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Category Archives: Resveratrol
Published January 15 2018
According to the World Health Organization, the number of people with diabetes has risen from 108 million in 1980 to 422 million in 2014 (1). The disease especially has a high prevalence in the Western countries, and it has been linked extensively with heart attacks, strokes, high blood pressure, kidney failure, and blindness. For this reason, a lot of research has gone into the disease progression and treatment options available for diabetes. In this article Im going to discuss four different types of diabetes, along with some of the natural treatment options available. Then towards the end of this article Ill discuss how each type relates to thyroid health.
Before discussing the different types of diabetes, Id like to answer the question why is there an increased prevalence of diabetes? Although genetics is a factor in the development of the different types of diabetes, the main reason why there has been an increased prevalence is due to poor diet, along with other lifestyle factors. This is especially true with type 2 diabetes, but it is also a factor in the other types of diabetes as well.
Lets go ahead and look at the different types of diabetes:
Type 1 diabetes is an autoimmune condition that involves the immune system attacking the pancreas. Beta cells are destroyed in the pancreas, and these beta cells are responsible for the production of insulin. Insulin is involved in the regulation of blood glucose levels. Consequently, there isnt a way for glucose in the blood to enter the cells without insulin, resulting in high blood sugar. Adolescents typically develop this type, which is why type 1 diabetes once was referred to as juvenile diabetes. However, adults can also develop type 1 diabetes, although many times they actually have type 1.5 diabetes, which Ill discuss later in this article.
Potential Causes of Type 1 Diabetes
Just as is the case with other autoimmune conditions, genetics plays a role in the development of type 1 diabetes. Some children who are born with a particular genotype variation with a family history of the disease have a 1 in 5 chance of developing this condition (2). Interestingly, more than 85 percent of children who have type 1 diabetes dont have a family history (2). Just as is the case with Hashimotos thyroiditis and Graves disease, we can t change the genetics of those with type 1 diabetes, but we can modify diet and lifestyle factors, which can have a huge impact.
In the past I wrote a blog post where I discussed the triad of autoimmunity. This is also known as the 3-legged stool of autoimmunity, and according to this triad, the development of any autoimmune condition requires the following three components: 1) a genetic predisposition, 2) an environmental trigger, and 3) a leaky gut. And while the damage to the beta cells supposedly cant be reversed, in type 1 diabetes the goal still should be to find and remove the environmental triggers and heal the gut. This of course is true will all autoimmune conditions, including Graves disease and Hashimotos.
Diagnosis of Type 1 Diabetes
The diagnosis of type 1 diabetes is usually based on a persons symptoms and blood tests. Some of the common symptoms patients with type 1 diabetes experience include excessive thirst, hunger, blurry vision, lethargy, and weight loss. These symptoms occur because since insulin isnt available to shuttle glucose into cells, they are left without an immediate source of energy.
Laboratory tests involve testing fasting blood sugar, glycosylated hemoglobin (A1C), and an oral glucose tolerance test. Its also a good idea to test for fasting insulin. These tests will usually be conducted initially. C-peptide is a 31 amino acid peptide that can also provide some valuable information, and it is more reliable than insulin as a measure of endogenous insulin secretion (3). In type 1 diabetes we would expect the C-peptide levels to be low, while someone with type 2 diabetes will usually have normal or high levels of C-peptide.
As is the case with other autoimmune conditions, it is also possible to test for autoantibodies. These include antibodies to insulin (IAA), glutamic acid decarboxylase (GAD) and protein tyrosine phosphatase (IA2). These antibodies can be tested at most labs, including Labcorp and Quest Diagnostics.
Conventional Treatment Options For Type 1 Diabetes
Conventional treatment options usually involve providing dose-dependent amounts of insulin the patient has to take at regular intervals. Even though type 1 diabetes is an autoimmune condition, conventional medical treatment doesnt do anything to improve the health of the persons immune system.
Natural Treatment Options For Type 1 Diabetes
Although there is no cure for type 1 diabetes, the overall goal should be to improve the health of the persons immune system. This involves removing any environmental triggers and healing the gut. Even though the person with type 1 diabetes might need to take insulin, its important to keep in mind that someone with one autoimmune condition is more likely to develop other autoimmune conditions in the future. Improving the health of the persons immune system will decrease the chances of other autoimmune conditions developing in the future. In addition, it might slow down or prevent further damage to the beta cells of the pancreas, which means that the person wont need to take as high of a dosage of insulin.
Curcumin. This is a potent natural treatment option for type 1 diabetes. This is the compound that gives turmeric its orange-yellow color. One study showed that curcumin helps to reduce the release of proinflammatory cytokines and suppresses T cell activity (T cells aid in the destruction of insulin-producing beta cells) (4). Some patients with type 1 diabetes have also used curcumin supplements help control high blood sugar. Another study I came across showed that both curcumin and resveratrol can enhance the function of the pancreatic beta cells (5).
Gymnema sylvestre. This herb has been shown to cause insulin secretion from the beta cells, and might even help with beta cell regeneration (6) (7). This isnt to suggest that taking gymnema will reverse type 1 diabetes, but taking 500 to 1,000 mg/day might help with insulin secretion.
Type 2 diabetes doesnt involve an autoimmune component, although it does alter the way glucose is used in the body. This condition is characterized by either a lack of insulin, or the bodys inability to use insulin efficiently, the latter which causes a state known as insulin resistance. Either way, the person with type 2 diabetes will have high blood glucose levels. About 90 % of people who have diabetes have type 2 diabetes (8).
Although genetics can play a role in the development of type 2 diabetes, lifestyle and environment seem to be much greater factors. Obesity, weight gain, smoking, and physical inactivity are all risk factors (9).
Its also worth mentioning that pregnant women can develop gestational diabetes, which is the most common medical complication of pregnancy (10). Dietary changes and exercise usually are recommended initially, although oral hypoglycemic agents or insulin may be given if the blood sugar levels remain high. Gestational diabetes is similar to type 2 diabetes, but usually resolves itself after the woman gives birth. However, women who develop gestational diabetes are often at greater risk for developing diabetes later on.
Just as is the case with the other types of diabetes, the diagnosis of type 2 diabetes involves analyzing the patients symptoms and ordering specific tests. In the beginning stages the person might not experience any obvious symptoms, and so its commonly found during routine testing. For example, someone might obtain a fasting glucose as part of a routine physical, and upon seeing this value elevated the doctor orders additional tests, such as the hemoglobin A1C and the oral glucose tolerance tests. If the blood sugar levels remain continuously high then the person may experience symptoms such as excessive thirst, frequent urination, fatigue, nausea, and dizziness.
Conventional Treatment Options For Type 2 Diabetes
Depending on the severity of the patients condition, some medical doctors will initially recommend diet and lifestyle changes without giving medication. Speaking of medication, metformin is an anti-hyperglycemic drug, and it usually is the first line of therapy recommended to those who have type 2 diabetes. The main way it helps those with type 2 diabetes is by greatly decreasing glucose production in the liver (11). There is also evidence that metformin can help to restore ovarian function in PCOS, reduce fatty liver, and to lower microvascular and macrovascular complications associated with type 2 diabetes (11). However, there is evidence that long-term use of metformin can cause a vitamin B12 deficiency and anemia (12).
In some severe cases of type 2 diabetes the person may need to take insulin. But usually this is a last resort, and many people do fine taking metformin. Of course the overall goal should be to improve the health of the individual so that they hopefully wont need to take metformin or insulin, at least not for a prolonged period of time.
Natural Treatment Options For Type 2 Diabetes
Eating well and exercising regularly can help with many different health conditions, and without question this includes type 2 diabetes. With regards to diet, eating a standard Paleo or autoimmune Paleo diet can help, although some healthcare professionals recommend a ketogenic diet for type 2 diabetes. This involves a diet that is high in fat and low in carbohydrates, and the body converts the fat into energy instead of the carbohydrates.
Ketosis vs. Ketoacidosis
When talking about a ketogenic diet, some people get concerned about diabetic ketoacidosis. This is a serious complication of diabetes, and it occurs when there are very high levels of ketones in the body. This is more common in those people with type 1 diabetes, although it can also affect those with type 2 diabetes who dont properly manage their health. Ketoacidosis happens when your body is unable to produce enough insulin, and some of the symptoms include frequent urination, excessive thirst, nausea and vomiting, abdominal pain, weakness or fatigue, and/or shortness of breath (13). In addition, the person will usually have high blood sugar levels and high ketone levels in the urine.
How does this differ from ketosis? Ketosis is considered to be a mild form of ketoacidosis. When someone is eating a lower amount of carbohydrates and is eating a good amount of healthy fats (i.e. avocados, coconut oil, fatty fish) their body will create ketones. With the ketogenic diet the body is essentially using fat for energy instead of glucose.
Berberine. I mentioned how metformin is the most common conventional medical treatment for type 2 diabetes. For those who are looking for a natural option, berberine is something to consider taking. Berberine is an isoquinoline derivative alkaloid isolated from the herb Rhizoma Coptidis, and it has anti-hyperglycemic properties (14). Not only is berberine a potent oral hypoglycemic agent, but it also has beneficial effects on lipid metabolism (15). In other words, berberine not only can help to lower fasting glucose and hemoglobin A1C levels, but can also help lower total cholesterol and LDL.
Chromium. A few studies have shown that chromium can benefit those with type 2 diabetes by helping with glycemic control and increasing insulin sensitivity (16) (17) (18).
Magnesium. Intracellular magnesium plays a key role in regulating insulin action, and oral magnesium supplementation can have beneficial effects on blood glucose levels (19) (20).
Fish oils. Fish oil supplementation is a natural treatment option for patients with type 2 diabetes. One study has shown that the omega-3 fatty acids in fish oil can help improve insulin sensitivity (21).
Cinnamon. Research has demonstrated that patients taking oral cinnamon daily reduced their blood glucose and triglyceride levels (22). As for conventional treatment, patients are often started off with metformin, which increases insulin sensitivity.
Exercise. While eating well and taking nutritional supplements can decrease insulin resistance associated with type 2 diabetes, studies also show that exercise can help to increase insulin sensitivity (23) (24).
Type 1.5 diabetes, also known as latent autoimmune diabetes of adulthood (LADA), has characteristics of both type 1 and type 2 diabetes. It is similar to type 2 diabetes in that 1) it is diagnosed during adulthood, and 2) has a slow onset. However, it is similar to type 1 diabetes in that the person has autoantibodies that damage the beta cells of the pancreas, and as a result, insulin therapy will eventually be required. Type 1.5 diabetes accounts for 2%-12% of all cases of diabetes (25).
What frequently happens is that someone is mistakenly diagnosed as having type 2 diabetes, and as a result may be put on an oral hypoglycemic agent such as metformin. But while this can greatly help someone with type 2 diabetes, type 1.5 involves destruction to the beta cells of the pancreas, and so eventually the person will become insulin dependent.
Type 1.5 diabetes is often a result of genetic, environmental, and lifestyle factors.
In addition to screening the person for blood sugar imbalances (i.e. fasting glucose, hemoglobin A1C), autoantibody tests can be ordered. This includes antibodies to insulin, glutamic acid decarboxylase (GAD) and protein tyrosine phosphatase . The most common autoantibody present is GAD, and this usually results in a slower destruction of the beta cells than other types of antibodies.
LADA has also been sub-classified as type I and II. Patients with higher GAD antibody (GADA) levels are classified as LADA 1, and are more similar to type 1 diabetics, while patients with lower levels of GADA are classified as LAD2, and are more similar to type 2 diabetics (26).
C-peptide might also play a role in the early detection of those with type 1.5 diabetes. I mentioned C-peptide earlier, and discussed how it is usually low in type 1 diabetics, while in those with type 2 diabetes it is usually high or normal. It seems that those with type 1.5 diabetes have normal or decreased C-peptide levels, and so if someone has elevated levels of C-peptide this would rule out type 1.5 diabetes (27).
Conventional Treatment Options For Type 1.5 Diabetes
The treatment of patients with type 1.5 diabetes can be complex. Insulin therapy is typically used to help delay the onset of islet cell failure. Sometimes oral hypoglycemic agents (i.e. metformin) will also be administered. Just as is the case with type 1 diabetes, nothing is done to improve the health of the immune system from a conventional medical standpoint.
Natural Treatment Options For Type 1.5 Diabetes
As for natural treatment options, agents that can lower blood glucose levels and increase insulin sensitivity can be taken. I mentioned some of these earlier, including berberine, chromium, magnesium, and alpha lipoic acid. However, just as is the case with type 1 diabetes, with type 1.5 diabetes the autoimmune component also needs to be addressed. In other words, the environmental triggers need to be detected and removed, and the leaky gut needs to be healed.
Some researchers label Alzheimers disease as being a neuroendocrine disease, and the reason for this is because of the shared molecular and cellular features among type 1 and type 2 diabetes associated with memory deficits and cognitive decline in the elderly (28). As a result, many refer to Alzheimers as being type 3 diabetes.
Because glucose is the primary fuel for the brain, if someone has problems with the uptake and utilization of glucose, then this can essentially cause the brain to starve. This in turn can cause oxidative stress, impairments in homeostasis, and increased cell death (29). The inhibition of insulin/ insulin-like growth factor (IGF) signaling mediates Alzheimers disease neurodegeneration (29). In other words, chronic deficits in insulin can lead to the development of Alzheimers disease, which has characteristics of insulin deficiency that is associated with type 1 diabetes, as well as insulin resistance that is more characteristic of type 2 diabetes. Its also worth mentioning that amyloid beta protein deposits on the pancreas in patients with type 2 diabetes are similar to the protein deposits that occur in the brain in type 3 diabetes (30).
As mentioned previously, issues with insulin and IGF are contributors to type 3 diabetes progression. Although Alzheimers disease has characteristics of both type 1 and type 2 diabetes, the research shows that people who have type 2 diabetes are at increased risk for developing Alzheimers disease (30). In fact, those with type 2 diabetes have almost twice the risk of developing Alzheimers when compared to those who only have insulin resistance.
Conventional Treatment Options For Type 3 Diabetes
Although most medical doctors dont recognize Alzheimers disease itself as being a type of diabetes, keep in mind that many of these people will be diagnosed with type 2 diabetes. As a result, some people with Alzheimers will be given dietary and lifestyle advice, along with medications to lower blood glucose such as metformin. However, drugs are also commonly given to treat the cognitive symptoms, such as memory loss. These drugs include cholinesterase inhibitors (Aricept, Exelon, Razadyne) and memantine (Namenda).
Natural Treatment Options For Type 3 Diabetes
If Alzheimers disease is indeed a form of diabetes, then it makes sense to do what is necessary to lower and stabilize blood sugar levels. As I mentioned earlier in this article, this should be addressed through dietary and lifestyle factors, although nutritional supplements can also be of benefit. Here are a few nutrients/herbs that have been shown in the research to benefit those with Alzheimers disease:
Gingko. A few different studies show that Ginkgo biloba has neuroprotective properties, and might play a role in the treatment and prevention of Alzheimers disease (31) (32).
Bacopa. A few studies show that Bacopa monnieri can enhance cognition and has neuroprotective effects against Alzheimers disease (33) (34).
Curcumin. Curcumin has many different health benefits, and this includes helping people with Alzheimers by inhibiting the formation and promoting the disaggregation of amyloid-B plaques (35) (36).
Resveratrol. Like turmeric, resveratrol has many different health benefits, and it also seems to have neuroprotective benefits in animal models of Alzheimers disease (37) (38).
Green tea. Epigallocatechin-3-Gallate (EGCG), is the main and most significantly bioactive polyphenol found in solid green tea extract, and there are a few studies demonstrating the beneficial effects of EGCG in the treatment of Alzheimers disease (39) (40).
Vitamin D. Human studies strongly support a correlation between low levels of vitamin D and cognitive impairment or dementia, and it might play a role in preventing and even stopping neurogeneration in those with Alzheimers disease (41) (42).
Fish oils. Patients with Alzheimers have been shown to have lower docosahexaenoic acid (DHA) levels, and supplementation with DHA might help to prevent or delay the onset of cognitive decline associated with Alzheimers disease (43) (44).
How Do These Diabetic Conditions Relate To Thyroid Health?
Type 1 Diabetes. Those with one autoimmune condition have a greater risk of developing another autoimmune condition in the future. And there seems to be a higher prevalence of thyroid autoimmunity in those with type 1 diabetes. One cross-sectional study confirmed that there is an association between thyroid autoimmunity and type 1 diabetes (45). Out of 58 patients, 18 had hypothyroidism, with only one patient experiencing transient hyperthyroidism. Another study involving 1,304 patients showed that the incidence of autoimmune thyroid disease is high (46). Another study involving children and adolescents showed a high prevalence of subclinical hypothyroidism (47).
Type 1.5 Diabetes. Since type 1.5 diabetes also has an autoimmune component, it shouldnt be surprising that the research shows an increase prevalence of thyroid autoimmunity with this condition. One study investigated the relationship between type 1.5 diabetes and thyroid autoimmunity, and it found that there is a higher risk of thyroid autoimmunity, especially for those with higher levels of GAD antibodies (48). Another study revealed higher levels of both thyroid peroxidase and thyroglobulin antibodies in those with type 1.5 diabetes (49). I wasnt able to find any evidence that showed an increase in Graves disease antibodies in those with type 1.5 diabetes.
Type 2 Diabetes. Although type 2 diabetes isnt an autoimmune condition, there still seems to be a relationship between this type of diabetes and thyroid conditions. Some suggest that having a hypothyroid or hyperthyroid condition can lead to type 2 diabetes due to impaired glucose utilization and disposal in muscles, the overproduction of glucose output in the liver cells, and enhanced absorption of splanchnic glucose, which in turn contribute to insulin resistance (50). Another study looked at the association of thyroid function with the risk of type 2 diabetes, and the study showed that higher TSH levels were associated with a higher diabetes risk, even when it was within the lab reference range (51). In other words, if the TSH is within the lab reference range, but outside of the optimal range, then this might lead to an increased risk of developing type 2 diabetes.
This doesnt mean that most people with a thyroid hormone imbalance will develop type 2 diabetes, but only that they will be more susceptible to developing this condition. The good news is that improving diet and lifestyle factors, along with correcting the thyroid hormone imbalance will greatly improve your chances of NOT developing type 2 diabetes.
Type 3 Diabetes. Both hypothyroidism and hyperthyroidism can cause reversible dementia (52), but this doesnt mean that these conditions can cause Alzheimers disease. One study involving 1,864 people looked at the relationship of TSH levels to the risk of developing Alzheimers disease (52). Over a follow-up period of 12.7 years, women with the lowest and highest TSH levels demonstrated an increased risk of developing Alzheimers disease, but the same study showed that TSH levels were not related to Alzheimers disease in men (52).
Another study I came across looked at the relationship between thyroid hormone replacement and the development of Alzheimers disease (53). Beta amyloid plaque accumulation is a factor with Alzheimers disease, and T3 can increase the production of these plaques (53). The results suggested that taking thyroid hormone medication may be associated with a faster rate of the diagnosis of dementia related to Alzheimers disease. However, there were a few limitations to this study, and more research is needed. In addition, the same study discussed how thyroid hormones play a significant role in the production and survival of microglial cells, which help to remove beta amyloid plaque from the brain.
I realize this was a lot of information, but hopefully you have a better understanding of the different types of diabetes. Type 2 diabetes is the most common type, and unlike type 1 and 1.5 diabetes, it does not involve an autoimmune component. Many refer to Alzheimers as type 3 diabetes. The conventional approach for all of these types of diabetes is to lower blood glucose levels through diet and medication, and sometimes insulin therapy is administered, especially in type 1 and 1.5 diabetes. Natural treatment options also incorporate dietary changes, but nutritional supplements and herbs are also utilized. Plus you also need to remember to address the autoimmune component in type 1 and type 1.5 diabetes.
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Were going to let you in on a secret: Maintaining a fresh, youthful complexion is as simple as reading the ingredient list on the back of your skincare products. Heres one to remember: ferulic acid. Its a glow-getting antioxidant found in the cell walls of grains such as rice and oats and the seeds of apples and oranges. It plays a key role in the plants protection and self-preservation, and when applied topically to your face,it helps to slow the aging process by reducing the effects of damaging free radicals on the skin. Ahead, five ferulic-acid-packed products your skincare routine has been missing.
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Ferulic acid plays a major role here. Not only does it help reduce the effects of sun damage, it enhances the efficacy of the rest of the ingredients, leaving you looking bright and fresh.
Dr. Dennis Gross $88
We love this lightweight serum for two reasons. High concentrations of resveratrol and ferulic acid fight signs of aging caused by free radical damage and reduce redness. And the best part: It costs only $8.
The Ordinary $7
This cocktail of ferulic acid and vitamins C and E is basically a drink from the fountain of youth. A few drops help protect you from UVA/UVB rays (you still need sunscreen!), infrared radiation and ozone pollution for 72 hours.
This super-potent serum brightens skin, improves elasticity and diminishes fine lines and wrinkles. Bring on the compliments.
As if neutralizing pollution and free radicals for a healthy, youthful appearance wasn't enough, this blend offerulic acid and vitamin E visibly reduces dark spots and wrinkles. And for an added bonus,pumpkin ferment extract and pomegranate enzyme work together to gently exfoliate dead skin for a glowing complexion.
Drunk Elephant $80
Free radicals are very reactive molecules that reproduce a response to the environmental toxins and cellular actions in your body.
This is typically a result of energy production in your mitochondria that happens when you burn your food as fuel.
But what are mitochondria? Well, in short, mitochondria are the vital engines in nearly every one of your cells that produce over 90% of the energy currents in your body. These energy currents are known as ATP (adenosine triphosphate). This is your bodys biochemical way to store and use energy.
In the past, many thought it was wise to indiscriminately suppress those productions of free radicals with antioxidants, but newer research shows that isnt such a wise strategy.
There are special types of non-typical antioxidants that produce their effects through a process called hormesis a term we use to describe health benefits from taking low doses of something that is otherwise toxic, or even lethal at higher doses.
For example, many of the fruits and veggies you eat are loaded with natural compounds called polyphenols. The plant produces these polyphenols to ward off pests and predators.
The polyphenols are toxic to the predators, but since we are much larger, and we take them in far smaller doses, they actually cause our body to develop a protective response that makes us stronger. This brings me to one of my new passions: you can improve mitochondrial dysfunction by taking advantage of these beneficial polyphenols.
And one very special type of polyphenol is called resveratrol, which is extracted from Japanese Knotweed Root.
Resveratrol may help promote a normal immune response in your body.*
Plus, resveratrol potentially benefits you by how it...
Resveratrol reduces oxidative stress damage to your cardiovascular system by neutralizing free radicals.* And it helps support your body's inherent defense system, too.*
This potent antioxidant is somewhat different than other antioxidants. It not only helps you neutralize harmful free radicals, but it can cross the blood-brain barrier to help protect your brain and nervous system as well.*
Many folks believe that a good way to promote health is to drink a glass of red wine on a regular basis.*
There may be some truth here. Red wine does contain resveratrol.
However, there's one catch You'd need several bottles of wine per day to experience any of the benefits scientists have uncovered with resveratrol.
And drinking large amounts of wine or other alcoholic beverages not only places stress on your liver, but also increases your insulin levels, which can negatively impact on your health.
Further, many experts are now questioning the value of drinking wine for health reasons at all...
Its dangers may easily outweigh any potential benefits resveratrol can provide.
So how can you reap the potential benefits of resveratrol without the alcohol, sugar, and calories of red wine? There's an easy answer and I'll tell you about it in just a minute.
But first, let's discuss some simple ways you can take control of unhealthy free radical levels...
Every day of your life, you face exposure to dangerous free radicals. No matter how healthy a lifestyle you lead or how nutritious and clean a diet you eat, this is simply a fact of life.
Fortunately, it's not all bad, as your normal bodily functions such as breathing, metabolism, and physical activity generate free radicals. Your immune system also generates free radicals to help neutralize viruses and bacteria.
But some free radicals are the result of environmental factors such as pollution, radiation, pesticides, and cigarette smoking.
As part of normal functioning, your body is capable of keeping free radicals in check and neutralizing them, unless you...
Exposing your body to these types of conditions may overwhelm it with free radicals and cause damage.
Plus, free radical damage accumulates over time. So, the longer your lifestyle and environment expose you to this damage, the greater your consequences, and the greater potential impacts to your overall health.
First of all, address the unhealthy habits listed above.
Then consider going the next step and find ways to fortify your healthy diet with antioxidant-rich food.
Antioxidants provide your body with built-in protection against free radicals and help you neutralize and keep them under control.
Antioxidants provide your body with built-in protection against free radicals and help you neutralize and keep them under control.
Your body needs both types of antioxidants because each one targets different types of cells and tissues for free radical scavenging...
The bottom line... to fight and help neutralize pesky free radicals, you need both types of antioxidants from as many sources as possible.* When taken together, the efficacy of lipid- and water-soluble antioxidants is enhanced even more.*
When it comes to a lipid-soluble antioxidant, I believe I've identified a super-nutrient like no other in astaxanthin. You can check out my site for more info on Astaxanthin with ALA and all its phenomenal benefits.*
And I believe resveratrol is one of your best sources for a water-soluble antioxidant. However, as with just about every nutrient, if you can get it from the food you eat, that's my top recommendation.
A Bountiful Source of Resveratrol
Purple Defense contains 50 mg of Resveratrol per serving.
With an overall 3,500 ORAC (Oxygen Radical Absorbance Capacity) value per capsule, Purple Defense capsules provide a powerful antioxidant blend.
The ORAC value for Purple Defense is achieved by using the most sophisticated and accurate equipment possible. The machine is a fluorescence microplate reader (Fluoroskan Ascent FL).
ORAC values can easily be inflated with any machine though. Using an ethanol solvent will artificially inflate the ORAC value. That's why each batch is tested using an acetone/water solvent. So you can rest assured that you're actually getting 3,500 in each dose.
Now that I've clearly identified resveratrol as one of your best water-soluble antioxidant sources... what's the best way to make sure you consume enough of this antioxidant?
Just like there are issues with other fruits, vegetables, and red wine, such is the case with grapes.
You see, the skin and seeds of the grapes provide you with the most potent supplies of antioxidants... not the fruit itself.
The meat of the fruit contains sugary fructose that can raise your insulin levels. And of course you can't really ingest the skins without eating the fruit inside, too!
As for grape seeds, most people don't like to eat them as they tend to be tough and have a somewhat bitter taste. And some grape processing actually removes the seeds prior to distribution at your local store.
So, what can you do?
There's a simple solution. It's called Purple Defense.
Even if you could find and tolerate eating a healthy supply of grape seeds it would be almost impossible for you to chew the seeds enough to get the equivalent benefit you can from the pulverized seeds in my formula, Purple Defense.
Why? Pulverizing the seeds makes them more digestible.*
Plus, here are additional reasons why Purple Defense should be your No. 1 resveratrol and water-soluble antioxidant source:
So, now you see some of the reasons why I highly recommend Purple Defense as one of your best resveratrol and water-soluble antioxidant sources.
And of course, as I continually stress on my site, no supplement replaces a healthy diet of wholesome, unprocessed foods. But this grape seed powder is an excellent complement to your healthy diet in providing you free radical protection and the longevity support of resveratrol.
Each capsule of Purple Defense contains the amount of resveratrol that you would find in 39 eight-ounce glasses of wine. The Japanese Knotweed Root Extract contains 50% resveratrol, ensuring you get a consistent amount in each serving.
Even more importantly it is there as a whole food complex. Combined with other fruit complexes, Purple Defense provides a synergistic blend of micronutrients to give you the full benefits of the foods themselves.
You see, I am somewhat skeptical of scientists who isolate single nutrients with the belief that isolated nutrients can provide a full array of benefits. In my mind, the whole food complex is nearly always superior. And with Purple Defense, you receive the benefits of whole foods.
Purple Defense is rigorously tested for quality, potency, and purity.
Purple Defense grape seed does not require refrigeration. When stored properly, you'll find it will last up to two years.
No known drug interactions (however, those allergic to grapes should not take it).
What makes our Purple Defense resveratrol formula stand out from all the competitors?
First of all, I chose a formula with a proprietary process called OxyPhyte. This unique process concentrates the antioxidant power of specific compounds and preserves the ORAC value. It does this by extracting the phytonutrients responsible to provide you maximum activity.
The bottom line the OxyPhyte process used to formulate Purple Defense helps provide you with very high potency water-soluble antioxidants from the grapes. Not all grape seed formulas use this process.
And this formula even goes beyond grapes. Take a look at why this grape seed formula is so unique.
So, the Purple Defense formula even goes beyond nutritious grapes in providing you additional sources of water-soluble of antioxidants and nutrients.
But how do you know how well these antioxidants work against free radicals?
Over a 138-year time frame, the U.S. Agricultural Research Service (in-house arm of the USDA), developed a method to determine free radical scavenging activity against the peroxyl radical for both water-soluble and lipid-soluble substances.
This methodology, called Oxygen Radical Absorbance Capacity (ORAC), evolved over the years and today is a good indicator for measuring the antioxidant capacity of foods. The higher the ORAC value, the more antioxidant squelching capacity the food or supplement has.
For example, here's a chart showing Purple Defense nutrients and their potent Oxygen Radical Absorbance Capacity (ORAC) values (on a per gram basis).
Purple Defense OxyPhyte Nutrients ORAC Values Compared to Other Fruits and Vegetables
It should be clear from the above chart as to the antioxidant potency of the grape seed extract in Purple Defense... even more potent than whole blueberries.
With the total combination of grape seed extract, grape skins, black currant extract, and plum extract, Purple Defense is certainly up to the task.
So, when choosing an antioxidant source, make sure to compare its ORAC values to determine just how well it scavenges free radicals.
There should be little doubt in your mind about how well Purple Defense does this!
You've discovered numerous choices when it comes to protecting yourself from free radical damage and promoting longevity of your cells and tissues.
There are many foods that provide you very good sources of polyphenols and potent antioxidants to help you neutralize the damaging effects of free radicals.
So, I encourage you to consume these foods in moderation. And, of course, your preference should always be for fresh, organic, and raw sources.
At the same time, complement your wholesome diet with Purple Defense, your No. 1 source for water-soluble antioxidants and resveratrol. I believe the research is solid and provides a simple strategy to leverage the hormetic benefits of incredibly useful polyphenols.
Don't wait until free radicals rule your body and your health.* Order Purple Defense today.
Longevinex is more than plain resveratrol
To learn more about resveratrol and longevity go to ResveratrolNews.com
We also added nutrients that synergize resveratrols anti-aging capabilities of Longevinex
Longevinex cites its own proprietary studies in both animals and humans to substantiate its claims
Longevinex only resveratrol-based nutraceutical to pass toxicity testing.
Journal: Food Chemistry Toxicology Sept 2013, Sept 2013
Longevinex molecularly mimics a calorie-restricted diet; activates 9-times more longevity genes than plain resveratrol.
Journal: Experimental Gerontology, Sept 2008
Longevinex dilates (widens) arteries and improves blood flow upon physical exertion twice that of plain resveratrol.
Journal: Nutrition Research, Nov 2011
Longevinex protects the rodent heart from experimentally-induced heart attack better than plain resveratrol.
Journal: Experimental Clinical Cardiology, Winter 2010
Promotes health and longevity
Opaque vege caps to protect from light
100 mg (produces 9-fold greater biological effect than equal dose of plain resveratrol due to synergistic action with other molecules
$32.95/box$98.85 Buy 3, get 1 Free($24.72/Box)
Promotes health and longevity
+ youthful appearance
Opaque vege caps to protect from light
100 mg (produces 9-fold greater biological effect than equal dose of plain resveratrol due to synergistic action with other molecules
$49.95/Box$149.85 Buy 3, get 1 Free ($37.47/Box)
Features, benefits, detailed description
Resveratrol based synergy blend
Resveratrol based synergy blend developed especially to promote youthful appearance
Enzyme activated garlic
Enzyme activated garlic developed especially to promote healthy digestion
Resveratrol acts as an antioxidant and inhibits oxidation of low density lipoproteins (LDL)(21), plateletaggregation, and eicosanoid synthesis(4). It also induces nitric oxide (NO) production(24)(25) and increases arterial blood flow(8). These actions may contribute to its purported cardiovascular health benefits.
Resveratrol acts as an anti-inflammatory agent by inhibiting cyclooxygenase (COX) activity(26). It has been shown to decrease C-reactive protein and tumor necrosis factor, and to increase anti-inflammatory interleukin-10 and intercellular adhesion molecule-1 in humans(5). Resveratrol decreases oxidative stress and improves insulin sensitivity by increasing protein kinase activities(10). It decreases circulating insulin-like growth factor-1 (IGF-I) and IGF-binding protein-3 (IGFBP-3) levels(27) which may account for its antidiabetic effects in humans.
Preliminary data suggest that resveratrol increases the life span of yeast cells by activating sirtuins(1)(2). Recent study shows it inhibits human Sirt3 and stimulates Sirt5, in addition to Sirt1(28).
In vitro and animal studies show that resveratrol has anticancer activities. It inhibits proliferation of cancer cells via apoptosis and by exerting anti-estrogenic effects(14)(15)(16)(17). However, contradictory data from other studies showed that it acts as a phytoestrogen and could activate genes that are normally regulated by estrogens(18) or androgens(19).
Trans-resveratrol appears to decrease methylation of the tumor suppressor gene RASSF-1alpha in women at increased breast cancer risk(29). In addition, reductions in breast cancer cell migration and invasion were observed after treatment with resveratrol(30)(31). Resveratrol growth factor heregulin-beta1 (HRG-beta1) mediated matrix metallopeptidase 9 (MMP-9) expressions in human breast cancer cells(30).
Resveratrol may help reduce prostate tumorigenesis through a reduction inprostatic levels of mTOR complex 1 (mTORC1) activity and increased expression of SIRT1(32). Another study demonstrated that resveratrol modulates steroid hormone-dependent pathways to inhibit prostate cancer cell growth. However, resveratrol also increases angiogenesis and inhibitsapoptosis in vivo(19).
In an animal model, resveratrol downregulated p21and upregulated cyclin E leading to S-phase accumulation and apoptosis in neuroblastoma cells(14). Italso inhibitedCYP1A1, CYP1A2, and CYP1B1 enzymesin tumor cells, perhapsexerting antitumor effects as some of these enzymes are known to be involved in the activation of procarcinogens and toxins(22)(23).
Protective effects of resveratrol against doxorubicin-induced cardiotoxicity are due to upregulation of SIRT1-mediated p53 deacetylation.(20). It also protects against cisplatin-induced cardiotoxicity through the suppression of oxidative stress(19).
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Big Pharma is drooling over the prospect of getting it all to themselves.
Resveratrol, a substance found in the skin of red grapes as well as in pomegranates and Japanese knotweed, has been a popular dietary supplement for many years. It has anti-inflammatory and antiviral properties, possibly the potential to extend life, prevent several different cancers, protect the heart, ameliorate common diabetes symptoms, and control plaque in the brain and otherwise help with Alzheimers disease. And that isnt even a complete list. Its clear why drug companies are excited.
Resveratrol is widely available as a dietary supplementbut may not be for long if we are not vigilant. A new study has thrown the excitement over resveratrol into high gear. Results from ten years of research have just been published by David Sinclair, a Harvard Medical School genetics professor and the studys senior author. The research validated earlier findings that resveratrol may protect against age-related diseases because it turns on the SIRT1 gene that recharges mitochondria.
Sinclairs earlier research was partly discounted by other scientists in 2009 and 2010. They suspected that resveratrol might only seem to activate the SIRT1 gene because studies used a synthetic fluorescent chemical to track the effect. Since these synthetic chemicals are not found in nature, they reasoned, the experiment is not reproducible in humans. In this study, however, Sinclair used naturally occurring amino acids to track the benefits, which affirmed the compounds benefits.
Sinclair is not a disinterested party. He is the founder of Sirtris Pharmaceuticals, which focuses on developing resveratrol drugs, that is drugs that will mimic resveratrols effects with new and thus patentable molecules. Pharmaceutical giant GlaxoSmithKline (GSK) acquired Sirtris in 2008 for $720 million. GSK subsequently abandoned its work on resveratrol-based drug SRT501 because the drug didnt appear to work on cancer patients and worsened kidney damage. Its likely, however, that the new findings will prompt GSK to restart its work on a resveratrol-based drug; resveratrol is already the subject of at least two dozen clinical trials.
Because Resveratrol is also the subject of an investigational new drug (IND) application, GSK could petition FDA to ban natural resveratrol. Yes, that s how warped the law is. Apply for FDA approval for something synthetic, new-to-nature, and thus potentially much more dangerous, and you can then try to ban the natural substance on which your product was based.
This is governed by a provision in the law, as we explained last year. There is an absolute prohibition against banning the natural substance if it is grandfathered (that is, marketed before 1994) or if the FDA has accepted a New Dietary Ingredient (NDI) notification from supplement manufacturers.
Supplement companies have tried to file NDIs for resveratrol, but the FDA has rejected them all, stating that an IND had already been filed, so they wont accept an NDI. Despite resveratrol being a natural component of food and a constant part of the food supply, it may be hard to prove that it was marketed before 1994. This, of course, merely reveals the illogic of the grandfathering process: it was put in place as a means of proving the safety of an ingredient, but instead its being used to protect the pharmaceutical industry.
New drug applications (INDs) are confidential, but we can make an educated guess that Sirtris Pharmaceuticals is one of the companies that filed an IND since they have already started clinical drug trials (an IND is required before clinical drug trials). If they are successful, resveratrol will then be available in an expensive, synthetic drug form, likely requiring a prescription at a very high cost and a disease condition for access. It will be tempting for the drug company to then try to have the FDA ban the natural form of resveratrol. It is our job to prevent that by making it painful for both the company and the FDA.
In this context, lets remember what happened to pyridoxamine, one of the three primary natural forms of vitamin B6. Biostratum, the North Carolina-based manufacturer of a planned pyridoxamine-based drug called Pyridorin, petitioned the FDA for market exclusivity, and FDA kowtowed, effectively prevented any substance containing pyridoxamine from being marketed as a dietary supplement. To date no drug has even appeared, so we have neither natural B vitamin nor drug, an outcome that is all too typical of FDA illogic and misuse of power.A similar petition has been filed regarding P5P, the natural form of B6 that is most bio-available. All other forms of B6 must be converted by the body to this form to be used, and without it we would all die. Is this really something to ban and make into an exclusive, prescription-only drug? (If you have not already done so, please send your message to FDA and Congress to make sure P5P remains available as a supplement.)
If the dietary supplement version of resveratrol becomes threatened, rest assured that ANH-USA will be with you on the front lines, fighting to maintain your access to this amazing nutritional ingredient.
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