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Linking Insulin Resistance and Mitochondrial Damage

Posted: May 6, 2010 at 8:18 am

From EurekAlert!: "The muscles of elderly people and of people with type 2 diabetes contain lower concentrations of a protein known as PARL (short for 'presenilin-associated rhomboid-like'). PARL plays an important role within cells in remodeling power-generating mitochondria. It's PARL's job to oversee mitochondria's quality control, specifically by maintaining their integrity as the cellular components undergo normal processes of fission and fusion. The findings provide yet another link between insulin resistance and the function of mitochondria. ... When mitochondria aren't functioning properly, food doesn't get metabolized to the level that it should ... Instead of getting burned, fats accumulate in cells where they impair insulin's action. As mitochondria fail to work efficiently, they also produce more damaging free radicals. ... Relative to younger people, older people showed signs of insulin resistance. They also had fewer numbers of mitochondria and lower expression of the PARL gene. ... We hypothesize that impaired PARL function is an important risk factor for the development of insulin resistance in skeletal muscle by decreasing mitochondrial mass and energetics and increasing oxidative stress, thus contributing to impaired glucose metabolism. As insulin resistance continues to develop, mitochondrial function, oxidative damage, and PARL activity may decline further, leading to a vicious cycle that eventually contributes to the development of [diabetes] or other age-associated diseases, including sarcopenia."

View the Article Under Discussion: http://www.eurekalert.org/pub_releases/2010-05/cp-nci042810.php

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Recommendation and review posted by Fredricko

Calorie Restriction Boosts Immune Function

Posted: May 6, 2010 at 8:18 am

The Seattle Times notes recent research: "A new study finds that calorie restriction may bolster the immune system in adults. Researchers [randomly] placed 46 overweight, but not obese, men and women age 20 to 40 on one of two diets for six months: one in which calories were reduced 10 percent, and another in which they were reduced 30 percent. All food was supplied to the test subjects. The participants were tested to see what effect calorie restriction had on their immune system. They were given a delayed-type hypersensitivity test, which can detect allergens, among other things, and is considered a way to check whole-body immune response. Researchers also checked T-cells, a kind of white blood cell, and another immune system marker. At the end of the six months, [delayed type hypersensitivity] response went up in both the 10 percent and the 30 percent calorie-restricted groups compared with the beginning of the study. Both groups also showed improvement in T-cell function."

View the Article Under Discussion: http://seattletimes.nwsource.com/html/living/2011767490_calories03.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Recommendation and review posted by Fredricko

International Stem Cell Corporation Signs Financing Agreement

Posted: May 6, 2010 at 8:17 am

OCEANSIDE, CA –May 5, 2010 – International Stem Cell Corporation (ISCO.OB), http://www.intlstemcell.com, today announced it has entered into a definitive agreement dated May 4, 2010 (‘the Agreement”) with Socius CG II, Ltd. (“Socius”), pursuant to which Socius has committed to purchase a single tranche of up to $10 million in non-convertible Series F Preferred Stock (the "Preferred Stock") from ISCO. The Company issued a warrant to purchase $13,500,000 worth of the Company’s Common Stock, the exercise price of the warrant being determined by the closing bid price for the Company’s Common Stock on the trading day immediately preceding the date the Company initiates the sale of the Series F Preferred.

The Company anticipates that the Closing of the Preferred Stock sale will take place 20 business days after the issuance of the Warrants. Proceeds from these sales will be used to provide general working capital and to fund additional development of the Company's proprietary Parthenogenetic Stem Cell Lines, development of commercial research products, and other research and development programs and related business activities.

Additional details on the transaction are contained in the Company's Form 8-K filed today with the Securities and Exchange Commission.

A prospectus relating to this offering is available from:
Investor Relations
International Stem Cell Corporation
2595 Jason Court
Oceanside, CA 92056

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):
International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology.

FORWARD-LOOKING STATEMENTS:
Statements pertaining to anticipated future events, including the anticipated closing of the sale of Preferred Stock, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in satisfying the conditions to closing. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.
Key Words: Stem Cells, Biotechnology, Parthenogenesis

CONTACTS:
International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
[email protected]
Or
Brian Lundstrom, President
760-940-6383
[email protected]
WEST\21949392.1

Recommendation and review posted by Fredricko

Voting

Posted: May 6, 2010 at 8:16 am

I have not blogged about the election.  I was going to but other things got in the way and I decided not to.  However, if some really stupid MPs are elected then I will be sure to comment from my usual perspective.

If anyone is interested my voting intention is described on my posterous page.

http://gimpyblog.posterous.com/

Any comment should be left there.

Recommendation and review posted by G. Smith

Diet: For every 1% increase in omega-3 intake, HDL levels rose by 2.5 mg/dL

Posted: May 6, 2010 at 8:16 am

HDL levels lower than 40 mg/dL are considered a risk factor for heart disease, while levels of 60 mg/dL or higher are thought to be optimal.

Omega-3 fats, for instance, have been linked to lower risks of age-related vision loss and dementia among older adults.

Fish Oil Comes from “The Most Important Fish in the Sea”: Menhaden
Nearly every fish a fish eater likes to eat eats menhaden (shown here). Bluefin tuna, striped bass, redfish and bluefish are just a few of the diners at the menhaden buffet. All of these fish are high in omega-3 fatty acids but are unable themselves to synthesize them. The omega-3s they have come from menhaden.

References:

Diet changes improve older adults' cholesterol too | Reuters.
http://www.reuters.com/article/idUSTRE61I49N20100219
Image source: Menhaden B. tyrannus from the Chesapeake Bay. Wikipedia, Brian.gratwicke, Creative Commons Attribution 2.5 License.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Recommendation and review posted by G. Smith

How do you keep up with health news?

Posted: May 6, 2010 at 8:16 am

Steve Rubel asks How do you keep up with industry news - RSS, email newsletters, Twitter, Facebook or other (elaborate)? He now primarily uses newsletters, Twitter and Facebook to follow several dozen sources. He uses his RSS reader as an archive:

http://www.facebook.com/steverubelstream

This does not work very well for me. Google Reader is still one of my primary sources for health information - I channel Twitter feeds, YouTube subscriptions, Flickr and podcasts through it as well.

The RSS reader collects all rich media in one place - a true "inbox for the web". The disjointed approach described by Steve Rubel above can be confusing to many and a time-waster to even more. Everybody has their own preferences, of course.

For example, Steve abandoned his popular blog MicroPersuation to move to life-stream, then Facebook. Alternatively, I decided to stay with my blogs and send their updates to Twitter and Facebook. My blog is still my home on the web. You can build a professional profile on LinkedIn, Google and (may be) on Facebook but I decided to keep a separate website just for profile information. You can build it for free on Blogger.com by Google, control every aspect of it, and the only expense is the fee for domain registration ($10).

Comments from Google Buzz:
Tim Sturgill - I've started to use GR as you are for Twitter. I wish Twitter had RSS for direct messages as well.
Vamsi Balakrishnan - I use Google Reader for my news sites (both tech and health). And, for the individual people I follow, like you, I'd use my Buzz. Every few days I log on to Twitter to check messages / replies / etc.
Lakshman Swamy - GR and buzz!

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.


Recommendation and review posted by G. Smith


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