Category Archives: Hypothyroidism

Hypothyroidism and Supplements -- Natural Supplements That May Help Your Hypothyroidism
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In conjunction with World Thyroid Day (May 25), we take a look at thyroid problems that may occur during pregnancy, and how this affects the developing foetus.

THYROID diseases may be broadly divided into two categories:

Hormonal problems, which may be due to an excess of thyroid hormone production (hyperthyroidism) or the opposite, which is insufficient thyroid hormone production (hypothyroidism).

An enlarged thyroid gland (goitre) or nodules in the gland, which may be cancerous or non-cancerous.

Generally, only hormonal problems affect pregnancy. Optimal levels of thyroid hormone are essential to health from foetal life to adulthood. This review will therefore concentrate only on hyperthyroidism and hypothyroidism.

Problems with conception

Both hyperthyroidism and hypothyroidism affect the levels of female hormones, leading to menstrual problems and infertility. In addition, women with hypothyroidism may have raised prolactin levels (the hormone which promotes breast milk production, so high levels simulate breastfeeding), further diminishing fertility.

Diagnosing hypothyroidism in pregnancy is a problem because it is usually silent. The women at risk would be those with a family history of thyroid disease. However since anyone can develop hypothyroidism, and since it may be harmful to the pregnancy and foetus, all pregnant women and those intending to be pregnant should ideally be screened.

However, this is not universally accepted. In the US, this is the norm, but not in the UK. Other countries go a step further and screen all women over a certain age whether or not they intend to have a child.

The reason for this controversy is because studies have not proven conclusively that population wide screening at the expense of the government will lead to an improvement in pregnancy and foetal outcomes. But if cost is not a problem, I would suggest that pregnant women or those contemplating pregnancy request for a simple blood test to screen for hypothyroidism.

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18. Thyroid disease

In conjunction with World Thyroid Day (May 25), we take a look at thyroid problems that may occur during pregnancy, and how this affects the developing foetus.

THYROID diseases may be broadly divided into two categories:

Hormonal problems, which may be due to an excess of thyroid hormone production (hyperthyroidism) or the opposite, which is insufficient thyroid hormone production (hypothyroidism).

An enlarged thyroid gland (goitre) or nodules in the gland, which may be cancerous or non-cancerous.

Generally, only hormonal problems affect pregnancy. Optimal levels of thyroid hormone are essential to health from foetal life to adulthood. This review will therefore concentrate only on hyperthyroidism and hypothyroidism.

Problems with conception

Both hyperthyroidism and hypothyroidism affect the levels of female hormones, leading to menstrual problems and infertility. In addition, women with hypothyroidism may have raised prolactin levels (the hormone which promotes breast milk production, so high levels simulate breastfeeding), further diminishing fertility.

Diagnosing hypothyroidism in pregnancy is a problem because it is usually silent. The women at risk would be those with a family history of thyroid disease. However since anyone can develop hypothyroidism, and since it may be harmful to the pregnancy and foetus, all pregnant women and those intending to be pregnant should ideally be screened.

However, this is not universally accepted. In the US, this is the norm, but not in the UK. Other countries go a step further and screen all women over a certain age whether or not they intend to have a child.

The reason for this controversy is because studies have not proven conclusively that population wide screening at the expense of the government will lead to an improvement in pregnancy and foetal outcomes. But if cost is not a problem, I would suggest that pregnant women or those contemplating pregnancy request for a simple blood test to screen for hypothyroidism.

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Thyroid disease

WEDNESDAY, May 22 (HealthDay News) -- People with heart failure are more likely to experience poorer health from having a thyroid gland that is even mildly underactive, according to a new study.

And among black patients, the researchers found an increased risk of death linked to the condition, which is known as hypothyroidism.

"This study is the first to show that African-Americans who have hypothyroidism face a greater risk of death than patients of other racial and ethnic groups," Dr. Connie Rhee, of Brigham and Women's Hospital in Boston, said in a news release from the Endocrine Society. "This elevated risk exists despite the fact that hypothyroidism is less common in the African-American population compared to other groups."

"More research is needed to confirm these findings and to determine the underlying reasons why hypothyroidism has a differential impact on people of different races and ethnicities," Rhee said.

Hypothyroidism occurs when the thyroid doesn't produce enough hormones. The researchers noted that people with mild forms of the condition have thyroid function at the low end of the normal range.

In conducting the study, Rhee and her colleagues analyzed information on about 750 patients with hypothyroidism, including nearly 700 people with a mild form of the condition.

Although it's unclear why hypothyroidism has a different effect on people of various races and ethnicities, the study authors said doctors should not take a blanket approach to assessing people's risk for the condition and determining whether they require treatment.

"Our data suggest that mild hypothyroidism may, in fact, be harmful in specific populations, including people with heart failure," Rhee said in the news release. "A one-size-fits-all approach may not be appropriate for assessing risk and determining whether treatment is required for [mild] hypothyroidism."

More than 9.5 million people in the United States have hypothyroidism, the study authors said.

The study is scheduled for publication in the June issue of the Journal of Clinical Endocrinology & Metabolism.

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Underactive Thyroid and Heart Failure a Bad Combination: Study

Kingsport, Tennessee (PRWEB) June 12, 2013

Intellectual Property Executives (IPE) announced today that it is now recruiting participants for the second phase of clinical trials for its new T3 drug to treat hypothyroidism, BCT303. BCT303 successfully completed Phase-1 in August 2012 at Georgetown University Hospital.

BCT303, classified as a 505(b)(2) drug, is a formulation improvement to the active ingredient Liothyronine Sodium, which is already approved by the Food and Drug Administration (FDA). BCT303 utilizes IPEs patent-pending platform technology for sustained effects and improved stability.

IPE utilized the same platform technology to formulate its T4 drug candidate, BCT304, and its Reverse-T3 drug candidate, BCT305, both of which are ready for IND submission. It has also identified additional 505(b)(2) applications, including treatments for pain-relief and anti-inflammation.

The purpose of this Phase-2 study is to test the efficacy of BCT303, a new thyroid hormone preparation. The thyroid gland produces two thyroid hormones: mostly T4 and a smaller amount of T3. Thyroid hormone therapy for hypothyroidism or thyroid cancer is generally provided using levothyroxine, which is a synthetic form of T4. T4 is converted into the active hormone T3 in the circulation. Therefore, some researchers believe that T3 levels in T4-treated patients may be slightly lower than in individuals whose own thyroid gland is functioning normally. Symptoms of hypothyroidism have been suggested to occur because of this possible T3 deficiency, although this is controversial.

Studies of T3, added to or substituted for T4 in traditional levothyroxine regimens, have generally not shown any benefit of T3. However, it is still possible that no benefit is seen because of the short duration of action or "half-life" of T3. This short-life makes it necessary to dose T3 twice or three times daily. Despite multiple daily doses of T3, T3 levels during its therapy tend to be troubled by peaks and troughs. These peaks can be associated with symptoms of excessive thyroid hormone levels.

This study will look at TSH and thyroid hormone levels following a daily dose of a new preparation of T3 that may have longer duration of action than liothyronine. This preparation of T3 is called Thyromax or BCT303. The investigators believe that steady levels of T3 will be seen after taking Thyromax. The investigators believe that in patients with hypothyroidism use of Thyromax in the correct dose will produce normal TSH levels, without producing symptoms of too much thyroid hormone. The goal of future studies is to test whether Thyromax may be a potential treatment for hypothyroidism, by comparing it with traditional levothyroxine therapy.

Visit http://ipeamerica.com/bct303-clinical-trials to learn more about the Phase-2 clinical trial.

ABOUT IPE:

Intellectual Property Executives (IPE) is a pharmaceutical technology discovery and development corporation located in Kingsport, Tennessee, USA. For more info on IPEs portfolio of patented technology and pipeline of drug candidates, go to http://www.ipeamerica.com.

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IPE Kicks Off Phase-2 Clinical Trial for New Hypothyroid Drug