Category Archives: Resveratrol

What Are the Best Resveratrol Supplements to Buy?

Reviewed by the BioHackers Lab Team | Last updated: March 22, 2020

I was interested to find out what are some of the best resveratrol supplements for me to review.

People look to supplement with resveratrol to help provide anti-oxidant and longevity effects.

So I went out researching online for what are some of the highest rated & most recommended resveratrol supplements and brands available to buy online.

The list of recommended resveratrol supplements for you to compare.

Overview

Based in Sacramento, California, Purely Beneficial is dedicated to providing the purest health supplements available. They sell a number of supplements, including apple cider vinegar, elderberry, tart cherry, charcoal and others. At the time of this writing, they are undergoing a website update, so there is not much else to learn about them online. You can contact them by phone or email or subscribe to be notified when they launch their revamped site. Their resveratrol is a blend of 605 milligrams plus antioxidants. (ref)

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Overview

With headquarters located in Lake Worth, Florida, MAAC10 is committed to the idea that mitochondrial health and cellular respiration are the keys to wellness. They pride themselves on a holistic approach and they have tons of informative content on their website, specifically on the science behind their products. They sell nicotinamide mononucleotide, NADH + CoQ10 and, of course, resveratrol. Their formula includes their trademark Bioperene, which helps the resveratrol to bypass the liver and go directly into the bloodstream. (ref)

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Overview

Toniiq is a brand that is getting lots of good reviews online from what we can see. We found there is a certificate of authenticity on one of the Amazon customer reviews, however, the company doesnt display any CoA certificate on their website for any products. (ref)

Overview

Purest Vantage is dedicated to creating high quality supplements that help people maintain optimal health. They are also committed to quality and take pride in their contaminant-free products. They offer several supplements including magnesium oil, activated charcoal and B-complex in addition to resveratrol. Their website doesnt have much else to offer, but you can contact them at their headquarters in Orlando, Florida. Their resveratrol is a blend, containing 600 milligrams of resveratrol plus antioxidants. (ref)

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Overview

Life Extension has a huge inventory of herbs, supplements and skincare products. They have been around for over 35 years and make over 350 different supplements. One of the most useful features of their website is their Supplement Finder, where users can input some basic information and find out which supplements are right for them. Life Extension also offers lab testing services and an educational magazine. (ref)

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Overview

Based in Henderson, Nevada, BulkSupplements is true to their name, offering over 400 different supplements and ingredients. You can search for products by category or goal, making it easy to sift through a lot of information. You can also order their products in many different sizes, which is convenient. Their website features an informative blog that answers relevant questions pertaining to supplemental nutrition. (ref)

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Overview

Jarrow has been making and supplying supplements since 1977. Their scientific panel ensures the quality and integrity of each product. Their website features a database of all their products, as well as a store locator so customers can easily find them. The company has received numerous awards for product quality since 2002. Their resveratrol supplement contains the full dose in one capsule, so it is that much easier to take. (ref)

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I know you were looking for what are the best options, but here is some more detail as to why we might need good resveratrol products to help us easily take this anti-aging supplement.

If this is not what youre looking for then why not also review these other mitochondria health supplements like, nicotinamide riboside, nicotinamide mononucleotide, oxaloacetate and CoQ10 supplement options.

Resveratrol is a chemical found naturally in certain foods such as grapes, mulberries, red wine and peanuts. In plants, it is produced to defend against fungal infections and other threats. (ref)

In humans, it is often used as a medicine for high cholesterol, heart disease and even cancer, although there is still not a lot of evidence around its effectiveness. (ref)

Even though evidence is sparse, there is still some data showing that resveratrol has the potential to help with many medical conditions. (ref)

Here are some of the benefits of resveratrol:

Resveratrol has also been shown to reduce blood pressure and improve heart function in patients with cardiovascular disease, as well as treat liver disease. (ref)

A 2012 study showed that a 2,000 milligram dose of trans-resveratrol twice a day was tolerated well when taken with a meal that was not high in fat. Diarrhea was the only major side effect observed. (ref)

The health benefits of resveratrol are very much dependent on dose. It can be beneficial for a variety of conditions when taken in low doses, but high doses can actually worsen some illnesses. One potential use for a high dosage of resveratrol is in fighting cancer. (ref)

For specifics, we can look at animal studies, which have demonstrated positive effects of various dosages. While these numbers are supported by evidence, they are not infallible.

Here are suggested doses for different medical conditions: (ref)

When taken as a food, there are rarely any side effects. But there are some potential risks when taking resveratrol in supplement form. (ref)

Side effects include:

Resveratrol should be avoided if you are pregnant or breastfeeding, have a bleeding disorder, have a hormone-sensitive cancer or are having surgery. (ref)

Last updated: March 22, 2020

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Best Resveratrol Supplements (2020 Review)

Resveratrol, a natural polyphenolic compound, is produced by a variety of plants, such as grapes, peanuts and some berries, in response to various biotic and abiotic stresses, including stress, injury, UV-radiation and bacterial and fungal infection. Emerging scientific evidence suggests that resveratrol might be a potent anticancer candidate. The antitumor actions are largely attributed to the antioxidant property of resveratrol. It is also available as a dietary supplement. Consult your doctor to determine whether resveratrol supplements are safe for you.

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If you are experiencing serious medical symptoms, seek emergency treatment immediately.

As of 2011, there have not been many clinical trials and observations to determine the optimal pharmacological doses of resveratrol. The results of several animal studies conducted by the New York Langone Medical Center suggest that daily doses of 500mg of resveratrol might be safe and potent.

Resveratrol from grape seeds has been widely studied for its potential chemopreventive and therapeutic effects. Grape seeds are preventive agents against various human diseases associated with free radicals, including diabetes, heart disease and cancer. Grape seed extract is available as a supplement in several forms such as capsules, tablets and liquid extracts. The University of Maryland Medical Center recommends 25mg to 150mg of a standardized grape seed extract per day to protect your body from oxidative damage caused by free radicals 2.

Although resveratrol reportedly prevents or treats many human ailments in animal models, few published studies have examined the optimal therapeutic dosage. For adults, the recommended dose for resveratrol supplementation is 40mg daily, according to Dr. Johan Auwerx, a resveratrol researcher at the Huntington College of Health Sciences 1. Preliminary studies reviewed by the Linus Pauling Institute at Oregon State University have shown that trans-resveratrol is absorbed more efficiently by the body, but more studies are needed to evaluate the bioavailability of these interesting polyphenols in humans 3.

As of 2011, the most recent evidence suggests that resveratrol has no prominent side effects. However, further studies are needed to ensure its safety for pregnant and nursing women. Be on the safe side and avoid its use until more information is available. Resveratrol is a natural supplier of estrogen, a female reproductive hormone that fuels the development of breast cancer. Therefore, women at high risk of breast cancer should not consume resveratrol. Resveratrol may also decrease the therapeutic effects of anticoagulants, such as warfarin, and could increase the risk of bleeding.

The Wrap Up

Resveratrol, a natural polyphenolic compound, is produced by a variety of plants, such as grapes, peanuts and some berries, in response to various biotic and abiotic stresses, including stress, injury, UV-radiation and bacterial and fungal infection. Preliminary studies reviewed by the Linus Pauling Institute at Oregon State University have shown that trans-resveratrol is absorbed more efficiently by the body, but more studies are needed to evaluate the bioavailability of these interesting polyphenols in humans. However, further studies are needed to ensure its safety for pregnant and nursing women. Resveratrol is a natural supplier of estrogen, a female reproductive hormone that fuels the development of breast cancer. Therefore, women at high risk of breast cancer should not consume resveratrol.

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Resveratrol Recommended Dosage | Healthfully

Resveratrol is a polyphenol antioxidant that may help to prevent heart disease, cancer, diabetes, and early signs of aging. In fact, resveratrol has been shown to influence gene expression to turn on factors that code for longevity in cells. Natural sources of resveratrol are red wine, grapes, peanuts, berries, chocolate, certain vines and a plant known as Japanese knotweed. Despite the many proposed health benefits of resveratrol, there are some negative effects with this compound, especially for those using certain drugs.

Resveratrol may interact with several medications. The Linus Pauling Institute reports that resveratrol may inhibit cytochrome 3A4, which may cause interactions with HMG-CoA reductase inhibitors, calcium channel agonists, anti-arrhthmic agents, HIV protease inhibitors, immunosuppressants, antihistamines, and erectile dysfunction medications. In addition, the natural blood pressure-lowering and anti-coagulant effects of resveratrol may cause interaction with blood pressure, anti-platelet, and anticoagulant medication, as well as NSAIDs such as aspirin and ibuprofen.

Resveratrol has shown both estrogen agonist and estrogen antagonist effects in cell culture studies. Estrogen agonists act to simulate the effects of endogenous estrogens. Antagonists of the estrogen hormone bind to receptor sites, blocking the effects of the hormone. Resveratrol has a similar chemical structure to synthetic estrogen agonists. The estrogen hormone can aggravate estrogen-dependent tumors in prostate and breast cancers. These tumors have many estrogen receptors, because they require the hormone to be able to grow. The Linus Pauling Institute recommends that more research is needed before those at risk for tumor growth ingest concentrated resveratrol supplements.

Although rare, anecdotal gastrointestinal side effects have been reported by resveratrol users. Stomach upset and cramping, diarrhea, and/or decreased appetite may occurwith large doses of resveratrol. Dietary supplements affect each individual differently, so some may be more susceptible to digestive side effects than others.

Resveratrol has been shown to have natural anti-inflammatory effects in the body, according to the Life Extension Foundation. By inhibiting COX enzymes that cause inflammation on a cellular level, resveratrol should theoretically help with conditions such as osteoarthritis. However, some people have reported joint pain and tendinitis with resveratrol use. Commonly affecting the Achilles tendon, resveratrol has also caused joint pain in other areas, sometimes accompanied by tingling and/or numbness in arms, legs, hands and feet.

Read more from the original source:
Negative Effects of Resveratrol | Livestrong.com

Trans-resveratrol is one form of a compound produced by some plants to combat fungal infection. When ingested, trans-resveratrol might provide health benefits, ranging from protection against disease to antiaging properties. Research into the potential benefits of trans-resveratrol is ongoing, but few human studies have been performed so far.

The polyphenoic compound resveratrol belongs to the group of chemical compounds called stilbenes. Resveratrol comes in two forms, cis and trans, both of which may be attached to a glucose molecule. When attached to glucose, resveratrol is called a glucoside. Both the cis and trans forms can be found in nature, but they may not have the same biological properties when ingested. Most research on the potentially beneficial effects of resveratrol have been performed on the trans isomer.

Much of the evidence for the activity of trans-resveratrol is from laboratory studies, not human clinical trials. In the lab, trans-resveratrol acts as a powerful antioxidant, binds to estrogen receptors, inhibits tumor activity and affects cellular enzymes. Most research done on trans-resveratrol uses doses much higher than the amounts found in natural sources. Animal studies have linked trans-resveratrol to heart protective effects, anticancer activity and antiaging properties. Some studies link wine consumption to decreased mortality and a lower risk of heart disease, such as a 2004 study published in the "American Journal of Epidemiology." Since wine, particularly red wine, is a major source of trans-resveratrol, this may be a mechanism behind wine's protective effects 23. However, more studies are required to establish a definitive link.

Trans-resveratrol metabolism occurs rapidly once it is ingested, which means that it doesn't spend much time in the body before being altered and eliminated. The levels of trans-resveratrol and its metabolites are at their highest about 30 minutes after consumption, according to the Linus Pauling Institute 1. Few studies have been done on the metabolites themselves, so it is not known whether they share the same biological activity as trans-resveratrol or if they become inert after being altered by the body.

The main dietary source of trans-resveratrol is red wine, but other forms of wine and other grape products also contain this compound. Because resveratrol is concentrated in the skins of grapes, the amount of time a wine or juice spends in contact with the skins can affect the resveratrol content. Red wines and dark grape juices have more trans-resveratrol than white wine or juice. Other berries, including bilberries, cranberries and blueberries, also contain trans-resveratrol. Peanuts and peanut butter are another food source of resveratrol.

The Wrap Up

Trans-resveratrol is one form of a compound produced by some plants to combat fungal infection. In the lab, trans-resveratrol acts as a powerful antioxidant, binds to estrogen receptors, inhibits tumor activity and affects cellular enzymes. Most research done on trans-resveratrol uses doses much higher than the amounts found in natural sources. Since wine, particularly red wine, is a major source of trans-resveratrol, this may be a mechanism behind wine's protective effects3. However, more studies are required to establish a definitive link.

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What Is Trans Resveratrol? | Healthfully

Resveratrol

Resveratrol (Trans-resveratrol) is a polyphenolic constituent with beneficial health effects and found naturally in trace amounts in the skins of grapes, red wine, and peanuts.1 Japanese knotweed (Polygonum cuspidatum) is one of the most concentrated sources of trans-resveratrol.

The French Paradox (the low incidence of cardiovascular disease despite high fat consumption in France) has led investigators to suggest that adequate intake of resveratrol from daily red wine intake (common in France) may reduce the risk of cardiovascular disease.2

Resveratrol is known to act as an antioxidant that decreases cellular oxidative stress.2 Resveratrol has also been found to contribute to improving insulin sensitivity and glucose utilization as well as inhibiting excessive blood clotting and inflammation.2-5 It has been suggested in preclinical and clinical studies that resveratrol may have anti-cancer effects through its ability of suppressing various types of tumor cell growth.6

High intake of Resveratrol (more than 1,000 mg/d for 29 consecutive days) may cause symptoms such as: nausea, diarrhea, and stomach pain.7 Due to its anti-platelet function, resveratrol may increase bruising and bleeding for individuals taking anticoagulant drugs (e.g., warfarin/coumadin or heparin), anti-platelet drugs (e.g., clopidogrel/Plavix or dipyridamole/Persantine) , and non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, ibuprofen, diclofenac, or naproxen.8 It is recommended for women with the history of estrogen sensitive cancers to consult with the doctor before taking Resveratrol supplement.7

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Resveratrol - Shaklee Health Resource

Resveratrol is a polyphenol present in and commonly ingested through grapes, red wine, berries, and peanuts.1 It is also a constituent of some Chinese and Japanese traditional medicines. Resveratrol is reported to have many health-promoting effects, with its potential anti-aging properties initiating its notoriety in the lay press. It is also reported to have anti-inflammatory, anti-oxidative, and anticancer effects. These studies have primarily been conducted in vitro and in animal models.

Though mechanisms of anticancer effects of resveratrol have been identified, the ability to translate these findings to in-human studies is a challenge.2 Resveratrol has low bioavailability in humans. Though it is easily absorbed in the small intestine, it undergoes extensive metabolism resulting in a low plasma concentration of trans-resveratrol.

As a result, various routes of administration have been tested in animal models, including via intravenous and oral transmucosal routes, which increase plasma levels. A micronized form has been developed for human studies, which increases the surface area and solubility of resevatrol and increases plasma concentrations by approximately 3.6-fold compared with non-micronized resveratrol.

Preclinical Studies

Numerous in vitro studies across different cancer cell lines have demonstrated that application of resveratrol results in cell growth inhibition and increased apoptosis.1,3 Several mechanisms have been attributed to these properties. Resveratrol has been demonstrated to modulate cyclin-dependent kinases resulting in cell cycle arrest, particularly at the G0/G1 checkpoint, although some studies have also shown cell cycle arrest at the G2/M and S checkpoints.

Apoptosis appears to be induced primarily through increased caspase activity, though noncaspase-dependent mechanisms have also been reported. Resveratrol has also been shown to inhibit some signaling pathways that frequently aberrant in different cancers, such as EGFR, mTOR/AKT, JAK/STAT, and PI3-kinase. Resveratrol has also demonstrated antioxidant properties and may protect DNA from oxidative damage.4

The mechanisms of the effect of resveratrol on breast cancer cells is less clear.5 Though studies have shown that the anticancer properties of resveratrol extend to breast cancer cells and animal models, it has also been shown to activate the estrogen receptor and, at higher concentrations, may upregulate the expression of HER2, both in the absence of estradiol.

Studies in rodent models have demonstrated that the topical application of resveratrol decreased the incidence of skin tumors and suppressed melanoma growth, with markers indicating increased apoptosis.1 In other cancer models, oral ingestion through diet, water, or oral gavage resulted in decreased tumor volume, weight, and growth with decreased metastasis and angiogenesis across multiple cancer types including those of the breast, prostate, lung, and colon. Similar results were found in animal models of liver cancer, though most studies used abdominal injection for resveratrol administration.

More:
Resveratrol and Cancer - Cancer Therapy Advisor