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Huntington's Disease – Stem Cell Therapy Potential

Posted: March 19, 2012 at 9:11 pm

Editor's Choice Academic Journal Main Category: Huntingtons Disease Also Included In: Stem Cell Research Article Date: 19 Mar 2012 - 10:00 PDT

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However, according to a study published March 15 in the journal Cell Stem Cell, a special type of brain cell created from stem cells could help restore the muscle coordination deficits that are responsible for uncontrollable spasms, a characteristic of the disease. The researchers demonstrated that movement in mice with a Huntington's-like condition could be restored.

Su-Chun Zhang, a University of Wisconsin-Madison neuroscientist and the senior author of the study, said:

In the study Zhang, who is an expert in creating various types of brain cells from human embryonic or induce pluripotent stem cells, and his team focused on GABA neurons. The degradation of GABA cells causes the breakdown of a vital neural circuit and loss of motor function in individuals suffering from Huntington's disease.

According to Zhang, GABA neurons generate a vital neurotransmitter, a chemical that helps support the communication network in the brain that coordinates movement.

Zhang and his team at the UW-Madison Waisman Center, discovered how to generate large quantities of GABA neurons from human embryonic stem cells. The team's goal was to determine whether these cells would safely integrate into the brain of a mouse model of Huntington's disease.

The researchers discovered that not only did the cells integrate, they were projected to the right target and were able to effectively restore the damaged communication network and restore motor function.

Zhang says that the results were astonishing, as GABA neurons reside in the basal ganglia, a part of the brain which plays a vital role in voluntary motor coordination. However, the GABA neurons exert their influence at a distance on cells in the midbrain via the circuit powered by the GABA neuron chemical neurotransmitter.

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Huntington's Disease - Stem Cell Therapy Potential

Recommendation and review posted by G. Smith

Tengion to Host Conference Call to Provide a Business Update and Report Fourth Quarter 2011 Financial Results on March …

Posted: March 19, 2012 at 9:11 pm

WINSTON-SALEM, N.C., March 19, 2012 /PRNewswire/ -- Tengion, Inc. (NASDAQ: TNGN - News), a leader in regenerative medicine, today announced it will host a conference call and live audio webcast on Monday, March 26, 2012, at 5:00 p.m. EDT to provide a business update and discuss its fourth quarter 2011 financial results.

To participate in the call, please dial 1-800-638-4930 (domestic) or 1-617-614-3944 (international) and reference access code 34844557.

The conference call can be accessed from the Investors section of the Company's website or directly at http://edge.media-server.com/m/p/o4v89uyi/lan/en. The webcast will also be archived on the website.

About Tengion

Tengion, a clinical-stage regenerative medicine company, is focused on discovering, developing, manufacturing and commercializing a range of neo-organs, or products composed of living cells, with or without synthetic or natural materials, implanted or injected into the body to engraft into, regenerate, or replace a damaged tissue or organ. Using its Organ Regeneration Platform, the Company creates neo-organs using a patient's own cells, or autologous cells. Tengion's proprietary product candidates harness the intrinsic regenerative pathways of the body to regenerate a range of native-like organs and tissues. The Company's product candidates are intended to delay or eliminate the need for chronic disease therapies, organ transplantation, and the administration of anti-rejection medications. An initial clinical trial is ongoing for the Company's lead product candidate, the Neo-Urinary Conduit, an autologous implant that is intended to catalyze regeneration of native-like bladder tissue for bladder cancer patients requiring a urinary diversion following bladder removal. The Company's lead preclinical candidate is the Neo-Kidney Augment, which is designed to prevent or delay dialysis by increasing renal function in patients with advanced chronic kidney disease. Tengion has worldwide rights to its product candidates.

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Tengion to Host Conference Call to Provide a Business Update and Report Fourth Quarter 2011 Financial Results on March ...

Recommendation and review posted by G. Smith

Medical Equipment Annual Deals Analysis 2012

Posted: March 19, 2012 at 9:10 pm

NEW YORK, March 19, 2012 /PRNewswire/ --Reportlinker.com announces that a new market research report is available in its catalogue:

http://www.reportlinker.com/p0180789/Medical-Equipment-Annual-Deals-Analysis-2012.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply

Medical Equipment Annual Deals Analysis 2012

Data presented in this report is derived from GlobalData's proprietary in-house Medical eTrack deals database as well as primary and secondary research.

Scope

- Analyze market trends for the medical equipment/medical devices market in the global arena - Review of deal trends in anesthesia and respiratory devices, cardiovascular devices, dental devices, diabetes care devices, diagnostic imaging, drug delivery devices, endoscopy devices, ENT devices, healthcare IT, hospital supplies, in vitro diagnostics, nephrology and urology devices, neurology devices, opthalmic devices, patient monitoring, surgical equipment, and wound care management segments- Analysis of M&A, Equity/Debt Offerings, Private Equity, Venture Financing and Partnerships in the medical equipment market-

of medical equipment deals globally in the last five years- Information on the top deals that took place in the medical equipment market- Geographies covered include North America, Europe, Asia Pacific, South & Central America, and Middle East & Africa- League Tables of financial advisors in M&A and equity/debt offerings. This includes key advisors such as Morgan Stanley, Credit Suisse, and Goldman Sachs- Review the financial metrics, such as operating profit ratio, P/E ratio, and EV/EBITDA on mergers and acquisitions

Reasons to buy

- Enhance your decision making capability in a more rapid and time sensitive manner- Find out the major deal performing segments for investments in your industry- Evaluate type of companies divesting / acquiring and ways to raise capital in the market- Do deals with an understanding of how competitors are financed, and the mergers and partnerships that have shaped the medical equipment market- Identify major private equity/venture capital firms that are providing finance in the medical equipment market- Identify growth segments and opportunities in each region within the industry- Look for key financial advisors where you are planning to raise capital from the market or for acquisitions within the industry- Identify top deals makers in the medical equipment market1 Table of contents1 Table of contents 21.1 List of Tables 41.2 List of Figures 72 Medical Equipment, Global, Deals Summary 102.1 Medical Equipment, Global, Deals Analysis, 2011 102.1.1 Medical Equipment, Global Deals Analysis, 2011 by Quarter 112.2 Medical Equipment, Global, Number of Deals by Type, 2011 132.3 Medical Equipment, Global, Top Deals, 2011 142.4 Medical Equipment, Global, Top Deals, Summaries, 2011 152.4.1 Johnson & Johnson Enters Into An Agreement To Acquire Synthes 152.4.2 Takeda Pharmaceutical Completes Acquisition Of Nycomed International For $13.7 Billion 152.4.3 Apax Partners, CPPIB And PSPIB Complete Acquisition Of Kinetic Concepts For $6.1 Billion 162.4.4 Johnson & Johnson Completes Public Offering Of Notes For $4.4 Billion 162.4.5 Thermo Fisher Completes Acquisition Of Phadia 162.4.6 Texas Instruments Completes Public Offering Of Notes For $3.5 Billion 172.4.7 Blackstone Group Completes Acquisition Of Emdeon For $3 Billion 172.4.8 Endo Pharmaceuticals Acquires American Medical Systems 172.4.9 Kinetic Concepts Completes Public Offering Of Second Lien Senior Secured Notes For $2.5 Billion 172.4.10 Thermo Fisher Scientific Completes Public Offering Of Senior Notes For $2.1 Billion 183 Medical Equipment, Top Deal Makers, 2011 194 Medical Equipment, Global, Deal Summary, by Type 204.1 Medical Equipment, Global, Deals by Type, 2007-2011 204.2 Medical Equipment, Global, Merger and Acquisition Deals, 2011 214.2.1 Medical Equipment, Global Merger and Acquisition Deals, 2011 by Quarter 224.2.2 Top M&A Deals in 2011 234.3 Medical Equipment, Global, Equity Offerings, 2011 244.3.1 Medical Equipment, Global, Equity Offerings, 2011 by Quarter 254.3.2 Medical Equipment, Global, IPO Deals, 2011 264.3.3 Medical Equipment, Global, Secondary Offerings Deals, 2011 284.3.4 Medical Equipment, Global, PIPE Deals, 2011 294.4 Medical Equipment, Global, Debt Offerings, 2011 304.4.1 Medical Equipment, Global, Debt Offerings, 2011 by Quarter 314.4.2 Medical Equipment, Global, Public Debt Offerings, 2011 324.4.3 Medical Equipment, Global, Private Debt Placements, 2011 334.5 Medical Equipment, Global, Partnership Deals, 2011 344.5.1 Medical Equipment, Global, Partnership Deals, 2011 by Quarter 354.5.2 Partnership Deals in 2011 364.6 Medical Equipment, Global, Private Equity Deals, 2011 384.6.1 Medical Equipment, Global Private Equity Deals, 2011 by Quarter 394.6.2 Top Private Equity Deals in 2011 404.7 Medical Equipment, Global, Venture Financing Deals, 2011 414.7.1 Medical Equipment, Global, Venture Financing Deals, 2011 by Quarter 424.7.2 Medical Equipment, Global, Venture Capital Deals by Stage of Financing, 2011 434.7.3 Medical Equipment, Global, Top Venture Financing Firms, 2011 444.7.4 Medical Equipment, Global, Top Venture Financing Deals in 2011 455 Medical Equipment, Global, Deal Summary, By Market 465.1 Medical Equipment, Global, In Vitro Diagnostics Deals, 2011 465.1.1 Medical Equipment, Global, In Vitro Diagnostics Deals, 2011 by Quarter 485.1.2 In Vitro Diagnostics - Deals of the Year 495.2 Medical Equipment, Global, Healthcare IT Deals, 2011 515.2.1 Medical Equipment, Global Healthcare IT Deals, 2011 by Quarter 525.2.2 Healthcare IT - Deals of the Year 535.3 Medical Equipment, Global, Cardiovascular Devices Deals, 2011 545.3.1 Medical Equipment, Global, Cardiovascular Devices Deals, 2011 by Quarter 555.3.2 Cardiovascular Devices - Deals of the Year 565.4 Medical Equipment, Global, Orthopedic Devices Deals, 2011 575.4.1 Medical Equipment, Global, Orthopedic Devices Deals, 2011 by Quarter 585.4.2 Orthopedic Devices - Deals of the Year 595.5 Medical Equipment, Global, Diagnostic Imaging Deals, 2011 605.5.1 Medical Equipment, Global, Diagnostic Imaging Deals, 2011 by Quarter 615.5.2 Diagnostic Imaging - Deals of the Year 625.6 Medical Equipment, Global Surgical Equipment Deals, 2011 635.6.1 Medical Equipment, Global, Surgical Equipment Deals, 2011 by Quarter 645.6.2 Surgical Equipment - Deals of the Year 655.7 Medical Equipment, Global, Drug Delivery Devices Deals, 2011 665.7.1 Medical Equipment, Global Drug Delivery Devices Deals, 2011 by Quarter 675.7.2 Drug Delivery Devices - Deals of the Year 685.8 Medical Equipment, Global, Anesthesia and Respiratory Devices Deals, 2011 705.8.1 Medical Equipment, Global, Anesthesia and Respiratory Devices Deals, 2011 by Quarter 715.8.2 Anesthesia and Respiratory Devices - Deals of the Year 725.9 Medical Equipment, Global, Hospital Supplies Deals, 2011 735.9.1 Medical Equipment, Global Hospital Supplies Deals, 2011 by Quarter 745.9.2 Hospital Supplies - Deals of the Year 755.10 Medical Equipment, Global, Neurology Devices Deals, 2011 765.10.1 Medical Equipment, Global, Neurology Devices Deals, 2011 by Quarter 775.10.2 Neurology Devices - Deals of the Year 785.11 Medical Equipment, Global, Ophthalmic Devices Deals, 2011 795.11.1 Medical Equipment, Global, Ophthalmic Devices Deals, 2011 by Quarter 805.11.2 Ophthalmic Devices - Deals of the Year 815.12 Medical Equipment, Global, Patient Monitoring Deals, 2011 825.12.1 Medical Equipment, Global, Patient Monitoring Deals, 2011 by Quarter 835.12.2 Patient Monitoring - Deals of the Year 845.13 Medical Equipment, Global, Nephrology and Urology Devices Deals, 2011 855.13.1 Medical Equipment, Global, Nephrology and Urology Devices Deals, 2011 by Quarter 865.13.2 Nephrology and Urology Devices - Deals of the Year 875.14 Medical Equipment, Global, Wound Care Management Deals, 2011 885.14.1 Medical Equipment, Global, Wound Care Management Devices Deals, 2011 by Quarter 895.14.2 Wound Care Management - Deals of the Year 905.15 Medical Equipment, Global, Diabetes Care Devices, Deals, 2011 915.15.1 Medical Equipment, Global, Diabetes Care Devices, Deals, 2011 by Quarter 925.15.2 Diabetes Care Devices - Deals of the Year 935.16 Medical Equipment, Global, Dental Devices Deals, 2011 945.16.1 Medical Equipment, Global, Dental Devices Deals, 2011 by Quarter 955.16.2 Dental Devices - Deals of the Year 965.17 Medical Equipment, Global, Endoscopy Devices Deals, 2011 975.17.1 Medical Equipment, Global, Endoscopy Devices Deals, 2011 by Quarter 985.17.2 Endoscopy Devices - Deals of the Year 995.18 Medical Equipment, Global, Ear, Nose and Throat Devices Deals, 2011 1005.18.1 Medical Equipment, Global, ENT Devices Deals, 2011 by Quarter 1015.18.2 ENT Devices - Deals of the Year 1026 Medical Equipment, Deal Summary, By Geography 1036.1 Medical Equipment, North America Region, Deals, 2011 1036.1.1 Medical Equipment, North America Region, Deals, 2011 by Quarter 1046.1.2 North America Deals of the Year 1056.2 Medical Equipment, European Region, Deals, 2011 1076.2.1 Medical Equipment, European Region, Deals, 2011 by Quarter 1086.2.2 Europe Deals of the Year 1096.3 Medical Equipment, Asia-Pacific Region, Deals, 2011 1106.3.1 Medical Equipment, Asia-Pacific Region, Deals, 2011 by Quarter 1116.3.2 Asia-Pacific Deals of the Year 1126.4 Medical Equipment, Rest of the World (ROW), Deals, 2011 1136.4.1 Medical Equipment, Rest of the World, Deals, 2011 by Quarter 1146.4.2 Rest of the World Deals of the Year 1157 Medical Equipment, Global, Top Financial Advisors 1167.1 Medical Equipment, Global, Top Financial Advisors, M&A, 2011 1167.2 Medical Equipment, Global, Top Financial Advisors, Equity Offerings, 2011 1177.3 Medical Equipment, Global, Top Financial Advisors, Debt Offerings, 2011 1188 Medical Equipment, Global, Top Legal Advisors 1198.1 Medical Equipment, Global, Top Legal Advisors, 2011 1199 Further Information 1209.1 Methodology 1209.2 About GlobalData 1209.3 Contact Us 1219.4 Disclosure information 1219.5 Disclaimer 121

List of Tables

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Medical Equipment Annual Deals Analysis 2012

Recommendation and review posted by G. Smith

Nanotechnology for Medical Diagnostics

Posted: March 19, 2012 at 9:10 pm

NEW YORK, March 19, 2012 /PRNewswire/ --Reportlinker.com announces that a new market research report is available in its catalogue:

Nanotechnology for Medical Diagnosticshttp://www.reportlinker.com/p0799334/Nanotechnology-for-Medical-Diagnostics.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Nanotechnology

Following on from our "Nanotechnology for Drug Delivery" series of reports we are turning the focus onto medical diagnostics with our latest report: "Nanotechnology for Medical Diagnostics"

Nanotech enabled medical diagnostics promise to improve just about everything that can be improved from a diagnostics point of view: earlier detection of disease, higher sensitivity, higher accuracy, higher throughput capability, more results per assay; time saving and cost-effectiveness.

As with our "Nanotechnology for Drug Delivery" series of reports, this report provides a market numbers for the nanotech enabled medical diagnostic market between 2000-2010 and a market forecast for the period 2011-2021.

Report Scope

Two sets of data are presented in this report:

The TAM growth for NMBD between 2000-2010;TAM forecast for NMBD between 2011- 2021.

Both sets of data are segmented into;

TAM (US$ millions, % share, and CAGR) for:

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Nanotechnology for Medical Diagnostics

Recommendation and review posted by G. Smith

Paragon Innovations Helps Diabetics Cut the (Refrigerator) Cord, with Design of New Temperature Control Device

Posted: March 19, 2012 at 9:10 pm

Paragon Innovations Helps Diabetics Cut the (Refrigerator) Cord, with Design of New Temperature Control Device

Say goodbye to coolers and ice packs. Available this summer from Kewl Innovations, amazing nano-technology-driven device will keep medicine temps consistent for days.

Paragon has been instrumental in the design of Kewls new product, which is scheduled to hit the market this summer. The small, lightweight device can control and monitor the temperature of medications over several days, making travel easier than ever. With a single charge, the device can ensure medicine is properly refrigerated without a gel pack, ice chest or other bulky and unreliable cooling methods.

Paragon is working with Kewl to leverage several advanced methodologies in the new product, which relies on nanotechnology, advanced software and long-lasting rechargeable batteries.

The development of this product presented a unique challenge. Providing accurate, long-lasting temperature control in a small, portable device requires expertise across multiple engineering disciplines, said Tom Borger, president and chief executive officer for Kewl Innovations, Inc., which is headquartered in Richardson. Paragon attacked this complex problem and is helping us create a product we are excited to take to the marketplace.

The Kewl product will represent a breakthrough in consumer healthcare. It will be the first time a single product has solved three significant problems for individuals who rely upon insulin and similar medications: long-term temperature control, portability in a small format, and extended battery life over several days.

Were always happy to help clients solve their engineering challenges, but this product from Kewl Innovations is particularly exciting, said Michael Wilkinson, chief executive officer for Paragon. With a single device, patients who once felt tethered to their homes and their refrigerators will be given the freedom to travel, without worrying about their medication or their schedule.

About Paragon Innovations A leading engineering and product development services provider, Paragon Innovations, Inc., specializes in medical devices, video displays and portable wireless devices. Founded in 1990, Paragon Innovations has worked with Fortune 500 companies, as well as startup ventures, to provide turn-key electrical, mechanical and industrial design engineering services from concept development to market launch. The company is headquartered in Richardson, Texas. For more information, visit http://www.paragoninnovations.com.

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Paragon Innovations Helps Diabetics Cut the (Refrigerator) Cord, with Design of New Temperature Control Device

Recommendation and review posted by G. Smith

The Ultimate Medical School Lecture – Video

Posted: March 19, 2012 at 9:10 pm

25-02-2012 12:51 WashU Med 2014 Second-Year Class Show. Produced by Hallie Morris, Philip Perez and David Rubins.

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The Ultimate Medical School Lecture - Video

Recommendation and review posted by G. Smith


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