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Regenerative Medicine New York | Stem Cell Therapy

Posted: October 11, 2018 at 7:46 pm

Stem cell therapy is a form of regenerative medicine that utilizes the bodys natural healing mechanism to treat various conditions.

Stem cells are being used in regenerative medicine to renew and repair diseased or damaged tissues, and have shown promising results in treatments of various orthopedic, cardiovascular, neuromuscular and autoimmune conditions.

Stem cells are present in all of us acting like a repair system for the body. However, with increased age sometimes the optimum amounts of stem cells are not delivered to the injured area. The goal of stem cell therapy is to amplify the natural repair system of the patients body.

There are two major types of stem cells embryonic stem cells and adult stem cells. Embryonic stem cells (ESCs) are stem cells derived from human embryos. They are pluripotent, which means they have the ability to develop into almost any of the various cell types of the body.

As the embryo develops and forms a baby, stem cells are distributed throughout the body where they reside in specific pockets of each tissue, such as the bone marrow and blood. As we age, these cells function to renew old and worn out tissue cells. These are called adult stem cells or somatic stem cells. Like embryonic stem cells, adult stem cells can also replicate into more than one cell type, but their replication is restricted to a limited number of cell types.

The unique self-regeneration and differentiating ability of embryonic stem cells can be used in regenerative medicine. These stem cells can be derived from eggs collected during IVF procedures with informed consent from the patient. However, many questions have been raised on the ethics of destroying a potential human life for the treatment of another.

Adult stem cells are most commonly obtained from the bone marrow, specifically the mesenchymal stem cells, which have the ability to replicate into cells that form the musculoskeletal system such as tendons, ligaments, and articular cartilage. They can be obtained from the iliac crest of the pelvic bone by inserting a needle and extracting the stem cells from the bone marrow.

Currently, stem cell therapy is used to treat various degenerative conditions of the shoulder, knees, hips, and spine. They are also being used in the treatment of various soft tissue (muscle, ligaments and tendons) as well as bone-related injuries.

You may be a good candidate for stem cell therapy if you have been suffering from joint pain and want to improve your quality of life while avoiding complications related to invasive surgical procedures.

The procedure begins with your doctor extracting stem cells from your own bone marrow. Bone marrow is usually aspirated from your hip region. Your doctor will first clean and numb your hip area. A needle is then introduced into an area of your pelvic bone known as the iliac crest. Bone marrow is then aspirated using a special syringe and the sample obtained is sent to the laboratory. In the laboratory, the aspirate is spun in a machine for 10 to 15 minutes and a concentrated stem cell sample is separated.

Your doctor then cleans and numbs your affected area to be treated and then, under the guidance of special x-rays, injects the stem cells into the diseased region. The whole procedure usually takes less than one hour and you may return home on the same day of the procedure.

The disadvantage of adult stem cell therapy is lack of data about its long-term effects as it is a newer evolving therapy.

Stem cell therapy is generally considered a safe procedure with minimal complications, however, as with any medical procedure, complications can occur.

Some risks factors related to stem cell therapy include infection as the stem cells may become contaminated with bacteria, viruses or other pathogens that may cause disease during the preparation process.

The procedure to either remove or inject the cells also has the risk of introducing an infection to the damaged tissue into which they are injected. Rarely, an immune reaction may occur from injected stem cells.

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Regenerative Medicine New York | Stem Cell Therapy

Recommendation and review posted by G. Smith

Regenerative Medicine – DMOS – Des Moines Orthopedic Centers

Posted: October 11, 2018 at 7:46 pm

What regenerative medicine options do you offer?

DMOS offers three types of regenerative medicine options, all commonly used to treat different musculoskeletal conditions, including arthritis, muscle strains, tendon and ligament injuries.

The injection type differs based on the patient assessment and their individualized needs.

By definition, PRP is a collection of growth factors (which are proteins that are important in the healing of injuries), that can have controlled levels of white and red blood cells, based on the healing process necessary. Laboratory studies have shown that the increased concentration of growth factors in PRP can potentially speed up the healing process. Many world-class athletes use PRP therapy to repair their sports injuries faster.

Technically, BMAC is a collection of growth factors and cells, which include stem cells. Physicians use BMAC when they believe the potential upside of containing mesenchymal stem cells (MSCs) is necessary for treatment.

This injection serves to help as a local anti-inflammatory and reset the bodys natural balance in the arthritic joint. In technical terms, APS is a denatured PRP that delivers proteins, which block arthritic pain receptors. APS may be the preferred course of treatment based on if the patient exhibits radiographic evidence of knee, hip or shoulder OA (osteoarthritis).

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Regenerative Medicine - DMOS - Des Moines Orthopedic Centers

Recommendation and review posted by G. Smith

Syracuse Regenerative Medicine –

Posted: October 11, 2018 at 7:46 pm

Regenerative injection therapy for tendons, ligaments, muscles and spine conditions.

About Regenerative Injection Therapies (RIT).

Regenerative injections broadly deals with the use of biologic materials to enhance the body's own repair mechanisms to help heal previously non-reparable tissues. The goal of these non-surgical procedures is to help heal the source of pain, not to simply mask it. The exact mechanism is evolving, but science points toward enhancing and stimulating healing and stabilizing factors of the local tissues.

Regenerative injection treatments offer a viable alternative for individuals considering elective orthopedic surgery or joint replacement due to arthritis or injury. Patients experience very little down time and they typically avoid the long, painful rehabilitation periods that can follow surgery. Since 2014, Regenerative Spine & Musculoskeletal Medicine has provided state of the art regenerative cellular therapies to help patients find relief from pain without invasive surgeries.

The Procedures:


This treatment involves injecting a proliferant (usually dextrose) into weakened or injured joints, ligaments, or tendons. With a precise injection of a mild irritant solution directly on the site of injury, prolotherapy creates a mild, controlled inflammation that stimulates the bodys natural healing mechanism to lay down new tissue on the weakened area. Additional treatments repeat the process, allowing a gradual build-up of tissue to help restore strength to the area and relieve pain. Injection sessions are done 3-6 weeks apart, and usually a series of 3 injection sessions is done and then the response is assessed. The average number of treatment sessions is between 3 and 6.

Perineural Injections:

Peri-neural injections involves injecting diluted dextrose solutions superficially along the pathway of chronically inflamed nerves. They can be used for any part of the body where nerve pain exists. After the first treatment, pain relief may initially last for a period of four hours to four days. Repeated treatments (usually 6-8 sessions) are necessary, given every 1-3 weeks.

Platelet Rich Plasma Therapy (PRP):

During PRP therapy, a small vial of your own blood is drawn and placed in a centrifuge to separate the platelet-rich plasma from other blood components. This highly concentrated platelet-rich layer contains growth factors and a variety of cells. Growth factors stimulate local cells for tissue repair and remodeling. Your PRP is injected into and around the area of injury. Several injections may be done at the injured site at one time to fully treat the area. Many times only one injection is needed. If there is an incomplete response to treatment additional injections may be advised.

Cell Therapy:

Stem cells(MSCs) are readily available and can be harvested from your bone marrow through a needle. Once injected into an area of injury, MSCs secrete bioactive molecules to modulate repair and offer the potential to regenerate injured cartilage, ligament, tendons, or muscle. MSCs can be thought of as the manager of your bodys innate healing potential. Many times only one injection is needed. If there is an incomplete response to treatment additional injections may be advised.

Lipoaspirate (Fat) Graft:

Lipo aspirate therapy is a gentle process that uses your body's own fat tissue to cushion and support areas of injury or damage as your body heals itself. The fat is taken from the stomach, flank or thigh areas using a local anesthetic. It is especially effective for areas where there are soft tissue defects such as tears or arthritis. This type of injection is used in collaboration with PRP or bone marrow aspirate cell injections, which deliver growth factors to the injured area.

Alpha 2 Macroglobulin (A2M):

A2M is a naturally occurring molecule found in your blood that acts as a powerful protector against cartilage breakdown and progression of arthritis. A small vial of your own blood is drawn and placed in a centrifuge to separate the blood components, then is injected. A2M attaches to and removes the destructive enzymes that damage cartilage cells in the joint. The A2M is soothing to the joint and acts like a natural anti-inflammatory.

What parts of the body can benefit from regenerative treatments?

Spinal Injections:

Spinal procedures can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids. Epidural nerve blocks, spine ligaments, facet joint, sacroiliac joint and intervertebral disc injections with platelets/growth factors may be performed. The injection is performed in the same manner as conventional spine injections with the use of x-ray guidance to ensure accurate placement of the treatment.

Joint, tendon, ligament, muscle Injections:

Musculoskeletal injections can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids. Whenever appropriate the injection is performed with the use of x-ray or ultrasound guidance along with full safety and sterile precautions.

What conditions can benefit from regenerative injections?

Will insurance cover my Regenerative Injection?

Insurance companies will not pay for the cost of the Regenerative treatment. The cost of your injection can be discussed after your visit once you and the provider have decided on the most appropriate treatment option for you.

What sets Regenerative Spine & Musculoskeletal Medicine apart from others?

As the popularity of RIT grows, other medical professionals are beginning to perform these procedures, with great variation in training and background. Rene S. Melfi, M.D. is a physician specializing in non-surgical spine, orthopedic and musculoskeletal performance and function. With three national board certifications and Fellowship training in interventional spine and musculoskeletal medicine, Dr. Melfi has been performing spine and orthopedic injections since 2002. Dr. Melfi is also certified in Integrative Medicine and Acupuncture, and offers suggestions to enhance your results with recommendations for proper nutrition and supplements.

Your procedure at Regenerative Spine & Musculoskeletal Medicine is carefully chosen based on review of the latest evidence based medicine. Image guidance with x-ray or ultrasound is used, when appropriate, to confirm accurate placement of cellular therapy to optimize your results.

Call today for your appointment and a premier experience in Regenerative Injection therapy in Central New York 315-701-4000.

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Syracuse Regenerative Medicine -

Recommendation and review posted by G. Smith

The McGowan Institute for Regenerative Medicine | UPMC

Posted: October 11, 2018 at 7:46 pm

Merging Science with Technology to Treat Disease

Regenerative medicine uses clinical procedures to repair or replace damaged or diseased tissues and organs, versus some traditional therapies that just treat symptoms.

To realize the vast potential of tissue engineering and other techniques aimed at repairing damaged or diseased tissues and organs, the University of Pittsburgh School of Medicine and UPMCestablished the McGowan Institute for Regenerative Medicine. The McGowan Institute serves as a single base of operations for the Universitys leading scientists and clinical faculty working to develop tissue engineering, cellular therapies, and artificial and biohybrid organ devices.

The McGowan Institute is the most ambitious regenerative program in the nation, coupling biology, clinical science, and engineering. Success in our mission will impact patients lives, bring economic benefit, serve to train the next generation of researchers, and advance the expertise of our faculty in the basic sciences, engineering, and clinical sciences. Our efforts proudly build upon the pioneering achievements of the Thomas E. Starzl Transplantation Institute.

While there are certain select therapies based on regenerative medicine principles now in clinical use, much work lies ahead to realize the potential of this growing field. Advances in the underlying science, engineering strategies to harness this science, and successful commercial activities are all required to bring new therapies to patients.

The McGowan Institute sponsors a podcast series on regenerative medicine. Listen to some of the world's leading regenerative medicine researchers and physicians talk about their work.

Listen to the most recent podcasts.

Dr. Steven Little Receives International Young Investigator Award for Development of Novel Drug Delivery Systems

The Controlled Release Society has announced that McGowan Institute for Regenerative Medicine faculty member and University of Pittsburgh professor Steven Little, PhD, is the recipient of its 2018 Young Investigator Award. The honor annually recognizes one individual in the world, 40 years of age or younger, for outstanding contributions in the science of controlled release.

Learn more.

Dr. Stephen Badylak at the World Advanced Therapies & Regenerative Medicine Congress

Learn more.

From Technology Developed at the McGowan Institute, LyGenesis Closes $3 Million Series A Financing to Advance Its Organ Regeneration Technology to the Clinic

Learn more.

Living Donor Liver Transplant: A Lifesaving Option for All Patients with Liver Failure

Learn more.

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The McGowan Institute for Regenerative Medicine | UPMC

Recommendation and review posted by G. Smith

Regenerative Medicine Florida Musculoskeletal Institute

Posted: October 11, 2018 at 7:46 pm

Stem Cell Injections

The use of amniotic fluid and stem cells in medicine is much older and more widespread than people might think. It has been used to diagnose prenatal conditions for more than 70 years, and to treat injury, pain and scarring for nearly a century. What makes this therapy so exciting is the wealth of research and real-life application that supports its usefulness in not only relieving pain and assisting healing, but also in regenerating damaged soft tissues, including ligaments, tendons and cartilage. What this means to patients is the genuine possibility of healing injured tissues, making amniotic fluid/stem cell injection a revolutionary approach to managing, and even healing, ligament damage, tendonitis and osteoarthritis.

FMI utilizes NuCel bioactive amniotic suspension (HCT/P) to treat and repair soft tissue and to assist in certain types of orthopaedic surgery. NuCels more than 17,000 applications have proven it safe and effective at reducing pain, inflammation and scarring, and assisting in healing.

NuCel is derived from amniotic membranes from consenting donors, not from fetal tissue. NuCel contains concentrated multipotential stem cells, which are cells with the ability to make more of themselves, and growth factors, which are the naturally-occurring agents that can stimulate cell migration to injury sites to actively repair tissues. These agents are combined with all-natural hyaluronic acid and proteins to assist in delivery and support healing and healthy cell regeneration. NuCel is fully regulated by the FDA and has been used in thousands of patients without a single reported rejection, allergic response or other adverse reaction.

NuCel is not presently covered by insurance, which may cause some patients to be concerned about cost. But because NuCel has the potential to actually heal injuries and pain conditions, it can delay and even prevent the need for surgery, making it a preferred option for some patients.

FMIs Dr. Carl Ollivierre is not only a provider of NuCel, but also a patient who has successfully used it to treat his own posterior tibial tendinitis. Dr. Ollivierre provides NuCel injections at both FMI locations.

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Regenerative Medicine Florida Musculoskeletal Institute

Recommendation and review posted by G. Smith

RMI | National Institutes of Health (NIH)

Posted: October 11, 2018 at 7:46 pm


Regenerative medicine is an emerging area of science that holds great promise for treating and even curing a variety of injuries and diseases. Regenerative medicine includes using stem cells and other technologiessuch as engineered biomaterials and gene editingto repair or replace damaged cells, tissues, or organs. Stem cell-based approaches are under development in labs around the world, and some have already moved into clinical trials. Such progress notwithstanding, much work remains to be done toward the development of safe and effective regenerative medicine products and to realize the full potential of this field.

The 21st Century Cures Act, passed in December 2016, established the Regenerative Medicine Innovation Project (RMIP) to accelerate the field by supporting clinical research on adult stem cells while promoting the highest standards for carrying out scientific research and protecting patient safety. In recognition of the integral role of the Food and Drug Administration (FDA) in the successful development of this field, NIH is leading the RMIP in coordination with FDA.

The 21st Century Cures Act authorizes $30 million in federal awards over four years (20172020) for the RMIP. Importantly, the Act requires award recipients to match the federal funds provided with at least an equal amount of non-federal funds.This matching requirement will amplify the federal investment and could help stimulate collaboration and develop key partnerships across the public and private sectors.

Congress allocated $2 million for the RMIP in FY 2017. To make optimal use of these funds, researchers were invited to submit applications for competitive revisions to support clinical studies involving adult stem cells. Eight awards were issued in September 2017.

On December 6-7, 2017, the NIH and FDA hosted a public Regenerative Medicine Innovation Workshop that brought together key stakeholders to explore the state of regenerative medicine clinical research involving adult stem cells with a focus on approaches to the development of safe and effective products. Video recordings from each session are available. The deliberations at this workshop were instrumental in helping to identify some of the major needs, opportunities, and challenges in the regenerative medicine field.

Input from the workshop and other sources informed the development of the next round of funding opportunity announcements (FOAs) published in August 2018. These FOAs solicit new investigator-initiated projects, which may either involve a clinical trial or entail late stage Investigational New Drug (IND)- or Investigational Device Exemption (IDE)-enabling clinical research. Applicants who have questions about these opportunities may consult our Frequently Asked Questions, and those with additional questions are encouraged to either consult the relevant program officer listed in the FOA, or write to [email protected].

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RMI | National Institutes of Health (NIH)

Recommendation and review posted by G. Smith

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