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Category Archives: Pharmacogenomics

Irinotecan – Wikipedia

IrinotecanClinical dataTrade namesCamptosar (US), Campto (EU), Onivyde (liposomal)AHFS/Drugs.comMonographMedlinePlusa608043Pregnancycategory O=C7OCC=6C(=O)N2C(c1nc5c(c(c1C2)CC)cc(OC(=O)N4CCC(N3CCCCC3)CC4)cc5)=C/C=6[[email protected]@]7(O)CC Irinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer and small cell lung cancer.[1] For colon cancer it is used either alone or with fluorouracil.[1] For small cell lung cancer it is used with cisplatin.[1] It is given by slow injection into a vein.[1] Common side effects include diarrhea, vomiting, bone marrow suppression, hair loss, shortness of breath, and fever.[1] Other severe side effects include blood clots, colon inflammation, and allergic reactions.[1] Those with two copies of the UGT1A1*28 gene variant are at higher risk for side effects.[1] Use during pregnancy can result in harm to the baby.[1] Irinotecan is in topoisomerase inhibitor family of medication.[2] It works by blocking topoisomerase 1 which results in DNA damage and cell death.[1] Irinotecan was approved for medical use in the United States in 1996.[1] It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system.[3] In the United Kingdom it is available as a generic medication and costs the NHS about 114.00 pounds per 100mg.[2] It is made from the natural compound camptothecin.[1] Its main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan. The regimen XELIRI consists of capecitabine and irinotecan.[4][5] The most significant adverse effects of irinotecan are severe diarrhea and extreme suppression of the immune system.[6] Irinotecan-associated diarrhea is severe and clinically significant, sometimes leading to severe dehydration requiring hospitalization or intensive care unit admission Continue reading

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UW-Madison study links nicotine addiction to genetic variation in … – Madison.com

Some smokers have more of an urge to light up right after they wake up, and UW-Madison researchers have identified a reason: genetic variation in a substance that breaks down nicotine in the brain. The finding, by scientists at UW-Madison and Washington University in St Continue reading

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MediMap – pharmacogenomic testing for adults and children …

MediMap is a one-time Pharmacogenomics (or “PGx”) test that may indicate how a person will respond to specific prescription medications. Your MediMap test results can help guide your healthcare providers to ensure better medication choices and doses based on your genetic makeup… leading to more effective illness management and improved health Continue reading

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Updating the landscape of direct-to-consumer pharmacogenomic testing – Dove Medical Press

Back to Browse Journals Pharmacogenomics and Personalized Medicine Volume 10 Kelly K Filipski,John D Murphy,Kathy J Helzlsouer Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA Abstract: Pharmacogenomics has identified important druggene interactions that affect the safety and efficacy of medications. Continue reading

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Home [www.esptnet.eu]

(April 14, 2017) Dear ESPT member,First of all, I would like to thank you for your continued support of the European Society for Pharmacogenomics and Personalized Therapy (ESPT). With this email, I would like to update you on the activities of ESPT, and inform you about interactions with you as members regarding the direction and strategies of our society. The ESPT Board has been strengthened in October 2016 by Dr .Sanja Stankovic (Belgrade, Serbia) and Csilla Sipeky (Turku, Finland) Continue reading

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Frost & Sullivan Awards Akonni Biosystems for its Groundbreaking TruDiagnosis Molecular Diagnostics Platform – Markets Insider

Akonni’splatform delivers accurate, multiplexed analysis in a low-cost format, offering a valuable solution for healthcare applications such as disease prediction and prevention, early diagnosis, identification of drug resistance, and treatment monitoring. SANTA CLARA, California, Aug. Continue reading

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