademark of Spark Therapeutics Inc., used under license by Novartis Pharmaceuticals Canada Inc.

References

Novartis Pharmaceuticals Canada Inc. Luxturna(voretigene neparvovec) Product Monograph. April 20, 2022

Patel U BM, de Lsleuc L, et al. Voretigene Neparvovec: An Emerging Gene Therapy for the Treatment of Inherited Blindness. CADTH Issues in Emerging Health Technologies Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016. 2018 (169)

Novartis. Data on file. 2018.

Astuti GD et al. Comprehensive genotyping reveals RPE65 as the most frequently mutated gene in Leber congenital amaurosis in Denmark. European Journal of Human Genetics 2016; 24: 107179.

Morimura H et al. Mutations in the RPE65 gene in patients with autosomal recessive retinitis pigmentosa or Leber congenital amaurosis. Proceedings of the National Academy of Sciences of the USA. 1998; 95: 308893.

SOURCE Novartis Pharmaceuticals Canada Inc.

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Novartis and the pan-Canadian Pharmaceutical Alliance (pCPA) conclude negotiations for Luxturna, a gene therapy for previously untreatable inherited...

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