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Category Archives: Gene therapy

Hydration forces as a tool for the optimization of core-shell nanoparticle vectors for cancer gene therapy

Soft Matter, 2012, Advance ArticleDOI: 10.1039/C2SM26389K, PaperM. J. Santander-Ortega, M. de la Fuente, M. V. Lozano, M. E. Bekheet, F. Progatzky, A. Elouzi, I. F. Uchegbu, A. G. SchatzleinThe high cationic charge density of the polymers used in synthetic gene therapy vectors makes these systems toxic and induces non-specific interactions with blood components.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)

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Trio of Genome-Sequencing Studies Offers a Broader View of Lung Cancer

From Nature magazine

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“Junk” DNA Holds Clues to Common Diseases

When the draft of the human genome was published  in 2000, researchers thought that they had obtained the secret decoder ring for the human body. Armed with the code of 3 billion basepairs of As, Ts, Cs and Gs and the 21,000 protein-coding genes, they hoped to be able to find the genetic scaffolds of life --both in sickness and in health. [More]

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"Junk" DNA Holds Clues to Common Diseases

When the draft of the human genome was published  in 2000, researchers thought that they had obtained the secret decoder ring for the human body. Armed with the code of 3 billion basepairs of As, Ts, Cs and Gs and the 21,000 protein-coding genes, they hoped to be able to find the genetic scaffolds of life --both in sickness and in health. [More]

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Are Phage Viruses the Forgotten Cure for Superbugs? [Excerpt]

Excerpted from The Forgotten Cure: The Past and Future of Phage Therapy , by Anna Kuchment . (Copernicus Books, 2011. Reprinted by   permission of Springer Science+Business Media)

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Nonviral gene therapy targeting cardiovascular system

The goal of gene therapy is either to introduce a therapeutic gene into or replace a defective gene in an individual's cells and tissues. Gene therapy has been urged as a potential method to induce therapeutic angiogenesis in ischemic myocardium and peripheral tissues after extensive investigation in recent preclinical and clinical studies. A successful gene therapy mainly relies on the development of the gene delivery vector. Developments in viral and nonviral vector technology including cell-based gene transfer will further improve transgene delivery and expression efficiency. Nonviral approaches as alternative gene delivery vehicles to viral vectors have received significant attention. Recently, a simple and safe approach of gene delivery into target cells using naked DNA has been impro...

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