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Trialing Stem Cells to Heal Heart Damage

Posted: April 14, 2010 at 8:20 am

Via EurekAlert!, another example of testing stem cells and heart regeneration: “Some patients with heart muscles seriously affected by coronary heart disease may soon be able to benefit from an innovative treatment. Researchers [are] evaluating the safety, feasibility and efficacy of injecting stem cells into the hearts of patients while they are undergoing coronary bypass surgery. These stem cells could improve healing of the heart and its function. The IMPACT-CABG (implantation of autologous CD133+ stem cells in patients undergoing coronary artery bypass grafting) protocol evaluates this experimental procedure, which is destined for patients suffering from ischemic heart disease, in which the blood supply to the heart is decreased and associated with heart failure. These patients undergo open-heart coronary bypass surgery, performed by the medical team to improve perfusion of the heart muscle. A few weeks ago, the first patient received progenitor CD133+ stem cells isolated from his bone marrow and enriched, [and] has been doing very well ever since. Already, improvement has been noted in the contraction capacity of his heart, which has improved its ability to pump blood.”

View the Article Under Discussion: http://www.eurekalert.org/pub_releases/2010-04/chdl-hcy_1041110.php

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Recommendation and review posted by G. Smith

How Exercise Can Awaken Your Creative Genius Within

Posted: April 13, 2010 at 8:21 am

Are you looking for another reason to exercise? Exercise can improve your life by increasing creativity, focus and intelligence.

Many people look at exercise as a requirement.  They know they are supposed to exercise, but they don’t necessarily enjoy it.  As a result, many dieters find that they are forcing themselves to exercise.  On the other hand, often people who aren’t trying to lose weight skip exercising altogether.  As you know, everyone should exercise because there are countless health benefits to exercising, which include fighting diseases like stroke, osteoporosis, diabetes and high blood pressure.

However, it is important to realize that exercise can improve your life in ways that are not necessarily even fitness related.  Exercise can allow you to find solutions, boost creativity and improve your focus.

A recent study at the National Cheng Kung University in Taiwan showed that the brainpower of mice improves when they are allowed to exercise. When mice are forced to exercise more than they normally would, the mice’s thinking power improves yet further.  Scientists noted major developments in the brain when the mice were pushed beyond their natural exercise inclinations.

So does the brainpower improve because of increased blood flow to the brain?  Interestingly, a recent study out of Columbia University and the Salk Institute showed that exercise’s improvements in focus and thinking result from more than just blood flow.  Scott Small and Fred Gage conducted this experiment.  They found that during exercise, muscles contract and chemicals and proteins are released.  One protein called IGF-1 releases chemicals in the brain that stimulate neurons to branch out in new directions. The end result is new connections between our brain cells.  These new connections are responsible for making us smarter!

As you boost your focus and mental ability, you also boost your creativity when you exercise.  Keith Sawyer, PhD the author of the book Group Genius: The Creative Power of Collaboration stated “Physical activity gets your mind into the bodily experience, so that subconscious connections can pop up.”  Exercise also releases cortisol from your body.  If there is too much cortisol in your system caused by stress, your ability to be creative shuts down.

Make sure that you do not force too much exercise on yourself.  After all, overtraining can lead to injuries and can be counterproductive to improving your life.  Exercise for at least 30 minutes at a time.  If you are looking to find creative ideas, consider exercising alone as an exercise companion may distract you.  Bring a small notepad and jot down ideas.

Once you understand these benefits of exercising, you will be more likely to want to integrate exercise in your daily routine.  If you are having difficulty focusing or being creative, you will quickly find that exercise can be the solution to your problems.

Sources:
living.health.com
smallbusiness.yahoo.com

Discuss this post in Frank Mangano’s forum!

Recommendation and review posted by Fredricko

Selection Effects and Longevity Genes

Posted: April 13, 2010 at 8:21 am

How is it possible for evolutionary selection to favor genetic variants beneficial in human old age, long after reproduction is impossible? An open access paper examines this question: "Evidence points towards the existence of a strong heritable component of human longevity. Around a quarter to a third of the variability of lifespan can be attributed to the action of genes. One of the best examples of a gene affecting survival in old age is the apolipoprotein E gene APOE. ... One of the major ideas in the evolutionary theory of ageing is the suggestion that, because the force of natural selection declines with age, alleles with deleterious effects seen only at older ages can reach higher frequencies than those that have their effects earlier in life. Therefore, if a gene exerts an effect only after the end of the reproductive phase of the lifespan it has been thought unlikely that it could have been subject to significant direct selection pressure ... It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E) and non-genetic risk factors (gender, diet, smoking, alcohol, exercise) that, because there is a statistical distribution of ages at which these genes exert their influence on morbidity and mortality, the effects of selection are in fact non-negligible."

View the Article Under Discussion: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848859/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Recommendation and review posted by Fredricko

Trialing Stem Cells to Heal Heart Damage

Posted: April 13, 2010 at 8:21 am

Via EurekAlert!, another example of testing stem cells and heart regeneration: "Some patients with heart muscles seriously affected by coronary heart disease may soon be able to benefit from an innovative treatment. Researchers [are] evaluating the safety, feasibility and efficacy of injecting stem cells into the hearts of patients while they are undergoing coronary bypass surgery. These stem cells could improve healing of the heart and its function. The IMPACT-CABG (implantation of autologous CD133+ stem cells in patients undergoing coronary artery bypass grafting) protocol evaluates this experimental procedure, which is destined for patients suffering from ischemic heart disease, in which the blood supply to the heart is decreased and associated with heart failure. These patients undergo open-heart coronary bypass surgery, performed by the medical team to improve perfusion of the heart muscle. A few weeks ago, the first patient received progenitor CD133+ stem cells isolated from his bone marrow and enriched, [and] has been doing very well ever since. Already, improvement has been noted in the contraction capacity of his heart, which has improved its ability to pump blood."

View the Article Under Discussion: http://www.eurekalert.org/pub_releases/2010-04/chdl-hcy_1041110.php

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Recommendation and review posted by Fredricko

Health experts’ tips for safe international travel

Posted: April 13, 2010 at 8:19 am

CDC video: Health experts suggest that you take several key steps to be protected against injury or illness when travelling to developing nations. This includes packing a health kit, bringing medications, and getting immunizations for safe and healthy travel.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow on Twitter and Buzz, and connect on Facebook.


Recommendation and review posted by G. Smith

Johns Hopkins Medicine podcast now has a blog

Posted: April 13, 2010 at 8:19 am

The weekly podcast by Johns Hopkins Medicine now has a blog hosted for free at Blogger.com by Google:

http://hopkinspodblog.blogspot.com

I have been a regular listener for years and have found the podcast to be both educational and enjoyable - not a common combination.

The weekly podcast looks at the top medical stories of the week for people who want to become informed participants in their own health care. The presenters are Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine, and Rick Lange M.D., professor of medicine at Johns Hopkins and vice chairman of medicine at the University of Texas Health Science Center at San Antonio.

Image source: Johns Hopkins

Posted at Clinical Cases and Images. Stay updated and subscribe, follow on Twitter and Buzz, and connect on Facebook.


Recommendation and review posted by G. Smith


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