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International Stem Cell Corporation Signs Financing Agreement

Posted: May 6, 2010 at 8:17 am

OCEANSIDE, CA –May 5, 2010 – International Stem Cell Corporation (ISCO.OB),, today announced it has entered into a definitive agreement dated May 4, 2010 (‘the Agreement”) with Socius CG II, Ltd. (“Socius”), pursuant to which Socius has committed to purchase a single tranche of up to $10 million in non-convertible Series F Preferred Stock (the "Preferred Stock") from ISCO. The Company issued a warrant to purchase $13,500,000 worth of the Company’s Common Stock, the exercise price of the warrant being determined by the closing bid price for the Company’s Common Stock on the trading day immediately preceding the date the Company initiates the sale of the Series F Preferred.

The Company anticipates that the Closing of the Preferred Stock sale will take place 20 business days after the issuance of the Warrants. Proceeds from these sales will be used to provide general working capital and to fund additional development of the Company's proprietary Parthenogenetic Stem Cell Lines, development of commercial research products, and other research and development programs and related business activities.

Additional details on the transaction are contained in the Company's Form 8-K filed today with the Securities and Exchange Commission.

A prospectus relating to this offering is available from:
Investor Relations
International Stem Cell Corporation
2595 Jason Court
Oceanside, CA 92056

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology.

Statements pertaining to anticipated future events, including the anticipated closing of the sale of Preferred Stock, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in satisfying the conditions to closing. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.
Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
[email protected]
Brian Lundstrom, President
[email protected]

Recommendation and review posted by Fredricko


Posted: May 6, 2010 at 8:16 am

I have not blogged about the election.  I was going to but other things got in the way and I decided not to.  However, if some really stupid MPs are elected then I will be sure to comment from my usual perspective.

If anyone is interested my voting intention is described on my posterous page.

Any comment should be left there.

Recommendation and review posted by G. Smith

Diet: For every 1% increase in omega-3 intake, HDL levels rose by 2.5 mg/dL

Posted: May 6, 2010 at 8:16 am

HDL levels lower than 40 mg/dL are considered a risk factor for heart disease, while levels of 60 mg/dL or higher are thought to be optimal.

Omega-3 fats, for instance, have been linked to lower risks of age-related vision loss and dementia among older adults.

Fish Oil Comes from “The Most Important Fish in the Sea”: Menhaden
Nearly every fish a fish eater likes to eat eats menhaden (shown here). Bluefin tuna, striped bass, redfish and bluefish are just a few of the diners at the menhaden buffet. All of these fish are high in omega-3 fatty acids but are unable themselves to synthesize them. The omega-3s they have come from menhaden.


Diet changes improve older adults' cholesterol too | Reuters.
Image source: Menhaden B. tyrannus from the Chesapeake Bay. Wikipedia, Brian.gratwicke, Creative Commons Attribution 2.5 License.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.

Recommendation and review posted by G. Smith

How do you keep up with health news?

Posted: May 6, 2010 at 8:16 am

Steve Rubel asks How do you keep up with industry news - RSS, email newsletters, Twitter, Facebook or other (elaborate)? He now primarily uses newsletters, Twitter and Facebook to follow several dozen sources. He uses his RSS reader as an archive:

This does not work very well for me. Google Reader is still one of my primary sources for health information - I channel Twitter feeds, YouTube subscriptions, Flickr and podcasts through it as well.

The RSS reader collects all rich media in one place - a true "inbox for the web". The disjointed approach described by Steve Rubel above can be confusing to many and a time-waster to even more. Everybody has their own preferences, of course.

For example, Steve abandoned his popular blog MicroPersuation to move to life-stream, then Facebook. Alternatively, I decided to stay with my blogs and send their updates to Twitter and Facebook. My blog is still my home on the web. You can build a professional profile on LinkedIn, Google and (may be) on Facebook but I decided to keep a separate website just for profile information. You can build it for free on by Google, control every aspect of it, and the only expense is the fee for domain registration ($10).

Comments from Google Buzz:
Tim Sturgill - I've started to use GR as you are for Twitter. I wish Twitter had RSS for direct messages as well.
Vamsi Balakrishnan - I use Google Reader for my news sites (both tech and health). And, for the individual people I follow, like you, I'd use my Buzz. Every few days I log on to Twitter to check messages / replies / etc.
Lakshman Swamy - GR and buzz!

Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook.

Recommendation and review posted by G. Smith

Industrial Strength Lungs

Posted: May 6, 2010 at 8:16 am

Anatomical lung necklace by missyindustry at Etsy

Anatomical lung necklace by missyindustry at Etsy

Handmade from sterling silver.
1.5 inches long.
Curb chain is 20 inches long.
Oxidized finish

Industrial style lungs by missyindustry over at Etsy for $62.  Found this after a friend asked me to find a lung-themed gift for her boyfriend who recently quit smoking. Great idea!

Recommendation and review posted by G. Smith

The Taxidermy of Mr. Walter Potter and his Museum of Curiosities, Melissa Milgrom

Posted: May 6, 2010 at 8:16 am

Melissa Milgrom--author of Still Life: Adventures in Taxidermy and panelist at the recent Congress for Curious People--has just published a nice article about that undisputed king of Victorian anthropomorhic taxidermy, animal artist and museologoist Walter Potter; following is a brief excerpt:

Athletic toads? Rats gambling in a dollhouse of decadence? How about bespectacled gentlemen lobsters?

No, this isn’t Wes Anderson’s sequel to Fantastic Mr. Fox, but the work of English Victorian taxidermist Mr. Walter Potter. Potter was famous for his over-the-top anthropomorphic scenes—kittens at the tea table; guinea pigs playing cricket—which were displayed in his Museum of Curiosities from 1861 until 2003 when his wondrous collection was sold in a contentious auction, which I attended in Cornwall.

One of England’s oldest private museums, Potter’s belonged to the era of the amateur nature lover when museums were spirited jumbles, not the sober typologies they would become post-Darwin. Potter’s verged on the freakish: random, cluttered, crammed to the rafters with curios and oddities, weird accumulations and creatures that were stuffed, pickled, dissected, and deformed. And I was lucky, though it filled me with sadness, to wander through Potter’s crooked corridors on its very last day...

Had Potter attended the Great Expo (very likely) he would have seen among the taxidermy displays a comic depiction of Goethe’s fable Reinecke the Fox reenacted with semi-human foxes. Sounds childlike—and it was in the best, most passionate way—but in the days before irony anthropomorphism was a form of endearment (imagine Beatrix Potter, no relation). More so, the facial expressions were expertly manipulated, raising the taxidermic bar and inspiring followers.

Known as the Grotesque School, “mirth-provoking” characters were the equivalent of a blockbuster movie. Queen Victoria herself stopped to linger and laugh at a frog shaving another frog. And taxidermists began transforming all sorts of animals into tiny humans: crows playing violin, frogs doing the cancan, squirrels as Romeo. None were as ambitious as Mr. Walker Potter...

You can read the full article on the Wonders and Marvels blog by clicking here. You can find out more about Milgrom's Still Life--which contains a nice discussion of Potter and his work--by clicking here. If the life and work of Walter Potter is of interest, I also highly highly recommend that you check out the wonderful, lavishly-illustrated Walter Potter and his Museum of Curious Taxidermy, written by Congress for Curious People lecturer Pat Morris; you can do so by clicking here or by visiting Observatory (more on that here).

All images are of Walter Potter's work and are drawn from the wonderful Ravishing Beasts blog; you can see them in context by clicking here.

Recommendation and review posted by G. Smith

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