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Resveratrol – Evolutionary.org

Posted: December 3, 2018 at 10:46 am

Resveratrol is a plant compound, also known as polyphenol, which helps protect the plant when injured, and to fight off bacteria and fungi. The best food sources of this compound are the skin of grapes, berries, and peanuts. In fact, red wine has become popularized as 'healthy' because of the resveratrol it contains; however, compared to the unhealthy amounts of alcohol, the amount of resveratrol it contains is minimal.

Fig 1. Resveratrol

History

The first time, resveratrol was discovered by the Japanese, when they isolated this compound from plant roots in 1940's. However, it wasn't until 1992 that it became popular, when its presence in wine was suggested as a plausible explanation for its heart protective effects. As a result, in the past decade many fitness supplements have added this compound as a performance enhancing ingredient.

How it Works

The mechanisms of action of resveratrol are not fully understood, but it appears to mimic biochemical effects of calorie restriction. As a matter of fact, studies have shown that it activates Sirtuin 1, PGC-1a, and it improves the mitochondria's functionality.

Bodybuilding

When a bodybuilder comes off cycle, their Luteinizing hormone (LH) is suppressed and their testosterone drops as the hormone esters leave the body, allowing estrogen to fluctuate wildly up or down. Even with a comprehensive post cycle therapy (PCT), the steroid user is left exposed in between cycles to catabolism and estrogen rebounds. We call this dangerous period 'bridging'.

During a 'bridge' gains can be difficult, as the body is trying to balance itself out. Therefore, resveratrol's ability to raise testosterone levels, without suppressing LH, makes it a perfect compound to run during this period. In fact, a Korean study showed that after 28 days on resveratrol, subjects' testosterone levels increased by up to 50%.

In addition, resveratrol's benefits come into play during a bridge because it is one of the few natural compounds in existence that can boast being both a selective estrogen receptor modulator (SERM) and an aromatase inhibitor (AI). As a result, you get a bump in LH, testosterone, and it lowers estrogen.

Moreover, its anti-oxidant properties and organ protecting benefits will help cleanse out the body further, so the steroid user can recover fully before their next steroid cycle.

There is one property of resveratrol that deserves special attention and offers even more benefits for all athletes, whether they use steroids or not. A Canadian study showed that resveratrol improved endurance by an average of 21%.

Other Benefits

There has been extensive research on resveratrol that showed numerous additional benefits.

Side Effects

Clinical studies have shown no issues when resveratrol is used for long periods of time. However, as with any supplement, you should never abuse it.

Dosage

Try to eat more grapes, berries and natural peanut butter. Then add 25-50 milligrams (mgs) a day of resveratrol from supplementation.

Where to find it

As mentioned above, it would take a large amount of wine, or other foods, to get the benefits you want from resveratrol. Therefore, the best way to take advantage of this compound is through supplementation.

One supplement, that is designed specifically for athletes and for bodybuilders in between cycles is called BRIDGE by N2BM.com. It contains 25mgs per serving of resveratrol and 9 other ingredients, all designed to help you 'bridge' from one cycle to the other.

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Resveratrol - Evolutionary.org

Recommendation and review posted by G. Smith

Bee Gees – Immortality (Live in Las Vegas, 1997 – One Night Only)

Posted: December 2, 2018 at 1:45 pm

Join Bee Gees on Facebook http://facebook.com/beegees & Twitter http://twitter.com/beegeesofficialFrom the album & film 'BEE GEES - ONE NIGHT ONLY'

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Manx Productions Inc. 1997 Barry Gibb, The Estate of Robin Gibb and The Estate of Maurice Gibb, under exclusive license to Warner Strategic Marketing Inc., a Warner Music Group Company

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Bee Gees - Immortality (Live in Las Vegas, 1997 - One Night Only)

Recommendation and review posted by G. Smith

About | Human Reproduction | Oxford Academic

Posted: December 2, 2018 at 1:41 pm

Human Reproduction features full-length, peer-reviewed papers reporting original research, concise clinical case reports, as well as opinions and debates on topical issues.

Papers published cover the clinical science and medical aspects of reproductive physiology, pathology and endocrinology; including andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, early pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues.

The highest scientific and editorial standards are maintained, along with a rapid rate of peer review and publication.

Human Reproduction is covered by the following major indexing services:

Abstracts on Hygiene and Communicable Diseases Abstracts in Anthropology Agbiotech News and Information Animal Breeding Abstracts Biological Abstracts BIOSIS Previews British Nursing Index CAB Abstracts Current Contents /Clinical Medicine Current Contents /Life Sciences Dairy Science Abstracts Derwent Drug File EMBASE Environmental Science and Pollution Management Excerpta Medica Abstract Journals Forest Products Abstracts Forestry Abstracts Global Health Horticultural Abstracts Index Veterinarius Journal Citation Reports /Science Edition Pharmacoeconomics and Outcome News PROQUEST DATABASE : Magazines PROQUEST DATABASE : MEDLINE with Full Text PROQUEST DATABASE : ProQuest 5000 PROQUEST DATABASE : ProQuest 5000 International PROQUEST DATABASE : ProQuest Central PROQUEST DATABASE : ProQuest Discovery PROQUEST DATABASE : ProQuest Health & Medical Complete PROQUEST DATABASE : ProQuest International Academic Research Library PROQUEST DATABASE : ProQuest Medical Library PROQUEST DATABASE : ProQuest News & Magazines PROQUEST DATABASE : ProQuest Pharma Collection PROQUEST DATABASE : ProQuest Research Library

PubMed Reactions Weekly Review of Aromatic and Medicinal Plants Review of Medical and Veterinary Mycology Rural Development Abstracts Science Citation Index Expanded (SciSearch) Science Citation Index Soybean Abstracts Sugar Industry Abstracts The Standard Periodical Directory Tropical Diseases Bulletin Veterinary Bulletin Weed Abstracts

This information is taken from the Journal Citation Reports, published annually as part of the Science Citation Index by ISI.

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About | Human Reproduction | Oxford Academic

Recommendation and review posted by G. Smith

Cryonics | Futurist Transhuman News Blog

Posted: November 30, 2018 at 6:43 am

Cryonics is an effort to save lives by using temperatures so cold that a person beyond help by todays medicine might be preserved for decades or centuries until a future medical technology can restore that person to full health. Cryonics is a second chance at life. It is the reasoned belief in the advancement of future medicinal technologies being able to cure things we cant today.

Many biological specimens, including whole insects, many types of human tissue including brain tissue, and human embryos have been cryogenically preserved, stored at liquid nitrogen temperature where all decay ceases, and revived. This leads scientists to believe that the same can be done with whole human bodies, and that any minimal harm can be reversed with future advancements in medicine.

Neurosurgeons often cool patients bodies so they can operate on aneurysms without damaging or rupturing the nearby blood vessels. Human embryos that are frozen in fertility clinics, defrosted, and implanted in a mothers uterus grow into perfectly normal human beings. This method isnt new or groundbreaking- successful cryopreservation of human embryos was first reported in 1983 by Trounson and Mohr with multicellular embryos that had been slow-cooled using dimethyl sulphoxide (DMSO).

And just in Feb. of 2016, there was a cryonics breakthrough when for the first time, scientists vitrified a rabbits brain and, after warming it back up, showed that it was in near perfect condition. This was the first time a cryopreservation was provably able to protect everything associated with learning and memory.

See the article here:

Cryonics

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Cryonics | Futurist Transhuman News Blog

Recommendation and review posted by G. Smith

7 Health Benefits of Resveratrol Supplements

Posted: November 27, 2018 at 11:44 pm

If you've heard that red wine can help lower cholesterol, chances are you've heard of resveratrol the much-hyped plant compound found in red wine.

But beyond being a healthful part of red wine and other foods, resveratrol has health-boosting potential in its own right.

In fact, resveratrol supplements have been linked to many exciting health benefits, including protecting brain function and lowering blood pressure (1, 2, 3, 4).

This article explains what you need to know about resveratrol, including seven of its main potential health benefits.

Resveratrol is a plant compound that acts like an antioxidant. The top food sources include red wine, grapes, some berries and peanuts (5, 6).

This compound tends to be concentrated mostly in the skins and seeds of grapes and berries. These parts of the grape are included in the fermentation of red wine, hence its particularly high concentration of resveratrol (5, 7).

However, much of the research on resveratrol has been done in animals and test tubes using high amounts of the compound (5, 8).

Of the limited research in humans, most has focused on supplemental forms of the compound, in concentrations higher than those you could get through food (5).

Because of its antioxidant properties, resveratrol could be a promising supplement for lowering blood pressure (9).

A 2015 review concluded that high doses may help reduce the pressure exerted on artery walls when the heart beats (3).

That type of pressure is called systolic blood pressure, and appears as the upper number in blood pressure readings.

Systolic blood pressure typically goes up with age, as arteries stiffen. When high, it's a risk factor for heart disease.

Resveratrol may accomplish this blood-pressure-lowering effect by helping to produce more nitric oxide, which causes blood vessels to relax (10, 11).

However, the authors of that study say more research is needed before specific recommendations can be made about the best dose of resveratrol to maximize blood pressure benefits.

Several studies in animals have suggested that resveratrol supplements may change blood fats in a healthy way (12, 13).

A 2016 study fed mice a high-protein, high-polyunsaturated fat diet and also gave them resveratrol supplements.

Researchers found the average total cholesterol levels and body weight of the mice decreased, and their levels of "good" HDL cholesterol increased (13).

Resveratrol seems to influence cholesterol levels by reducing the effect of an enzyme that controls cholesterol production (13).

As an antioxidant, it also may decrease the oxidation of "bad" LDL cholesterol. LDL oxidation contributes to plaque buildup in artery walls (9, 14).

In one study, participants were given grape extract that had been boosted with extra resveratrol.

After six months of treatment, their LDL had gone down by 4.5% and their oxidized LDL had gone down by 20% compared to participants who took an unenriched grape extract or a placebo (15).

The compound's ability to extend lifespan in different organisms has become a major area of research (16).

There's evidence that resveratrol activates certain genes that ward off the diseases of aging (17).

It works to achieve this in the same way as calorie restriction, which has shown promise in lengthening lifespans by changing how genes express themselves (18, 19).

However, it's not clear if the compound would have a similar effect in humans.

A review of studies exploring this connection found that resveratrol increased lifespan in 60% of the organisms studied, but the effect was strongest in organisms that were less related to humans, such as worms and fish (20).

Several studies have suggested that drinking red wine can help slow down age-related cognitive decline (21, 22, 23, 24).

This may partly be due to the antioxidant and anti-inflammatory activity of resveratrol.

It seems to interfere with protein fragments called beta-amyloids, which are crucial to forming the plaques that are a hallmark of Alzheimer's disease (21, 25).

Additionally, the compound may set off a chain of events that protects brain cells from damage (21).

While this research is intriguing, scientists still have questions about how well the human body is able to make use of supplemental resveratrol, which limits its immediate use as a supplement to protect the brain (1, 2).

Resveratrol has been shown to have several benefits for diabetes, at least in animal studies.

These benefits include increasing insulin sensitivity and preventing complications from diabetes (26, 27, 28, 29).

One explanation for how resveratrol works is that it may stop a certain enzyme from turning glucose into sorbitol, a sugar alcohol.

When too much sorbitol builds up in people with diabetes, it can create cell-damaging oxidative stress (30, 31).

Here are a few more benefits resveratrol may have for people with diabetes (28):

Resveratrol may even provide more benefits for people with diabetes than those who don't have it. In one animal study, red wine and resveratrol were actually more effective antioxidants in rats with diabetes than in rats who didn't have it (32).

Researchers say the compound could be used to treat diabetes and its complications in the future, but more research is needed.

Arthritis is a common affliction that leads to joint pain and loss of mobility (33).

Plant-based supplements are being studied as a way to treat and prevent joint pain. When taken as a supplement, resveratrol may help protect cartilage from deteriorating (33, 34).

Cartilage breakdown can cause joint pain and is one of the main symptoms of arthritis (33).

One study injected resveratrol into the knee joints of rabbits with arthritis and found that these rabbits suffered less damage to their cartilage (34).

Other research in test tubes and animals has suggested that the compound has potential to reduce inflammation and prevent damage to joints (33, 35, 36, 37).

Resveratrol has been studied, especially in test tubes, for its ability to prevent and treat cancer. However, results have been mixed (30, 38, 39).

In animal and test-tube studies, it has been shown to fight several kinds of cancer cells, including gastric, colon, skin, breast and prostate (40, 41, 42, 43, 44).

Here's how resveratrol may combat cancer cells:

However, since the studies so far have been carried out in test tubes and animals, much more research is needed to see if and how this compound might be used for human cancer therapy.

No major risks have been revealed in studies that have used resveratrol supplements. Healthy people seem to tolerate them well (47).

However, it should be noted that there aren't enough conclusive recommendations about how much resveratrol a person should take in order to get health benefits.

And there are some cautions, especially regarding how resveratrol could interact with other medications.

Since high doses have been shown to stop blood from clotting in test tubes, it's possible it could increase bleeding or bruising when taken with anti-clotting drugs, such as heparin or warfarin, or some pain relievers (48, 49).

Resveratrol also blocks some enzymes that help clear certain compounds from the body. That means some medications could build up to unsafe levels. These include certain blood pressure medications, anxiety meds and immunosuppressants (50).

If you currently use medications, then you may want to check with a doctor before trying resveratrol.

Lastly, it's widely debated how much resveratrol the body can actually use from supplements and other sources (51).

However, researchers are studying ways of making resveratrol easier for the body to use (6, 52).

Resveratrol is a powerful antioxidant with great potential.

It's shown promise regarding a variety of health conditions, including heart disease and arthritis. However, clear dosage guidance is still lacking.

More:

7 Health Benefits of Resveratrol Supplements

Recommendation and review posted by G. Smith

Neurology & Neurosurgery Services l Neurology l University …

Posted: November 27, 2018 at 11:41 pm

UH Neurological Institutes centers of excellence are focused on investigating and developing advanced treatments for neurological disorders. The following list includes a link to each center:

The internationally known specialists at UH Neurological Institutes Brain Health & Memory Center are at the forefront of research, diagnosis and treatment of a variety of memory and cognitive disorders. With a commitment to holistic patient care, our multidisciplinary team provides cutting-edge evaluation and advanced therapies for patients suffering from conditions such as Alzheimers disease, Parkinsons disease, dementia and short- and long-term memory loss. Our team is leading the way in research, both in learning more about certain neurological diseases and developing promising new therapies to treat various disorders. The Brain Health & Memory Center is also committed to providing support, assistance and resources to help families dealing Alzheimers and other conditions.Learn more about how we treat brain health and memory disorders.

University Hospitals Neurological Institutes Brain Tumor & Neuro-Oncology Center offers the most advanced diagnostic and treatment services for adults and children with both benign and malignant brain tumors. Our experts collaborate with the nationally recognized specialists at University Hospitals Seidman Cancer Center and develop highly personalized treatment plans for every patient. Patients can also participate in clinical trials that give them access to new treatments that may not be available at other hospitals.Learn more about how we treat brain tumors.

UH Neurological Institutes Community Neurology Center provides patients with all the expertise, services and testing of our Institute at convenient, close-to-home locations. The neurologists and neurosurgeons at our community facilities have access to a team of other specialists to help diagnose and treat a variety of neurological disorders. Combined with state-of-the-art technology for diagnostics and treatment, our integrated approach ensures that each patient receives comprehensive, individualized care. The Community Neurology Center services include back, spine and brain surgery, and treatment for conditions such as Alzheimers disease, epilepsy, fibromyalgia, multiple sclerosis, migraines and stroke.Learn more about how we treat general neurological conditions.

UH Neurological Institutes Comprehensive Stroke Center has the countrys highest designation available for stroke centers, and it is the largest and most experienced program in northeast Ohio dedicated to caring for stroke patients. Partnered with Case Western Reserve Universitys School of Medicine, our experts are engaged in research aimed at improving care. Our physicians specialize in managing diseases in patients who are high-risk and our rehabilitation specialists use state-of-the-art techniques to help speed up recovery.Learn more about how we treat stroke and neurovascular conditions.

The Epilepsy Center at the UH Neurological Institute is nationally recognized as one of the best in the country for treating seizure disorders in both adults and children. Our epilepsy specialists take an integrated, patient-based approach to care, evaluating each case and devising a treatment plan that will work best for each patient. The centers researchers have pioneered new medical therapies and surgical procedures for epilepsy, and clinical trials allow patients to have access to some of the newest, most innovative treatments around. Working hand in hand with Case Western Reserve School of Medicine and University Hospitals Rainbow Babies & Childrens Hospital, the Epilepsy Centers goal is to help patients live seizure-free lives by providing them with world-class care.Learn more about how we treat epilepsy.

UH Neurological Institutes Functional & Restorative Neurosurgery Center is dedicated to the restoration of function affected by neurological disease and the development of new technologies to improve brain health and optimize the quality of life for patients with neurological disease or disorders. Learn more about ourFunctional & Restorative Neurosurgery Center.

University Hospitals Multiple Sclerosis and Neuroimmunology Program diagnoses and treats patients with Multiple Sclerosis (MS) and other neuroimmunological conditions. Learn how we treat multiple sclerosis and neuroimmunology disorders.

The Music and Medicine Center at UH Neurological Institute is a unique program dedicated to diagnosing and treating music-related injuries and medical problems. A collaboration between University Hospitals Cleveland Medical Center and Case Western Reserve University, the center uses coordinated efforts to advance the knowledge in the field of music and medicine. Through patient care and research, the Music and Medicine Center hopes to improve understanding on how music affects the body and to develop technology that will enhance health through music.Learn more about how we treat music related medical problems.

Critically ill patients with neurological or neurosurgical disease receive superior, specialized care at UH Neurological Institutes Neurocritical Care Center. Our staff of highly trained neurological and critical care specialists uses the most advanced techniques and technology to treat patients, providing exceptional care while placing emphasis on the patient and his or her individual needs.Learn more about how we treat conditions that requireneurocritical carepatients.

The Neurological & Behavioral Outcomes Center is a collaboration between UH Neurological Institute and Case Western Reserve University School of Medicine and is devoted to analyzing and improving patient outcomes. Our team of leading neurological specialists utilizes some of the latest innovations in clinical care. The center is working to advance patient care in the areas of brain tumors, epilepsy, memory and cognition and stroke.Learn more about ourNeurological & Behavioral Outcomes Center.

UH Neurological Institutes Neuromuscular Center is one of the top institutions in the country for treating a host of complex neuromuscular and autonomic disorders. Led by some of the most respected physicians in the field, the Neuromuscular Center offers innovative diagnostic and therapeutic services for conditions such as muscular dystrophies, Guillain-Barre Syndrome and ALS (Lou Gehrigs Disease). Our team is dedicated to providing comprehensive care to help improve our patients quality of life.Learn more about how we treat neuromuscular conditions.

The Neuropsychiatry Center at UH Neurological Institute specializes in treating psychological problems that can occur in patients with neurological disorders. Our nationally recognized neuro-psychiatrists provide high-quality care for both adults and children who suffer from such co-occurring disorders, helping to improve function and reduce the rates of complications.Learn more about how we treat neuropsychiatric conditions.

The goal of the Neuroscience Nursing Practice Center is to research, develop and apply the most advanced neuroscience nursing practices available in order to provide patients with a superior level of care. The center is dedicated to bridging the gap between research and clinical practice, providing patients with the tools and support they need and developing relationship for improved outcomes. Our clinical staff strives to apply these neuroscience nursing techniques through every step of the treatment process, from initial diagnosis through follow-up visits.Learn more about ourNeuroscience Nursing Practice Center.

The Parkinsons & Movement Disorders Center is dedicating to diagnosing, evaluating and delivering therapeutic services for a range of neurological movement disorders. The longest-running program in Ohio devoted solely to movement disorders, our specialists care for patients with conditions such as Dystonia, Essential tremors, Huntingtons disease, Parkinsons disease, spasticity and Tourette syndrome.Learn more about how we treat movement disorders.

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