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Clinical Trials | Genetic Medicine

Posted: June 15, 2018 at 8:48 am

COPD RESEARCH STUDY

Biology of the Oral Epithelium of Electronic Cigarette Smokers

Little is known about the oral health risks of smoking electronic cigarettes, an increasingly popular form of inhaled alternative tobacco products. Based on the knowledge that adverse effects are observed at the biologic level long before clinical abnormalities manifest, we propose to evaluate the oral epithelium of chronic e-cigarette smokers and those who have never smoked. This study involves a telephone questionnaire, a screeningvisit and a study visit.

Primary Investigator: Ronald G. Crystal, M.D.

Sponsor: National Institutes of Health (NIH), Weill Cornell Medicine

Study Type: Study Type

Phase I Randomized, Double-Blind, Placebo Control Study for an Anti-Cocaine Vaccine

This dose-ranging, placebo-controlled, double-blind study assesses the safety and preliminary efficacy of an anti-cocaine vaccine called dAd5GNE, designed to prevent cocaine from reaching the brain. The study will take place over a period of 32 weeks from the time of vaccine administration. The subject will be randomly assigned to receive either the active dAd5GNE anti-cocaine study drug or placebo, and will receive a total of six doses. The first dose will be administered at week zero, and five boosters will be administered at four-week intervals, during weeks four, eight, 12, 16 and 20. Subjects will receive $25 per visit (up to $75 per week) for ~32 weeks, in order to compensate for travel (this is a total of ~$2,400 per subject over the course of the entire study).

Primary Investigator: Ronald G. Crystal, M.D.

Sponsor: National Institutes of Health (NIH)

Study Type: Study Type

Collection of Airway, Blood and/or Urine Specimens from Subjects for Research Studies

This clinical trial is a protocol to obtain blood, urine and/or airway specimens, from individuals with or without lung disorders, in order to carry out laboratory studies concerning genetic expression, gene transfer, infection, proteins and human genes, and to store specimens for future genetic studies. Specimens collected may include blood, urine and airway samples (nasal, airway brushing, biopsy, lavage and/or washings) from consenting subjects.

Primary Investigator: Ronald G. Crystal, M.D.

Sponsor: National Institutes of Health (NIH), Cystic Fibrosis Foundation, Boehringer Ingelheim and Weill Cornell Medicine

Study Type: Study Type

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Clinical Trials | Genetic Medicine

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