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Bridging The Public Knowledge Gap Around Cell And Gene …

Posted: February 16, 2019 at 10:43 am

By Morrie Ruffin, ARM Foundation for Cell and Gene Medicine

Cell and gene therapies hold the potential to transform medicine; however, if patients are to gain access to these therapies, we must increase public awareness and understanding of how these therapies can benefit them. According to a review of recent research studies that measured U.S. public opinion related to gene medicine,1 the public is not yet aware of gene medicine; is unfamiliar with the terms being used to describe the topic; and, when faced with multiple therapeutic options, is worried about making informed decisions.

The knowledge gap that exists around cell and gene medicine could delay achievement of our shared goal of accelerating the development of potentially curative therapies for a host of life-threatening diseases. One of the top priorities of the ARM Foundation for Cell and Gene Medicine is to increase public awareness and understanding of cell and gene medicine through education projects that highlight the clinical and societal benefits of gene medicine and the life-saving possibilities that these medical advances could bring.

Fearing Unknowns

In April 2016, the New England Journal of Medicine published an analysis of 17 public opinion polls. More than half of those surveyed said they had heard either a little (48 percent) or a lot (9 percent) about gene editing before participating in the survey; 42 percent said they had not heard about gene editing.2 A 2017 Science magazine article concluded there is a broad mandate for public engagement.3 Preliminary research conducted on behalf of the ARM Foundation for Cell and Gene Medicine indicates individuals do not yet see anything fundamentally wrong with gene medicine but are hesitant about its unknowns. People also tell us they are more likely to trust information about gene medicine from a nonprofit organization than the government or pharmaceutical or biotechnology companies.

These findings also mirror a 2014 study, published in Human Gene Therapy, which found that more than 50 percent of respondents said their number one concern was not receiving all the information. According to its authors, delivering effective, evidence-based communications on gene therapy, engaging the research and medical communities as well as the public in a conversation about the ethics of gene therapy, is a priority.4

Call For Clarity

According to our interviewers, research interviewees admit they are confused when people talk about gene therapy. Most struggle to understand the differences in terms, such as somatic and germline gene editing, and concede that a better understanding may affect their opinions of gene medicine. They indicate they would appreciate more information on how gene therapy may be used. One major opportunity for education is information and data suggesting that gene medicine may help treat nonheritable diseases and conditions.

The risk of public misperception is, of course, significant. Gene medicine is advancing at an unprecedented pace with the potential to benefit millions of patients and even the potential to ease the burden of incurable diseases. Public engagement and education, research transparency, and independent level setting based on the facts can help smooth the path to societal acceptance of gene medicine as a viable, nonthreatening treatment option. As we have learned from the research published in Science and other journals as well as our interview-based research, participants who can answer factual questions about gene editing and CRISPR are more in favor of gene therapy.

Moving Gene Medicine Into The Mainstream

The foundation recently launched a strategic communications program designed to generate awareness and support of gene medicine.

The program will inform the public of:

We believe the research is urging us to develop jargon-free content thats easy to access and includes compelling, clear illustrations that summarize the science.

The foundation will support the industry with:

How Gene Therapy Leaders Can Become Involved

Industry and other relevant organizations are invited to become a part of this important education program.

The foundation seeks volunteers to:

The foundation serves as the educational and information catalyst on issues fundamental to making gene and cell therapies, tissue-engineered products, and other regenerative medicine treatments available to patients. By examining, quantifying, clarifying, and informing stakeholders of the clinical and societal benefits of these therapies, as well as convening discussions to raise awareness about the sectors progress and challenges, we can accelerate patient access to safe, efficacious, and potentially curative therapies.

Visit thearmfoundation.org or contact [email protected] for more information.

References:

About The Author:

Morrie Ruffin is co-founder of the Alliance for Regenerative Medicine (ARM) and co-founder, board member and executive director of its 501c3 affiliate, the ARM Foundation for Cell and Gene Medicine. Ruffin is also co-founder and managing partner of Adjuvant Partners, a business development and strategic advisory firm. He has held executive and business development positions at various organizations, including what is now the Biotechnology Innovation Organization (BIO). Earlier, Ruffin worked as a senior legislative assistant for a U.S. senator. He received his MA in international studies and economics from the Johns Hopkins School for Advanced International Studies and his BA from the University of Virginia.

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