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James P. Hogan (writer) – Wikipedia

Posted: October 15, 2019 at 10:43 am

James Patrick Hogan

James Patrick Hogan

London, England

Dromahaire, County Leitrim, Ireland

James Patrick Hogan (27 June 1941 12 July 2010) was a British science fiction author.[1]

Hogan was born in London, England. He was raised in the Portobello Road area on the west side of London. After leaving school at the age of sixteen, he worked various odd jobs until, after receiving a scholarship, he began a five-year program at the Royal Aircraft Establishment at Farnborough studying the practice and theory of electrical, electronic, and mechanical engineering. He first married at the age of twenty. He married three more times and fathered six children.[citation needed]

Hogan worked as a design engineer for several companies and eventually began working with sales during the 1960s, traveling around Europe as a sales engineer for Honeywell. During the 1970s he joined the Digital Equipment Corporation's Laboratory Data Processing Group and during 1977 relocated to Boston, Massachusetts to manage its sales training program. He published his first novel, Inherit The Stars, during the same year to win an office bet.[citation needed]

He quit DEC during 1979 and began writing full-time, relocating to Orlando, Florida, for a year where he met his third wife Jackie. They then relocated to Sonora, California.[citation needed] Hogan died of heart failure at his home in Ireland on Monday, 12 July 2010, aged 69.[2]

Most of Hogan's fiction is so-called hard science fiction.

Hogan's fiction also represents anti-authoritarian social opinions and as such forms part of anarchistic science fiction. Many of his novels have strong anarchist or libertarian themes,[3][citation needed] often promoting the idea that new technological advances render certain social conventions obsolete. For example, the effectively limitless availability of energy that would result from the development of controlled fusion power would make it unnecessary to limit access to energy resources. Essentially, energy would become free. This melding of scientific and social speculation is clearly present in the novel Voyage From Yesteryear (influenced strongly by Eric Frank Russell's story "And Then There Were None") about a technologically advanced anarchist society in the Alpha Centauri system, a starship sent from Earth by a dictatorial government, and the events after their first contact. The story features concepts of civil disobedience, post scarcity and gift economy.[4][citation needed]

During his later years, Hogan's contrarian and anti-authoritarian opinions favored those widely considered extremist. He was a proponent of Immanuel Velikovsky's version of catastrophism,[5] and of the Peter Duesberg hypothesis that AIDS is caused by pharmaceutical[6] use rather than HIV (see AIDS denialism).[7] He criticized the idea of the gradualism of evolution,[8][9] though he did not propose theistic creationism as an alternative. Hogan was skeptical of the theories of climate change and ozone depletion.[10]

Hogan also endorsed the idea that the Holocaust did not happen in the manner described by mainstream historians, writing that he found the work of Arthur Butz and Mark Weber to be "more scholarly, scientific, and convincing than what the history written by the victors says".[11] Such theories were considered by many[who?] to contradict his opinions concerning scientific rationality;[how?] he stated repeatedly that these theories had his attention due to the good quality of their presentation a quality he believed established sources should attempt to emulate, rather than resorting to attacking their originators.[citation needed]

During March 2010, in an essay defending Holocaust denier Ernst Zndel, Hogan stated that the mainstream history of the Holocaust includes "claims that are wildly fantastic, mutually contradictory, and defy common sense and often physical possibility".[12]

Compilations of novels in the "Giants series".

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James P. Hogan (writer) - Wikipedia

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Nanomedicine and Nanotechnology Peer Reviewed Journals

Posted: October 15, 2019 at 10:43 am

Pubmed NLM ID: 101562615SJR H Index:19ICDS 2017: 3.8RG Journal Impact: 0.55

Journal of Nanomedicine and Nanotechnology is an open access bi-monthly journal publishing peer-reviewed articles in all major and minor specializations of Nanomedicine and Nanotechnology.

The Journal of Nanomedicine and Nanotechnology primarily focuses on synthesis and characterization of nanoparticles and nanomaterial for engineering, biological and biomedical applications as well as innovative theoretical concepts having substantial pharmacological, toxicological or clinical relevance. Nanomedicine and Nanotechnology includes the manuscript related to Nanomedicine, Nanotechnology, Material Science Research, Nanobiotechnology, Nanoengineering, Nanobiopharmaceutics, Nanoelectronics, Nanofluids, Nano delivery, etc.

The journal is an online international Journal publishing all aspects of Nanomedicine and Nanotechnology including research article, review article, case study, mini-review, opinion, editorial, prospective, etc. Journal is trying to create the basic platform to maintain the international community for upcoming researcher.

The journal encourages researchers, professors, academicians, doctors, faculties, and students from all over the world to submit their findings or new results related to the journal. All articles will be published and archived through single blind peer-review process. Readers can access or download the published articles free of cost. Journal is following peer-review and publication under open access creative commons attribution license.

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Nanorobotics – Wikipedia

Posted: October 15, 2019 at 10:43 am

"Nanobots" redirects here. For the They Might Be Giants album, see Nanobots (album).

Nanorobotics is an emerging technology field creating machines or robots whose components are at or near the scale of a nanometer (109 meters).[1][2][3] More specifically, nanorobotics (as opposed to microrobotics) refers to the nanotechnology engineering discipline of designing and building nanorobots, with devices ranging in size from 0.110 micrometres and constructed of nanoscale or molecular components.[4][5] The terms nanobot, nanoid, nanite, nanomachine, or nanomite have also been used to describe such devices currently under research and development.[6][7]

Nanomachines are largely in the research and development phase,[8] but some primitive molecular machines and nanomotors have been tested. An example is a sensor having a switch approximately 1.5 nanometers across, able to count specific molecules in a chemical sample. The first useful applications of nanomachines may be in nanomedicine. For example,[9] biological machines could be used to identify and destroy cancer cells.[10][11] Another potential application is the detection of toxic chemicals, and the measurement of their concentrations, in the environment. Rice University has demonstrated a single-molecule car developed by a chemical process and including Buckminsterfullerenes (buckyballs) for wheels. It is actuated by controlling the environmental temperature and by positioning a scanning tunneling microscope tip.

Another definition[whose?] is a robot that allows precise interactions with nanoscale objects, or can manipulate with nanoscale resolution. Such devices are more related to microscopy or scanning probe microscopy, instead of the description of nanorobots as molecular machines. Using the microscopy definition, even a large apparatus such as an atomic force microscope can be considered a nanorobotic instrument when configured to perform nanomanipulation. For this viewpoint, macroscale robots or microrobots that can move with nanoscale precision can also be considered nanorobots.

According to Richard Feynman, it was his former graduate student and collaborator Albert Hibbs who originally suggested to him (circa 1959) the idea of a medical use for Feynman's theoretical micromachines (see biological machine). Hibbs suggested that certain repair machines might one day be reduced in size to the point that it would, in theory, be possible to (as Feynman put it) "swallow the surgeon". The idea was incorporated into Feynman's 1959 essay There's Plenty of Room at the Bottom.[12]

Since nanorobots would be microscopic in size, it would probably be necessary[according to whom?] for very large numbers of them to work together to perform microscopic and macroscopic tasks. These nanorobot swarms, both those unable to replicate (as in utility fog) and those able to replicate unconstrainedly in the natural environment (as in grey goo and synthetic biology), are found in many science fiction stories, such as the Borg nanoprobes in Star Trek and The Outer Limits episode "The New Breed".Some proponents of nanorobotics, in reaction to the grey goo scenarios that they earlier helped to propagate, hold the view that nanorobots able to replicate outside of a restricted factory environment do not form a necessary part of a purported productive nanotechnology, and that the process of self-replication, were it ever to be developed, could be made inherently safe. They further assert that their current plans for developing and using molecular manufacturing do not in fact include free-foraging replicators.[13][14]

A detailed theoretical discussion of nanorobotics, including specific design issues such as sensing, power communication, navigation, manipulation, locomotion, and onboard computation, has been presented in the medical context of nanomedicine by Robert Freitas.[15][16] Some of these discussions[which?] remain at the level of unbuildable generality and do not approach the level of detailed engineering.

A document with a proposal on nanobiotech development using open design technology methods, as in open-source hardware and open-source software, has been addressed to the United Nations General Assembly.[17] According to the document sent to the United Nations, in the same way that open source has in recent years accelerated the development of computer systems, a similar approach should benefit the society at large and accelerate nanorobotics development. The use of nanobiotechnology should be established as a human heritage for the coming generations, and developed as an open technology based on ethical practices for peaceful purposes. Open technology is stated as a fundamental key for such an aim.

In the same ways that technology research and development drove the space race and nuclear arms race, a race for nanorobots is occurring.[18][19][20][21][22] There is plenty of ground allowing nanorobots to be included among the emerging technologies.[23] Some of the reasons are that large corporations, such as General Electric, Hewlett-Packard, Synopsys, Northrop Grumman and Siemens have been recently working in the development and research of nanorobots;[24][25][26][27][28] surgeons are getting involved and starting to propose ways to apply nanorobots for common medical procedures;[29] universities and research institutes were granted funds by government agencies exceeding $2 billion towards research developing nanodevices for medicine;[30][31] bankers are also strategically investing with the intent to acquire beforehand rights and royalties on future nanorobots commercialisation.[32] Some aspects of nanorobot litigation and related issues linked to monopoly have already arisen.[33][34][35] A large number of patents has been granted recently on nanorobots, done mostly for patent agents, companies specialized solely on building patent portfolios, and lawyers. After a long series of patents and eventually litigations, see for example the Invention of Radio, or the War of Currents, emerging fields of technology tend to become a monopoly, which normally is dominated by large corporations.[36]

Manufacturing nanomachines assembled from molecular components is a very challenging task. Because of the level of difficulty, many engineers and scientists continue working cooperatively across multidisciplinary approaches to achieve breakthroughs in this new area of development. Thus, it is quite understandable the importance of the following distinct techniques currently applied towards manufacturing nanorobots:

The joint use of nanoelectronics, photolithography, and new biomaterials provides a possible approach to manufacturing nanorobots for common medical uses, such as surgical instrumentation, diagnosis, and drug delivery.[37][38][39] This method for manufacturing on nanotechnology scale is in use in the electronics industry since 2008.[40] So, practical nanorobots should be integrated as nanoelectronics devices, which will allow tele-operation and advanced capabilities for medical instrumentation.[41][42]

A nucleic acid robot (nubot) is an organic molecular machine at the nanoscale.[43] DNA structure can provide means to assemble 2D and 3D nanomechanical devices. DNA based machines can be activated using small molecules, proteins and other molecules of DNA.[44][45][46] Biological circuit gates based on DNA materials have been engineered as molecular machines to allow in-vitro drug delivery for targeted health problems.[47] Such material based systems would work most closely to smart biomaterial drug system delivery,[48] while not allowing precise in vivo teleoperation of such engineered prototypes.

Several reports have demonstrated the attachment of synthetic molecular motors to surfaces.[49][50] These primitive nanomachines have been shown to undergo machine-like motions when confined to the surface of a macroscopic material. The surface anchored motors could potentially be used to move and position nanoscale materials on a surface in the manner of a conveyor belt.

Nanofactory Collaboration,[51] founded by Robert Freitas and Ralph Merkle in 2000 and involving 23 researchers from 10 organizations and 4 countries, focuses on developing a practical research agenda[52] specifically aimed at developing positionally-controlled diamond mechanosynthesis and a diamondoid nanofactory that would have the capability of building diamondoid medical nanorobots.

The emerging field of bio-hybrid systems combines biological and synthetic structural elements for biomedical or robotic applications. The constituting elements of bio-nanoelectromechanical systems (BioNEMS) are of nanoscale size, for example DNA, proteins or nanostructured mechanical parts. Thiol-ene ebeam resist allow the direct writing of nanoscale features, followed by the functionalization of the natively reactive resist surface with biomolecules.[53] Other approaches use a biodegradable material attached to magnetic particles that allow them to be guided around the body.[54]

This approach proposes the use of biological microorganisms, like the bacterium Escherichia coli[55] and Salmonella typhimurium.[56]Thus the model uses a flagellum for propulsion purposes. Electromagnetic fields normally control the motion of this kind of biological integrated device.[57]Chemists at the University of Nebraska have created a humidity gauge by fusing a bacterium to a silicone computer chip.[58]

Retroviruses can be retrained to attach to cells and replace DNA. They go through a process called reverse transcription to deliver genetic packaging in a vector.[59] Usually, these devices are Pol Gag genes of the virus for the Capsid and Delivery system. This process is called retroviral gene therapy, having the ability to re-engineer cellular DNA by usage of viral vectors.[60] This approach has appeared in the form of retroviral, adenoviral, and lentiviral gene delivery systems.[61] These gene therapy vectors have been used in cats to send genes into the genetically modified organism (GMO), causing it to display the trait.[62]

3D printing is the process by which a three-dimensional structure is built through the various processes of additive manufacturing. Nanoscale 3D printing involves many of the same process, incorporated at a much smaller scale. To print a structure in the 5-400m scale, the precision of the 3D printing machine is improved greatly. A two-steps process of 3D printing, using a 3D printing and laser etched plates method was incorporated as an improvement technique.[63] To be more precise at a nanoscale, the 3D printing process uses a laser etching machine, which etches into each plate the details needed for the segment of nanorobot. The plate is then transferred to the 3D printer, which fills the etched regions with the desired nanoparticle. The 3D printing process is repeated until the nanorobot is built from the bottom up. This 3D printing process has many benefits. First, it increases the overall accuracy of the printing process.[citation needed] Second, it has the potential to create functional segments of a nanorobot.[63] The 3D printer uses a liquid resin, which is hardened at precisely the correct spots by a focused laser beam. The focal point of the laser beam is guided through the resin by movable mirrors and leaves behind a hardened line of solid polymer, just a few hundred nanometers wide. This fine resolution enables the creation of intricately structured sculptures as tiny as a grain of sand. This process takes place by using photoactive resins, which are hardened by the laser at an extremely small scale to create the structure. This process is quick by nanoscale 3D printing standards. Ultra-small features can be made with the 3D micro-fabrication technique used in multiphoton photopolymerisation. This approach uses a focused laser to trace the desired 3D object into a block of gel. Due to the nonlinear nature of photo excitation, the gel is cured to a solid only in the places where the laser was focused while the remaining gel is then washed away. Feature sizes of under 100nm are easily produced, as well as complex structures with moving and interlocked parts.[64]

Potential uses for nanorobotics in medicine include early diagnosis and targeted drug-delivery for cancer,[65][66][67] biomedical instrumentation,[68] surgery,[69][70] pharmacokinetics,[10] monitoring of diabetes,[71][72][73] and health care.

In such plans, future medical nanotechnology is expected to employ nanorobots injected into the patient to perform work at a cellular level. Such nanorobots intended for use in medicine should be non-replicating, as replication would needlessly increase device complexity, reduce reliability, and interfere with the medical mission.

Nanotechnology provides a wide range of new technologies for developing customized means to optimize the delivery of pharmaceutical drugs. Today, harmful side effects of treatments such as chemotherapy are commonly a result of drug delivery methods that don't pinpoint their intended target cells accurately.[74] Researchers at Harvard and MIT, however, have been able to attach special RNA strands, measuring nearly 10nm in diameter, to nanoparticles, filling them with a chemotherapy drug. These RNA strands are attracted to cancer cells. When the nanoparticle encounters a cancer cell, it adheres to it, and releases the drug into the cancer cell.[75] This directed method of drug delivery has great potential for treating cancer patients while avoiding negative effects (commonly associated with improper drug delivery).[74][76] The first demonstration of nanomotors operating in living organisms was carried out in 2014 at University of California, San Diego.[77] MRI-guided nanocapsules are one potential precursor to nanorobots.[78]

Another useful application of nanorobots is assisting in the repair of tissue cells alongside white blood cells.[79] Recruiting inflammatory cells or white blood cells (which include neutrophil granulocytes, lymphocytes, monocytes, and mast cells) to the affected area is the first response of tissues to injury.[80] Because of their small size, nanorobots could attach themselves to the surface of recruited white cells, to squeeze their way out through the walls of blood vessels and arrive at the injury site, where they can assist in the tissue repair process. Certain substances could possibly be used to accelerate the recovery.

The science behind this mechanism is quite complex. Passage of cells across the blood endothelium, a process known as transmigration, is a mechanism involving engagement of cell surface receptors to adhesion molecules, active force exertion and dilation of the vessel walls and physical deformation of the migrating cells. By attaching themselves to migrating inflammatory cells, the robots can in effect hitch a ride across the blood vessels, bypassing the need for a complex transmigration mechanism of their own.[79]

As of 2016[update], in the United States, Food and Drug Administration (FDA) regulates nanotechnology on the basis of size.[81]

Soutik Betal, during his doctoral research at the University of Texas, San Antonio developed nanocomposite particles that are controlled remotely by an electromagnetic field.[82] This series of nanorobots that are now enlisted in the Guinness World Records,[82] can be used to interact with the biological cells.[83] Scientists suggest that this technology can be used for the treatment of cancer.[84]

The Nanites are characters on the TV show Mystery Science Theater 3000. They're self-replicating, bio-engineered organisms that work on the ship and reside in the SOL's computer systems. They made their first appearance in season 8.

Nanites are used in a number of episodes in the Netflix series "Travelers". They are programmed and injected into injured people to perform repairs.

Nanites also feature in the Rise of Iron 2016 expansion for Destiny in which SIVA, a self-replicating nanotechnology is used as a weapon.

Nanites (referred to more often as Nanomachines) are often referenced in Konami's "Metal Gear" series being used to enhance and regulate abilities and body functions

Borg Nanoprobes perform the function of maintaining the Borg cybernetic systems, as well as repairing damage to the organic parts of a Borg. They generate new technology inside a Borg when needed, as well as protecting them from many forms of disease.

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Nanorobotics - Wikipedia

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University Neurology Cole Neuroscience Center – UTMC

Posted: October 14, 2019 at 6:43 am

Welcome tothe University Neurology Cole Neuroscience Center. We are a full-service neurology clinic, offering neurological consultation, Nerve Conduction Studies (electrical testing of nerve function), EMG (a test of muscle and nerve function), and EEG (brainwave testing).

Our Center was established as a result of the generous support of Robert and Monica Cole and the ColeFamily Foundation. The Cole Family Foundation made a strong commitment not only to clinical care, but also to research in the field of neuroscience. Through solid leadership and financial support of the Cole Family Foundationthe commitment to clinical excellence is evidenced by the growth in the patient population from a few hundred fifteen years ago to over 5,000 patients. Scientific research started with Cole Familys participation as the major benefactor in the acquisition of the first PET scan at TheUniversity of Tennessee Medical Center and the endowment of a chair in Molecular Neuro Imaging.

Our specialists work together to develop treatment plans that assist the entire family. From access to the latest diagnostic tools and the newest clinical trials, to offering counseling and long-term care options, the University Neurology Cole Neuroscience Center has so much to offer especially hope.

Conditionstreated in our office include:

Wetake a multidisciplinary approach to patient care. This effort is coordinated by our neurologistsas well as advanced registered nurse practitioners, social workers, registered nurses and a team of cognitive evaluation specialists.

Spanning beyond traditional approaches, the primary medical team also consults with neuroradiologists, neurosurgeons, nutritionists, and physical, occupational, respiratory, and speech therapists. The result of this collaboration is a unique program of care developed with each patient and their caregiver that addresses all their specific needs.

Download new patient packets and get general patient information. Learn More

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University Neurology Cole Neuroscience Center - UTMC

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Knoxville Neurology Specialists Joins Covenant Health

Posted: October 14, 2019 at 6:43 am

We are pleased to welcome the board-certified neurologists of Knoxville Neurology Specialists to Covenant Health and Fort Sanders Regional Medical Center.

Knoxville Neurology Specialists is the practice of Timothy Braden, MD; Darrell Thomas, MD; Joel Torres, MD; and Gregory Wheatley, MD. Together, the physicians bring more than 60 years of combined medical experience treating diseases of the brain, spine and nervous system. Almost all conditions can be treated within their practice, as they subspecialize in different areas of neurology, including adult neurology, epilepsy, and neuromuscular diseases.

Learn more about the neurologists below.

Board Certified in Neurology

Neurology,Wake Forest Baptist Medical Center

University of Tennessee, Memphis

Board Certified in Neurology

Electrodiagnosis and Neuromuscular Diseases,University of Alabama

Neurology,Bowman Gray School of Medicine

University of Tennessee, MemphisKnoxville Neurology

Board Certified in Neurology

Neuromuscular Medicine,Wake Forest Baptist Medical Center

Neurology,Wake Forest Baptist Medical Center

East Tennessee State UniversityJames H. Quillen College of Medicine

Board Certified in Neurology

Epilepsy,University of Alabama School of Medicine

Electrophysiology,Mayo Clinic

Neurology,West Virginia University Hospital

University of Tennessee, Memphis

Knoxville Neurology Specialistsat Fort Sanders Regional Medical Center501 20th Street, Suite 505Knoxville, TN 37916

For an appointment with one of our neurologists or for more information about the medical services provided at Knoxville Neurology Specialists, call(865) 546-0157.

Here are directions to help you easily find our office.

Tags for this post:Covenant Health, Covenant Medical Group, Darrell Thomas, Dr. Darrell Thomas, Dr. Gregory Wheatley, Dr. Joel Torres, Dr. Timothy Braden, fort sanders regional medical center, Gregory Wheatley, Joel Torres, Knoxville Neurologist, Knoxville Neurology, Knoxville Neurology Specialists, Timothy Braden

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Knoxville Neurology Specialists Joins Covenant Health

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Nashville Regenerative Orthopedics – Stem Cell Therapy …

Posted: October 14, 2019 at 6:41 am

Select a Problem Area

If you have pain, we're here to help. Regenexx Procedures are patented stem cell and blood platelet procedures that are used to treat a wide range of joint and spine conditions.

Click a problem area to discover what Regenexx can do for you.

The Regenexx family of non-surgical stem-cell & blood platelet procedures are next generation regenerative injection treatments for those who are suffering from shoulder pain due to arthritis, rotator cuff and shoulder labrum tears, overuse injuries, and other degenerative conditions. Regenexx is also a viable alternative for those considering shoulder replacement surgery.

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Regenexx Procedures are advanced stem cell and blood platelet procedures for foot and ankle conditions. Before you consider ankle surgery, fusion or replacement, consider the worlds leading stem cell and prp injection treatments.

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The Regenexx family of non-surgical stem-cell & blood platelet procedures are next generation regenerative injection treatments for those who are suffering from pain or reduced range of motion due to basal joint / cmc arthritis, hand arthritis, or other injuries & conditions in the hand.

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The Regenexx family of non-surgical stem cell and blood platelet procedures offer next-generation injection treatments for those who are suffering from knee pain or may be facing knee surgery or knee replacement due to common injuries, arthritis, overuse and other conditions.

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ACL Procedure VideoIn-Depth with Dr. John Schultz ACL Procedure Video

The Regenexx family of non-surgical stem-cell & blood platelet procedures are next generation regenerative injection treatments for those who are suffering from pain, inflammation or reduced range of motion due tocommon elbow injuries, arthritis and overuse conditions.

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The Regenexx family of hip surgery alternatives are breakthrough, non-surgical stem-cell treatments for people suffering from hip pain due to common injuries, hip arthritis & other degenerative problems related to the hip joint.

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Regenexx has many non-surgical platelet and stem cell based procedures developed to help patients avoid spine surgery and high dose epidural steroid side effects. These procedures utilize the patients own natural growth factors or stem cells to treat bulging or herniated discs, degenerative conditions in the spine, and other back and neck conditions that cause pain.

View Details About Spine Treatments

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Intradiscal Procedure Video

Regenexx has many non-surgical platelet and stem cell based procedures developed to help patients avoid spine surgery and high dose epidural steroid side effects. These procedures utilize the patients own natural growth factors or stem cells to treat bulging or herniated discs, degenerative conditions in the spine, and other back and neck conditions that cause pain.

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