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Resveratrol Lift Firming Serum – Caudalie | Sephora

Posted: December 6, 2017 at 11:41 am

Which skin type is it good for? Normal Oily Combination Dry Sensitive

What it is:A resculpting treatment serum to reshape, define, and lift the look of skin for a youthful appearance.

Solutions for:- Fine lines and wrinkles- Loss of firmness and elasticity- Dryness

If you want to know moreThis oil-free, innovative resculpting serum is formulated with Caudalie’s new breakthrough patent of stabilized vine resveratrol (for firmness) and micro hyaluronic acids (for volume) to visibly recontour, refirm, and replump aging skin. For the first time, these molecules’ synergy is being harnessed to support skin’s natural production of hyaluronic acid, so the skin is plumped from within. The formula is further enriched with a peptide composition that works on natural collagen and elastin to lift the look of facial contours and reduce visible effects of aging. The light, hydrating texture blends into the skin without any sticky residue and can be applied under makeup.

What it is formulated WITHOUT:- Parabens- Sulfates- Phthalates

What else you need to know:Resveratrol Lift Firming Serum is winner of a Womens Health 2017 Beauty Award.

Research has unveiled a surprising synergy between a molecule from grapevine called resveratrol, and a complex of micro hyaluronic acids. While each ingredient is effective on its own, the combination is a breakthrough because it helps support the skin’s own production of natural hyaluronic acid. Hyaluronic acid is naturally present in the skin and plays an important role in hydration and preservation. A decrease in hyaluronic acid quantity and quality with age leads to dryness and the appearance of wrinkles. Caudalie’s new patented complex helps support the skin to make its own natural hylauronic acid. This product is noncomedogenic and tested under dermatological supervision.

Research results:% of satisfaction, 100 people, 7 days: – 80% of testers reported denser skin

% of satisfaction, 100 people, 28 days: – 91% of testers reported firmer skin- 76% of testers reported lifted skin

% of satisfaction, 33 people, 56 days: – 85% of testers reported smoothed wrinkles

Continued here:

Resveratrol Lift Firming Serum – Caudalie | Sephora

Recommendation and review posted by Fredricko

Irinotecan – Wikipedia

Posted: December 6, 2017 at 11:40 am

IrinotecanClinical dataTrade namesCamptosar (US), Campto (EU), Onivyde (liposomal)AHFS/Drugs.comMonographMedlinePlusa608043Pregnancycategory

O=C7OCC=6C(=O)N2C(c1nc5c(c(c1C2)CC)cc(OC(=O)N4CCC(N3CCCCC3)CC4)cc5)=C/C=6[[email protected]@]7(O)CC

Irinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer and small cell lung cancer.[1] For colon cancer it is used either alone or with fluorouracil.[1] For small cell lung cancer it is used with cisplatin.[1] It is given by slow injection into a vein.[1]

Common side effects include diarrhea, vomiting, bone marrow suppression, hair loss, shortness of breath, and fever.[1] Other severe side effects include blood clots, colon inflammation, and allergic reactions.[1] Those with two copies of the UGT1A1*28 gene variant are at higher risk for side effects.[1] Use during pregnancy can result in harm to the baby.[1] Irinotecan is in topoisomerase inhibitor family of medication.[2] It works by blocking topoisomerase 1 which results in DNA damage and cell death.[1]

Irinotecan was approved for medical use in the United States in 1996.[1] It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system.[3] In the United Kingdom it is available as a generic medication and costs the NHS about 114.00 pounds per 100mg.[2] It is made from the natural compound camptothecin.[1]

Its main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan. The regimen XELIRI consists of capecitabine and irinotecan.[4][5]

The most significant adverse effects of irinotecan are severe diarrhea and extreme suppression of the immune system.[6]

Irinotecan-associated diarrhea is severe and clinically significant, sometimes leading to severe dehydration requiring hospitalization or intensive care unit admission. This side-effect is managed with the aggressive use of antidiarrheals such as loperamide or co-phenotrope with the first loose bowel movement.

The immune system is adversely impacted by irinotecan. This is reflected in dramatically lowered white blood cell counts in the blood, in particular the neutrophils. The patient may experience a period of neutropenia (a clinically significant decrease of neutrophils in the blood) while the bone marrow increases white cell production to compensate.

Irinotecan is activated by hydrolysis to SN-38, an inhibitor of topoisomerase I. This is then inactivated by glucuronidation by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1). The inhibition of topoisomerase I by the active metabolite SN-38 eventually leads to inhibition of both DNA replication and transcription.[6]

The molecular action of irinotecan occurs by trapping a subset of topoisomerase-1-DNA cleavage complexes, those with a guanine +1 in the DNA sequence.[7] One irinotecan molecule stacks against the base pairs flanking the topoisomerase-induced cleavage site and poisons (inactivates) the topoisomerase 1 enzyme.[7]

Click on genes, proteins and metabolites below to link to respective articles. [ 1]

Irinotecan is converted by an enzyme into its active metabolite SN-38, which is in turn inactivated by the enzyme UGT1A1 by glucuronidation.

People with variants of the UGT1A1 called TA7, also known as the “*28 variant”, express fewer UGT1A1 enzymes in their liver and often have Gilbert’s syndrome. During chemotherapy, they effectively receive a larger than expected dose because their bodies are not able to clear irinotecan as fast as others. In studies this corresponds to higher incidences of severe neutropenia and diarrhea.[8]

In 2004, a clinical study was performed that both validated prospectively the association of the *28 variant with greater toxicity and the ability of genetic testing in predicting that toxicity before chemotherapy administration.[8]

In 2005, the FDA made changes to the labeling of irinotecan to add pharmacogenomics recommendations, such that irinotecan recipients with a homozygous (both of the two gene copies) polymorphism in UGT1A1 gene, to be specific, the *28 variant, should be considered for reduced drug doses.[9] Irinotecan is one of the first widely used chemotherapy agents that is dosed according to the recipient’s genotype.[10]

Irinotecan received accelerated approval from the U.S. Food and Drug Administration (FDA) in 1996 and full approval in 1998.[11][12]

During development, it was known as CPT-11.

A liposome encapsulated version of irinotecan sold as Onivyde, was approved by FDA in October 2015 to treat metastatic pancreatic cancer.[13] It gained EU approval in October 2016.[14]

Read more:
Irinotecan – Wikipedia

Recommendation and review posted by Fredricko

Integrative Centers for Science and Medicine – Home

Posted: December 5, 2017 at 12:46 pm

center for biomedical education

The mission of the Center for Biomedical Education encompasses education in the basic medical and clinical sciences and educational research related to the training of medical doctors. CBE undertakes and fosters conferences, meetings, workshops, and publications by and for medical educators. Activities further the purposes of ICSM by promoting effective training of medical doctors and thereby conferring a benefit to society.

IIHER is a nonprofit research organization with origins dating back to 1991 whose purpose it is to investigate human evolutionary biology using the widest possible purview. IIHER serves as the basis for paleoanthropological research expeditions, primarily to Africa. Active now is the East Libya Neogene Research Project to the late Miocene site of Sahabi and the middle Miocene site of Jabal Zaltan, Libya.

The primary activity of CFSHR is the forensic scientific investigation of primarily skeletonized human remains worldwide, particularly those found in circumstances indicating abuses of human rights, such as mass graves, ethnic cleansing, torture, or genocide. A secondary activity is forensic assistance lent to medical examiners offices and regional law enforcement agencies primarily in Oregon, California, and Washington in solving missing person and homicide cases.

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Integrative Centers for Science and Medicine – Home

Recommendation and review posted by Guinevere Smith

Ramapo College of New Jersey || TAS: Biochemistry (B.S.)

Posted: December 5, 2017 at 12:43 pm

Biochemistry is an interdisciplinary field concerned with the chemical composition, structure, and molecular functions of living organisms. Knowledge derived from the disciplines of chemistry, physics, and biology is used to understand the processes that operate in cells and organisms, including their metabolism and regulation. Biochemistry attempts to understand the uniqueness of complex evolving living systems; how living organisms harvest energy from their environment to produce and maintain their complexity; and how these structures replicate themselves. The knowledge garnered from biochemical research has been applied to solve problems in areas ranging from agriculture to medicine. Specific areas of biochemistry include principles of protein structure (amino acid chemistry, peptide and protein structure and protein folding), enzymes (mechanisms, enzyme kinetics and inhibition), nucleic acids (nucleotides and nucleic acid chemistry, DNA sequencing, protein and genetic engineering) and metabolism (carbohydrate structure, glucose catabolism, citric acid cycle).

A bachelor’s degree in biochemistry provides the essential background and training that can open a variety of career pathways for students upon graduation. The biochemistry major is excellent preparation for professional studies in the health sciences; for secondary school teaching in the biological and physical sciences; for research in the pharmaceutical and chemical industry; for technical writing, sales, and service; and as the basis for graduate studies. The combination of chemistry, molecular biology, enzymology, and genetic engineering found in biochemistry provides the foundation to contribute to the rapidly expanding field of biotechnology.

At the end of their studies at Ramapo, graduating Biochemistry majors should:

Ramapo has modern laboratories for chemistry, biochemistry, genetics, molecular biology, and physics that are utilized in the major. There are opportunities for students to do research with faculty and for experiential learning through cooperative education in nearby industry. The program is supported by computer labs that are available for student use to supplement the instruction in the lecture and laboratories. The major in Biochemistry is offered by the School of Theoretical and Applied Science and leads to a B.S. degree.

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Ramapo College of New Jersey || TAS: Biochemistry (B.S.)

Recommendation and review posted by Guinevere Smith

Gene Therapy Hits a Peculiar Roadblock: A Virus Shortage …

Posted: December 3, 2017 at 11:43 pm

Few gene-therapy companies have the factories or expertise to make the viruses for use in clinical trials, where standards are exacting and comprehensive. The firms that can do it are swamped with orders and requests.

The result is a logjam. Firms exploring new gene therapies may wait for years in line for bespoke viruses, said Dr. Jim Wilson, director of the gene therapy program at the University of Pennsylvanias Perelman School of Medicine.

Its a real issue, said Udit Batra chief executive of MilliporeSigma, which makes viruses under contract for drug companies.

MilliporeSigma and other such manufacturers, he added, are oversubscribed, although companies like ourselves have doubled capacity to keep up with the demand.

One of the few big companies producing a gene therapy, Novartis, recently got approval from the F.D.A. to market a treatment for a rare blood cancer.

But to get the viruses it needed, Novartis signed up years in advance with Oxford BioMedica, agreeing to three contracts starting in 2013 that, with incentives, add up to as much as $195.2 million and that included a provision to pay Oxford a share of the royalties when the drug was approved.

Only a few hundred patients a year might need Novartiss treatment, and the company is charging $475,000 for the one-time therapy.

Other gene therapy companies are not always able to afford the manufacturing costs or find a manufacturer. Some have taken to buying slots in virus production queues years in advance like buying a nonrefundable airline ticket long before your vacation and hoping you can get away when the time comes.

Other firms are hedging their bets. Worried that production at one company will fail as can happen with the finicky viruses they buy places in line at two contract companies.

Still other biotechs have simply been shut out, unable to get their viruses made.

Then there is BioMarin, one of the larger and more successful biotech companies, which decided to spend several hundred million dollars to build its own virus-manufacturing plant. It does not plan to make viruses for anyone but itself.

We dont want to be in a queue, thats for sure, said Robert Baffi, head of technical operations at BioMarin. The new facility also will give the company complete control over manufacturing, he added.

The process of developing a gene therapy usually starts with academic researchers who do the preliminary tests. For the viruses they need, they often turn to a few academic medical centers with expertise in the requirements for early clinical research.

But there, too, demand far exceeds capacity. At Indiana University, we are backed up through 2018, said Dr. Kenneth Cornetta, a professor of molecular and medical genetics.

After a gene therapy gets through initial tests in an academic setting, researchers may license it to a biotech company or form their own small company. Then they have to find a manufacturer who will make their viruses according to the exacting standards required for treating patients.

Delays arise at every step. The contract virus-maker has to translate the small-scale production used for research purposes into a recipe for commercial production, where standards are extensive and documentation exhaustive. And the maker has to negotiate a contract to do all this.

Those two steps can easily take a year, said John Dawson, chief executive of Oxford BioMedica. When the contractor finally is ready to start making the viruses, it can be six months to a year before they are ready assuming there are no glitches along the way.

Manufacturing custom-made viruses can cost biotech firms a third or more of their development budget, even for diseases so rare that they expect to treat only a dozen or so patients in their final study, Dr. Wilson said.

The gene therapy companies often have no drugs on the market and need money. But investors have become wary of companies that do not have a ready source of viruses.

Youve got to believe that every time someone gives a pitch to an investor, the investor will say, What are you doing about manufacturing? Dr. Wilson said.

The whole development enterprise has become nerve-racking, researchers said. You dont know until the end that you have a product that is good enough to be used in a treatment, said Dr. David Williams of Harvard.

Or, as officials at Bluebird Bio can attest, whether you have any product at all.

The company was formed in 2010, hoping to show that gene therapy could work in adrenoleukodystrophy, a rare and fatal neurodegenerative disease that strike boys. That was before the virus production logjam had begun, and all seemed well. Bluebird gave a virus manufacturer its recipe for making needed viruses.

Then, said Nick Leschly, the companys chief executive, he got bad news. Using Bluebirds recipe, the manufacturing company said it was going to cost Bluebird a million dollars to create enough viruses to treat one patient.

The company scurried to find ways to improve the efficiency of its recipe. Finally, they were ready to start anew. Manufacturing began, but months later there was nothing to show for it.

We got no virus, Mr. Leschly said.

It was an Apollo 13 moment, he added. We put everyone in a room and said, We have to figure this out. Everything at the company is now stopped. Nothing can be done without virus.

They finally found the source of the problem the acidity of the solution used to grow the viruses was slightly off, killing them.

While the recipe for making viruses can affect prices, the cost of a new treatment also depends on how many patients will take the drug and how many cells from each patient must be altered by a virus.

If a company wanted to deliver a gene therapy to the lung or liver, where the organs surface area is huge, the current price could be as much as $3 million per patient commercially unviable, said Mr. Dawson of Oxford BioMedica.

Oxford is improving its methods, he said, and should soon be able to cut that cost to approximately $300,000 per patient. Methods are improving, Mr. Dawson said, and his expectation is that it might cost a mere $30,000 for the viruses in the future.

The costs of testing the drug and marketing it are, of course, out of his hands.

Originally posted here:
Gene Therapy Hits a Peculiar Roadblock: A Virus Shortage …

Recommendation and review posted by Guinevere Smith

Biochemistry – Test Directory

Posted: December 2, 2017 at 9:41 pm

1,25 Dihydroxyvitamin D (1,25 Dihydroxycholecalciferol)11-Deoxycortisol17-Hydroxyprogesterone5 Hydroxyindoleacetic acid (5HIAA)68 kD Inner Ear Protein AntibodyAcetylcholine Receptor AntibodyAcetylcholine Receptor Cluster AntibodiesACTHAcyl-carnitine profile (plasma)Adalimumab Level and AntibodiesAdenovirusADH (Antidiuretic hormone, AVP, Vasopressin)Adrenal Cortex AntibodyAlanine Aminotransferase (ALT)AlbuminAlbumin (24 hour urine)AlcoholAlcohol (Urine)AldosteroneAldosterone:Plasma Renin Activity RatioAlkaline Phosphatase (ALP)Alkaline Phosphatase (ALP) IsoenzymesAlpha Fetoprotein (AFP-tumour marker)Alpha subunit (Pituitary polypeptide)Alpha-1 Acid Glycoprotein (Orosomucoid)Alpha-1 Antitrypsin (A1AT)Alpha-1 Antitrypsin (A1AT) FaecalAlpha-1 Antitrypsin (A1AT) PhenotypingAlpha-galactosidase (Fabry) (Blood Spot)Alpha-glucosidase / acid maltase (Pompe) (Blood Spot)AlphavirusAlternative Pathway Complement Function (AP50)Aluminium – 24 hour urineAluminium – dialysateAluminium – random urineAluminium – serumAluminium – tissueAluminium – waterAmikacin LevelAmino Acids (CSF)Amino Acids (plasma)Amino Acids (urine)AmiodaroneAmmoniaAmoebic SerologyAMPA AntibodyAmphiphysin AntibodyAmylaseAmylase (Fluid)Amylase (urine)Amylase IsoenzymesAndrogen profile (females) – Includes testosterone, SHBG, DHA sulphate and FAIAndrostenedioneAngiotensin Converting Enzyme (ACE)Angiotensin Converting Enzyme (ACE) (CSF)Antenatal Screens (Syphilis, HIV, Hep B surface antigen)Anti Basal Ganglia Antibody (ABGA)Anti HBsAnti StaphAnti Strep (DNAase)Anti XaAnti-IgA AntibodiesAntimony – 24hr urineAntimony – tissueAntimony – urine (random)Antimony – whole bloodAnti-Mullerian Hormone (AMH)Anti-Neutrophil Cytoplasmic Antibody (ANCA)Anti-Nuclear Antibody (ANA)ApoE genotypingApolipoprotein A1 (Apo A1)Apolipoprotein B (Apo B)Apolipoprotein E genotypeApolipoprotein E phenotypeAPTTAquaporin 4 Antibody (AQP4)ArbovirusArray CGHArsenic – hairArsenic – tissueArsenic – whole bloodArsenic (24hour urine)Arsenic (random urine)Arthropod Borne VirusesAscitic FluidASOAspartate Aminotransferase (AST)Aspergillus IgG AntibodyAutoimmune ProfileAvian IgG antibodiesBAL and bronchial trapBarium – 24hr urineBarium – serumBarium – urine (random)Bartonella (Cat Scratch)Beryllium – serumBeryllium – urine (random)Beta 2 Glycoprotein 1 AntibodyBeta HydroxybutyrateBeta Interferon Neutralising AntibodyBeta-2 microglobulin (B2M)BicarbonateBilary stent cultureBile AcidsBile cultureBile Pigments (Urine)BilharziaBilirubin (conjugated)Bilirubin (CSF) – XanthochromiaBilirubin (total)Bilirubin (urine)Biogenic Amines (HVA and VMA (HMMA)) – paediatricBiotinidaseBismuth – 24hr urineBismuth – urine (random)Bismuth – whole bloodBlood Culture (Adult)Blood Culture (Paediatric)Blood FilmBone cultureBone Marrow & Blood for AFB cultureBordetella Pertussis SerologyBorrelia IgM/IgGBrain Natriuretic Peptide (BNP)Bromide – serumBrucellaBuprenorphine (Subutex) (urine)C. difficile ToxinC1 Esterase Inhibitor (C1EI) (Antigenic)C1 Esterase Inhibitor (C1EI) (Functional)C1q AntibodiesC1q LevelC3 Nephritic FactorCA125CA153CA199Cadmium – 24hr urineCadmium – tissueCadmium – urine (random)Cadmium – whole bloodCaeruloplasminCaffeineCalcitoninCalcium (adjusted)Calcium (urine)Calcium Creatinine Clearance RatioCalcium Creatinine Ratio (Urine)Camplylobacter SerologyCannabisCAPD fluid cultureCAPD Tip cultureCarbamazepine (Tegretol)Carbohydrate Deficient Transferrin (CDT)CarboxyhaemoglobinCarcinoembryonic Antigen (CEA)Cardiac Muscle AntibodyCardiolipin Antibodies (ACA) / Phospholipid Antibodies (APL)Catecholamines (Plasma)CD4 PanelCD4/CD8CDT – See C. Difficile ToxinCervical swabChikungunyaChlamydia EyesChlamydia Female Screening ProgrammeChlamydia Female SymptomaticChlamydia First Catch UrineChlamydia SerologyChlorideChloride (Sweat test)Cholesterol (total)Cholesterol (total):HDL Cholesterol ratioCholinesterase (for phenotyping)Cholinesterase (for poisoning – RBC Cholinesterase)Chromium – 24hr urineChromium – bloodChromium – hip fluidChromium – Ortho-bloodChromium – Ortho-serumChromium – serumChromium – tissueChromium – urine (random)Chromium – waterChromogranin A and/or BChromosome Studies (Karyotype)Citrate (urine)CJD (CSF)Classical Pathway Complement Function (CH100)Clauss FibrinogenClobazamClonality studies (B and T-cell clonality)ClozapineCMV IgGCMV IgMCMV PCRCMV SerologyCoagulation ScreenCobalt – 24hr urineCobalt – bloodCobalt – hip fluidCobalt – Ortho-bloodCobalt – Ortho-serumCobalt – serumCobalt – tissueCobalt – urine (random)Coeliac DQ2/DQ8 analysisCollagen type II antibodyComplement C3 and C4Contact LaboratoryContact lens cultureCopper – 24hr UrineCopper – Random UrineCopper – SerumCopper – TissueCopper – WaterCortisolCortisol (urine)Cotinine (urine)Cough swabCoxiellaCoxsackie (Enterovirus) DetectionC-PeptideC-peptide (Urine)C-Reactive Protein (CRP)Creatine kinase (CK)CreatinineCreatinine (urine)Creatinine ClearanceCrosslaps (Beta-Crosslaps)CrossmatchCryoglobulinCryptococcal AgCSFCSF GlucoseCyclic Citrullinated Peptide AntibodiesCyclosporinCystic Fibrosis Genetic AnalysisCystine (urine screen)Cystine (urine, quantitative)CytogeneticsD-DimerDengue FeverDHA SulphateDigoxinDihydrotestosterone (DHT)Diptheria AntibodyDirect Antiglobulin Test (DAT)DNA (Genetic) analysisDown’s Screen – Combined Test (1st trimester)Down’s screen – Quadruple Test (2nd trimester)Drain FluidDrugs of abuse screen (urine)dsDNA AntibodyEar effusion cultureEar SwabEar swab – deepEBV EBNAEBV VCA IgG/IgMEcstasyeGFR (Estimated Glomerular Filtration Rate)Elastase (faecal)EMU for TBENA (Extractable Nuclear Antigen) Antibodies (Ro, La, Sm, RNP, Scl-70, Jo-1)Endomysial Antibodies (EMA)Enterovirus DetectionEosinophil Cationic ProteinEpstein Barr Virus IgMErythrocyte Sedimentation Rate (ESR)ErythropoietinEssential Fatty AcidsEthylene GlycolExpressed breast milk – NICU at St Peters Hospital onlyEye swab (Not Chlamydia)Factor AssaysFactor V Leiden mutationFaecal calprotectinFaeces – See Stool culture/ova/cysts/parasitesFasciolaFerritinFilariaFlavivirusFlecainideFollicle Stimulating Hormone (FSH)Free (non-esterified) Fatty Acid (NEFA)Free and Acyl-carnitine profile (Blood Spot)Free Androgen Index (FAI)Free catecholamines (Biogenic Amines)Free T3 (FT3)Free T4 (FT4)Free TestosteroneFructosamineFull Blood count (FBC)Fungal PrecipitinsG6PD ScreenGABAb Receptor AntibodyGabapentinGalactose-1-phosphate uridyl transferase (GalPUT)Gamma glutamyl transferase (GGT)Ganglioside Antibodies (GM1 and GQ1b)Gastric Parietal Cell AntibodiesGastrinGenital swabGentamicinGlandular Fever ScreenGliadin Antibodies (IgG and IgA)Glomerular Basement Membrane (GBM) AntibodiesGlucoseGlucose Tolerance Test (GTT)Glutamic Acid Decarboxylase Antibody (GAD)Glycine Receptor AntibodiesGlycosaminoglycans (mucopolysaccharides) (Urine)Gold – 24hr UrineGold – Random UrineGold – SerumGonococcal cultureGroup and Save (Adult)Group and Save (Baby)Group and Save AntenatalGrowth hormone (GH)Gut hormone profileH. Pylori Faecal Antigen DetectionHaemochromatosis (HFE) genotypingHaemochromatosis Gene (HFE)Haemoglobin A1c (HbA1c)Haemoglobinopathy Screen (HPLC)Haemophilus Influenzae B Antibodies (Specific Functional Antimicrobial Antibodies)HaptoglobinHb H Inclusion BodiesHBcoreHBsAgHDL Cholesterol (HDLC)Heinz BodiesHeparin Induced Thrombocytopenia (HIT)Hepatitis A IgGHepatitis A IgMHepatitis C antibodiesHer2 (SISH)Heterophillic Antibodies (thyroid interference)Hevylite AssayHistone AntibodiesHIV Ag/Ab comboHIV Viral LoadsHLA B27 genotypingHMGCoAR Antibodies(3-hydroxy-3-methylglutaryl-CoA Reductase Abs)HomocysteineHomocystine (urine)Homovanillic Acid (HVA)HR-Urticaria TestHuman Leucocyte Antigen (HLA)HVS for vaginal dischargeIA2 AntibodiesIGF Binding Protein 3 (IGFBP3)IgG SubclassesImmunofixationImmunoglobulin DImmunoglobulin E (Total)Immunoglobulins (IgG, IgA and IgM)Immunoreactive Trypsin (IRT) (blood spot)Infliximab Level and AntibodiesInfluenza A/BInhibin AInhibin BInsects for IdentificationInsulinInsulin AntibodiesInsulin-like Growth Factor 1 (IGF-1)Insulin-like growth factor binding protein (IGFBP1)Insulin-like growth factor binding protein (IGFBP2)Insulin-like Growth Factor II (IGF-II)Intrinsic Factor AntibodiesIronIron – 24hr UrineIron – Random UrineIron – TissueIron – WaterISACIslet Cell AntibodiesIUCD cultureJak2 activating mutationJoint FluidKetones (urine) (qualitative)Lactate (ASPH)Lactate (CSF)Lactate (RSCH/FPH)Lactate / pyruvate ratioLactate dehydrogenase (LD, LDH)Lactose intolerance testingLamotrigineLaxative abuse screen (urine)LDL-cholesterol (LDL-C) (calculated)Lead – 24hr UrineLead – Random UrineLead – TissueLead – WaterLead – Whole BloodLegionella antigen – Urine sampleLevetiracetam (Keppra)Line cultureLipaseLipoprotein (a)LithiumLiver Kidney Microsomal (LKM) AntibodiesLow Affinity ACHR ClusterLupus anticoagulant screenLuteinising hormone (LH)LVSLymphocyte FunctionLymphocyte PhenotypeMagnesium – 24hr UrineMagnesium – Random UrineMagnesium – Red Blood CellMagnesium – serumMagnesium – TissueMagnesium – WaterMalarial ScreenManganese – 24hr UrineManganese – Random UrineManganese – SerumManganese – TissueManganese – Whole BloodMannose Binding Lectin (MBL)Measles IgGMeningococcal C AbsMeningococcal PCRMercury – 24hr UrineMercury – Random UrineMercury – TissueMercury – Whole BloodMetadrenalines (Metanephrines) (Plasma)Metadrenalines (Metanephrines, biogenic amines)Metal work cultureMethotrexateMethylmalonic acidMicropolyspora Faeni IgG AntibodyMitochondrial Antibody (AMA)Molecular GeneticsMolybdenum – 24hr UrineMolybdenum – Random UrineMolybdenum – SerumMRSA screenMTHFR (5,10-methyleneterahydrofolate reductase) variantMumps IgGMuSK (Muscle Specific Kinase) AntibodiesMycology – Skin / Nails / HairMycoplasmaMycoplasma GATMyelin Associated Glycoprotein AntibodyMyelin Oligodendrocyte Glycoprotein (MOG) AntibodiesMyeloperoxidase/MPO AntibodiesN-Acetyl-Beta-Glucosaminidase (NAG)NephrostomyNeuronal Antibodies (Anti Neuronal Antibodies)Neurone Specific Enolase (NSE)Neurotransmitters (CSF) (Monoamine metabolites)Neutrophil FunctionNext-Generation SequencingNickel – 24hr UrineNickel – Random UrineNickel – SerumNickel – TissueNMDA AntibodiesNon-HDL Cholesterol (calculated)Norovirus and RotavirusNose swab cultureNPA (Nasopharyngeal aspirate)N-Telopeptide (Collagen Crosslinks)Occult Blood (faecal)OestradiolOligoclonal Bands (CSF)Oncology HCGOral Anticoagulant Therapy MonitoringOrganic Acids (urine)Orthopaedic tissue samplesOsmolalityOsmolality (urine)OsteocalcinOvarian AntibodiesOxalate (urine)Oxidative Burst or NBT (NitroBlue Tetrazolium)P1NP (Procollagen Extension Peptide)Panton Valentine Leukocidin (PVL) analysisParacetamolParaprotein QuantitationParaquat (urine)Parasites/ticks/worms for IdenificationParathyroid Hormone (PTH)Paroxysmal Nocturnal haemoglobinuria (PNH)Parvovirus IgGParvovirus IgMPenile swabPerl’s stain for IronpH (Faecal)pH (Urine, CSF, Fluid)PhenobarbitonePhenylalaninePhenytoin (Epanutin)PhosphatePhosphate (24 hour urine)Phospholipase A2 Receptor AbsPhytanic acidPlacental alkaline phosphatase (PLAP)Plasma EGFR analysisPlasma ViscosityPlatinum – Random UrinePlatinum – SerumPleural FluidPneumococcal Antibodies (Specific/Functional Antimicrobial Antibodies)Pneumococcal antigen – Urine samplePorphobilinogen (PBG) screenPorphyrin screen (blood)Porphyrin screen (faeces)Porphyrin screen (urine)PotassiumPotassium (urine)Pouch of Douglas fluidPrimidone (mysoline)ProcalcitoninProcollagen peptide type III (PIIINP)ProgesteroneProinsulinProlactinProstate Specific Antigen (PSA)Protein (ascitic fluid)Protein (CSF)Protein (total protein)Protein (urine) 24h collection no longer required – see belowProtein ElectrophoresisProtein:creatinine ratio (TPCR)Prothrombin mutationPSA (Free)PsittacosisPTH-related peptide (PTH-RP)Purine Pyrimidine screen (blood)Purine Pyrimidine screen (urine)Purkinje Cell Antibodies (Hu, Ri, Yo) also known as Neuronal AntibodiesPus (Culture and Gram Stain)Pus for Mycobacterial CulturePus SwabQ FeverQuantiferonQuinsy pus cultureRBC Folate LevelReninReticulocytesRetinol Binding ProteinRheumatoid FactorRSVRubella IgGRubella IgMSaccharomyces Abs (IgG and IgA)SalicylateSalivary Gland AntibodiesSchistosomesSelenium – Random UrineSelenium – SerumSemen cultureSerotoninSerum Amyloid ASerum FolateSerum Free Light ChainsSerum Protein ElectrophoresisSex Hormone Binding Globulin (SHBG)Silicon – 24hr UrineSilicon – FluidSilicon – Random UrineSilicon – SerumSilver – 24hr UrineSilver – Random UrineSilver – WaterSilver – Whole BloodSirolimusSkeletal Muscle AntibodiesSkin (Epidermal) AntibodiesSmooth Muscle AntibodiesSodiumSodium (sweat)Sodium (urine)Soluble Transferrin Receptor (STfR)Specific Immunoglobulin E (IgE)Sperm AntibodiesSputum – Mycobacterial culture (TB)Sputum routine cultureSquamous Cell Carcinoma (SCC) AntigenStaphylococcal carriage cultureSteroid ProfileStone (Calculus) analysisStool cultureStool for ova/cysts/parasitesStriated Muscle Antibodies also known as Skeletal Muscle AntibodiesSugar Chromatography – faeces (reducing substances)Sugar Chromatography – urine (reducing substances)Sulphocysteine (Urine)Sulphonylurea Screen (serum)Sulphonylurea Screen (urine)Supra pubic aspirate and nephrostomyurostomy specimens for microscopy and cultureSyphilisTacrolimus (FK506)Tau Protein (Beta-2-transferrin, asialotransferrin)Tellurium – 24hr UrineTellurium – Random UrineTellurium – Whole BloodTestosteroneTetanus Toxoid Antibodies (Specific/Functional Antimicrobial Antibodies)Thallium – Random UrineThallium – TissueThallium – Whole BloodTheophyllineThiopentone (Thiopental)Thiopurine metabolites (6-Thioguanine nucleotide and 6-Methylmercaptopurine) (Nucleotides)Thiopurine Methyltransferase (TPMT) (Azathioprine sensitivity)Threadworm – sellotape slideThroat swab cultureThrombin TimeThrombophilia ScreenThyroglobulinThyroglobulin AntibodiesThyroid Peroxidase AntibodiesThyroid Stimulating Hormone (TSH)Thyroid Stimulating Hormone (TSH) Receptor AntibodiesTicks for IdentificationTin – Random UrineTin – TissueTin – WaterTin – Whole BloodTip cultureTissue – Non sterile ( routine Culture and Gram stain )Tissue – sterileTissue Transglutaminase AntibodiesTitanium – 24hr UrineTitanium – Hip FluidTitanium – Random UrineTitanium – SerumTitanium – TissueTitanium Orthopedic Blood – Whole BloodTobramycin Antibiotic levelTotal human Chorionic Gonadotrophin (hCG)ToxoplasmaTransferrinTransferrin Glycoforms (Paediatrics)Transferrin Saturation (%)TrichomonasTriglyceridesTrimethylamine (TMA)Troponin I (ASPH and external referrals)Troponin I (FPH)Troponin I (RSCH)Troponin T (FPH)TryptaseTSH (Blood Spot)T-SpotTungsten – SerumUltrasensitive C-Reactive Protein (CRP)UrateUrate (urine)UreaUrea (urine)Urea, creatinine and Electrolytes (urine)Urinary Electrophoresis for Bence-Jones ProteinUrine – surgically obtainedUrine for MC&SUrine for Mycobacterial culture (TB)Urine HaemosiderinUrine Microalbumin:Creatinine Ratio (Albumin:Creatinine Ratio)UrobilinogenVacuolated LymphocytesValproate (sodium) (Epilim)Vanadium – Random UrineVanadium – SerumVanadium – TissueVancomycinVanillylmandelic acid (VMA, HMMA)Very Long Chain Fatty AcidsVigabatrinViral Haemorrhagic FeverVitamin AVitamin B1 (Thiamine)Vitamin B12 LevelVitamin B2 (Riboflavin)Vitamin B6 (Pyridoxal phosphate)Vitamin C (Ascorbic acid)Vitamin D (25-Hydroxyvitamin D)Vitamin E (vitamin E:cholesterol ratio)Voltage-Gated Calcium Channel AntibodiesVoltage-Gated Potassium Channel (VGKC) Complex AntibodiesVon Willibrand FactorVZIgGWhite Cell Enzymes (Lysosomal Enzymes)Whooping CoughWorms for IdentificationWound CultureY MicrodeletionsZinc – 24hr UrineZinc – Random UrineZinc – SerumZinc – TissueZinc – Water

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Recommendation and review posted by Guinevere Smith

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