Category Archives: Human Genetic Engineering

This paper was issued to PLoS ONE at 14:00 (PST) on February 9 2012.

Induced pluripotent stem cells (iPSCs) generated by epigenetic reprogramming of personal somatic cells have limited therapeutic capacity for patients suffering from genetic disorders. Here we demonstrate restoration of a genomic mutation heterozygous for Pkd1 (polycystic kidney disease 1) deletion (Pkd1(+/-) to Pkd1(+/R+)) by spontaneous mitotic recombination.

Notably, recombination between homologous chromosomes occurred at a frequency of 1-2 per 10,000 iPSCs. Southern blot hybridization and genomic PCR analyses demonstrated that the genotype of the mutation-restored iPSCs was indistinguishable from that of the wild-type cells.

Importantly, the frequency of cyst generation in kidneys of adult chimeric mice containing Pkd1(+/R+) iPSCs was significantly lower than that of adult chimeric mice with parental Pkd1(+/-) iPSCs, and indistinguishable from that of wild-type mice.

This repair step could be directly incorporated into iPSC development programmes prior to cell transplantation, offering an invaluable step forward for patients carrying a wide range of genetic disorders.

More information: Cure of ADPKD by selection for spontaneous genetic repair events in Pkd1-mutated iPS cells, Li-Tao Cheng, et al. Stem Cell Engineering, Institute for Frontier Medical Scinences, Kyoto University, JAPAN, Urology, Teikyo University, JAPAN, Cardiovascular and Neuronal Remodelling, LIGHT, Leeds University, UK, PLoS ONE 7(2): e32018. doi:10.1371/journal.pone.0032018

Provided by Kyoto University

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Cure of ADPKD by selection for spontaneous genetic repair events in Pkd1-mutated iPS cells

11-07-2011 10:39 Cornell Professor Doug Antczak delivers the Reunion lecture celebrating Cornell University Library's exhibition "Animal Legends." Dr. Antczak explores the relationship between humans and animals in the context of selective breeding and genetic engineering, explaining how these processes have put evolution on 'fast forward' for several domesticated species, and how they are thus bringing Myth closer to Reality, and vice versa.

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Hybrids

GIA announces the release of a comprehensive global outlook on Genetic Engineering Industry. The disparity in demand and supply arising due to increasing global population and stagnant food production is a major factor responsible for growing food crisis, and also a reason for nations to view genetic engineering (GE) as a viable solution. The benefits of GM crops and its subsequent commercialization have considerably helped in overcoming food shortage, alleviation of poverty, tackling biodiversity and other socio-economic issues.

San Jose, California (PRWEB) February 07, 2012

Follow us on LinkedIn – Genetic engineering (GE) deals with the manipulation of genes for human welfare. The versatility of genetic engineering has extended its benefits to agriculture, medicine, diagnosis and several other industries. These advancements helped in dealing with several socio-economic issues and more importantly the blistering issue of global food crisis. As global population grows and climate change impacts crop yields, GM crop varieties offer a healthy and safe alternative to traditionally produced crops in order to meet the future food demand. Modern breeding techniques are an effective amalgamation of traditional breeding protocols and advanced biotechnology methods including the use of genetic engineering to develop plants that have certain exceptional properties. For instance, market assisted selection uses genetic markers to identify traits in plants such as drought tolerance and improved yield, without the need to actually transfer genes from donor to target organisms. Genetically modified (GM) foods are being commonly used, with a significant share of staples such as soybeans and corn being produced in genetically modified varieties.

The growing consumer awareness about the benefits of GM crops is a primary driver for increasing consumer interest in the biotech foods. Ever since the commercialization of GM crops in 1996, agricultural biotechnology has spread very rapidly and currently, 29 countries cultivating GM crops are reaping its benefits. While markets such as the US, Brazil and Argentina have already accepted GM seed products, Europe, after opposing biotech crops for years, is now beginning to realize the benefits of GM foods. China and India, the countries with ever-growing population and yet self-sufficient food production, increasingly favor GM crops. Korea and Japan, both of which largely depend on imports of food in order to meet their food requirements, exhibit a moderate attitude towards GM foods. The US is the largest producer of GM crops covering an area of 69 million hectares in 2011 and accounts for almost three-fourth of total GE crops production across the world. Canada, Argentina, and Brazil are home to genetically modified soy, corn and canola, while China produces insect resistant rice.

Despite the fact that biotech crops offers innumerous benefits, the industry has been facing tough challenges with regard to ethical and moral issues, herbicide and pesticide resistance, species specific action and others. For instance, the European Union still remains indecisive over the acceptance of biotech crops in context of the potential threats associated with it. Several countries in the European Union banned the cultivation of genetically modified potato and maize attributable to concerns over antibiotic resistance. Globally, several protocols have been laid to ensure safe transfer, use and handling of biotechnologically modified living organisms. Adoption of cost-effective measures to prevent environmental degradation is a prime agenda of the protocols. Important precautions included regulations on international trade of genetically altered crops to curb the spread of associated diseases, pests and ensure fair trade practices.

The research report titled “Genetic Engineering: A Global Outlook” announced by Global Industry Analysts, Inc., provides a collection of statistical anecdotes, market briefs, and concise summaries of research findings. The report offers an aerial view of the industry, highlights latest developments, and discusses demand drivers, issues and concerns, and regulatory environment. Discussion on the industry’s most noteworthy regional market, the US, is amply detailed with unbiased research commentary to provide the reader a rudimentary understanding of the prevailing market climate. Market discussions in the report are punctuated with fact-rich market data tables. Regional markets elaborated upon include United States, Canada, India, China, and South Africa among others. Also included is an indexed, easy-to-refer, fact-finder directory listing the addresses, and contact details of companies worldwide.

For more details about this comprehensive industry report, please visit –

http://www.strategyr.com/Genetic_Engineering_Industry_Market_Report.asp

About Global Industry Analysts, Inc.

Global Industry Analysts, Inc., (GIA) is a leading publisher of off-the-shelf market research. Founded in 1987, the company currently employs over 800 people worldwide. Annually, GIA publishes more than 1300 full-scale research reports and analyzes 40,000+ market and technology trends while monitoring more than 126,000 Companies worldwide. Serving over 9500 clients in 27 countries, GIA is recognized today, as one of the world's largest and reputed market research firms.

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Global Food Crisis to Spur Sturdy Growth of Genetically Engineered Crops, According to New Report by Global Industry ...

16-12-2011 08:23 Subscribe! http://www.hdgamespoilers.com for HD Trailers, Let's Plays (look for that *awesome face* at the bottom right), Highlights, and No Commentary Playthroughs. - Visit: MeTee.com Support this Youtube channel and Design and Publish a T-Shirt using the link above. This channel is brought to you by MeTee T-Shirts: T-shirt design in seconds and always free shipping. Buy Resident Evil Operation Raccoon City (or any Amazon product) through this link to support this channel: http://www.amazon.com Feel free to download this video and upload it to your own channel using: http://www.keepvid.com - Twitter twitter.com Facebook Like: tinyurl.com Email Game Videos: HDgamespoilers.com - Genetic engineering is a popular subject of fiction, especially science fiction. During the early twentieth century, science fiction writers began to consider the possible alteration of human beings and other species, either through the natural alteration of genes or by the use of deliberate genetic engineering. Stories of mutated humans first became common in the 1930s pulp magazines and in the British scientific romances of the time, mutation often providing the justification for stories of supermen. Such narratives provide scientifically rationalized accounts of the transformation of human beings and nature, a theme of timeless fascination, as shown by the many examples in ancient mythology and earlier forms of fiction. While narratives that depict unexpected and uncontrolled mutation (eg as a result of radioactivity ...

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09-01-2012 00:30 PREVIOUS VIDEO THAT WAS BLOCKED:vimeo.com "Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use." ECCLESIASTIC FREEMASONRY ALLEGORY Homo Habilis was African. Neanderthal was the result of a human egg being fertilized by Great Ape sperm. Humans evicted Neanderthal who then migrated to Atlantis (Antarctica) Pre Ice Age Antarctica thus became the Garden of Eden Neanderthal, the genetic engineering DOG PRIEST, is Eden's God. Neanderthal engineered Adam and Eve, the half-baked semite Cro Magnan, as Tan (brown) Romany Gypsies. Adam and Eve were later evicted from Antarctica (Atlantis I) for spying on the Neanderthal GE laboratory and migrated to Sri Lanka, and later, to Egypt. Noah and his clan were the descendants of Adam and Eve when an induced cataclysmic TSUNAMI, TIDAL WAVE, and/or FLOOD forced them to move their Ark (genetic engineering laboratory) from Sri Lanka, to K2, in the Himalayan Mountains. On orders from their Neanderthal GOD, NOAH, a Cro Magnan SEMITE, would then genetically and human engineer the Yellow Asian race first, and later, the White Indo-European Caucasians second, both of these at K2. You know the rest of the tollgaters tax collecting story, as the ...

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10-01-2012 05:20 Subscribe! http://www.hdgamespoilers.com for HD Trailers, Let's Plays (look for that *awesome face* at the bottom right), Highlights, and No Commentary Playthroughs. - Visit: MeTee.com Support this Youtube channel and Design and Publish a T-Shirt using the link above. This channel is brought to you by MeTee T-Shirts: T-shirt design in seconds and always free shipping. Buy Resident Evil Operation Raccoon City (or any Amazon product) through this link to support this channel: http://www.amazon.com Feel free to download this video and upload it to your own channel using: http://www.keepvid.com - Twitter twitter.com Facebook Like: tinyurl.com Email Game Videos: HDgamespoilers.com - Genetic engineering is a popular subject of fiction, especially science fiction. During the early twentieth century, science fiction writers began to consider the possible alteration of human beings and other species, either through the natural alteration of genes or by the use of deliberate genetic engineering. Stories of mutated humans first became common in the 1930s pulp magazines and in the British scientific romances of the time, mutation often providing the justification for stories of supermen. Such narratives provide scientifically rationalized accounts of the transformation of human beings and nature, a theme of timeless fascination, as shown by the many examples in ancient mythology and earlier forms of fiction. While narratives that depict unexpected and uncontrolled mutation (eg as a result of radioactivity ...

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Resident Evil Operation Raccoon City - Triple threat cinematic Trailer [1080p HD PS3, Xbox 360, PC] - Video