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Category Archives: Longevity Medicine

The immune system another contributor to increasing longevity, staying young inside – Cleveland Jewish News

We talk a lot about avoiding a threat like COVID-19. You likely know avoiding gatherings, social distancing, washing hands, not shaking hands, not touching your face and wearing masks and person protective gear are important.

But your body is designed to protect you from outside threats. Your immune system is a highly organized and mobile unit, designed to fight to protect you.

Unlike other parts of the body, the immune system is difficult to visualize. After all, you know what the heart looks like and where it beats. But your immune system is just that: a system. It involves a variety of cells and messages between them. Plus, its something that patrols your entire body.

Think about it as any kind of protect-and-defend system it just happens at a microscopic level. It goes through a very similar process as societal defense mechanisms.

And like the city police, state police, FBI, etc., there is a lot of redundancy built into the system, designed to help you. Your skin serves as the first, outer shield to your insides. Even protection for your ears thats what wax is for nose and lungs have filters and cilia that act like brooms, trying to make sure bad stuff from the outside stays outside.

Once inside, or against an inside renegade like a cancer cell, this defense system is action. Its what rushes in when you scrape yourself. When you have a cold or are sick from a virus, your immune cells recognize some nasty stuff causing problems and send in other immune cells to fight them. The result of that fight is what you see or feel coughing, runny nose, inflammation, fever and things of that sort.

You also might see it when you cut yourself or twist an ankle. Redness or swelling are a result of those immune cells identifying a problem and sending in cells to heal the area. Ultimately, its what heals you.

Yet when we talk about vibrant longevity, its not just about how your body handles the flu or a bum joint. Its much more about how your immune system handles the major threats that if not defeated, will kill you, like MERS, SARS, COVID-19 or a cancer. Strengthening your immune system is key for keeping you young inside.

It should be noted your immune system, after you turn about 50, loses some of its juice. It is less able to identify and attack invaders, which is the reason self-engineering your immune system is vital and you should do all you can to keep it in top shape.

Tips for self-engineering your immune system

Quality sleep: Poor sleep is associated with decreased immune function and decreased rate of vaccines working, for that very reason. That means not only getting at least 7 hours of sleep, but also making sure its quality sleep. Good sleep hygiene, meaning no screens in the bedroom and not eating for a few hours before sleep, is crucial to making sure you get rest. Getting great sleep for several days prior to a flu shot boosts its success in protecting for influenza viruses.

Manage stress: One of the major threats to your immune system is chronic stress, which causes a cascade of hormonal responses that weakens your immune function over time. And while were of the belief theres no such thing as total stress relief stress is simply a byproduct of living a fulfilling life we believe there are ways to self-engineer the effects that negative and chronic stress can have on the body. Of course stress management can take many shapes and forms, and you should engage in those activities that work for you, as long as theyre healthy a nightly assembly line of martinis does not qualify. Meditation, deep breathing, social connections by phone or video chat in this time of social distancing, and at least 10 other techniques have been shown to increase immune function.

Enjoy healthy food: Vegetables are natures best protective medicine theyre fortified with so many good-for-you compounds and nutrients. When it comes to preventing or fighting enemies of longevity, if theres one thing you can do to help reduce your risk, its to make a conscious effort to cover more of your plate with veggies and fruits. Make them great tasting, and it helps to avoid red and processed meat, simple sugar, syrups and carbs that are not 100% whole grain. The best approach is to diversify your portfolio of fruits and vegetables think leafy greens, cruciferous vegetables, berries and citrus fruits.

This will help improve the chances that all your micronutrients vitamins A, B, C and D, and minerals like zinc and selenium are covered. Its also a good idea to supplement with half a multivitamin-multimineral supplement twice a day (morning and night) to ensure all of your bases are covered. Taking it for several weeks prior to a flu shot is another way to boost the flu shots success in protecting you for influenza viruses.

Move, move, move: Any movement is great, but increasing progressively over time can boost immune functioning. Note, though, that over-exercising is associated with decreased immune function. Training by running continuously for more than two hours, or biking more than two hours continuously, would classify as over-exercising, as doing more than two hours of exercises continuously causes inflammation and depresses your immune system.

Cut out toxins: This includes vaping, smoking cigarettes and consuming too much alcohol.

Cover your cough.

Get vaccines.

Wash your hands.

Yes, you get to engineer your immune system so it can help you ward off the current headline threat, as well as the big longevity stopper cancer. Take the opportunity.

Dr. Michael Roizen writes about wellness for the Cleveland Jewish News. He is chief wellness officer and chair of the Wellness Institute at Cleveland Clinic.

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Shingles vaccine makes an impact around the world and right here in Rockford – Rockford Register Star

Although most people are aware that the College of Medicine graduates 55 physicians each year, many of whom eventually practice in Winnebago County, the research enterprise of the campus is less well known. In particular, a remarkable breakthrough in the prevention of shingles occurred two years ago which should make every Rockfordian proud. Shingles is a painful skin rash that can cause itching and excruciating pain, and occasionally blindness.

Without a preventive vaccine it will impact 1 out of every 3 people and can be particularly serious for those who are elderly or have impaired immune systems. The exciting news is that a vaccine developed right here in Rockford is providing protection to millions of people around the world.

Two years ago, the U.S. Food and Drug Administration approved a new vaccine to prevent herpes zoster or shingles, a painful condition caused by the chickenpox virus. After childhood chickenpox, the virus becomes dormant in neurons and may reactivate in adults to cause shingles. The vaccine, marketed by GSK under the brand name ShingrixTM, is now the recommended vaccine for adults over age 50. It is not only safer, but is more effective than the existing live vaccine.

Abbas Vafai, Ph.D., the scientist who developed the Shingrix vaccine, worked on its development when he was an associate professor of microbiology at the University of Illinois College of Medicine Rockford from 1990 to 1997 and also had worked on the vaccine at the University of Colorado. The U.S. Food & Drug Administration approved the vaccine for use in October 2017. Since then, the Centers for Disease Control has recommended Shingrix for all adults over age 50.

Because of this, its use for all adults 50 years and older is warranted the only problem has been getting enough of it made to meet the worldwide demand. Vaccine shortage have been felt in Rockford and throughout the country.

We are incredibly excited about Dr. Vafais success with vaccine development and are extremely proud that a vaccine developed on the Rockford campus of the University of Illinois College of Medicine is now impacting the health of people worldwide.

Because some of the work on the vaccine was conducted on the Rockford campus, a portion of the profits will go to the College of Medicine Rockford. The total of what the College of Medicine Rockford and its Department of Biomedical Sciences may receive in royalties over the course of the seven years is predicted to be over $10 million. These are dollars that allow us to continue to educate tomorrows scientists and physicians and support cutting-edge research.

As the UIC Health Sciences Campus-Rockford on Parkview Avenue continues to thrive and grow, so does the Rockford community. In fact, an economic impact study conducted in 2016 indicated the campus had an impact of over $58.2 million to the Rockford Metro Area the equivalent of 898 jobs.

For those whose doctor recommends the Shingrix vaccine, they can expect the vaccine, given in two doses, will prevent what could be a serious and painful condition. The vaccine is also extremely effective in preventing a consequence of shingles called postherpetic neuralgia. Postherpetic neuralgia occurs in 10% to 18% of individuals who have shingles and is characterized by a severe chronic pain condition that can last for years.

Biomedical research at the College of Medicine continues to explore new ways to improve health and prevent disease. State-of-the-art research in the areas of prostate cancer, lung cancer, eradication of parasitic infections, improving the longevity of joint replacements and stem cell treatment of severe debilitating neurologic diseases, occurs daily on campus. With the support of our community, the next major medical breakthrough could again come from the University of Illinois College of Medicine Rockford and its team of researchers in the Department of Biomedical Sciences and other academic departments.

Dr. Alex Stagnaro-Green is the regional dean of the University of Illinois College of Medicine at Rockford.

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Shingles vaccine makes an impact around the world and right here in Rockford - Rockford Register Star

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How to live longer: The hot drink proven to increase life expectancy – how much to drink – Express

Drinking a certain type of beverage has been linked to longer life. What is this drink and how much of it should you consume?

Research published in the European Journal of Epidemiology collated data from 40 studies, including 3,852,651 subjects and 450,256 causes of death, and found coffee had an inverse association with mortality (death).

The researchers found this to be true irrespective of age, overweight status, alcohol drinking, smoking status, and caffeine content of coffee.

They went on to say that between two to four cups of coffee every day was associated with reduced all-cause and cause-specific mortality, compared to no coffee consumption.

In The New Journal of Medicine, a 13-year study observed 229,119 men and 173,141 women who were 50 to 71 years of age at baseline, and their consumption of coffee.

The researchers found there was a significant inverse association between coffee consumption and mortality.

Adding to this body of work, PubMed Central published a research paper detailing how drinking coffee is linked to lower mortality irregardless of which country participants were from.

The Journal of Nutrition has a study that reveals coffee is full of antioxidants.

READ MORE: Vitamin B12 deficiency symptoms: What colour is your skin? Your risk of condition revealed

Harvard Universitys School of Public Health report antioxidants donate electrons to free radicals within the body.

A large amount of free radicals a byproduct of turning food into energy, exercising, or caused by exposure to cigarette smoke, air pollution and sunlight are capable of damaging cells and genetic material.

Free radicals steal electrons from nearby substances that yield them, altering the affected substances structure.

An excessive, chronic amount of free radicals in the body causes oxidative stress, thereby damaging cells which can lead to chronic diseases.

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Antioxidants work by donating electrons to free radicals without turning into electron-hungry scavenges themselves.

Antioxidants are also involved in mechanisms to help repair DNA and maintain the health of cells.

The NHS add: Drinking coffee can be part of a healthy, balanced diet. Current guidelines recommend drinking no more than around four cups a day.

Do you simply add a teaspoonful of granules, pour over some milk and add hot water?

Or do you enjoy sipping on a cappuccino, maybe a latte, or flat white?

For chocolate lovers, theres mocha, and for those who enjoy a stronger hit of caffeine, theres the classic espresso.

Depending on the coffee bean, types of roast from light to dark and serving size, each cup can have different levels of caffeine.

The Alcohol and Drug Foundation defines caffeine as a stimulant drug

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AI identified coronavirus before it spread. Here’s how it can contain future contagious viruses – Fox Business

Billionaire Mark Cuban discusses the fastest growing industries and the streaming wars.

Tech and medical experts say artificial-intelligence technology holds the key to preventing potential virus pandemics and outbreaks like novel coronavirus.

Researchers at the Toronto-based AI platform BlueDot identified COVID-19 on Dec. 31 just hours after local officials in Wuhan, China, reported the city's first diagnoses, but it took the Chinese government weeks to make an official announcement.

"Coronavirus is a huge wake-up call for us in a positive way because ofhow important AI technology is and how medicine should embrace AI technology so it can recognize viruses like [COVID-19]," Sergey Young,founder ofa $100 millioninvestment fund dedicated to making longevity affordable and accessible called the Longevity Vision Fund, told FOX Business.

A worker wearing protective gear sprays disinfectant as a precaution against the coronavirus in Seoul, South Korea, Thursday, Feb. 27, 2020. (AP Photo/Ahn Young-joon)

"It's also a negative wake-up call because we are still human beings with a lack of trust in AI, and human beings have a weakness in terms of how we respond to AI," Young added.

Investors, tech experts and health care experts alike are starting to become more comfortable with the integration of AI in the medical field, including its use in identifying diseases that have the potential to become widespread. AI "is a huge search machine that searches the world's data," Young said.

AS CORONAVIRUS SPREADS, MORGAN STANLEY RELOCATING WALL STREET TRADERS

Imagine the world's biggest library. AI uses algorithms that could scan through all the books in that library in a fraction of the time that humans would be able to. For example, BlueDot's AI technology was able to identify coronavirus in just a day when its technology picked up signs of anunusual pneumonia coming from a market in Wuhan on Dec. 30, CNBC Make It reported on Wednesday.

BlueDot founder and CEOKamran Khan, who worked as an epidemiologist and physiciantreating patients in Toronto during the 2003 SARS outbreak, said the purpose of AI and companies that use it like BlueDot is to "spread knowledge faster than the diseases spread themselves."

It would have been impossible for humans to come to the same conclusions about COVID-19 in December without AI, which partners with big tech and big pharma tosearch millions and billions of databases for keywords on social media, financial transactions, hospital data, people reporting unusual trends,travel activity and a number of other data to make connections between two unlikely factors, Young said.

COVID-19 has since spread to 85 countries outside of China with95,333 confirmedcases within and outside the origin country. The virus has killed3,015 in Chinaand 267 elsewhere as of March 5, according to data from the World Health Organization.

CORONAVIRUS TEST KITS DELAYED, DR. ANTHONY FAUCI CONFIRMS

Despite knowing about the virus weeks before it began to rapidly spread, officials refrained from spreading informationYoung says the issue has to do with human trust in technology and AI, and AI's ability to connect dots that humans likely would not.

"Where AI is similar to human intelligence is that it tries to look for all relevant data and analyze it," Young said. "Where AI is unlike human intelligence is its enormous capacity to search, analyze and link data, and often come up with very unusual correlations.AI will not be scared to present unusual data correlations at the risk of sounding stupid" like humans would.

This undated photo provided by U.S. Centers for Disease Control and Prevention shows CDCs laboratory test kit for the new coronavirus. (CDC via AP)

"The overall issue is two problems. One: We live in a world of oversupply of information. There is so much noise that we need AI to handle it. It is impossible for WHO and other world organizations to see abnormal activity coming from one specific direction," Young explained.

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"Two: I think we missed the point in the development of global health crisis. We didn't realize that like technology, viruses do not have borders. If people think it's just a China problem, that will create more problems," Young said. "The level of globalization today, not just in technology but human-to-human interactions," continues to develop.

Young and Kahn both said federal organizations like WHO that help fight infectious disease are too reliant on old systems and traditional medical research practices.

"What I learned during SARS is, lets not get caught flatfooted, lets anticipate rather than react," Kahn told CNBC. "If we rely on government agencies to report information about infectious disease activity, we may not always get that in the most timely way or as quickly as we would like."

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Longevity and Anti-Aging Drugs

Were living longer these days, but that hasnt stopped newer branches of medicine from trying to enhance and further extend our lifespans.

Researchers in longevity medicine and biogerontology are studying drugs and compounds that can prevent and reverse aging on the cellular level.

Over the past few years, public interest in longevity issues has grown, but that interest is mostly in health-extending therapies, not simply life-extending therapies. Most people are interested in living longer, but only if they can also be healthier longer, Sonia Arrison, author of 100 Plus: How the Coming Age of Longevity Will Change Everything, From Careers and Relationships to Family and Faith, and founder of Singularity University in California, told Healthline.

While many people are focused on lifestyle changes, the addition of drugs rapamycin and metformin are two that Arrison mentioned gives humans more options to extend their lives as well as the quality of their lives.

Compared with preventative drugs such as statins to avoid having a heart attack, anti-aging drugs fight multiple diseases at once instead of focusing on one ailment, Arrison added.

A person who goes by the name Reason, a technologist and author on FightAging.org, which highlights health- and longevity-enhancing medical technologies, told Healthline that the drugs are targeting a wide range of age-related ailments and diseases.

All age-related diseases are age-related because they are caused by the processes of aging, which is to say an accumulation of damage in cells and tissues, Reason wrote in an email.

Read more: Botox may have long-lasting, anti-aging effects

The field of geroprotection involves understanding cell senescence, which is when cells stop dividing.

When senescent cells no longer divide, they stop functioning, so organ health deteriorates. Cell senescence also causes the release of proinflammatory cytokines, which damage tissues.

This arena involves the use of geroprotectors, which are compounds that can stop or reverse cellular aging, and senolytics, which are compounds that can pinpoint and destroy senescent cells.

This is why researchers are looking into geroprotectors and senolytics, which requires long spans of time to understand.

In essence, todays researchers may never see the outcomes of the research theyve started because it can take decades to study. Nevertheless, scientists continue to try to understand these compounds and how they can alter our cells.

Researchers are also looking into our cells telomeres, which are short segments of DNA in our chromosomes that protect cells from wear and tear that comes with aging. As cells divide, they can shorten and no longer protect the chromosome or cell.

Lengthening them is the focus of recent research. Last year, a BGRF study was able to lengthen human telomeres.

A recent report in the journal Cell detailed how peptides were able to boost the life span of mice. The study examined how cell therapy could reverse poor age-related kidney function, fur loss, and frailty in mice.

Scientists are looking into whether or not the approach can also prolong the life span of mice. Human safety studies are in the works.

Reason said there are two schools of thought when exploring extending life through genetic pathways.

One approach is to alter cellular metabolism and make cells age more slowly, but the work is difficult and expensive. The other is to fix old tissue because we understand how it compares with young tissue.

No one yet fully understands everything these [older] cells do to us, but the fastest way to find out is to get rid of them, and we know that doing that in mice extends life and reverts aspects of aging, Reason explained.

Either you slow down the damage, or you repair the damage. Aging is damage. It is in the how of achieving one of those goals that all the complexity starts up, Reason added.

Read more: Beer may keep your DNA young, study says

The Human Aging Genomic Resources (HAGR) website recently released DrugAge, a database of lifespan-extending drugs and compounds.

It includes 418 compounds that were recorded from studies on 27 different model organisms.

HAGR already operates the GenAge database of age and longevity-related genes in humans and model organisms. They also operate AnAge, which has aging and longevity records of more than 4,000 species, the GenDR database of genes associated with the life-extending effects of dietary restriction, and LongevityMap, which includes more than 2,000 human gene and genetic variations linked to longevity.

DrugAge incorporates earlier efforts by Biogerontology Research Foundation (BGRF) scientists, who produced Geroprotectors.org. Right now, its the largest database of its kind.

According to the research teams from BGRF and the University of Liverpool, pharmaceuticals have not targeted most age-related pathways. The research is only focused on a small number of pathways that are currently known.

The goal behind the database is to pave the way for discovery of new life span-extending and health span-extending compounds.

I am confident that it [DrugAge] will gain widespread use in the aging research community, and represents a significant milestone along the way to the coming paradigm shift in modern healthcare away from single disease treatment and toward geroprotective multi-disease prevention, Dmitry Kaminskiy, managing trustee of BGRF, said in a statement.

Franco Cortese, deputy director and trustee of BGRF, said in a statement the database will be extremely valuable for biogerontologists. The BGRF did not respond to Healthlines request for comment.

Already, researchers are using the data to identify trends and develop a better understanding of the comparative effects of geroprotectors on organisms.

Arrison is excited when she sees people teaming up globally to battle human disease and decline something that the DrugAge team is hoping to do with their database.

The more knowledge the health community can get, the better. The wonderful thing about the internet is that knowledge gets distributed faster, making the quest for cures that much quicker, Arrison added.

Read more: Study breaks down aging process, may lead to solutions

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Beverage For Longevity: Drink This Hot Cup Daily To Increase Life Expectancy – International Business Times

KEY POINTS

How to live longer is a quest that almost everyone engages in. A lot of people are conscious of the kind of food they eat, as well as the kind of beverages they drink. One hot drink that has been proven to help in lowering mortality is green tea. By drinking this daily, you would be able to increase life expectancy.

The Evergreen Studies

A study conducted in Japan by the Department of Public Health and Forensic Medicine showed how daily green tea consumption could result in reducing mortality. The study involved 40,530 people aged between 40 and 79.

The participants did not have a history of coronary heart disease, stroke, or cancer at the start of the experiment. They found after the 11-year experiment that green tea did wonder for the overall health of the participants and significantly reduced mortality rates. green tea for longevity Photo: Free-Photos - Pixabay

In another study that was published in ScienceDirect, it also ascertained how consuming green tea was associated with the same great benefits as with other studies concerning mortality rates.In the above study, the researchers from the Department of Epidemiology at Okayama University Graduate School of Medicine investigated around 14,001 elderly citizens who were between 65 to 84 years old.

They completed a questionnaire, which asked them about the frequency of their green tea consumption. The researchers found that those who consumed up to 7 cups of green tea a day lived longer compared to those who consumed less than a cup.

As per the Division of Health in Warwick Medical School, it showed how green tea would create highly favorable effects, especially on getting the heart healthy and avoiding cardiovascular diseases.Aside from this, they also found out that green tea can help lower bad cholesterol. It also staves off high blood pressure. With all these great benefits that green tea provides to the body, you will experience what it is like to be healthier the moment you consume green tea.

More Longevity Tips

In addition to drinking green tea daily, try to engage in a more active lifestyle. Try to engage in cardio exercises daily; you can spend 30 minutes a day to exercise. Also, try to control your blood sugar and blood pressure. Getting these under control will also help in giving you more years.

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