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Category Archives: Gene Medicine

MUTYH gene – Genetics Home Reference – NIH

Cheadle JP, Sampson JR. Exposing the MYtH about base excision repair and human inherited disease Continue reading

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PIK3CA gene – Genetics Home Reference – NIH

Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B. Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature. Continue reading

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CDH1 gene – Genetics Home Reference – NIH

Carneiro F, Oliveira C, Suriano G, Seruca R. Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer. J Clin Pathol Continue reading

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SOD1 gene – Genetics Home Reference – NIH

At least 200 mutations in the SOD1 gene have been found to cause amyotrophic lateral sclerosis (ALS), a condition characterized by progressive muscle weakness, a loss of muscle mass, and an inability to control movement. Most of these mutations change one of the protein building blocks (amino acids) in the superoxide dismutase enzyme. Continue reading

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METIS Precision Medicine The one gene company

METISis a B-corp* founded in April 2017 by the confluence of a handful of scientists, among the leaders of oncogene research, and a group of visionary investors with the mission of translating cancer research findings into precision medicine in cancer treatments. Backed by over three decades of research focused on a specific oncogene, METIS benefits from a profound knowledge of the biology and pathology driven by the oncogene MET, including cancer. METIS is developing human anti-MET antibodies with the potential to be first-in class to treat diseases with a significant unmet medical need Continue reading

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On Human Gene Editing: International Summit Statement

Date: Dec. 3, 2015 FOR IMMEDIATE RELEASE Fundamental research into the ways by which bacteria defend themselves against viruses has recently led to the development of powerful new techniques that make it possible to perform gene editing that is, precisely altering genetic sequences in living cells, including those of humans, at much higher accuracy and efficiency than ever before possible. These techniques are already in broad use in biomedical research Continue reading

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