POSTDOC POSITION in Characterization of factors involved in metabolism of stalled replication forks and their possible disease relevance
Department Department of BiologyFaculty of Medicine
Deadline 29 Feb 2020
Start date March/April 2020 or upon agreement but no later than by 30th November 2020
Masaryk University, Brno, Czech Republic invites excellent scientists to apply for POSTDOC POSITION in Characterization of factors involved in metabolism of stalled replication forks and their possible disease relevance
Description:
The integrity of DNA continually resists the presence of physical and chemical carcinogens in our environment. In addition to exogenous agents, DNA undergoes spontaneous decay, including replication errors, oxidative and other damages which arise from common metabolic processes. The repair of damaged DNA is vital for the maintenance of genome integrity, and as aresult, all organisms have evolved awide variety of DNA repair pathways that can restore DNA structure and its genetic information.
The main objective of our research is to decipher the intrinsic functions of homologous recombination (HR) which has adual role in the maintenance of genome stability. First, it promotes the faithful repair of DNA double-strand breaks (DSBs) belonging among of the most lethal forms of DNA damage. Moreover, HR is responsible for the creation of genetic variability during meiosis by directing the formation of reciprocal crossovers that result in random combinations of alleles and traits. Changes in the execution and regulation of recombination are linked to human infertility, miscarriage and genetic diseases, particularly cancer thus emphasizing the importance of better understanding the mechanism and regulation of this pathway.
To achieve our goals, we utilize awide range of different methods from biochemistry, molecular biology, genetics, structural biology, and biophysics that are well established in our lab. Since we believe that interdisciplinary approach is needed to fully understand the fundamental biological processes, we also collaborate with numerous specialists.
The successful candidate should:
Specific criteria can be filled, i.e.:
The application should include:
MU offers the opportunity to get:
Anticipated start date:The position is available from March/April 2020 or upon agreement but no later than by 30th November 2020.
The submission deadline is29th February 2020.
Please submit your application by e-mail tovrablikova@med.muni.cz
Areview of applications will commence immediately after the deadline. Short-listed candidates will be invited for interview within one month of the deadline.
Further information about:
prof. MUDr. Martin Repko, Ph.D.dkan
Visit link:
Postdoc Position, Department of Biology job with MASARYK UNIVERSITY | 193197 - Times Higher Education (THE)
Recommendation and review posted by G. Smith
