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Category Archives: David Sinclair

Lifespan: Why We Age_and Why We Don’t Have To: David A …

Lifespanis entertaining and fast-paceda whirlwind tour of the recent past and a near future that will see 90 become the new 70. In a succession of colorfully titled chapters (The Demented Pianist, A Better Pill to Swallow), Sinclair and LaPlante weave a masterful narrative of how we arrived at this crucial inflection point., Nature Journal

Sinclairs work on slowing the aging process, and even reversing some aspects of it, could lead to the most significant set of medical breakthroughs since the discovery of antibiotics nearly a century ago., Sydney Morning Herald

"In this insightful and provocative book that asks questions about how we age, and whether humans can overcome decay and degeneration, Sinclair grapples with some of the most fundamental questions around the science of aging. The result is an elegant and exciting book that deserves to be read broadly and deeply." -- Siddhartha Mukherjee, Pulitzer Prizewinning and #1 New York Times bestselling author

There are few books that have ever made me think about science in a fundamentally new way. David Sinclairs book did that for me on aging. This is a book that anyone who ages must read. -- Leroy Hood, PhD, professor at the California Institute of Technology, inventor, entrepreneur, member of all three US National Academies, and co-author of Code of Codes

If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100 plus years, then David Sinclairs new bookLifespan, which reads like a detective novel, will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant. -- Mark Hyman, MD, director of the Cleveland Clinic Center for Functional Medicine and #1 New York Times bestselling author

This is the most visionary book about aging I have ever read.Seize the dayand seize this book! -- Dean Ornish, MD, founder and president of the Preventative Medicine Research Institute and New York Times bestselling author of UnDo It!

In Lifespan, David Sinclair eloquently tells us the secret everyone wants to know: how to live longer and age slower. Boldly weaving cutting-edge science with fascinating bits of history, sociology, and morality, Sinclair convinces us that it is not only possible to live beyond one hundred years, it is inevitable that we will be able to one day do so. If you are someone who wants to know how to beat aging, Lifespan is a must-read. -- William W. Li, MD, New York Times bestselling author of Eat to Beat Disease

For years, the aging field has been about vitamins, juicebars, and snake oil. Now, in a seminal book, Harvard Professor David Sinclair has changed the landscape: he has combined precise science, practical translation, and autobiography to produce a rare book that is insightful, inspiring, and informative. He has translated a wealth of molecular detail into a program that we can all use to live longer and healthier. This is part of the ongoing revolution in aging and chronic disease, and there is no one who is better suited to write such an authoritative book than David Sinclair. For anyone interested in understanding the aging process, living longer, and avoiding the diseases of aging, this is the book to read. -- Dale Bredesen, MD, New York Times bestselling author of The End of Alzheimer's

A visionary book from one of the most masterful longevity scientists of our time. Lifespan empowers us to change our health today while revealing a potential future when we live younger for longer. -- Sara Gottfried, MD, New York Times bestselling author of The Hormone Cure

Prepare to have your mind blown. You are holding in your hands the precious results of decades of work, as shared by Dr. David Sinclair, the rock star of aging and human longevity. -- Dave Asprey, founder and CEO of Bulletproof and New York Times bestselling author of The Bulletproof Diet

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David Sinclair supplements and protocol explained NMN …

If you watched any of David Sinclair videos you probably noticed that he looks younger than he actually is. When I saw the video it made me think that this guy must be doing something that works for him. I did some research, and that brought me to his Joe Rogan podcast, where he explains exactly what he is doing to stay young.

I would highly suggest that you go watch the video as he gives out a massive amount of valuable information.

I will first give you an overview of all the things he does and then later try to explain how everything comes together

List of things David Sincalir consumes or does

Sirtuins are genes which protect all organisms from deterioration and disease. NMN and Resveratrol are molecules which essentially mimic the effects of the sirtuin genes.

NMN also boosts NAD levels (which sirtuins need to function)

Nicotinamide mononucleotide is a nucleotide derived from ribose and nicotinamide. Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide.

Formula: C11H15N2O8PMolar mass: 334.2192 g/mol

Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.

Molar mass: 228.25 g/molFormula: C14H12O3Solubility in water: 0.03 g/LMelting point: 261 to 263 C (502 to 505 F; 534 to 536 K)Appearance: white powder with; slight yellow castSolubility in DMSO: 16 g/L

Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain. It is taken by mouth.

Molar mass: 129.1636 g/molFormula: C4H11N5Excretion: Urine (90%)Trade name: Glucophage, otherBioavailability: 5060%Elimination half-life: 48.7 hours

There are 3 pathways related to aging:

Intermittent fasting is an umbrella term for various eating diet plans that cycle between a period of fasting and non-fasting over a defined period. Intermittent fasting is under preliminary research to assess if it can produce weight loss comparable to long-term calorie restriction.

The main idea is that you ideally skip a meal or two, therefore putting your body in a state of starvation which triggers different processes in the body, which are proved to have a broad variety of benefits, some of them include anti ageing benefits.

David recommends performing exercise regularly. He recommends running and doing resistance training.

David especially recommends exposing your body to temperature extremes which force your body to kick start protective mechanisms. He recommends doing a hot sauna immediately followed by cold water submersion.

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David Sinclair supplements and protocol explained NMN ...

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#70 – David Sinclair, Ph.D.: How cellular reprogramming could …

In this episode, David Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, returns to the podcast to discuss the content of his new book, Lifespan: Why We Age and Why We Dont Have To. This conversation focuses on the biological mechanisms involved in what David terms the Information Theory of Aging which provides insights into the clock that determines our aging and to what degree it can be manipulated. Our discussion on aging of course leads us into interconnected topics of epigenetics, sirtuins, cellular senescence, as well as what compounds David is personally taking for his own longevity. Additionally, we discuss the most up to date information related to NAD and longevity by looking at the potential benefits (if any) of supplemental agents (NAD precursors, NR, NMR, etc.) that pose a promise of increasing NAD.

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The SIR gene silent information regulator is a gene that controls other genes

The SIR enzyme is the master regulator of this cellular survival circuit

Figure 1. When SIR enzyme proteins detect stress in the cell (e.g. DNA breakage) the protein leaves the silent region to go and repair the DNA. When the problem is fixed, it returns to its original post, silencing genes. Image credit: (Alves-Fernandes and Jasiulionis, 2019)

Overtime, in the back-and-forth of repair SIR genes lose track of which genes should be silenced or not

We have some early evidence from mice that we can actually find that hard disk drive and reinstall the software so that its pristine again and we find that we can actually improve the health quite dramatically in parts of a mouses body. David Sinclair, Ph.D

What does Claude Shannons Information Theory of Communication have to do with aging?

{end of show notes preview}

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David A. Sinclair, Ph.D. is a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging.

He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co-discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where his laboratorys research has focused primarily on understanding the role of sirtuins in disease and aging, with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. He has also contributed to the understanding of how sirtuins are modulated by endogenous molecules and pharmacological agents such as resveratrol.

Dr. Sinclair is the co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freemans Through the Wormhole and other media.

He is an inventor on 35 patents and has received more than 25 awards and honors including the CSL Prize, The Australian Commonwealth Prize, Thompson Prize, Helen Hay Whitney Postdoctoral Award, Charles Hood Fellowship, Leukemia Society Fellowship, Ludwig Scholarship, Harvard-Armenise Fellowship, American Association for Aging Research Fellowship, Nathan Shock Award from the National Institutes of Health, Ellison Medical Foundation Junior and Senior Scholar Awards, Merck Prize, Genzyme Outstanding Achievement in Biomedical Science Award, Bio-Innovator Award, David Murdock-Dole Lectureship, Fisher Honorary Lectureship, Les Lazarus Lectureship, Australian Medical Research Medal, The Frontiers in Aging and Regeneration Award, Top 100 Australian Innovators, and TIME magazines list of the 100 most influential people in the world. [medapps.med.harvard.edu] His new book, Lifespan, explains why we age and why we dont have to.

David on LinkedIn: David A. Sinclair, Ph.D. A.O.

David on Twitter: @davidasinclair

David on Instagram: davidsinclairphdDavids book website: lifespanbook.com

BOSTON, MA - MAY 16: David A. Sinclair, Professor of Genetics and Director of the Paul F. Glenn Center for the Biology of Aging, poses for a portrait in the lab at Harvard Medical School in Boston on May 16, 2018. (Photo by Craig F. Walker/The Boston Globe via Getty Images)

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#70 - David Sinclair, Ph.D.: How cellular reprogramming could ...

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David Sinclair on Joe Rogan Podcast – chatting about NMN and …

Joe Rogan interviewed Dr Sinclair for 2 1/2 hours last week, and aired on his popular podcast on Jan 29th.

We were looking forward to this for weeks, as Dr Sinclair is always a great interview and probably the most knowledgable person on the planet regarding the current state of research on NAD+.

In case youre not that familiar, research with NAD+, and compounds to boost it like NMN and NR, are showing incredible results for health and longevity.

So if you want to be amazed and excited about the potential of stopping, or even reversing damage from aging (who doesnt?) check out Joe and David having a great chat

Heres a few notes taken by our friend David, from the NAD Boosters Facebook group

33:45 The epigenome and the cause of aging. Your DNA contains all your genes and the epigenome controls which genes are actually expressed, so that a liver cell can be a liver cell and a brain cell a brain cell. Over time, cells lose the ability to read the DNA, similar to a laser trying to read a scratched CD. Cells then become dysfunctional. In older people a liver cell might show up in the brain and a brain cell in the kidney, all because its becoming harder to read the CD and the wrong genes are getting expressed. So how do you polish the CD to get the information that was easy to read in your teens and twenties restored again, resetting your age? They havent actually polished the entire CD yet but they are currently working on ways to do this in order to reset the entire epigenome back to a younger age. See further explanation of this further down at 1:51:45. Theyve already figured out how to polish parts of the epigenome and repair tissue.

43 Advances in ability to reprogram the epigenome. Clinical trials in early 2020 will focus on restoring eyesight, repairing spinal injuries and more.

1:45:40 Sinclair has a company called Metro Biotech that makes super NAD Boosters. They are testing this developmental drug (called MIB-626) along with NMN.

1:51:45 New bioage test called the DNA clock. The epigenome changes over time due to methyls that bind to the DNA. The older you get the more methyls you accumulate (sunlight and x-rays are 2 examples of many that cause methyls to bind). Sinclair compares this to scratches on a CD that make the DNA harder to read. These build up over time, causing aging. They can now read the methyls (scratches) on your DNA and give you a precise bioage. Sinclair said they believe that they can now reverse these scratches on the CD. They are testing it now to reprogram the epigenome and re-grow optic nerves as well as reverse glocoma. Published results will be soon. As mentioned clinical trials in early 2020.

1:53:30 Gives a sneak preview they are about to announce a new academy for aging research made up of the top 20 longevity scientists in the world to produce white papers and opinions, sort of like a Manhattan Project for longevity research.

The official notes from the Joe Rogan Podcast:

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David Sinclair on Joe Rogan Podcast - chatting about NMN and ...

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NMN and NAD Reverse Aging of Blood Vessels in New Study

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Harvard professor Dr. David Sinclair reports that the NAD boosting NMN compound reverses aging in blood vessels and restores muscle strength in a new study published March 22nd. [This article firstappeared onLongevityFacts. Author:Brady Hartman.]

Using the NAD boosting molecule NMN, Dr. David Sinclairs team reversed blood vessel and muscle aging in mice, while boosting their exercise endurance. As Dr. Sinclair says

Weve discovered a way to reverse vascular aging by boosting the presence of naturally occurring molecules in the body that augment the physiological response to exercise addingThe approach stimulates blood vessel growth and boosts stamina and endurance in mice and sets the stage for therapies in humans to address the spectrum of diseases that arise from vascular aging.

The team says the achievement paves the way for similar therapies for humans and published the results of their study on March 22 in the journal Cell.

David A. Sinclair, Ph.D. is best known for his research on the NAD molecule and its role in increasing health in aging bodies. Dr. Sinclair is a professor in the Department of Genetics and a Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School (HMS) as well as a Professor at the University of New South Wales, Sydney.

In a video accompanying the new study, published by Harvard News, Dr. David Sinclair describes the compound NMN boosts levels of NAD in the bodies of aging mice, and how that restores muscle function.

Vascular aging leads to a deterioration in many organs and tissues throughout the human body, as Dr. David Sinclair says:

As we age, the tiniest blood vessels in our bodies wither and die, reducing the blood flow to organs and tissues. Vascular aging causes many diseases cardiovascular, neurological, muscle wasting, frailty, and even aging. Here at Harvard Medical School, weve reversed the process in mice, setting the stage for radical new therapies to help people. The new study has unraveled the cascade of interactions between blood vessels and muscles.

Dr. David Sinclair also describes the how aging of the cells lining our blood vessels leads to a decline in our vascular systems and muscles, saying:

Endothelial cells, which line the walls of blood vessels, are essential for the health and growth of the vessels. And as endothelial cells age, blood vessels begin to atrophy and die. Blood flow to many parts of the body diminishes, organs and tissues begin to function less well. Blood vessel demise hits muscles especially hard because muscles rely on a robust blood supply for their function. This process can be slowed down with regular exercise, but only up to a point. Over time, even exercise fails to stave off blood vessel demise and muscle loss.

The newstudy suggests that this loss of blood flow is a key driver behind age-related muscle loss and frailty. Even if we exercise, our muscles shrink as we get older, as Dr. David Sinclair says

The new findings have cracked the mystery behind this process. As our blood vessels age, they become deaf to the signals from exercise muscles. This actually leads to the muscles shrinking as we get older, and therefore were less able to exercise and grow new blood vessels. A vicious cycle indeed.

The declining levels of NAD in our bodies cause this aging process. However, using NMN to boost levels of NAD stimulates a sirtuin protein called SIRT1, asDr. David Sinclair describes

The two key players in the crosstalk between blood vessels and muscles are a molecule called NAD and a protein called SIRT1. NAD boosts SIRT 1, which in turn enables the conversation between muscles and blood vessels. But both NAD and SIRT1 decline as we age. They can no longer perform their role as the interface between muscles and blood vessels.

Finally, the researcher describes how giving the compound NMN to mice boosted their levels of NAD, producing remarkable results, as Dr. David Sinclair says,

In our new study, we gave mice NMN, a chemical compound commonly found in the body and previously shown to boost NAD levels, which in turn boosts SIRT1. These mice had better endothelial function, blood vessel growth and improved blood supply to their muscles.

The most striking effect of was a significant boost in the mices ability to exercise. The aging mice treated with NMN gained between 56 and 80 percent greater exercise capacity, compared with untreated ones by being able to run much farther on a treadmill. According to Dr. Sinclair, the mice treated with NMN had improved exercise capacity due to improvements in vascular function, saying

And what was most striking? These animals capacity for exercise improved dramatically. In fact, the old mice treated with NMN had up to 80 percent greater exercise capacity, compared with the untreated old mice.

Sinclair believes that the results achieved in mice can eventually be translated to humans, helping to counter age-related diseases with a vascular component, such as frailty, heart attack, stroke or even forms of dementia such as Alzheimers disease. As Dr. David Sinclair says in his parting words,

These results, I believe, can help millions of people who have lost their mobility, or simply can no longer exercise, either through frailty, disability or old age. This sets the stage for new medicines that will be able to restore blood flow in organs that have lost it, either through a heart attack, a stroke or even in patients with dementia.

Related: Trial suggests nicotinamide riboside (NR) may help vascular health.

Photo Credit: All images courtesy of Dr. David Sinclair / Harvard Medical School.

Diagnosis, Treatment, and Advice:This article is intended for informational and educational purposes only and is not a substitute for qualified, professional medical advice. The opinions and information stated in this article should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Consult a qualified and licensed physician for the diagnosis and treatment of any and all medical conditions. Experimental treatments to boost NAD such as NMN carry a much higher risk than FDA-approved ones. Dial 9-1-1, or an equivalent emergency hotline number, for all medical emergencies. As well, consult a licensed, qualified physician before changing your diet, supplement or exercise programs.Photos,Endorsements, & External Links:This article is not intended to endorse organizations, companies, or their products. Links to external websites, mention or depiction of company names or brands, are intended for illustration only and do not constitute endorsements.

Tags: Dr. David Sinclair, NAD, NMN

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NMN and NAD Reverse Aging of Blood Vessels in New Study

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Aging as a preventable disease and why living to 100 should be easy – Genetic Literacy Project

Science is investigating some intriguing clues suggesting that aging and death may not be as inevitable as we thought.

David Sinclair believes aging is a disease, the most common disease, and he believes it should be aggressively treated. His bookLifespan: Why We Age and Why We Dont Have Towas published in September 2019.

He believes a loss of information is the singular reason why we age. Not just digital information, but epigenetic information that is analog rather than digital. He characterizes the genome as a computer and the epigenome as software. The genetic information is the same in every cell; the epigenome is what instructs a cell to develop into a kidney cell rather than a heart cell.

Experiments with stem cells and cloning are intriguing. Gene therapy shows great promise but there are ethical concerns. Genetic analysis and new technologies are making great strides.

If even a few of the therapies and treatments that are most promising come to fruition, it is not an unreasonable expectation for anyone who is alive and healthy today to reach 100 in good health. [Sinclair said].

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Aging as a preventable disease and why living to 100 should be easy - Genetic Literacy Project

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