Although common, male baldness can have negative psychological effects and some studies have even linked it to a handful of serious illnesses. New research identifies the genetic variants involved in the condition, which could eventually enable researchers to predict a person’s chances of hair loss.
Male baldness – also referred to as androgenetic alopecia or male pattern baldness (MPB) – affects a significant number of people in the United States, as the condition accounts for over 95 percent of all hair loss in men.
According to the American Hair Loss Association, two thirds of U.S. adults will be affected by MPB to a certain degree by the age of 35, and around 85 percent of men will have experienced significant hair loss by the age of 50.
A lot of these men are seriously affected by the condition, which can have a negative effect on a person’s self-image, as well as on their interpersonal relationships.
Additionally, some genetic studies have even associated MPB with negative clinical outcomes such as prostate cancer and cardiovascular disease.
A new study – led by Saskia Hagenaars and David Hill of the University of Edinburgh in the United Kingdom – explores the genetic basis for the condition. The findings were published in the journal PLOS Genetics.
Scientists analyzed the genomic and health data of more than 52,000 men enrolled in the UK Biobank – an international health resource offering health information on more than 500,000 individuals.
The team located more than 250 independent genetic regions linked to severe hair loss.
The researchers split the 52,000 participants into two groups: a so-called discovery sample of 40,000 people and a target sample of 12,000 individuals. Based on the genetic variants that separated those with no hair loss from those with severe hair loss, the team designed an algorithm aimed to predict who would develop MPB.
The algorithmic baldness predictor is based on a genetic score, and although accurate predictions are still a long way off, the results of this study might soon enable researchers to identify subgroups of the population that are particularly prone to hair loss.
In the present study, researchers found that 14 percent of the participants with a submedian genetic score had severe MPB, and 39 percent had no hair loss. By contrast, 58 percent of those scoring in the top 10 percent on the polygenic score had moderate to severe MPB.
Co-lead author Saskia Hagenaars – a Ph.D. student at the University of Edinburgh’s Centre for Cognitive Aging and Cognitive Epidemiology – comments on the findings:
“We identified hundreds of new genetic signals,” Hagenaars says. “It was interesting to find that many of the genetics signals for male pattern baldness came from the X chromosome, which men inherit from their mothers.”
The study’s other lead author, Dr. David Hill, notes that the study did not collect data on the age of baldness onset, but only on hair loss pattern. However, he adds that, “we would expect to see an even stronger genetic signal if we were able to identify those with early-onset hair loss.”
To the authors’ knowledge, this is the largest genetic study of MPB to date.
The study’s principal investigator, Dr. Riccardo Marioni, from the University of Edinburgh’s Centre for Genomic and Experimental Medicine, explains the significance of the findings:
“We are still a long way from making an accurate prediction for an individual’s hair loss pattern. However, these results take us one step closer. The findings pave the way for an improved understanding of the genetic causes of hair loss.”
Learn how a drug promises robust new hair growth.
See the article here:
Genetic basis for male baldness identified in large-scale study – Medical News Today
- Genetic Carrier Screening - Hopkins Medicine - March 21st, 2017
- Tame the hype: Is medical genetics plagued by unfilled promises? - Genetic Literacy Project - March 21st, 2017
- Intraday Movers: Myriad Genetics, Inc. (NASDAQ:MYGN) , ICU Medical, Inc. (NASDAQ:ICUI) - NYSE Journal (press release) - March 21st, 2017
- Aevi shares smashed by a trial failure for ADHD genetic subgroup - Endpoints News - March 21st, 2017
- School of Medicine - U of U School of Medicine ... - March 15th, 2017
- Enabling Personlized Medicine for Minority Populations - Technology Networks - March 15th, 2017
- Nobody's business'? 5 Things to Know About Genetic Testing Bill - NBCNews.com - March 15th, 2017
- One in five breast cancer patients could benefit from existing treatment, genetic study reveals - Medical Xpress - March 15th, 2017
- Risk for Anorexia Could Be Genetic: Study - NBC Southern California - March 15th, 2017
- Genes Plus Erratic Sleep May Raise Odds for Obesity - Montana Standard - March 12th, 2017
- The House Bill That Could Sideline Medical Research And Digital Health - Huffington Post - March 12th, 2017
- Bilateral tinnitus is hereditary - Science Daily - March 10th, 2017
- Finding Medicine To Fit Your Genes - Huffington Post - March 10th, 2017
- UAB to Launch Statewide Genetics Initiative for Better Health for All Alabama Residents - Newswise (press release) - March 10th, 2017
- Wilson-Raybould wants Supreme Court advice on genetic non-discrimination bill - Medicine Hat News - March 10th, 2017
- Neanderthal teeth tell tales of diet and medicine - Ars Technica - March 8th, 2017
- Lifestyle choices condition colon and rectal cancer risk more than genetics - Medical Xpress - March 8th, 2017
- Genetic Testing Abused by Patient with Factitious Disorder - Monthly Prescribing Reference (registration) - March 8th, 2017
- Will Sickle Cell Be the Next Disease Genetic Engineering Cures? - Gizmodo - March 3rd, 2017
- UC Merced professor finds genetic triggers related to cancer - Merced Sun-Star - March 3rd, 2017
- Protecting Patients from Genetic Discrimination - The Scientist - March 2nd, 2017
- Awards and Honors Across Weill Cornell Medicine - Cornell Chronicle - March 2nd, 2017
- For precision medicine to work, physicians must incorporate holistic health factors, like belief - Genetic Literacy Project - March 2nd, 2017
- Awards and Honors Across Weill Cornell Medicine | Newsroom ... - Cornell Chronicle - March 2nd, 2017
- This well-known health-tech company has a new name - Nashville Business Journal - March 2nd, 2017
- Justice minister seeks input from premiers on genetic discrimination bill - Medicine Hat News - March 2nd, 2017
- WCM-Q study throws light on genetic medical research - Gulf Times - Gulf Times - February 28th, 2017
- Rare but fatal pediatric brain tumor may be stopped with new molecule - Medical News Today - February 28th, 2017
- It's easy money: Lab offers doctors up to $144000 a year to push dubious genetic tests, employees say - STAT - February 28th, 2017
- Discovery of genetic mutation may boost cancer therapies - Medical Xpress - February 27th, 2017
- WCM-Q study pushes the boundaries of genetic medical research - Al-Bawaba - February 27th, 2017
- BI announces COPD collaboration with Weill Cornell Medicine - Danbury News Times - February 26th, 2017
- Scientists find a striking number of genetic changes can occur early ... - Medical Xpress - February 26th, 2017
- Soon, Medication Will be Custom Tailored to Your Specific Genetics - Futurism - February 26th, 2017
- Clues to relationship between schizophrenia and rheumatoid arthritis - Science Daily - February 26th, 2017
- Personalized medicine may do more to treat rather than prevent chronic diseases - Medical Xpress - February 17th, 2017
- AP, HHMI collaborate on expanded science, health coverage - New Jersey Herald - February 17th, 2017
- Genetic predictors could improve PSA accuracy - ModernMedicine - February 17th, 2017
- Boehringer Ingelheim And Weill Cornell Medicine Announce New ... - Clinical Leader - February 17th, 2017
- Toxicology Conferences 2017 | Pharmacology Conferences ... - January 23rd, 2017
- Genetic code - Wikipedia - December 25th, 2016
- Center for Genetic Medicine Research - Choose Children's - December 6th, 2016
- Master of Science in Genetic Counseling | Icahn School of ... - November 30th, 2016
- Genetic Medicine - November 12th, 2016
- Medical genetics - Wikipedia - October 27th, 2016
- BRCA1 and BRCA2: Cancer Risk and Genetic Testing Fact ... - October 4th, 2016
- What is Genomic Medicine? - Genome.gov - September 8th, 2016
- preimplantation genetic diagnosis - Penn Medicine - July 8th, 2016
- Genomic Medicine - Genome.gov - July 8th, 2016
- Department of Genetic Medicine (Research) | Medicine ... - July 8th, 2016
- USC Institute for Genetic Medicine - July 8th, 2016
- Department of Genetic Medicine - Weill Cornell Medical College - July 8th, 2016
- National Human Genome Research Institute (NHGRI) - Homepage - July 8th, 2016
- Genetics - Wikipedia, the free encyclopedia - July 8th, 2016
- 23andMe - DNA Genetic Testing & Analysis - July 8th, 2016
- Graduate Program in Genetic Counseling : Center for ... - October 5th, 2015
- Genetic Counseling Program - University of South Carolina ... - September 25th, 2015
- Genetic Medicine : Division Home | Department of Medicine - September 17th, 2015
- Genome Medicine - September 6th, 2015
- NIH Clinical Center: Graduate Medical Education (GME ... - August 22nd, 2015
- Genetics & Medicine - National Center for Biotechnology ... - August 14th, 2015
- Medical genetics of Jews - Wikipedia, the free encyclopedia - August 14th, 2015
- Genetic testing - Wikipedia, the free encyclopedia - August 4th, 2015
- Medical genetics - Wikipedia, the free encyclopedia - August 1st, 2015
- Genetic Medicine - The University of Chicago Department of ... - August 1st, 2015
- Genetic Disease: Get the Definition of These Disorders - July 31st, 2015
- Home | HMS Department of Genetics - July 15th, 2015
- Medical Genetics at University of Washington - July 6th, 2015
- Genetics in Medicine - July 2nd, 2015
- Genetic Medicine | Department of Pediatrics | University ... - July 2nd, 2015
- Genetics and Genetic Testing - KidsHealth - May 28th, 2015
- Genetic engineering - Wikipedia, the free encyclopedia - May 20th, 2015
- Genetic Testing Clinical Reference For Clinicians ... - May 20th, 2015
- Kids Health - Down Syndrome - May 20th, 2015
- [email protected] Institute for Genetic Medicine Art Gallery - Video - March 28th, 2015
- Precision Medicine: How our Genes Can Help Determine Our Risk and Treatment for Disease - Video - February 21st, 2015
- 2014 NCAS Philip J. Klass Award Presentation to Steven Salzberg - Video - December 12th, 2014
- The Future of Genetic Medicine - Maureen Turner - Video - December 11th, 2014
- The Microbiome: A New Frontier in Human Health - Video - December 4th, 2014
- Translating genetic advances into day to day clinical practice - Video - August 5th, 2014
Recommendation and review posted by Guinevere Smith