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Category Archives: Genetic Medicine
06-01-2012 11:46 pennstatehershey.org In this episode of Medicine in Blue and White: The incredible connection between one fourteen year old boy -- and the thousands of people he has helped over the past forty years. Combining aerospace engineering and medical technology to help improve health care in developing countries. Never-before-seen-behavior under the microscope that could lead to a cure for some of the most challenging diseases we face. And a new way to test for what is -- literally -- an age-old problem.
22-11-2011 18:28 Video by Humberside Students Charlotte, Maria and Adrien for their Grade 11 Biology Project. It explores Genetically Modified Organisms. The sources used are as followed: Sources Adrien Bettio: Monsanto ~ Home . (nd). Monsanto ~ Home . Retrieved November 22, 2011, from http://www.monsanto.ca GM crops | Politics | guardian.co.uk . (nd). Latest US and world news, sport and comment from the Guardian | guardiannews.com | The Guardian . Retrieved November 22, 2011, from http://www.guardian.co.uk Losey, JE, Rayor, LS, and Carter, ME (1999). Transgenic pollen harms monarch larvae. Nature International weekly journal of science, 399. Retrieved October 22, 2011, from http://www.nature.com Nordlee, JA, Taylor, SL, Townsend, JA, Thomas, LA, and Bush, RK (1996). Identification of a Brazil-Nut Allergen in Transgenic Soybeans. The New England Journal of Medicine, 334, 688-692. Retrieved October 22, 2011, from http://www.nejm.org The World Book encyclopedia 2011 (2011 ed., pp. 85-86). (2011). Genetically Modified Food. Chicago, IL: World Book Inc.. Whitman, DB (nd). Genetically Modified Foods: Harmful or Helpful?. ProQuest. Retrieved October 22, 2011, from http://www.csa.com/discoveryguides/gmfood/overview.php Charlotte Tenszen: Barringtonzee, John, and J.Moriarity, Andrew. "Biotechnology-The Canadian Encyclopedia." The Canadian Encyclopedia. Np, nd Web. 24 Oct. 2011. Dixon. "Genetically modified food." bgm.com. Np, np Web. 20 Oct. 2011. Ratnasiri, Kalani. "Global Voices: Can GM foods help solve the global food crisis ...
London, Feb 8 (ANI): Researchers have discovered how mutations in the parkin gene lead to the incurable Parkinson's disease.
The University of Buffalo findings reveal potential new drug targets for the disease as well as a screening platform for discovering new treatments that might mimic the protective functions of parkin.
UB has applied for patent protection on the screening platform.
"This is the first time that human dopamine neurons have ever been generated from Parkinson's disease patients with parkin mutations," said Jian Feng, PhD, professor of physiology and biophysics in the UB School of Medicine and Biomedical Sciences and the study's lead author.
Since in 2007, when Japanese researchers announced they had converted human cells to induced pluripotent stem cells (iPSCs) that could then be converted to nearly any cells in the body, mimicking embryonic stem cells, Feng and his UB colleagues saw their enormous potential. They have been working on it ever since.
"This new technology was a game-changer for Parkinson's disease and for other neurological diseases," said Feng.
"It finally allowed us to obtain the material we needed to study this disease."
The current paper is the fruition of the UB team's ability to "reverse engineer" human neurons from human skin cells taken from four subjects: two with a rare type of Parkinson's disease in which the parkin mutation is the cause of their disease and two healthy subjects who served as controls.
"Once parkin is mutated, it can no longer precisely control the action of dopamine, which supports the neural computation required for our movement," asserted Feng.
The UB team also found that parkin mutations prevent it from tightly controlling the production of monoamine oxidase (MAO), which catalyses dopamine oxidation.
"Normally, parkin makes sure that MAO, which can be toxic, is expressed at a very low level so that dopamine oxidation is under control," Feng explained.
"But we found that when parkin is mutated, that regulation is gone, so MAO is expressed at a much higher level. The nerve cells from our Parkinson's patients had much higher levels of MAO expression than those from our controls.
We suggest in our study that it might be possible to design a new class of drugs that would dial down the expression level of MAO."
He noted that one of the drugs currently used to treat Parkinson's disease inhibits the enzymatic activity of MAO and has been shown in clinical trials to slow down the progression of the disease.
Parkinson's disease is caused by the death of dopamine neurons. In the vast majority of cases, the reason for this is unknown, Feng said. But in 10 percent of Parkinson's cases, the disease is caused by mutations of genes, such as parkin: the subjects with Parkinson's in the UB study had this rare form of the disease.
"We found that a key reason for the death of dopamine neurons is oxidative stress due to the overproduction of MAO," explains Feng.
"But before the death of the neurons, the precise action of dopamine in supporting neural computation is disrupted by parkin mutations.
This paper provides the first clues about what the parkin gene is doing in healthy controls and what it fails to achieve in Parkinson's patients."
He noted in this study that these defects are reversed by delivering the normal parkin gene into the patients' neurons, thus offering hope that these neurons may be used as a screening platform for discovering new drug candidates that could mimic the protective functions of parkin and potentially even lead to a cure for Parkinson's.
The study has been published in Nature Communications. (ANI)
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Genetic origins of Parkinson's disease identified
11-11-2011 10:58 New noninvasive tests that screen for genetic disease in a fetus can also tell the baby's sex in the seventh week. This could lead to gender selection, but doctors don't need to go along with it. Medscape expert commentator Dr. Arthur Caplan weighs in. View more Dr. Caplan videos on Medscape: medscape.com/index/section_10186_0
18-12-2011 05:11 "By chance, the light-skinned coloured fish that I used for that research also taught us a lot about how Europeans, how humans became lighter skinned ... what Professor Cheng discovered was perhaps one of the most important genetic mutations ever found. A single change among literally billions of coded instructions within Zebrafish DNA that reduced black pigment from their stripes... Soon after this, identical genetic mutation was found in fair-skinned Europeans ... not only did white-skinned people evolve from black-skinned people, but lighter-skinned people, whether they're European, or whether they're Asian, ... we're actually mutants, of the dark-skinned people..." Nina Jablonski breaks the illusion of skin color http://www.ted.com Always Revealing, Human Skin Is an Anthropologist's Map http://www.nytimes.com
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6/7 Skin Deep - white-skinned people evolved from black-skinned people - Video
Life Technologies this week named Alan Sachs as head of global research and development and Ronnie Andrews as president of medical sciences.
Sachs was previously the vice president of exploratory and translational sciences for Merck Research Laboratories, where he spent 10 years in various leadership roles, Life Tech said. Prior to that Sachs served an associate professor of biochemistry and molecular biology at the University of California, Berkeley, and as a Whitehead fellow at the Whitehead Institute for Biomedical Research.
Andrews joins Life Tech from GE Molecular Diagnostics, where he served as a segment leader following GE's 2010 acquisition of Clarient, where Andrews was CEO. Andrews has also held executive positions with Abbott Diagnostics, Roche Diagnostics, and Immucor.
Stephen O'Brien has left the National Cancer Institute's Laboratory of Genomic Diversity after 25 years to help launch a genome bioinformatics program at St. Petersburg University in Russia. O'Brien received a $5 million grant from the Russian Ministry of Education and Science last year under a program that aims to lure big-name researchers to Russia. Over the coming three years, O'Brien will spend at least four months per year in Russia working at the center, which is scheduled to open in May.
Saladax Biomedical said today that President and CEO Edward Erickson has resigned due to personal and family reasons, and that he will be replaced by Kevin Harter on an interim basis. Erickson will remain a member of the company's board of directors. Harter is a co-founder and senior VP of the Life Sciences Greenhouse, and he has served as executive chairman at Saladax.