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Category Archives: Nano Medicine

In vivo evaluation of CD38 and CD138 as targets for nanoparticle-based drug delivery in multiple myeloma – DocWire News

This article was originally published here

J Hematol Oncol. 2020 Nov 2;13(1):145. doi: 10.1186/s13045-020-00965-4.

ABSTRACT

BACKGROUND: Drug-loaded nanoparticles have established their benefits in the fight against multiple myeloma; however, ligand-targeted nanomedicine has yet to successfully translate to the clinic due to insufficient efficacies reported in preclinical studies.

METHODS: In this study, liposomal nanoparticles targeting multiple myeloma via CD38 or CD138 receptors are prepared from pre-synthesized, purified constituents to ensure increased consistency over standard synthetic methods. These nanoparticles are then tested both in vitro for uptake to cancer cells and in vivo for accumulation at the tumor site and uptake to tumor cells. Finally, drug-loaded nanoparticles are tested for long-term efficacy in a month-long in vivo study by tracking tumor size and mouse health.

RESULTS: The targeted nanoparticles are first optimized in vitro and show increased uptake and cytotoxicity over nontargeted nanoparticles, with CD138-targeting showing superior enhancement over CD38-targeted nanoparticles. However, biodistribution and tumor suppression studies established CD38-targeted nanoparticles to have significantly increased in vivo tumor accumulation, tumor cell uptake, and tumor suppression over both nontargeted and CD138-targeted nanoparticles due to the latters poor selectivity.

CONCLUSION: These results both highlight a promising cancer treatment option in CD38-targeted nanoparticles and emphasize that targeting success in vitro does not necessarily translate to success in vivo.

PMID:33138841 | DOI:10.1186/s13045-020-00965-4

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Nanorobotics Market Growth, Recent Trends By Regions, Type, Application And Geographical Analysis To 2026 – The Think Curiouser

Global Nanorobotics Market report provides in-depth analysis and detailed information by key players, end-users, applications, Competitor analysis, geography, Sales, Revenue, Price, Gross Margin, Market Share, Import-Export, Trends, CAGR value and how it is expected to reach from 2020 to 2026.

Global Nanorobotics Market Report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Nanorobotics market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status.

The global Nanorobotics market was valued at US$ 5.11 Bn in 2018 and is expected to reach US$ 10.71 Bn in 2026, growing at a CAGR of 9.9% during the forecast period.

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The report focuses on global major leading industry players providing information such as company profiles, product picture and specification, capacity, production, price, cost, revenue and contact information. Upstream raw materials and equipment and downstream demand analysis is also carried out.

Key Players covered in this Nanorobotics market report are

The report splits by major applications:

Then report analyzed by types:

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The Study Objectives Are:

The Nanorobotics industry development trends and marketing channels are analyzed. Finally, the feasibility of new investment projects is assessed, and overall research conclusions offered.

With the tables and figures the report provides key statistics on the state of the industry and is a valuable source of guidance and direction for companies and individuals interested in the market.

Development policies and plans are discussed as well as manufacturing processes and cost structures are also analyzed. This report also states import/export consumption, supply and demand Figures, cost, price, revenue and gross margins.

The Nanorobotics Market report provides key statistics on the market status of the Nanorobotics manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.

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Nanorobotics Market Growth, Recent Trends By Regions, Type, Application And Geographical Analysis To 2026 - The Think Curiouser

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Bio-convergence may be next big thing from Israel – Cleveland Jewish News

Testing new cancer drugs on 3D-printed tumor cells. Analyzing the gut microbiome to determine the best medicine for Crohns disease. Identifying genetic pairs so that a drug can turn off a cancer cell.

These are just a few of the overlaps of biology, physics, computer science, mathematics, engineering, materials science and nanotechnology that make up the new field of bio-convergence.

Testing new cancer drugs on 3D-printed tumor cells. Analyzing the gut microbiome to determine the best medicine for Crohns disease. Identifying genetic pairs so that a drug can turn off a cancer cell.

These are just a few of the overlaps of biology, physics, computer science, mathematics, engineering, materials science and nanotechnology that make up the new field of bio-convergence.

The Israel Innovation Authority is betting on bio-convergence as the next big thing from the startup nation.

The IIA announced in January that it would invest up to about $30 million in bio-convergence technologies and companies. In July, the governmental agency added a call for R&D proposals from academia and industry in the field of bio-convergence with a budget of $4 million.

In August, a third call for bio-convergence proposals this time for collaboration between Israeli and South Korean companies came with a $4.16 million budget and a plan to provide grants up to 50 percent of R&D expenses.

The bio-convergence push is a bit of a departure for the IIA.

We usually work in a bottom up approach and very seldom intervene and select a specific technological field for strategic investments, Anya Eldan, vice president of the IIAs Startup Division, said. In the past it has been cyber and fintech. Now weve identified bio-convergence as the next growth engine for the Israeli economy.

Developing disease-fighting drugs the old-fashioned way takes decades and billions of dollars. The new era of pharma will see researchers from multiple disciplines working together.

When we started to look for the next growth engine, we realized that none of the major pharmaceutical companies are invested in bio-convergence, Eldan explained. Theyre looking at biology but theyre not sure how to approach it.

Israel, however, is a small country where everyone knows one another, making it relatively easy to put together multidisciplinary teams.

On a folksier level, Eldan said Israelis large Friday night Shabbat dinners naturally foster collaboration.

People have to find things to talk about. So, a doctor mentions at the dinner table he has a patient without a solution and the engineer in the family says, That shouldnt be, and from there a startup is born.

This trend could have a major impact on the global health care system crisis. Health expenditures worldwide were expected to reach $10 trillion by 2022 even before the advent of COVID-19. Half the U.S. population is considered chronically ill, accounting for some 85% of the total expenditure on healthcare services.

The IIA has identified approximately 80 companies working in the field of bio-convergence. Much of the knowhow is tucked away in Israels academic centers.

Ronit Satchi Fainaro is a prime example.

Named Woman of the Year by the Israeli business publication Globes in 2019, Satchi Fainaro heads the 30-person cancer research and nano-medicine laboratory in the department of physiology and pharmacology at Tel Aviv University.

Satchi Fainaros lab includes research associates in biology, chemistry, medical engineering, bioinformatics and even an architecture student, she said. We are living in the post-genomic era, so theres a lot of room for computer science.

Satchi Fainaros lab developed a method for 3D printing cancerous brain tumors using MRI on images.

We do the image analysis and convert it to a file that a 3D printer can read. Then we create a 3D-printed tumor its like a Mini-Me of that tumor, she said, referring to the Mike Meyers character from the Austin Powers films.

Satchi Fainaros lab creates not one but up to 20 mini-tumors, which are then connected to a set of tubes and pumps that deliver simulated blood and most importantly chemotherapy or other cancer treatments. That allows physicians to test drugs on a perfect copy of the actual tumor.

Satchi Fainaro is also working on an immunotherapy nano-vaccine for melanoma and an immune-modulated response against Covid-19.

Jonathan Solomon and Assaf Oron are the CEO and chief business development officer, respectively, of BiomX, another Israeli bio-convergence pioneer.

BiomX is working on a treatment for Crohns and other inflammatory bowel diseases by sequencing the bacteria in a patients microbiome in order to deliver a gut-punch to the exact bacteria causing symptoms.

BiomXs technology is based on the hypothesis that these diseases are driven by the microbiome and that specific bacteria seem to be pro-inflammatory and antibiotic resistant, Solomon tells ISRAEL21.

Bacteriophage image courtesy of BiomX

Bio-convergence techniques assure that a patient receives the right phages a type of virus that infects bacteria to kill only the offending microbes.

Antibiotics are very indiscriminate killers, Solomon said, which leads to the killing of both harmful and beneficial bacteria and, in many cases, the development of antibiotic-resistant bacteria. Phages are very precise. There are no side effects.

Beyond IBD, acne and liver disease are next on BiomXs list. Even cancer is a possibility.

BiomXs technology was initially developed and licensed from the Weizmann Institute in Rehovot. The company has 100 employees and is publicly traded in the United States.

Then theres Pangea, whose bio-convergence niche is synthetic lethality.

Its a very simple notion with a confusing name, chief technology officer Tuvik Beker said.

The basic idea is that genes often act in pairs. If a gene is acting unnaturally in a tumor (for example, it may be shut down due to mutation or abnormal expression), identifying and shutting down the genes partner can selectively kill the malignant cells.

Pangea brings the computational element.

If there are 20,000 genes in the human genome, simple math means there are about 400 million gene pairs, Beker explained. To test all these pairs for synthetic lethality is very challenging.

As a result, most companies restrict themselves to a couple of hundred genes that they know are important in cancer. Pangea, by contrast, looks for paired genes that are vulnerable to collateral damage, not just the ones driving the tumor, Beker said.

The Tel Aviv-based company hopes to launch its service commercially as early as 2021 with a focus on providing personalized treatment recommendations.

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New Nanomedicine Approach Could Improve Effectiveness of COVID-19 Vaccine – AZoNano

Written by AZoNanoOct 29 2020

Researchers led by the University at Buffalo (UB) have devised a new method that could enhance the effectiveness of vaccines against the novel coronavirus, the virus that is responsible for causing COVID-19.

Jonathan F. Lovell, PhD, an associate professor in the Department of Biomedical Engineering at UB, is the principal investigator of the study titled SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination, published online in the Advanced Materials journal on October 28th, 2020.

COVID-19 has resulted in an uncontrollable global pandemic, which has infected a minimum of 40 million people around the world and resulted in over 220,000 deaths in the United States alone. As the disease started spreading in early 2020, biomedical researchers have been working actively to develop an effective vaccine.

Lovell thinks that one solution could be to develop vaccines that partly imitate the virus structure. One of the proteins on the virussituated on the characteristic COVID spikeincludes a component known as the receptor-binding domain, or RBD, which is its Achilles heel. Lovell stated that antibodies against this part of the virus have the ability to neutralize the virus.

It would be appealing if a vaccine could induce high-levels of antibodies against the RBD. One way to achieve this goal is to use the RBD protein itself as an antigen, that is, the component of the vaccine that the immune response will be directed against.

Jonathan F. Lovell, Associate Professor, Department of Biomedical Engineering, University at Buffalo

The researchers speculated that if the RBD is transformed into a nanoparticle (similar in size to the virus itself) rather than retaining it in its natural form as a tiny protein, it would produce higher levels of neutralizing antibodies and its potential to produce an immune response would increase.

Earlier, Lovells group had designed a technology that enables the simple transformation of small, purified proteins into particles by using liposomes, or small nanoparticles developed from naturally occurring fatty components.

In the latest study, the team added a unique lipid known as cobalt-porphyrin-phospholipid or CoPoP inside the liposomes. The lipid allows the RBD protein to quickly bind to the liposomes, developing more nanoparticles that produce an immune response, stated Lovell.

The researchers noticed that when the RBD was transformed into nanoparticles, it retained its correct, three-dimensional shape and the particles were stable in incubation conditions, analogous to those present in the human body.

High antibody levels were induced in laboratory rabbits and mice immunized with the RBD particles. When compared to other materials integrated with the RBD to improve the immune response, only the method with particles containing CoPoP ensured a powerful response.

According to Lovell, other vaccine adjuvant technologies cannot transform the RBD into particle-form.

We think these results provide evidence to the vaccine-development community that the RBD antigen benefits a lot from being in particle format. This could help inform future vaccine design that targets this specific antigen.

Jonathan F. Lovell, Associate Professor, Department of Biomedical Engineering, University at Buffalo

This research was funded by the U.S. National Institutes of Health, and the Facility for Electron Microscopy Research (FEMR) at McGill University. FEMR is supported by the Canadian Foundation for Innovation, Quebec Government, and McGill University.

Huang, W.-C., et al. (2020) SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination. Advanced Materials. doi.org/10.1002/adma.202005637.

Source: http://www.buffalo.edu/

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Market Players Eye Opportunities in Emerging Economies to Gain Ground in the Healthcare Nanotechnology (Nanomedicine) Market 2015 2021 – Eurowire

The Healthcare Nanotechnology (Nanomedicine) Market research report added by Market Study Report, LLC, provides a succinct analysis on the recent market trends. In addition, the report offers a thorough abstract on the statistics, market estimates and revenue forecasts, which further highlights its position in the industry, in tandem with the growth strategies adopted by leading industry players.

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The geographical reach of the Healthcare Nanotechnology (Nanomedicine) market has been meticulously segmented into United States, China, Europe, Japan, Southeast Asia & India, according to the report.

The research enumerates the consumption market share of every region in minute detail, in conjunction with the production market share and revenue.

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The competitive expanse of this business has been flawlessly categorized into companies such as

Key players in the global nanomedicine market include: Abbott Laboratories, CombiMatrix Corporation, GE Healthcare, Sigma-Tau Pharmaceuticals, Inc., Johnson & Johnson, Mallinckrodt plc, Merck & Company, Inc., Nanosphere, Inc., Pfizer, Inc., Celgene Corporation, Teva Pharmaceutical Industries Ltd., and UCB (Union chimique belge) S.A.

Key geographies evaluated in this report are:

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The valuation that each company holds, in tandem with the description as well as substantial specifications of the manufactured products have been enumerated in the study as well.

The Healthcare Nanotechnology (Nanomedicine) market research study conscientiously mentions a separate section that enumerates details with regards to major parameters like the price fads of key raw material and industrial chain analysis, not to mention, details about the suppliers of the raw material. That said, it is pivotal to mention that the Healthcare Nanotechnology (Nanomedicine) market report also expounds an analysis of the industry distribution chain, further advancing on aspects such as important distributors and the customer pool.

The Healthcare Nanotechnology (Nanomedicine) market report enumerates information about the industry in terms of market share, market size, revenue forecasts, and regional outlook. The report further illustrates competitive insights of key players in the business vertical followed by an overview of their diverse portfolios and growth strategies.

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Some of the Major Highlights of TOC covers:

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Market Players Eye Opportunities in Emerging Economies to Gain Ground in the Healthcare Nanotechnology (Nanomedicine) Market 2015 2021 - Eurowire

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Global Nanobots Market 2020 | Research Report Covers | (COVID-19 Analysis) | Industry Research, Drivers, Top Trends | Global Analysis And Forecast to…

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Global Nanobots Market 2020 | Research Report Covers | (COVID-19 Analysis) | Industry Research, Drivers, Top Trends | Global Analysis And Forecast to...

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