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Category Archives: Longevity

Notable Figures within the Anti-Aging Field | by Avinash Saravanan | Dec, 2023 – Medium

The anti-aging, longevity, and biohacking field is an area of research that focuses on the use of technology and science to improve human health and extend lifespan. It has been gaining traction in recent years as people become more interested in finding ways to live longer and healthier lives. The field encompasses a wide range of topics, including genetics, nutrition, exercise, and more. Researchers in this field are working to develop new technologies and therapies that can help people live longer, healthier lives.

In addition to researchers, there are influencers, investors, and other figures that are working to publicize the potential of what is possible with regards to reversing, slowing, or stopping the speed of biological aging. In this story, I would like to discuss notable figures within this field who have been in the public eye and what their contributions are. I would also like to discuss any holes in their work that is scientifically shaky.

David Sinclair is a professor of genetics at Harvard Medical School and a notable figure in the field of anti-aging, longevity, and biohacking. He has been studying the aging process for over 20 years and has made several breakthrough discoveries in the field of anti-aging. Sinclairs research focuses on the role of sirtuins, a family of proteins that play a key role in regulating cellular health and aging. He has also authored a book called Lifespan: Why We Age and Why We Dont Have To which discusses his research on aging and how it can be slowed down or even reversed.

Sinclairs research on sirtuins has shown that these proteins play a key role in regulating cellular health and aging. He has also published research stating that resveratrol, a compound found in red wine, activates sirtuins and can extend lifespan in yeast and other organisms. Whether this can be applied to humans is shaky, and there has been controversy regarding his promotion of resveratrol and more recently NMN or Nicotinamide mononucleotide which is a nucleotide used to improve mitochondrial health which decreases over time as people age. Questions regarding the experimental methodology used in his work have led to disagreements within the community regarding what supplements to actually take to reduce aging.

Sinclairs research has led to the development of several new therapies that have the potential to slow down or even reverse the aging process. His work has been widely recognized and criticized and he has received numerous awards for his contributions to the field of anti-aging research.

Peter Attia is a Canadian-American physician known for his work in longevity medicine. He is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan. Attia has played a key role in promoting the benefits of nutritional ketosis, intermittent fasting, and strategic exercise as powerful tools for enhancing longevity. He is also the host of The Drive, one of the most popular podcasts covering the topics of health and medicine.

Peter Attia He has played a key role in promoting the benefits of nutritional ketosis, intermittent fasting, and strategic exercise as powerful tools for enhancing longevity. Attia has also been a pioneer in longevity medicine, applying the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan . He has also co-founded the Nutrition Science Initiative (NuSI), with Gary Taubes, with a primary focus on promoting research in the field of nutrition and tackling the growing health challenges linked to obesity, diabetes, and metabolic diseases.

Peters approach in my opinion seems to be the most realistic and approachable since it focuses on concepts such as diet, caloric restriction, protein and muscle to avoid saracopenia, and drills down to what specifically leads to death later in life.

Bryan Johnson is an American entrepreneur, venture capitalist, and writer who has made significant contributions to the field of biological longevity. He is the founder and CEO of Kernel, a company that aims to develop advanced neural interfaces to treat neurological diseases and enhance human cognition. Johnson is also the founder of OS Fund, a venture capital firm that invests in early-stage science and technology companies.

Johnson has been a controversial figure in the field of anti-aging, longevity, and biohacking. He has been known for his strict commitment to anti-aging and longevity, but he wasnt always focused on his health. The biohacker and entrepreneur says he used to overeat carbs late at night but now avoids refined sugars. Johnson has also been criticized for lending his scientific prowess to commercializing possible life extension products such as NAD boosters. Despite these controversies, Johnsons more recent work with Blueprint has led to greater popularization of the longevity field in recent times.

Blueprint is a protocol developed by Bryan Johnson and a team of doctors. The project aims to measure all of his 70 organs and then maximally reverse the quantified biological age of each. Johnson publicly documents his self-experimental protocols and results, allowing us to be passengers on his longevity journey. His work with Blueprint has led to the popularization of the longevity field despite it being scientifically shaky. The primary reason for this is because his work with Blueprint is a sample size of 1 which makes it difficult to generalize his work to the greater population. This, in addition to some of the inaccessible treatments and the use of hundreds of supplements, has led to the questioning of his methods by much of the scientific community.

https://blueprint.bryanjohnson.co/

Aubrey de Grey is an English author and biomedical gerontologist which is the field that concerns itself with aging who has made significant contributions to the field of biological longevity. He is the author of The Mitochondrial Free Radical Theory of Aging and co-author of Ending Aging. De Grey is known for his view that medical technology may enable human beings alive today not to die from age-related causes. If you have heard of the term escape velocity which has been coined by De Grey, then you should be familiar with this concept.

De Grey is the founder and chief science officer of the Methuselah Foundation, a non-profit organization that aims to extend healthy human lifespan. De Grey has also proposed a framework called Strategies for Engineered Negligible Senescence (SENS), which aims to prevent or reverse age-related damage in the body. The SENS approach involves repairing or replacing damaged cells, proteins, and other molecules in the body that contribute to aging. De Greys work has been widely recognized and he has received numerous awards for his contributions to the field of anti-aging research.

Matt Kaeberlein is another biologist and biogerontologist who has made significant contributions to the field of biological longevity. He is currently a professor of pathology at the University of Washington in Seattle. Kaeberleins research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA).

Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Former Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project. His work has led to several breakthrough discoveries in the field of anti-aging research. Kaeberlein has also been a pioneer in longevity medicine, applying the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.

When it comes to the field of aging, we have so far been ignoring the significant strides made by Japanese researchers in the area of stem cells.

Shinya Yamanaka is a Japanese physician and researcher who has made significant contributions to the field of biological longevity. He is known for his work in stem cell research, particularly his discovery of induced pluripotent stem cells (iPSCs). Yamanakas research has focused on the use of iPSCs to develop new therapies for a variety of diseases, including Parkinsons disease, Alzheimers disease, and spinal cord injuries.

Yamanakas contributions to the field of biological longevity are significant. His discovery of iPSCs has revolutionized the field of regenerative medicine by providing a new source of stem cells that can be used to develop new therapies for a variety of diseases. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for his work on iPSCs. His research has led to several breakthrough discoveries that have helped people live longer, healthier lives. Much of David Sinclairs work cites the work of Shinya Yamanaka.

It should also be noted that he is an advisor for Altos Labs which is developing life extension therapies and has been invested in by Yuri Milner and Jeff Bezos.

This is still a very new field, so it has a mixture of cutting edge research, noise, snake oil, and an unbelievably high amount of liquid cash due to aging and death being a universal experience. At the moment, I think that because of its universality that the field should be more discussed in common discourse. Like the space industry, AI, and nuclear fusion, I think this field has quite a bit of potential and its approach to medicine can change the face of modern healthcare.

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Notable Figures within the Anti-Aging Field | by Avinash Saravanan | Dec, 2023 - Medium

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Longevity Expert Dr. Brett Osborn Outlines Key Steps to Healthier 2024 – BNN Breaking

Longevity Expert Dr. Brett Osborn Outlines Key Steps to Healthier 2024

As the clock ticks towards a new year, 2024, and the world pens down its New Years resolutions, Dr. Brett Osborn, a seasoned neurologist and longevity expert hailing from Florida, shares his wisdom on the roadmap to a healthier lifestyle with Fox News Digital. His recommendations are grounded in five key steps, each as integral as the other, designed to promote not just physical well-being but also cognitive health.

Dr. Osborns dietary advice leans towards a balanced diet, with a strong emphasis on maintaining a low glycemic index (GI). He cautions against the consumption of simple carbohydrates which have high GI scores, as they lead to spikes in insulin levels and negatively affect muscle mass. Instead, he vouches for the intake of healthy fats such as olive oil, avocados, nuts, and butter, coupled with moderate protein consumption from lean meats and fish.

The neurologist further underscores the importance of strength training, not only for physical health but also for cognitive function. Osborns prescription includes basic compound movements and progressive muscle overloading as key elements of an effective strength training regimen. He asserts that consistent strength training can help stave off age-related diseases like heart disease and cancer.

Monitoring blood pressure, according to Osborn, is a critical aspect of maintaining health. He recommends the use of an automated cuff to track daily readings and manage the risk of heart-related diseases. Alongside this, management of inflammation, hormone levels, and blood sugar regulation are crucial to slowing down the aging process. Osborn advocates for regular bloodwork to monitor health markers and take preventive measures to optimize body chemistry, thus ensuring a holistic approach to health and longevity.

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Longevity Expert Dr. Brett Osborn Outlines Key Steps to Healthier 2024 - BNN Breaking

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Alex Caruso praises LeBron James’ longevity as the Lakers visit the Bulls: ‘You can get blinded by the greatness’ – Chicago Tribune

Alex Caruso never takes a matchup with LeBron James lightly.

After spending three years as James teammate including a run to the NBA title in 2020 Carusois familiar with what it takes to face one of the best players in league history.

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When James and the Los Angeles Lakers come to the United Center to play the Chicago Bulls on Wednesday, Caruso knows his team will be energized for the matchup.

You play certain players, certain teams, its easy to get up for those games, Caruso said. Anytime one of the best players to ever play the game comes into your arena, youre gonna be ready.

James is still dominating the league in the 21st season of his NBA career. This is the same player who scored 25 points in his debut at age 18. Two decades later, he is still a top-15 scorer in the league, averaging 25.2 points, 7.2 assists and 7.6 rebounds per game.

For Caruso, those statistics arent shocking but he cherishes a reminder to appreciate the longevity of James career.

It doesnt surprise me but I have to put it in perspective and understand how great it is, Caruso said. Because you see it from him year after year after year after year. You can get blinded by the greatness that he puts up. It speaks for itself, how great it is. And its fun to watch as a basketball player outside of me having a relationship with him.

James, 38, still draws the same attention from fans and defenders, but his style of play has visibly changed over the last decade of his career. He makes a higher rate of shots from behind the arc while relying less on physicality to force his way to the rim. He still centers his scoring on seeking shots in the paint, but hes also developed a keen sense of ball movement that feeds the entire Lakers offense.

This adaptability is part of what Caruso, 29, respects about his former teammate.

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Thats been the thing in his career hes gotten better and hes changed his game, Caruso said. He used to be all downhill, mixed in a couple shots. Now hes shooting the ball really well, playing post-up, facilitating like he does.

But you expect nothing less. Hes been one of the smartest players to play the game. Hes smart enough to figure out what he needs to get better at and put the work in to get there.

Despite the size difference, the 6-foot-5, 186-pound Caruso is expected to shoulder the defensive assignment of attempting to shut down the 6-foot-9 James on Wednesday. Caruso knows the matchup will be a challenge especially physically.

I try to hope he doesnt catch it on the block because hes, like, 270 (pounds), Caruso joked.

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But overcoming a size disadvantage is Carusos defensive specialty. He utilizes a mix of tactics fronting to cut off passes, swatting at the ball to keep players from getting into a comfortable stance, using his lower center of gravity to bump big men off balance to diffuse players like Kevin Durant.

Caruso said hell enter Wednesdays game with the understanding that James will score plenty of points. But his goal for the Bulls is to repeat a team defensive performance like Monday, when they kept Joel Embiid from successfully clinching a Philadelphia 76ers comeback in the fourth quarter.

I just try to make it hard on him, Caruso said. Hes one of those guys like Joel (Embiid) tonight you do your best, theyre going to get their average. So its just about going out there and competing, trying to make it difficult.

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Alex Caruso praises LeBron James' longevity as the Lakers visit the Bulls: 'You can get blinded by the greatness' - Chicago Tribune

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Longevity Shaped by Lifestyle Choices, Says Hassan Vally – BNN Breaking

Lifestyle Choices Shape Longevity: Insights from Associate Professor Hassan Vally

As the world welcomes 2024, longevity and health emerge as top priorities for many around the globe. Associate Professor Hassan Vally from Deakin University, an unbiased voice in the field, has highlighted the importance of lifestyle choices, emphasizing that genetics only account for a quarter of our lifespan. The rest, he notes, is shaped by the decisions we make daily, from the food we eat to the activities we engage in.

According to Vally, diet plays a critical role in longevity and health. A plant-based diet, rich in nutrients, phytochemicals, antioxidants, and fiber, is protective against cellular damage and disease. Vally points to the Mediterranean diet as one of the healthiest options, lauded by the World Health Organization as a longevity-boosting habit. The Mediterranean diet not only nourishes the body but also shields it from heart disease, high blood pressure, and skin cancer.

Obesity is a pressing concern in developed countries, primarily driven by the ubiquity of high-calorie foods. Vally urges individuals to achieve a healthy weight, as obesity is linked to an array of health issues and psychological distress. Regular physical activity is another crucial component of a healthier life. It offers benefits like chronic illness prevention, stress reduction, and improved mental health. Moreover, strength training and compound exercises can significantly contribute to an increased lifespan.

Vally advises against smoking and vaping due to their association with numerous health risks. Quitting, he states, can lead to immediate benefits. Alongside physical health, he underscores the significance of social connections and psychological health. Loneliness correlates with an increased risk of early death and various diseases, emphasizing the importance of fostering and maintaining relationships for a healthier life.

As we enter 2024, it is crucial to prioritize our health and lifestyle choices. By opting for healthier diets, regular physical activity, maintaining a healthy weight, avoiding harmful habits like smoking, and nurturing our social connections, we can shape our path towards a longer, healthier life.

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Longevity Shaped by Lifestyle Choices, Says Hassan Vally - BNN Breaking

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airbus airspace cabin vision 2035+ to ensure longevity of air travel – Designboom

the Airbus Airspace Cabin Vision 2035+

The ability to board a soaring metal bird in the sky and explore all corners of the globe stands as a remarkable modern feat. Nevertheless, the increasing environmental concerns stemming from airline travel have captured global attention. Addressing these issues head-on, Airbus introduces Airspace Cabin Vision 2035+, a forward-thinking initiative encompassing deliberate strategies involving digitization, material advancements, and service enhancements to mitigate the environmental impact of airline cabins. In formulating this comprehensive, future-oriented plan, the company outlines measured steps to ensure the longevity of air travel that is mindful of both the planet and its passengers.

airline cabins can contribute to 10-20% of the overall environmental impact of an aircraft throughout its lifecycle

all images courtesy of Airbus

In a collaborative effort, Airbus, the aerospace products company, has joined forces with ten airlines and eight technology companies to redefine the impact and ambiance of airplane cabins. This specific space can contribute to 10-20% of the overall environmental impact of an aircraft throughout its lifecycle. Through the Airspace Cabin Vision 2035+ initiative, Airbus identifies key elements within this zone that can be optimized to mitigate environmental harm, all while prioritizing an elevated level of passenger comfort in future travel experiences.

Airbuss Airspace Cabin Vision 2035+ is a future initiative for mitigate the environmental impact of airline cabins

As part of the environmental initiative, Airbus is aiming to leverage the material properties of the cabin space. To achieve the 2035+ vision, the components within the cabin should be designed for recyclability, reusability, and repairability throughout their lifecycle. On the product side, the adoption of lighter, bionic elements is expected to reduce cabin weight by up to 40%. Additionally, cabin lining and components will be developed for current aircrafts using advanced materials. Transparency is a fundamental aspect of maintaining the project: this means a comprehensive rollout of these measures with the next generation of aircraft, accompanied by a disclosure of the environmental impact of cabin parts and operations.

the components within the cabin should be designed for recyclability, reusability, and repairability throughout their lifecycle

Enhancing environmental efficiency extends beyond alterations to the physical product; it also involves transforming the service elements of aircraft. Improvements in catering, such as pre-ordering meals for long-haul flights or grabbing snacks at the boarding gate for short-haul journeys, have the potential to decrease food waste by up to 15%. Airbus envisions the digitization of these service elements and the creation of effective touchpoints as crucial steps to bring these concepts to life.

improvements in catering services have the potential to decrease food waste and weight by up to 15%

a study and implementation of materials used in the cabin play a key role in reducing CO2 emissions

Airbus identifies key elements within the cabin that can be optimized to mitigate environmental harm, while also prioritizing passenger comfort

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The Secrets to Longevity Hidden in Ogimi, a Remote Okinawan Village – Rice Media

All photos by Edoardo Liotta for RICE Media.

Two days into my trip to Okinawa, we switched up our itinerary from the usual beaches and markets for a location more off the beaten path. 

After an early breakfastwhere we had onigiris and egg sandwiches under the crisp December airwe set off on a bus to the north of the island, on a drive that takes about an hour from where we are.

As we inch closer to our destination, I notice the traditional wood houses dispersed beneath banyan trees and the sprawling farmland that accompanies quaint restaurants and homes. Within the lush beauty of Okinawas subtropical hills lies the village of Ogimi. Once we reach our destination, we find a quiet refuge where time suddenly slows down.

Here, elderly villagers defy the usual expectations of ageing, moving through life with an agility that’s surprising. Featured recently in Netflixs Live to 100: Secrets of the Blue Zones, Ogimi village has a higher-than-usual concentration of elderly people who live past the age of 100 in good conditions. 

But the secret to their long lives isn’t just luck; it’s a blend of old customs, healthy eating, and strong community bonds.

Our first stop in Ogimi is a hidden culinary gem known as Emi no Mise (literally Emis Shop). Built from wood and nestled between dense foliage, this unassuming restaurant is a portal to not only the heritage of this island but also a deeper understanding of how the elderly here achieve their health.

Emi, the shops namesake, has become renowned for making her signature longevity meal. She cooks everything herself and gets all the fruits and vegetables she uses in the meals from her farm, which sits just across the restaurant.

There are different versions of the longevity meal. The plate I have features cold noodles, bitter gourd with eggs, tofu, sweet potato miso soup, and more. The dessert plate has homemade yoghurt, citrus jelly, an Okinawa doughnut, and the islands native shikuwasa citrus, which loosely resembles an orange.

What is striking about the longevity diet is how vegetable-heavy it issome plates are served with a simple piece of fish, just slightly bigger than an anchovy, and a little cube of pork. Instead, the tray is a lot heavier on legumes, fermented vegetables, beans, tofu, and starchy vegetables like purple sweet potatoes.

Green and entirely organic, the food we try at Emi no Mise encapsulates the dietary secrets that have contributed to the robust health and vitality of Okinawa’s elders for generations.

After lunch, we drive a couple of minutes to a discontinued elementary school, which has since turned into a community centre. Here, elderly people from Ogimi meet up for activities organised by the local government on a regular basis. Instead of going inside, we slowly pace to the side of the school where various plots of land slowly absorb the light rain that has started falling.

Our tour guide brings us to an elderly man who is busy gardening a melon plant. He stops to greet us and then starts sharing about his life.

I eat everything from the garden; that is my policy, he states. He continues to explain how in summer, when its too hot for some plants to grow, he will even eat stems and other parts of vegetables that are not usually prepared as food. And we also use every part of a pig but his hair and oink, he continues with a giggle. Yes, we eat their toes too.

So what is the secret to longevity, in your opinion? I ask him.

Having fun every day, he chuckles; his laughter, infectious and free-spirited, encapsulates the essence of a life well-lived in Ogimi.

To him, the elixir of longevity lies not just in sustenance but in the pursuit of joy. He proudly pulls out a notebook filled with photographs of his artistic creations made with vegetable parts. This is just one way he stays entertained. On many days, children from the village join him while he gardens, and he will prepare games for them using the crops of the season.

As we bid farewell, he leaves me with a parting gift, a local phrase that echoes with camaraderie and transcends language: “bye-onara.

As we return to the school and wait for our bus to our next destination, we get a moment to speak with Fumimaru Osaki, the Director of Ogimi’s tourism board. He tells us how his team works hard to create a symbiotic relationship between the elders of the village and the curious visitors seeking the secrets of longevity.

Osaki passionately strives to foster connections that transcend cultural gaps between the local elderly and tourists. Through the exchanges, he hopes visitors learn that the pursuit of a longer life is not a deliberate endeavour; it’s an organic consequence of a lifestyle in balance with nature, epitomized by the village’s commitment to organic living and the embrace of gardening and farming. By bringing visitors to the local elderly, he also helps keep them active and social.

While these plans are being executed excellently, Osaki shares a worrying truththe encroachment of modernity is threatening the delicate balance between humans and nature in Ogimi. In essence, as convenience becomes a priority nationwide, the life expectancy of locals is starting to drop.

Despite there now being cars and convenience stores, Ogimi, which is still largely rural, continues to be a place that is largely centred around nature.

Osaki, having left the city in mainland Japan for Ogimi, can’t imagine going back. Like many others, he found something profound in living with nature. To him, the quality of life in Okinawa cant be matched.

Quality of life is what matters more to the local government here than age in itself, he explains. When we ask what the age of the oldest person to live in Ogimi is, he says that the person who lived the longest outside a nursing home lived to 103.

Its ok to go to a nursing home, but the aim isnt to just live long at all costs, he continues.

Amid the serene and tranquil air, the game of gate ball emerges as a testament to the vitality and camaraderie that define the elderly here.

Played with a mix of strategic finesse and joyous energy, gate ball holds a special place in the hearts of the Okinawan elders who are eager to share their ways.

They demonstrate the game, showing us how participants engage in friendly competition, wielding mallets with precision to guide coloured balls through numbered gates. This leisurely sport not only fosters physical activityit also acts as a social glue, bringing neighbours together to stay active through engaging matches together.

This sport is a powerful reminder of the significance of social bonds in Okinawa’s recipe for longevity.

In many cultures, it is believed that the elderly are fragile and should stay home, protected from the elements. But in this village, its the opposite. Whether gardening in the fields, playing with kids, or during a match of the game ball, the elderly are out there living as vicariously as they ever did.

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