Search Immortality Topics:

Page 9,562«..1020..9,5619,5629,5639,564..9,5709,580..»


TV Ratings Report: NBA Finals Heat Up

Posted: June 14, 2013 at 1:12 pm

The Miami Heat didn't just dominate the second half of the NBA Finals last night, Game 4 of this back-and-forth series dominated the Thursday night television ratings.

Scroll down for a breakdown, which includes low numbers for Hannibal and an easy victory for ABC...

Finals Pic

8 p.m.
The Big Bang Theory rerun: 8.3 million/Two and a Half Men rerun: 6.3 million
Hell's Kitchen: 5 million
Save Me rerun: 2.4 million/Save Me: 2.2 million
The Vampire Diaries rerun: 870,000

9 p.m.
NBA Finals: 14.1 million
Person of Interest rerun: 6.5 million
Does Someone Have To Go?: 2.4 million
The Office rerun: 1.5 million/Parks and Recreation rerun: 1.5 million
Beauty and the Beast rerun: 630,000

10 p.m.
Elementary rerun: 5.6 million
Hannibal: 2 million

Source:
http://www.tvfanatic.com/2013/06/tv-ratings-report-nba-finals-heat-up/

Recommendation and review posted by G. Smith

Revenge Season 3 Q&A: How Will Jack React?

Posted: June 14, 2013 at 12:41 pm

I’m Amanda Clarke.

Yep, Emily Thorne finally said those words to Jack Porter to close out Revenge Season 2. So, as we bide our time this summer waiting for new episodes, what could possibly come next?

Leave it to Nick Wechsler (Jack) to shed some light on the question (and a few others) when we hung out at the ATX Television Festival this past weekend in Austin. Though they haven’t started shooting the new season yet, Wechsler had some theories and desires for how Jack should handle this shocking news, as well as what other TV show the actor would love to appear on...

-------------------------------------------

TV Fanatic: Where do you think we’ll find Jack mentally? Between his brother’s death and Emily dropping the bomb about being Amanda, what would you want for him?
Nick Wechsler: I would like for him to believe her. I would like for him to...basically, he has to go after Conrad Grayson now…but for him to maybe finally accept Emily, through seeing what it's done to Jack…this might actually be more interesting, if it took seeing Jack go down this dark revenge road to make her rethink her own revenge.

TVF: I actually hadn't thought about that. On the flip side of that is Emily and Jack teaming up in a way because they both have their issues with the Graysons.
NW: It's interesting because I think that would be a way for it to go because through this I think he's going to resent her. As much as it's like ‘oh my God, you've just revealed to me that you are…this explains the connection I've had to you all along, you are the girl that I've been in love with, but I'm also hurt that you've been lying and that you set up a sequence of events that led to me losing someone I thought was you, I thought was the love of my life.’

Jack Porter at the Bar

TVF: Because he truly fell in love with Amanda.
NW: Exactly. ‘So whether or not she was you, I ended up falling in love with whoever she was.’ So he's going to be upset with her but at the same time it has the potential to put him in her shoes. So it's like, wow, the reason he comes around to forgiving her [and] he's going to have to start Trojan-Horsing his way in. He's going to have to start lying to people to get some of this information out to try to take [the Graysons] down. So yeah. It's both the thing that's going to push her away, and the thing that's probably ultimately going to make him forgive her.

TVF: A therapist would make really good money living in The Hamptons, don’t ya think?
NW: Jack can't afford it, but yeah.

TVF: How do you feel like your life's changed in the last two years? Do you get recognized more? Is fame something different to deal with?
NW: I get recognized more, but it's never a problem. Everybody's really respectful and everything. I just went to Bali for 15 percent work and 85 percent play and it was amazing. But Australia is around the corner and [the show is] doing very well in Australia, so I got stopped a lot there. Recognizing someone from something they watch is rarer there so I got stopped more frequently.

Like in LA, I don’t get stopped nearly as much as I get stopped here in Austin or over there. As long as people aren't asking for too much or anything, like too much of your time or anything or whatever, but no, my life is no different, really. I still haven't bought a new car and I drive a 13-year-old piece of shit.

TVF: Do they make fun of you when you drive your car on the lot to shoot the show?
NW: Behind my back, I'm sure. I'm sure I'm paying less in rent than everyone in the cast. I didn't move. I mean, these are things I'm eventually going to change. Obviously, I'm going to get a new car, I'll probably move or whatever, but it hasn't changed my life. It's changed my opportunities.

TVF: Where do you see your career going beyond this show? Do you see more drama? Comedy?
NW: What means more to me is comedy just because that's what got me started acting. That's my favorite thing to do, is just sit around and riff with my friends, and make people laugh, and play ridiculous characters. Just talk as a character to my friend and we just keep doing this back and forth and it's got to be awful for girlfriends to sit through.

But I think I'm almost better suited to drama. Like whatever my thing is. And it's actually frustrating. It's like a part of me is jealous of the dramatic part of me because the dramatic part is getting a lot more attention. I'm not even sure I'm that good at [comedy] anymore because I haven't had many opportunities.

TVF: Okay, so you have your two and a half months off. You can go work on any show, like a guest spot or something. Do you have a show that's on the air now that you’d love to do?
NW: I've already done something on It's Always Sunny In Philadelphia but I think that show is so brilliant. I wish I could keep coming back as different characters. I love that show.

TVF: And they do a lot of improving stuff, right? Like they don’t keep tight to the script if I remember right, talking to them.
NW: Yeah, which is my kind of thing. But, also, just based on the strength of the first season because it's one of the funniest things I've ever seen, Eastbound and Down…I'd be honored to have had anything to do with their fourth and final season. That would be amazing.

Source:
http://www.tvfanatic.com/2013/06/revenge-season-3-qanda-how-will-jack-react/

Recommendation and review posted by G. Smith

Playing with Proteins

Posted: June 14, 2013 at 12:02 pm

On my first day at Chemistry World, I was surprised to see a box of toys sitting on the editor’s desk. Gifts for children? Executive stress relief? Maybe I’ve joined one of those funky dotcom-style offices where people just play with toys for ‘inspiration’?

Protein Building Set

Protein Building Set

The truth, I soon discovered, is a bit of all three – the main toy in the box was the Proteins Building Set, which describes itself as ‘the most accurate protein building set’ with which you can ‘build and learn about proteins’. It was designed and developed by Marcel Jaspars of the University of Aberdeen, working with Richard Zawitz of Californian toy maker, Tangle.

Jaspars had suggested Chemistry World might like to have a sample set, so I decided to follow his advice – build a protein and see what I learn.

The Protein Building Set itself consists of quarter-circle curved plastic tubes, designed to clip into one another like a very niche Lego set. These can be combined into circles, helices, waves or amorphous wibbles, and structures can be supported using thin clear plastic struts, to stop your proteins ‘denaturing’.

IgG Binding Domain

IgG Binding Domain

It’s undeniably fun to play with and to explore the structures one can create – but by just playing I don’t feel like I’m learning anything about proteins. Perhaps it’s time to look at the booklet that came with the set.

This is where it gets educational. There’s a lovely overview of the roles and structures of proteins, as well as an introduction to the use of models in science and how a Tangle toy inspired Jaspars to design this kit.  It explains how the pieces represent simplified amino acid residues, with the holes for struts placed in approximately the right place to show hydrogen bonding of C=O and N-H, even acknowledging and detailing the simplifications made to allow this. Then we get into the real meat – step by step instructions on how to build the actual structures of real proteins: The third IgG-binding domain from Streptococcal protein G; Ubiquitin and ?-Conotoxin MVIIA.

Conotoxin

Conotoxin

Building the IgG binding site took about half an hour – the instructions are easy to follow and include an accessible explanation of its role in disease. Constructing the protein involves learning the structure of ?-sheets and an ?-helix, but the real educational value comes from the dawning realisation that it’s the secondary and tertiary folding and cross bonding that gives the protein its structure, not simply the sequence of parts.

The Protein Building Set may not be as versatile as Lego, but it can be used to build some magnificent and real structures; Jaspars suggests visiting the Protein Data Bank for inspiration. With that in mind, it could easily find a home in the toy box waiting for a rainy afternoon, a biochemical 3D jigsaw puzzle. But it is certainly more than just a toy, and by elucidating the importance of shape in proteins it would also sit well in schools next to the molymod.

Digg This  Reddit This  Stumble Now!  Share on Facebook  Bookmark this on Delicious  Share on LinkedIn  Bookmark this on Technorati  Post on Twitter  Google Buzz (aka. Google Reader)  

Source:
http://prospect.rsc.org/blogs/cw/2013/06/14/playing-with-proteins/

Recommendation and review posted by G. Smith

Jim’s Notebook: Scandal, Royal Pains and Wilson Bethel!

Posted: June 14, 2013 at 11:20 am

While I was busy at the second annual ATX Television Festival in Austin last weekend, I managed to sit down with the folks making some of your favorite TV shows, gathering up scoop on their programs and, in the case of one actor, learning of his summer hiatus plans.

So this week’s Notebook gets emptied out with bits from Scandal’s gay couple, a Royal Pains pregnancy and what Hart of Dixie’s Wilson Bethel is up to over the next couple months...

Jim's Notebook

SCANDAL When it comes to playing the heightened drama on ABC’s hit series, Dan Bucatinsky (James) said that he can relate to a lot of the issues that plague his character and his partner Cyrus (Jeff Perry). “I live it every single day,” he said after the ATX panel for the show. “I'm a passionate father of my two kids and a passionate writer, performer, actor, and producer. And that tension between wanting both things so desperately is something that lives in James.”

Bucatinsky’s real-life partner is acclaimed writer/director Don Roos.

The actor, who is busy with Web Therapy on Showtime, Who Do You Think You Are on TLC (both of which he does with BFF Lisa Kudrow) and his writing gig on Grey’s Anatomy, added of what he’d like to see on Scandal Season 3: “I think it would be really interesting to see life at home challenge James and Cyrus while career is starting to explode I think that would be an interesting place to go, but there's no telling.”

Cyrus at Home

ROYAL PAINS The jaw-dropping moment in this week’s Royal Pains Season 5 is that Divya is pregnant. Because she’s not a mother yet in real life, actress Reshma Shetty told me that she chatted with some people close to her – literally. “My next-door neighbor has two kids,” she said so she was able to ask “in that period of time what happened to you? What happened to your body? How did you feel?” For her character, who usually does her best to keep her life in order, Shetty said, “this is the last thing that could possibly happen to her in her mind.”

And while the predictable thing to do would be to bring in Divya’s ultra-strict parents, Executive Producer Michael Rauch told me that he and his creative team took a different route. “What the writers do is send these conflicts back into the family unit, which is HankMed,” he said. “So, it will provide great conflict and issues to come up in season five with how we take care of her. So, rather than seeing it play out in Divya’s family, we get to see it play out in the HankMed family.”

WILSON BETHEL is using his Hart of Dixie hiatus keeping busy, but did doing improv on the CW’s revival of Whose Line Is It Anyway come easily for him? “I'm a bit of a loose cannon anyway so just being ridiculous in  the moment comes pretty natural to me but improv is scary as shit, man,” he told me in Austin last weekend. He said that working with seasoned improv talents (and host Aisha Tyler from Archer) made the experience easier. (The series kicks off July 16).

And for those who loved his Stupid Hype web series, Bethel is working on another one for The CW.  “It’s a new series called LA Rangers,” he said, “where me and my creative partner play Los Angeles park rangers in Griffith Park who are aspiring filmmakers. So we are in preproduction stages right now and we'll shoot that next month before going back to Hart of Dixie.” (More from my chat with Bethel about his hopes for Season 3 of Hart of Dixie coming next week on TV Fanatic.)

That’s a wrap for this week! Anything else you’re dying to know about your favorite show? Leave a comment here or you email me directly at jim@jimhalterman.com. And remember: follow @TVFanatic for all your TV scoop!

Source:
http://www.tvfanatic.com/2013/06/jims-notebook-scandal-royal-pains-and-wilson-bethel/

Recommendation and review posted by G. Smith

Noninvasive detection of fetal trisomy 21: systematic review and report of quality and outcomes of diagnostic accuracy studies performed between 1997 and 2012

Posted: June 14, 2013 at 9:33 am

BACKGROUND

Research on noninvasive prenatal testing (NIPT) of fetal trisomy 21 is developing fast. Commercial tests have become available. To provide an up-to-date overview of NIPT of trisomy 21, an evaluation of the methodological quality and outcomes of diagnostic accuracy studies was made.

METHODS

We undertook a systematic review of the literature published between 1997 and 2012 after searching PubMed, using MeSH terms ‘RNA’, ‘DNA’ and ‘Down Syndrome’ in combination with ‘cell-free fetal (cff) RNA’, ‘cffDNA’, ‘trisomy 21’ and ‘noninvasive prenatal diagnosis’ and searching reference lists of reported literature. From 79 abstracts, 16 studies were included as they evaluated the diagnostic accuracy of a molecular technique for NIPT of trisomy 21, and the test sensitivity and specificity were reported. Meta-analysis could not be performed due to the use of six different molecular techniques and different cutoff points. Diagnostic parameters were derived or calculated, and possible bias and applicability were evaluated utilizing the revised tool for Quality Assessment of Diagnostic Accuracy (QUADAS-2).

RESULTS

Seven of the included studies were recently published in large cohort studies that examined massively parallel sequencing (MPS), with or without pre-selection of chromosomes, and reported sensitivities between 98.58% [95% confidence interval (CI) 95.9–99.5%] and 100% (95% CI 96–100%) and specificities between 97.95% (95% CI 94.1–99.3%) and 100% (95% CI 99.1–100%). None of these seven large studies had an overall low risk of bias and low concerns regarding applicability. MPS with or without pre-selection of chromosomes exhibits an excellent negative predictive value (100%) in conditions with disease odds from 1:1500 to 1:200. However, positive predictive values were lower, even in high-risk pregnancies (19.7–100%). The other nine cohort studies were too small to give precise estimates (number of trisomy 21 cases: ≤25) and were not included in the discussion.

CONCLUSIONS

NIPT of trisomy 21 by MPS with or without pre-selection of chromosomes is promising and likely to replace the prenatal serum screening test that is currently combined with nuchal translucency measurement in the first trimester of pregnancy. Before NIPT can be introduced as a screening test in a social insurance health-care system, more evidence is needed from large prospective diagnostic accuracy studies in first trimester pregnancies. Moreover, we believe further assessment, of whether NIPT can be provided in a cost-effective, timely and equitable manner for every pregnant woman, is required.

Source:
http://humupd.oxfordjournals.org/cgi/content/short/19/4/318?rss=1

Recommendation and review posted by G. Smith

Assisted reproductive technology and birth defects: a systematic review and meta-analysis

Posted: June 14, 2013 at 9:33 am

BACKGROUND

It has been 10 years since we carried out a systematic search of the literature on birth defect risk in infants born following assisted reproductive technology (ART) compared with non-ART infants. Because of changes to ART practice since that review and the publication of more studies the objective of this review was to include these more recent studies to estimate birth defect risk after ART and to examine birth defect risk separately in ART singletons and multiples.

METHODS

We searched Medline, Embase and Current Contents databases (1978–2012). We used the same data extraction sheet and questionnaire we had used previously with the addition of a quality score to the questionnaire. Pooled relative risk (RR) estimates were calculated using a random effects model. All data were analysed using Comprehensive Meta-Analysis V2.

RESULTS

There were 45 cohort studies included in this review. ART infants (n = 92 671) had a higher risk of birth defects [RR 1.32, 95% confidence interval (CI) 1.24–1.42] compared with naturally conceived infants (n = 3 870 760). The risk further increased when data were restricted to major birth defects (RR 1.42, 95% CI 1.29–1.56) or singletons only (RR 1.36, 95% CI 1.30–1.43). The results for ART multiples were less clear. When all data for multiples were pooled the RR estimate was 1.11 (95% CI 0.98–1.26) but this increased to 1.26 (0.99–1.60) when the analysis was restricted to studies of ART twins where some adjustment was made for differences in zygosity distribution between ART and non-ART multiples.

CONCLUSIONS

Birth defects remain more common in ART infants. Further research is required to examine risks for important subgroups of ART exposure.

Source:
http://humupd.oxfordjournals.org/cgi/content/short/19/4/330?rss=1

Recommendation and review posted by G. Smith


Page 9,562«..1020..9,5619,5629,5639,564..9,5709,580..»