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International Stem Cell Corporation Provides Strategic Update on its Skin Care Program

Posted: April 9, 2010 at 8:31 am

OCEANSIDE, California - April 8, 2010 - International Stem Cell Corporation (ISCO.OB),, announces today that it’s wholly owned subsidiary, Lifeline Skin Care Inc., has achieved positive results in human safety tests of its cosmetic products and is moving forward with arrangements with Cosmetic Enterprises Ltd. for the manufacture of three cosmetic products. These developments allow Lifeline Skin Care to plan a launch of its cosmetic product line in the late summer or fall of 2010.

Cosmetic face products developed by Lifeline Skin Care Inc., contain extracts from human parthenogenetic stem cells (hpSC) combined with a vitamin complex and other active ingredients. The products utilize a form of nanotechnology to deliver concentrated active ingredients to damaged skin. Laboratory tests show that an active “complex” of stem cell extract has the ability to rejuvenate skin. Also, early human trials show that these cosmetic products moisturize skin and strongly indicate the ability to decrease the depth of wrinkles and provide factors that lead to anti-aging effects.

Lifeline Skin Care is working with Cosmetic Enterprises, Ltd., located in California, to formulate and package its unique skin care product. Cosmetic Enterprises is a well-known OTC drug licensed manufacturer with over 30 years of experience. Lifeline Skin Care’s “parthenogenetic stem cell complex” the product’s active ingredient, is made in Lifeline Skin Care’s laboratory in Oceanside, California.

According to Gregory S. Keller, MD, FACS, “These positive safety studies in human testing are important, especially considering that preliminary human trial data show that products of the production of International Stem Cell’s parthenogenetic stem cells have significant beneficial effects on the skin and might also provide long term benefits in reducing wrinkles and other visible signs of aging. These results are a significant step forward in making this unique product available to the public.” Dr. Keller was named the 2007 “Specialist of the Year in Facial Cosmetic Surgery” in Strathmore’s “Who’s Who”.

The results of recent human safety tests show there were no identifiable signs or symptoms of sensitization (contact allergy). Safety testing is a series of tests to insure the product does not cause negative reactions such as irritation to the skin. This completed round of testing allows Lifeline Skin Care to move forward confidently with its commercial manufacturing plans.
International Stem Cell Corporation is a pioneer in development of a new class of stem cells called “human parthenogenetic stem cells” which avoid critical ethical issues by eliminating the need to use fertilized embryos and can be immune-matched to large segments of the population. As of today, ISCO has successfully derived 10 hpSC lines. One of these lines (hpSC-Hhom-4), carries the most common immune type found across racial groups within the US population and can be immune-matched to millions of people.

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website,

To subscribe to receive ongoing corporate communications please click on the following link:

Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "should," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Skin Care, Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
[email protected]
Lifeline Skin Care Inc.
Ruslan Semechkin, PhD, CEO
[email protected]

Recommendation and review posted by G. Smith

Sunlight May Help Protect Men From Kidney Cancer

Posted: April 9, 2010 at 8:31 am

(HealthDay News) -- Men with jobs that expose them to high levels of sunlight are less likely to develop kidney cancer than those with little or no sunlight exposure at work, says a new study.

Previous research suggests that vitamin D, which is obtained from sun exposure and certain foods and supplements, may help prevent some cancers. Vitamin D is metabolized and most active within the kidneys.

This new study included 1,097 male and female kidney cancer patients and 1,476 healthy people in Europe who were interviewed about their work history and other demographic information.

Men with the highest levels of work-related exposure to sunlight were 24 percent to 38 percent less likely to have kidney cancer than other men. This association between job-related sunlight exposure and kidney cancer risk was not seen in women.

The study is published online March 8 in the journal Cancer. Read more...

Joint Mender for Joint Care

Recommendation and review posted by G. Smith

Magnesium for Memory

Posted: April 7, 2010 at 8:23 am

Make It Magnesium for Healthy Brain Function

A newly developed magnesium supplement may help boost memory.

Late last year I predicted that 2010 would be magnesium’s year.  And with the latest study on magnesium, my prediction is bearing fruit.

True, magnesium hasn’t dominated the health headlines this year like, say, vitamin D has in terms of frequency.  But in terms of import, magnesium’s time to shine is now, as a recent study suggests that this magnificent mineral helps buoy one’s memory.

Researchers from Israel’s Tel Aviv University recognized magnesium’s magnificence after supplementing two groups of rats with the same food regimen, but tinkered with one of the rat groupings by adding a new-fangled magnesium supplement that purports to better penetrate the brain than contemporary magnesium supplements.

Through brain scans and cognitive tests, researchers found that, indeed, the magnesium-supplemented group outperformed the other group both in cognitive function and brain development.

In a statement, the researchers said they were “pleased” by the findings, but they couldn’t help but be somewhat disconcerted by the findings at the same time.

Apparently when they used over the counter magnesium supplements, there was no measurable difference in cognition between the two groups.

Translation:  According to the researchers, magnesium supplements on the market today don’t help with brain function.

Now, this study should not suggest that magnesium supplements on the market don’t work period, only that they don’t seem to be effective for brain health and development.  Researchers are confident, however, that when the new and improved magnesium supplement becomes commercially available—magnesium-L-theronate, or MgT— it will help make memories magnificent.

In the meantime, increase your magnesium intake by supplementing with – you guessed it – magnesium-rich foods.

Some of the richest magnesium sources come from seeds (like pumpkin seeds), leafy greens (like spinach) and beans (like black beans).  A quarter cup of pumpkin seeds has 184 milligrams of magnesium, a cup of boiled spinach has 156 milligrams and a cup of black beans has 120 milligrams.

Not to be outdone as a solid source for magnesium is salmon.  A four-ounce serving of salmon has 138 milligrams of magnesium.  Other significant sources for magnesium in the seafaring family include halibut (4 oz.=121 mg), scallops (4 oz.=77 mg), tuna (4 oz.=72 mg) and shrimp (4 oz.=38 mg).

Adult men should be getting at least 420 milligrams of magnesium per day, while women should get about 320 milligrams per day.


Discuss this post in Frank Mangano’s forum!

Recommendation and review posted by Fredricko

Vitamin K Delivers Kick to Cancer Risk

Posted: April 7, 2010 at 8:23 am

Vitamin K Sources Have Cancer Preventive Properties

German researchers find link between low consumption of vitamin K2 and cancer (lung cancer, specifically).

All the rage these days in the health world is the importance of getting a daily dose of vitamin D in your diet, whether it’s through the foods you fix or the sun you soak.  As a result, other vitamins have been given short shrift.

Well what better way to reacquaint oneself with other vitamins than with a study that says increasing one’s vitamin K intake can lower cancer risk?

Now, before I get into the guts of the study, this is not to suggest that eating cabbage with every meal will somehow prevent cancer.  But what the study does suggest is that certain sources of vitamin K are more cancer preventive than others.

About a year ago, I wrote about the differences between vitamin K1 and vitamin K2. I wrote about vitamin K2 being a more nutritious form of vitamin K than it’s partner in nutrition, vitamin K1, but at that point vitamin K2 was being hailed for its link to bone and cartilage development.  So, runners and people battling arthritis were encouraged to eat sources of vitamin K2.

This time, however, vitamin K2 is being hailed for its cancer-prevention prowess.

Researchers from the German Cancer Research Center in Heidelberg, Germany discovered its cancer-fighting effects after analyzing the results of a 10-year study that involved approximately 24,300 adults.  All of the adults – between the ages of 35 and 64 – were cancer free at the outset.

That fact changed 10 years later.  By the end of the study, approximately 1,800 men and women were diagnosed with cancers of various kinds, with just less than one-fourth of them dying from their disease.

But when researchers looked at the decedents’ dieting patterns, as well as those who remained cancer free throughout the study period, they saw some patterns.

For instance, among those who ate vitamin K2 rich foods, they were 28 percent less likely to be among those who died of cancer.  But when researchers looked at people who had the lowest vitamin K2 intake, they were almost 50 percent more likely to have been diagnosed with lung cancer (the most commonly diagnosed cancer there is, by the way).

Comparatively, those who had the highest vitamin K2 intake, they were less than half a percent more likely to have lung cancer.

Findings were similar among other commonly diagnosed cancers (e.g. prostate):  the more vitamin K2 eaten, the less likely they were to develop cancer.

Coincidence?  Perhaps.  The researchers are loath to suggest definitively that it’s the vitamin K2 that did it because most of the participants who ate lots of vitamin K2 got it from cheese primarily.  Thus, it could another aspect of cheese that makes it so cancer friendly.

The study is published in the American Journal of Clinical Nutrition.

Now, as most of you know, I’m not an extremist when it comes to nutrition.  Virtually everything high in calories can be enjoyed so long as it’s in moderation.

Thus, while cheese is pretty high in saturated fat and cholesterol, there are enough good things in cheese to make it a healthful food when eaten in moderation.

But there are other healthy sources of vitamin K2 that you don’t have to scrimp on.  One of them is natto, which, like cheese, is a fermented food (vitamin K2 primarily comes from fermented foods).  I’ve never eaten natto, but seeing as how the Japanese have eaten it for well over a thousand years—a culture that is known for its long lifespan and healthy dieting habits—it’s clearly a food worth trying.

And who knows?  One bite may make you nutso for natto!


Discuss this post in Frank Mangano’s forum!

Recommendation and review posted by Fredricko

Faulty Circuits (preview)

Posted: April 7, 2010 at 8:23 am

In most areas of medicine, doctors have historically tried to glean something about the underlying cause of a patient’s illness before figuring out a treatment that addresses the source of the problem. When it came to mental or behavioral disorders in the past, however, no physical cause was detectable so the problem was long assumed by doctors to be solely “mental,” and psychological therapies followed suit.

Today scientific approaches based on modern biology, neuroscience and genomics are replacing nearly a century of purely psychological theories, yielding new approaches to the treatment of mental illnesses.


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Recommendation and review posted by Fredricko

How To: Getting Smart During Your Daily Commute

Posted: April 7, 2010 at 8:21 am

"The average American spends a good 100 minutes per day commuting to and from work. That amounts to about 433 hours per year! Now imagine using that time to learn something new — to read a great book, to take a class from a top university, to learn a new language.

We highlight our free audio resources that will maximize your drive time. Before getting started, make sure you have a big mp3 player and a way to listen to your mp3 player over your car speakers."

Getting Smart During Your Daily Commute | Open Culture


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Recommendation and review posted by G. Smith

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