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Category Archives: Pharmacogenomics

Genomics|Update|Non Communicable Diseases

FDA: The steps were taking to push precision medicine forward, by Meghana Keshavan, Med City News, September 23, 2015 Dr. Henry T. Continue reading



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Genomics|Update|Non Communicable Diseases

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Pharmacogenomics Program Mayo Clinic Center for …

Getting you the right drug at the right dose at the right time is the goal of pharmacogenomics, which involves studying how your specific DNA sequence influences your response to medications. The drugs available today to treat cancer, heart disease and other conditions are powerful agents that work as intended in most patients. Yet, in some people, a particular drug at the standard dose might not work well enough or may even trigger a serious adverse reaction. Continue reading



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Pharmacogenomics Program Mayo Clinic Center for ...

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Pharmacogenetics – Wikipedia, the free encyclopedia

Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects.[1] The term pharmacogenetics is often used interchangeably with the term pharmacogenomics which also investigates the role of acquired and inherited genetic differences in relation to drug response and drug behavior through a systematic examination of genes, gene products, and inter- and intra-individual variation in gene expression and function.[2] In oncology, pharmacogenetics historically is the study of germline mutations (e.g., single-nucleotide polymorphisms affecting genes coding for liver enzymes responsible for drug deposition and pharmacokinetics), whereas pharmacogenomics refers to somatic mutations in tumoral DNA leading to alteration in drug response (e.g., KRAS mutations in patients treated with anti-Her1 biologics).[3] Much of current clinical interest is at the level of pharmacogenetics, involving variation in genes involved in drug metabolism with a particular emphasis on improving drug safety. Continue reading



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Pharmacogenetics - Wikipedia, the free encyclopedia

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Personalized medicine and pharmacogenomics – Mayo Clinic

Personalized medicine and pharmacogenomics Pharmacogenomics holds the promise that drugs might one day be tailored to your genetic makeup. Modern medications save millions of lives a year Continue reading



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Personalized medicine and pharmacogenomics - Mayo Clinic

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Vanderbilt Pharmacogenomics

Welcome Clinicians and patients recognize that not every person responds to drugs in the same way. Some drugs carry a risk of adverse reactions that often seem to occur by chance Continue reading



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Vanderbilt Pharmacogenomics

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Pharmaceutical pharmacogenomics glossary & taxonomy

Pharmacogenomics is often referred to as a “revolution” or “the great new wave” in medicine – a future filled with promise not just for better, safer, and ore affordable healthcare (i.e. affordable for both consumers and third-party payers) but also, according to some, greater economic returns for drug makers. While there are in fact a handful of drugs on the market with genotype-based prescribing requirements, such as Herceptin, this next great wave has been slow to arrive. Continue reading



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Pharmaceutical pharmacogenomics glossary & taxonomy

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