Category Archives: Immortality

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The upcoming Judgement Day event from Marvel Comics puts Eternal against X-Men against Avenger for reasons. Mutants have been declared Deviants, and we know what Eternals do with Deviants.

But the Free Comic Book Day looks at why that changed and why the Eternals have no choice to do what they do. And never did.

Eternals were born that way. Created by the Eternals to remove the demonic Deviants from their influence on Earth. That's how Jack Kirby created it though the justification has been morally compromised over the years from a variety of creators and most notably the recent Marvel Studios movie. They see what is Deviancy and they exterminate it. And have done for millions of years. Including during the time of the Avengers 1,000,000 BC when Odin led the team.

Poor telepathic monkeys of a million years ago. Declared Deviants by the Eternals and then wiped out. That's genocide. And all because they were developing the same kind of Uni-Mind that the Eternals enjoy.

Of course humanity has evolved through that time with many deviancies. What makes a deviant and what does not? Given the many mutants on the Marvel Earth, why have they not been declared Deviant before now?

It's the grand Krakoan experiment, that has given mutants the gift of resurrection. Effective immortality, as long as Krakoa exists, the Cerebro network works and The Five are able to keep things going. And everyone gets to keep seeing Cyclops naked. But just as the Eternals are immortal, the mutants cannot be allowed to be.

And so if that is defined as Deviation by the Eternals, their genetic imperatives will be to wipe out mutants. They will have no choice. Or will they? This is AXE: Judgment Day from Kieron Gillen and Valerio Schiti, and an FCBD teaser drawn by Dustin Weaver. And you can find other FCBD spoilers with this handy dandy tag.

FCBD 2022 AVENGERS X-MEN #1 (NET)MARVEL COMICSJAN220029(W) Kieron Gillen, Gerry Duggan, Danny Lore (A) Dustin Weaver, Matteo Lolli, Karen Darboe (CA) Valerio SchitiFeaturing stories by an all-star lineup of creators including writers Kieron Gillen and Gerry Duggan and artist Dustin Weaver, FREE COMIC BOOK DAY: AVENGERS/X-MEN #1 will lay the groundwork for an event that will erupt across the Marvel Universe in 2022 and drastically alter the relationship between Earth's Mightiest Heroes and mutantkind.In Shops: Apr 20, 2022

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Why Eternals Have To Kill The X-Men (Free Comic Book Day Spoilers) - Bleeding Cool News

Television series

Immortality (Chinese: ; pinyin: Hoy Xng) is an upcoming Chinese television series based on the BL xianxia novel The Husky and His White Cat Shizun (Chinese: ; pinyin: r H H T De Bi Mo Sh Zn) by Meatbun Doesn't Eat Meat (Chinese: ; pinyin: Rubo Bch Ru) starring Luo Yunxi and Chen Feiyu.[2][3] The series is expected to air on Tencent Video with 50 episodes.[1]

The story is set in a tumultuous era where the world is facing a probable invasion by the demon world due to a rift in the heavens. The world's most powerful cultivator Chu Wanning (Luo Yunxi) did not forget his original intention of joining the world to help the Dao cultivation and sets out on a mission to protect the beings of the world. He uses his abilities to prevent the heavens from splitting and at the same time, his compassion and love influences his misguided disciple Mo Ran (Chen Feiyu) to return to the righteous path he has strayed from. Chu Wanning also successfully imparts the value of putting the greater good before personal desires to Mo Ran. In the end, the pair of teacher and disciple dedicate their lives and work together with the rest of the cultivating heroes to stop the villains' conspiracy and protect the world.[2]

Also known as Yuheng of the Night Sky () and the Beidou Immortal (), he is a grandmaster of the cultivation world who hides his caring and sensitive nature behind a cold exterior. He devotes his time to the thankless task of sealing the rifts in the barrier between the ghost realm and the mortal realm and often spends his spare time creating affordable mechanical devices such as the Holy Night Guardian so ordinary people can protect themselves from ghosts. Chu Wanning takes it upon himself to protect the people and rid the world of evil even if it means sacrificing himself.

Courtesy name: Mo Weiyu ()Mo Ran is Chu Wanning's third disciple, a confident, mischievous, and cheeky cultivator who isn't the brightest student in the sect. By chance, he gains mysterious memories of himself as Lord Taxian (), an immoral and murderous ruler who loathes Chu Wanning and vows to murder all the cultivators in the world. His personality slowly changes after being influenced by the fragmented memories implanted in his mind, and he must fight to regain his own consciousness as the kind and upright Mo Ran.

Courtesy name: Shi Mingjing ()Shi Mei presents herself as a kind-hearted, polite, and reasonable person who avoids conflict. She doesn't hold grudges and is often the mediator for Mo Ran and Xue Meng when they argue. However, she actually harbors a deadly secret, and must ultimately decide between revenge and life as she knows it.

Courtesy name: Xue Ziming ()The narcissistic young master of the Summit of Life and Death who is actually responsible and kind at heart. He respects his teacher Chu Wanning deeply and dearly loves his parents Xue Zhengyong and Madam Wang. Despite a carefree childhood, he is forced to grow up when disaster strikes his sect.

Master of the Summit of Life and DeathA kind and good-natured cultivator, he founds the Summit of Life and Death to protect the lower cultivation world from the ghost realm. He persuades Chu Wanning to join the sect after the latter leaves Rufeng Sect out of disgust.

Mistress of the Summit of Life and DeathA former senior disciple of the Lone Moon Night sect who loses the ability to cultivate in her youth. She is married to Xue Zhengyong.

He appears to be a gentleman, yet is in fact a hypocritical and ruthless leader who will sacrifice anyone for personal gain. He harbours a deep resentment against Chu Wanning.

A talented cultivator, he was betrayed by his older brother Nangong Liu and is exiled from Rufeng Sect. He later returns for revenge.

Founder of Rufeng Sect.

On January 6, 2020, CD HOME STUDIO released a casting call for the series, along with information of the participating staffs.[4] The series is produced jointly by Tencent Penguin Pictures and Otters Studio.[2] The series is directed by He Shupei,[4] and the main producers are credited to be Qi Shuai, Ye Fangcang and Wang Yirong.[4] On January 8, it was revealed that the drama has been filed on record at State Administration of Film Radio and Television (China).[1]

The series began filming on April 24, 2020 at Hengdian World Studios.

On January 21, 2020, Luo Yunxi and Chen Feiyu were announced as the main leads.[5]

A majority of the crew members, including world view design team Hua Tian, visual effects team TimeAxis, hair and makeup director Zeng Minghui and still photographer Li Ruoyu worked on 2018 fantasy romance drama Ashes of Love.[2] Chen Xin serves as the art director of the series, while Huang Wei is in charge of costume designs.[4][2] On January 21, 2020, the concept arts designed by Hua Tian were released on the series' official weibo.[6]

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Immortality (TV series) - Wikipedia

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A Record of a Mortal's Journey to Immortality (TV Series ...

Aging is a particularly troublesome affair, and until recently it was considered to be an inescapable fact of life. Over the past few decades, however, scientists have discovered that aging follows a predictable path. Unsurprisingly, there is great interest in avoiding that path.

As we age, we experience a gradual decline of physiological function. Over time, our cells accumulate damage and their performance suffers. When the damage reaches a threshold, cells die. Fortunately, there is a system for replacing the dying cells stem cells. Unfortunately, stem cells also age. Consequently, their performance suffers, and they lose their capacity to create healthy new cells.

The new biotechnology firm Altos Labs has recently announced it was taking on aging. At first glance, it is hard to get excited about this. After all, a half-dozen biotech firms have made similar statements over the past decade or so. Altos Labs, which has already secured $3 billion in funding, hasnt released much information about their strategy, only that they are focused on cellular rejuvenation programming to restore cell health and resilience, with the goal of reversing disease to transform medicine. Catchy sales pitch, but not a lot of substance.

Altos Labs has, however, released a lot of information about the scientists theyve recruited, and it is an impressive list, comprising some of the superstars in aging-related disorder research. These scientists backgrounds would suggest Altos Labs has a two-pronged research strategy: 1) reverse the damage that occurs as we age and 2) rejuvenate stem cells capacity to create healthy new cells. A spa day and a cocktail, basically.

Stress ages us. Thus, one of the keys to living a long and healthy life is to relax. We cant escape stress, but if we relax after a stressful event, we can escape many of the consequences of stress.

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Stress also ages our cells. Admittedly, they arent dealing with psychological stress from poverty or global pandemics, but they have their own problems, such as nutrient deprivation and viral infection. These cellular stressors can damage a cells proteins, and if there is a lot of damaged protein, a cell cant function well. Cells cannot escape stress. They may not become infected, but they will suffer some form of stress eventually. Luckily, cells have a mechanism for escaping the consequences of stress: the integrated stress-response (ISR) pathway.

When cellular stressors are detected, the ISR initiates spa mode. However, instead of relaxing while a masseuse rubs away muscle knots, cellular spa mode involves shutting down non-essential cellular operations and cleansing the cell of damaged proteins. If the cleansing is successful, the cell is rejuvenated. If not, then ISR presses the termination button. The cell dies, but ideally, a stem cell quickly creates a healthy new cell to replace it.

ISR is more active as we get older, which means cells spend more time in spa mode. A comparison of adult and older male mice demonstrated an increase of ISR activity levels in all tested tissues, including kidney, liver, colon, brain, testes, pancreas, lung, and heart.

However, it is not clear if the increase in ISR activity is a good thing. On one hand, it might promote health in old animals by rejuvenating cells. On the other hand, it might instead contribute to destroying cells unnecessarily.

Destroying a damaged cell can be a good thing, as long as it is quickly replaced with a healthy new cell. However, adult stem cells appear to age with the person. As stem cells age, their ability to create healthy new cells deteriorates. Consequently, a cell might die because ISR has determined it was too damaged, only to be replaced with a cell that is almost equally as damaged.

Essentially, this is like terminating an overstressed employee whose performance has dropped. Then, you wait six months to hire a new employee who is slightly less stressed. A couple months later, you lay off the new employee. During that six-month period, other employees will have to shoulder extra responsibility. Their stress will grow, their performance will drop, and next thing you know, youve laid off the whole department. Catastrophic organ failure is the main cause of age-related disorders.

It is tempting to speculate that inhibiting ISR in adults could solve a lot of problems. Sure, thered be no more spa day, but thered also be no more mass layoffs. But its not that simple. ISR inhibition does enhance memory and lifespan. However, ISR activation reduces the severity of Huntingtons disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis. Thus, the ISR appears to play a beneficial and detrimental role in health depending on the context. Altos Labs scientists will have to gain a better understanding of ISRs context-dependent effects before they can create new anti-aging therapeutics.

No matter how efficient the body is at rejuvenating cells, cells will die and need to be replaced. As we age, however, replacing cells takes more time. For example, healing of a fractured bone takes much longer in older individuals than in younger individuals.

Stem cells are responsible for replacing damaged cells. Like any other cell, stem cells are vulnerable to cellular stressors. This likely contributes to their own aging, but there is also evidence that stem cells DNA changes as during physiological aging. More specifically, the DNAs structure is changed (called an epigenetic change), but not the DNAs sequence. In other words, regardless of their age, stem cells keep the same genes; however, as stem cells age, some genes are tightly packaged up and no longer accessible.

Epigenetic changes are often helpful. For example, a liver-replenishing stem cell will package up all of its neuron genes. When that stem cell creates a new liver cell, the new cell cant accidentally express those neuron genes.

But in the case of aging, the epigenetic changes can be harmful. For example, in addition to packaging the neuron genes, an old liver-replenishing stem cell might package up two other genes:

When a new liver cell is created, it wont be able to access the cleansing gene. As a result, that cell will have a harder time cleansing itself of damaged proteins. Thus, it will die more quickly and need to be replaced again. Unfortunately, that replacement will be slow to arrive because the stem cell cant access the replication gene.

It is unclear why a stem cell would gradually package up helpful and important genes. One hypothesis is that this process ensures we will die. When old organisms die, it frees up resources for young, sexually reproductive organisms. Thus, there is an evolutionary advantage to death.

Regardless of why stem cells do this, it would be helpful to discover a way to liberate some of the genes packaged during aging. Scientists have suspected that this could reverse a stem cells aging-associated functional decline. In 2006, Shinya Yamanaka discovered the tools necessary to do this.

Yamanaka and his team showed that activating four gene regulators (now referred to as the Yamanaka factors) can reset a stem cells epigenetic changes, essentially turning it into a young stem cell. (Yamanaka won the Nobel Prize in Physiology and Medicine for this discovery, and he is a consultant for Altos Labs.)

However, its not as simple as giving a stem cell an endless supply of Yamanaka factor cocktails. When a stem cell is stimulated with all the Yamanaka factors at once, all the genes are unpackaged, resulting in an unspecialized stem cell. This is analogous to resetting your brain to what it was as a baby; your potential would be incredible, but you would need guidance to harness that potential. In the same way, unspecialized stem cells have the potential to become any type of cell, but they will need lots of guidance. And scientists have only begun to scratch the surface on how to guide cells in their development.

However, they might not need to know how to guide development if they want to treat age-related diseases. Researchers recently discovered that moderation is the key to avoiding the problem of unspecialization.

Essentially, stimulating cells with just the right Yamanaka factors at just the right time partially resets the stem cells. These partially reset cells retain their ability to create new cells without extra guidance. Experiments on mice have shown how a partial reset can stop the progression of progeria (a mutation-induced syndrome that mimics rapid aging), can promote the healing of injured muscles, and can protect the liver against medication-mediated damage.

Age-related disorders dementia, arthritis, cancers dont significantly shorten our life span. They are often more cruel than that. Instead, they shorten our health span. They steal our memories, our independence, and our tranquility. From what I can tell, Altos Labs isnt looking for the secret to immortality or even the secret to increasing the human lifespan. They (and all the other anti-aging biotech firms) seem to be searching for a way to make aging less cruel.

So, dont expect an elixir of life that grants immortality anytime soon. Perhaps in a few decades, well know enough about aging to entertain a discussion about extending the human lifespan. But until then, I suspect spas and moderate cocktails are the best path for aging gracefully.

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Anti-aging isn't a scam, but immortality almost certainly ...

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Originally posted here:
themoviedb.org

A mummy in the shape of a mermaid that is said to grant immortality to whoever tastes its flesh will be probed by Japanese scientists to trace its origin.

The bizarre 12-inch (30 centimetres) creature was allegedly caught in the Pacific Ocean, off the Japanese island of Shikoku, between 1736 and 1741.

It has now been preserved at a temple in Asakuchi city, Okayama prefecture in the southern part of Japans Honshu island.

The mummified object, which appears to have nails and teeth, hair on head and scales on its lower body, has been sent for a CT scan at the veterinary hospital of Kurashiki University of Science and the Arts.

JapansAsahi Shimbun newspaper said that mummy was found preserved in a box along with a note claiming the that it had been caught in a fishing net in the Pacific Ocean at some point between 1736 and 1741.

The dried mermaid was said to have been kept by a family and then passed to another before it was eventually acquired by a temple, which put it on display some four decades ago.

It is also being claimed that the object may have been produced as an item for export to Europe.

Hiroshi Kinoshita, of the Okayama Folklore Society, found the object while studying Kiyoaki Sato, a Japanese natural historian who researched mysterious creatures.

He said the creature could have religious significance.

Japanese mermaids have a legend of immortality. It is said that if you eat the flesh of a mermaid, you will never die, New York Post quoted Kinoshita as saying.

There is a legend in many parts of Japan that a woman accidentally ate the flesh of a mermaid and lived for 800 years.

He claimed that some people believed in the legend and used to eat the scales of mermaid mummies.

The scientists who are examining the mummy will publish their findings later this year.

(With inputs from agencies)

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Japanese scientists to probe origins of mummified mermaid ...