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Category Archives: Longevity

B careful: Humoral responses and COVID-19 severity – Science


Neutralizing antibody responses to SARS-CoV-2, though often of limited longevity, have generally been assumed to be protective against COVID-19 disease.

Prior analyses on thoracic lymph nodes and peripheral blood suggested a dysregulated humoral immune response early in COVID-19, including defective bcl-6+ follicular helper T cell TNF- production and loss of transitional and follicular B cells in severe disease. The cumulative data from recent publications suggested association of an aberrant extrafollicular (EF) B cell response with COVID-19 disease course. Prior work by Woodruff et al. characterized a unique group of IgD and CD27 double-negative (DN) EF B cells in systemic lupus erythematosus, associating the CXCR5negCD21negCD11c+ (DN2) subset with increased disease activity and poor clinical outcomes.

By applying this knowledge to high-dimensional B cell phenotyping stratified according to clinical COVID-19 disease severity, the authors not only validate previously known immune associations including elevated plasma IL-6 concentration, but also reveal that patients with life-threatening COVID-19 demonstrate significant expansion of peripheral blood DN2 cells, activated nave B cells, and antibody secreting cells (ASCs). They delineate a CD21negCD11cneg (DN3) B cell population that, when elevated in blood with two other EF populations including DN2 cells, associates with critical illness and high mortality in COVID-19 patients despite early neutralizing antibody responses. Elevated plasma C-reactive protein (CRP) also correlated with COVID-19 disease severity. The cumulative data offer a new perspective on pathogenic B cell responses in COVID-19 and support hypothesis-driven testing of the combined serum and B-lineage immune signature as a biomarker panel to screen for high-risk COVID-19 disease during infection and therapeutic interventions. These studies also provide insights into B cell effector pathways to consider in targeted immune therapies and COVID vaccine development.

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B careful: Humoral responses and COVID-19 severity - Science

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Hedman on longevity ahead of World Championship debut: "I will probably always be involved in the game until I drop" –

Deta Hedman will make her PDC World Championship debut at the age of 61 after a superb display at the PDC Women's Series.

Hedman is seen as one of the leading pioneers in Women's Darts with 'The Heart of Darts' despite never winning the BDO World Championship, one of the most successful of all time.

She will now take on Andy Boulton at the Alexandra Palace with a rapturous reception likely for the former two time World Master.

So what is the secret to the longevity of Hedman? She believes that it is still having the enjoyment for the game and believes she will be involved as long as is possible.

"I think it's having the love and enjoyment that I still do when I play and meeting up with some great friends," she said to Sky Sports.

"I'll just see where it takes me. I will probably always be involved in the game until I drop or when my memory fails me but I'm still loving it. I have my moments!"

In terms of the future of the ladies game, Hedman believes that if given the opportunity, the glass ceiling can firmly be smashed.

"You have Mikuru [Suzuki], Lisa and Fallon who have taken the game to another level. You have another young lady called Beau Greaves who I think is going to be phenomenal.

"If the opportunity is there like the men's in the PDC then I think you will see the ladies game change again. The standard will be so high it's unbelievable. It is there. Some of the ladies do have the game and it's like any sport. It's whether you really want it."

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Hedman on longevity ahead of World Championship debut: "I will probably always be involved in the game until I drop" -

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Longevity and Anti-senescence Therapy Market Growth and Current Status of Industry Surveyed in New Research Report | (2020-2027) – The…

Market Expertz latest study, titled Global Longevity and Anti-senescence Therapy Market, sheds light on the crucial aspects of the global Longevity and Anti-senescence Therapy market. The report aims to help readers accurately estimate the global market growth rate over the forecast period (2020-2027). Our market research team has meticulously performed quantitative and qualitative assessments of the Longevity and Anti-senescence Therapy market dynamics, considering a slew of factors, including market penetration, product portfolios, end-user industries, pricing structure, and the key drivers, constraints, opportunities, and challenges predominantly affecting market growth.

The latest market study broadly segments the industry based on the product type range, application gamut, end-use industry, key regions, and the competitive background. One of the central components of the report is a detailed explanation of the gross profits, revenue shares, sales volume, manufacturing costs, individual growth rate, and the financial standing of the leading market players. The developmental scope of the Longevity and Anti-senescence Therapy markets new entrants and established companies has also been emphasized in the report.

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Competitive Terrain:

The global Longevity and Anti-senescence Therapy market is highly consolidated due to the presence of numerous companies operating across this industry. The report depicts the current market standing of these companies, their past performances, demand and supply graphs, production and consumption patterns, sales network, distribution channels, and growth opportunities in the market. The leading market contenders listed in the report are:

Market segments by Top Manufacturers:

CohBarTA SciencesUnity BiotechnologyAgeX Therapeutics?IncPowerVision Inc.

The latest report is inclusive of an extensive coverage of the significant impact of the COVID-19 pandemic on the Longevity and Anti-senescence Therapy business sector. The coronavirus outbreak has drastically impacted the global economic landscape, and consequently, this particular business vertical. Therefore, the report provides the reader with a clear concept of the current scenario of this business vertical, estimating its COVID-19 aftereffects.

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Product Type SegmentationHemolytic Drug TherapyGene TherapyImmunotherapyOther Stem Cell Therapies

Industry SegmentationHospitalMedical Service InstitutionDrug and Device Sales

Geographical Scenario:

In this section of the report, market analysts have provided valuable insights into the geographical segmentation of the Longevity and Anti-senescence Therapy market. They have further estimated the current and future market valuations on the basis of the demand-supply dynamics and pricing structure of the leading regional segments. Moreover, the growth prospects of each regional segment have been meticulously extensively discussed in the report.

The global Longevity and Anti-senescence Therapy market is classified into the following regions:

Browse the full report description, along with the ToCs and List of Facts and Figures @

Highlights of the Table of Contents:

1.1 Research Scope

1.2 Key Longevity and Anti-senescence Therapy market segments

1.3 Target players

1.4 Market analysis by type

1.5 Market analysis by application

1.6 Key learning objectives

1.7 Report timeline

2.1 Global Longevity and Anti-senescence Therapy market size

2.2 Latest trends of the Longevity and Anti-senescence Therapy market by region

2.3 Key corporate trends

3.1 Global Longevity and Anti-senescence Therapy size by manufacturers

3.2 Global Longevity and Anti-senescence Therapy market key players

3.3 Products/solutions/services of major players

3.4 New entrants in the Longevity and Anti-senescence Therapy market

3.5 Mergers, acquisitions, joint ventures, and expansion plans

4.1 Global Longevity and Anti-senescence Therapy Sales by Product

4.2 Global Longevity and Anti-senescence Therapy by Product Revenue

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Longevity and Anti-senescence Therapy Market Growth and Current Status of Industry Surveyed in New Research Report | (2020-2027) - The...

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First Drive: The Fiat 500 EV proves this supermini’s unrivalled longevity – Aberdeen Evening Express

What is it?(Fiat)

Reinventing an icon is never easy, but thats exactly what Fiat was faced with when it decided to update the 500. Its played it safe by keeping the existing model on sale, but in many ways its also undergone a radical change by making the new model fully electric.

Thats right, the new generation 500 cannot be bought with an internal combustion engine. Instead its been completely reinvented with new underpinnings and a new look. As an urban car, on paper, the 500 is the perfect model for electrification, so lets find out if it stacks up.

Pretty much everything except for the name is new. Its the first Fiat Chrysler Automobiles vehicle to be built from the ground up as an electric vehicle, so its perhaps unsurprising that it has led with its most iconic model.

That makes it wider and longer than the outgoing model, gets level two autonomous driving features, a futuristic twist on the classic 500 styling, and two battery size choices with fast charging up to 85kW. Its also offered as both a hatchback and convertible.

The powertrain is impressively compact to maximise space in the cabin. Under the bonnet where an engine would typically live is a power electronic bay, which incorporates various aspects of the powertrain such as the charger module and power inverter. Beneath it sits the electric drive module, which has the motor and differential. Its output is 115bhp (or 94bhp on the smaller battery version) and 220Nm of torque.

Beneath the cabin sits the battery pack, which is available in 42kWh or 23.7kWh capacities, providing up to 199 and 115 miles of range respectively. The smaller battery can charge at a maximum rate of 50kW, which takes 30 minutes to get to 80 per cent of charge, while the larger one can take up to 85kW, which takes 35 minutes to reach 80 per cent.

In previous generations, the 500s trump card has always been its style, and while it hasnt been bad to drive, its far from class leading. However, the new 500 feels like a massive step up. Electric powertrains suit city cars down to the ground and this Fiat is no different.

The electric motor doesnt quite have the immediate kick of acceleration of some EVs, but its much more spritely than a petrol car when driving around town. Its comfortable, too, without suffering from the overly harsh ride some rivals struggle with.

The 500 could have been the worst car ever made and it would still sell by the boatload because Fiat absolutely nailed the retro-modern styling. This new model has seen the most dramatic change yet, because although its unmistakably a 500, its got an ultra-modern edge that would be well-suited to a concept car.

Despite being larger now, its not obvious from the outside, so its still got the charming dinky proportions we know and love. It has a solid front grille with a prominent 500 logo that should be tacky but has been implemented in a classy way, while the ring light around the oval headlights is a simple, modern yet characterful touch.

Again, the interior feels like its moved up a level. This is partly because the starting price is higher, as is the case with all EVs, so they tend to get more premium materials and style to help justify it. However, while the Fiat doesnt necessarily feel more premium, gone is the clunky, fussy interior of old and in its place is a sleek minimalist dashboard.

It has a simplified oval instrument binnacle design, which is about the only similarity with its predecessor. Now, the centre console is simply a prominent screen on the dashboard where most features are controlled from, as well as a few physical buttons below for the air conditioning and gear selection.

Prices start at 19,995 for the hatchback after the government grant, and 26,145 for the convertible. There are four trim levels on the hatchback, while the drop top goes without the entry level Action trim, which is only available with the smaller battery.

Standard equipment includes rear parking sensors, 15-inch alloy wheels, halogen headlights, air conditioning and digital instruments. However, theres no infotainment screen you get a smartphone cradle instead.

Step up to Passion and you get the larger battery, cruise control, automatic air conditioning and a seven-inch infotainment screen with Apple CarPlay and Android Auto. After this, Icon models get a leather steering wheel, passive entry with a wearable key, 16-inch alloy wheels, and 10.25-inch infotainment screen with sat nav.

Finally, the top-spec La Prima trim gets extensive extra equipment, including wireless phone charging, leather seats, 360-degree parking sensors, 17-inch alloy wheels, LED headlights and a six-speaker sound system.

Reinventing the Fiat 500 was a big ask. But you have to say fair play to the Italians because they have managed to find everything thats loved about the previous 500 and packaged it up in a modern-looking car with a future-proof electric powertrain.

Theres now more substance to the 500s style, because its great to drive, more spacious and has ultra-low running costs too. Its safe to say this city cars reign of success is likely to continue for a good while yet.

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First Drive: The Fiat 500 EV proves this supermini's unrivalled longevity - Aberdeen Evening Express

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Navajo Nation facing ‘major health care crisis’ as outbreak worsens | TheHill – The Hill

The Navajo Nation is rolling out new coronavirus restrictions as COVID-19 cases surge and hospitals are becoming overwhelmed by an influx of patients.

Navajo Nation President Jonathan Nez on Thursday announced an extension of a lockdown order that requires all residents to stay at home and on the reservation unless obtaining essential food, medication and other supplies, as well as exemptions for essential workers.

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Residents have been advised against gathering with people from outside their immediate household and to wear a mask in public.

The lockdown was initially expected to expire on Sunday but has been extended until Dec. 27 following an alarming surge of infections. As of Friday, 17,310 cases have been reported with 663 deaths.

A 57-hour weekend curfew will also kick off at 9 p.m. on Dec. 11 and last for three weeks.

The move comes as several medical and health care workers said the Navajo Nation is in a major health care crisis and pleaded with the public to stay home and adhere to public health guidelines to slow the spread of the virus during a virtual forum hosted by Nez and Vice President Myron Lizer.

Loretta Christensen, chief medical officer for Navajo Area Indian Health Service, told officials the coronavirus situation is leading to a shortage of hospital beds, oxygen supplies and medical personnel.

We have been in a state of emergency since the pandemic began here on the Navajo Nation, but that has now elevated to a major health care crisis, Nez said.

Our health experts are now saying that the current wave or surge is far more severe and troublesome than the wave that we saw in April and May, perhaps four or five times large according to projections, he said.

Nez on Thursday requested the Trump administration issue a Major Disaster Declaration to free up additional infrastructural and financial resources to better equip the nation to tackle the outbreak.

The Navajo Nation and other Native American communities have been disproportionately affected by the coronavirus pandemic.

According to the Centers for Disease Control and Prevention, American Indian or Alaska Native individuals are1.8 times more likely than their white counterparts to contract the virus, four times more likely to be hospitalized and2.6 times more likely to die from the infection.

The situation in the Navajo Nation comes as the U.S. reportedmore than 210,000 cases in a single day on Thursday, the highest figure yet, and more than 2,700 COVID-19 deaths.







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Study Finds That Blackcurrants Are Healthier Than You Think – Longevity LIVE

Blackcurrants have a beneficial effect on the blood glucose response after a meal. They balance the glucose response of ingested sugar by attenuating its rise and delaying its fall. The effect is likely associated with berry-derived polyphenolic compounds, anthocyanins, which are rich in blackcurrants.

The beneficial health effect of blackcurrants was supported by a recent study conducted at the University of Eastern Finland. In the clinical meal study (Maqua) the beneficial effect on postprandial glucose response was achieved by 75 g (1.5 dL) of blackcurrant. This is a remarkably smaller portion size than in earlier studies. Blackcurrants are often consumed with added sugar because of their natural sourness, which may be a cause of concern for health-conscious consumers. However, it seems that sugar consumed with blackcurrants is not as unhealthy as sugar consumed without berries.

The study was a collaboration between the Institute of Public Health and Clinical Nutrition at the University of Eastern Finland and Savonia University of Applied Sciences by utilizing the regional Food Valley ecosystem.

Berries are an important component of a healthy diet. They are rich in vitamins, minerals, dietary fiber, and polyphenols. So far, however, the EU has not authorized health claims for berries. In recent years, there have been many studies monitoring the effects of berries on glucose metabolism. Dark berries, such as blackcurrant and bilberry, had the most convincing results. Black-coloured berries, rich in anthocyanins, seem to attenuate the blood glucose response to added sugar, compared to a control product having the same amount of sugar. The same effect is demonstrated by anthocyanins extracted from blackcurrants. Polyphenolic compounds may slow down the absorption of glucose from the small intestine by interacting with carbohydrate-digesting enzymes and glucose transport proteins. In addition, polyphenolic compounds may reduce oxidative stress and inflammation.

26 healthy participants (22 female, 4 male) consumed three different test products and sugar water as a control product at four separate study visits. The test products were:

Each of them and the control product contained 31 g of available carbohydrates. They also had a similar composition of sugar components. Blood samples were taken before the meals in fasting state. Samples were also taken post-prandially in 15, 30, 45, 60, 90, 120, and 180 minutes after consuming the meal. The samples were analyzed for glucose, insulin, and free fatty acids.

Compared to sugary water, both blackcurrant products had attenuated postprandial glycaemic response. This was seen in reduced maximum glucose and insulin, delayed fall of glucose, and delayed rise of free fatty acids because of hypoglycaemia. The effect was enhanced for the blackcurrant product because of the innovative product base. The results support earlier findings on the beneficial effects of blackcurrants on blood glucose response after a meal, showing the effect with smaller portion size. Over a longer period of time, smaller variations in blood glucose and insulin levels, and improved insulin sensitivity, may decrease the risk of type 2 diabetes.

Blackcurrants are an interesting raw material for the food industry because of their high content of anthocyanins and easy availability. Blackcurrants have potential for being developed into new healthy and tasty products.

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Study Finds That Blackcurrants Are Healthier Than You Think - Longevity LIVE

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