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Category Archives: Pharmacogenomics

PHG Foundation – Interactive Tutorial: Pharmacogenomics …

Pharmacogenetics refers to the study of genetic influences on an individuals response to drugs. In pharmacogenetics, the analysis of a specific gene, or group of genes, may be used to predict responses to a specific drug or class of drugs. Pharmacogenomics refers collectively to all the genes that influence drug responses, and how genome-wide analysis may be used to identify such genes in the search for novel drug targets and/or key determinants of drug reactions Continue reading



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PHG Foundation - Interactive Tutorial: Pharmacogenomics ...

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MediMap genomics test – precision medicine at Inova …

Go to Inova Translational Medicine Institute Pharmacogenomics, also called PGx, combines the science of how medications work (pharmacology) with the science of how genetic differences can influence health (genomics).Inova is pleased to offer the MediMap PGx test to adults and children, as well asto newbornsdelivered atInova Womens Hospital. MediMap is part of the standard package of services offered to all babies born at Inova Womens Hospital located at Inova Fairfax Medical Campus, and it is therefore performed at no additional cost. Continue reading



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MediMap genomics test - precision medicine at Inova ...

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Pharmacogenetics – Wikipedia

Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects.[1] The term pharmacogenetics is often used interchangeably with the term pharmacogenomics which also investigates the role of acquired and inherited genetic differences in relation to drug response and drug behavior through a systematic examination of genes, gene products, and inter- and intra-individual variation in gene expression and function.[2] In oncology, pharmacogenetics historically is the study of germline mutations (e.g., single-nucleotide polymorphisms affecting genes coding for liver enzymes responsible for drug deposition and pharmacokinetics), whereas pharmacogenomics refers to somatic mutations in tumoral DNA leading to alteration in drug response (e.g., KRAS mutations in patients treated with anti-Her1 biologics).[3] Much of current clinical interest is at the level of pharmacogenetics, involving variation in genes involved in drug metabolism with a particular emphasis on improving drug safety. The wider use of pharmacogenetic testing is viewed by many as an outstanding opportunity to improve prescribing safety and efficacy. Driving this trend are the 106,000 deaths and 2.2 Million serious events caused by adverse drug reactions in the US each year.[4][unreliable medical source?] As such ADRs are responsible for 5-7% of hospital admissions in the US and Europe, lead to the withdrawal of 4% of new medicines, and cost society an amount equal to the costs of drug treatment.[5] Comparisons of the list of drugs most commonly implicated in adverse drug reactions with the list of metabolizing enzymes with known polymorphisms found that drugs commonly involved in adverse drug reactions were also those that were metabolized by enzymes with known polymorphisms (see Phillips, 2001). Continue reading



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Pharmacogenetics - Wikipedia

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Internships Internship Search and Intern Jobs …

Internships.com is the worlds largest internship marketplace bringing students, employers andhigher education institutionstogether in one centralized location. We specialize in helpingstudentsand young professionals find the right internship to kick start their career. Its no secret that internships are the most effective way for students to gain work experience before graduation Continue reading



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Internships Internship Search and Intern Jobs ...

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Polymorphisms of the dopamine transporter gene: influence …

Attention deficit-hyperactivity disorder (ADHD) is a very common and heterogeneous childhood-onset psychiatric disorder, affecting between 3% and 5% of school age children worldwide. Continue reading



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Polymorphisms of the dopamine transporter gene: influence ...

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FAQ About Pharmacogenomics – National Human Genome …

Frequently Asked Questions About Pharmacogenomics To view the PDF illustration on this page, you will need Adobe Reader. Pharmacogenomics uses information about a person’s genetic makeup, or genome, to choose the drugs and drug doses that are likely to work best for that particular person. This new field combines the science of how drugs work, called pharmacology, with the science of the human genome, called genomics. Continue reading



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FAQ About Pharmacogenomics - National Human Genome ...

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