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About Cryonics – The Cryonics Institute

A Brief Overview of the History of Cryonics

Robert Ettinger(The Father of Cryonics) introduced the concept of cryonics in 1962 with the publication of his seminal book,The Prospect of Immortality.The visionary new concept attracted worldwide attention when Doubleday published the first of several successful commercial editions, including several foreign language editions. Ettinger delved deeper into the subject of cryonics and life extension with his next book,Man Into Superman,further advancing the cryonics movement.

The idea of greatly extending lifespans through the science of cryonics captured peoples imaginations and organizations quickly sprang up in support of the concept. Ettinger himself formedThe Immortalist Society(originally the Cryonics Society of Michigan, and later the Cryonics Association) in 1967 to further promote and explore the concept of cryonics.

Less than a decade later, in 1976, Ettinger and other members of The Immortalist Society took the next logical step and formed a new organization to put the concept of cryonics into actual practice. Their goal was to offer The Prospect of Immortality to the public through reliable and affordable cryonics services.The Cryonics Institutewas formed in 1976 featuring the worlds first fully-operational cryonics facility, located in Clinton Township, Michigan.

Since then, The Cryonics Institute has been dedicated to advancing the concept and practice of cryonics, attracting members world-wide. Membership has grown to over 1,000 members in dozens of countries, including 117 patients cryopreserved at the Michigan facility.

Read More for the complete history of The Cryonics Institute.

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Cryonics: Could you live forever? | BBC Science Focus Magazine

For centuries, the worlds physicists, writers and philosophers have argued over whether time travel is possible, with most coming to the conclusion that its never going to happen.

But on an 800-acre plot of land just outside the small town of Comfort, Texas, a group of architects, engineers and scientists are building a Timeship that they say could transport tens of thousands of individuals to a far-distant future.

Their approach does not involve the use of flux capacitors, or zooming at light-speed through black holes.

Instead, the Timeship aims to store people at such low temperatures that their bodies are preserved for a future civilisation to reanimate them, a concept known as cryonics.

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Just as a spaceship allows people to move through space, Timeship will allow people to travel to another time in the future, explains Stephen Valentine, who is the director and principal architect of the Timeship project.

Valentine has been given a multimillion-dollar budget from anonymous donors to develop a Mecca for cryonics and life extension.

As well as a fortress-like building that can store frozen people, Timeship plans to store other precious biological samples such as organs, stem cells, embryos, and even the DNA of rare or threatened species.

The site will also house the worlds largest life extension research centre, the Stasis Research Park.

This concept shows how Timeship might look. The inner region is used for liquid nitrogen storage. The eight square-shaped structures house hundreds of frozen patients Timeship

The entire facility will be off-grid, using wind and solar energy to avoid potential power outages, and the location has been carefully chosen to be far from earthquakes, tornadoes, snowstorms and any other turmoil the world might throw at it in the next few hundred years.

You dont want to be near a military base or nuclear plant either, says Valentine, who speaks at a frantic pace with a theatrical Boston drawl.

He spent five years finding and designing the site, while studying pyramids, ancient tombs, bank vaults and medieval fortresses anything that has stood the test of time. He has even consulted experts on how to protect frozen time-travellers from the effects of a nearby two-megaton nuclear bomb.

The resulting design is an epic spaceship-castle hybrid, with thick, low, circular walls surrounding a central tomb-like chamber, where thousands of storage pods will be held under high security.

The exact technique that will be used to cool the bodies is not yet clear, but it is likely to involve the bodily fluids being drained and replaced with a solution that helps protect tissue from the formation of ice crystals.

The storage pods will use the cooling power of liquid nitrogen to keep the bodies at around -130C, and should be able to maintain low temperatures without power or human maintenance for up to six months, says Valentine.

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He hopes to start testing the first prototype pods next year.

The idea of freezing people in the hope of reawakening them is not new.

In January 1967, cancer patient James Bedford became the first person to be cryogenically frozen, and his body remains in cold storage to this day, in a capsule designed by American wigmaker and cryopioneer Edward Hope.

Various organisations and companies have offered similar services over the past decades, often using hopelessly crude freezing techniques or failing to store the bodies properly.

Edward Hope's cryocapsule deisgned to freeze James H. Bedford. Getty Images

Today, the cryogenic freezing of human stem cells, sperm, eggs, embryos and other small tissue samples is a routine part of scientific research and reproductive medicine in many countries.

Vitrification, a process that turns samples into a glass-like state rather than ice, was developed in the early 2000s as a way of overcoming the problems of ice formation in and around cells. Ice formation is an issue because it can cause dramatic differences in concentration inside and outside the cell, sucking water out and destroying it.

In late 2002 and early 2003, a team led by vitrification pioneer Gregory Fahy used a cocktail of antifreezes and chemicals to cryopreserve a whole rabbit kidney. The organ appeared to function normally after it was thawed and transplanted back into its donor.

Several other breakthroughs have encouraged Valentine, and the wealthy entrepreneurs backing Timeship, that freezing a person properly is now feasible. In 2015, a team from the company 21st Century Medicine claimed to have developed a new vitrification technique that preserved pig and rabbit brains without any visible damage.

Freezing embryos, eggs and sperm has become a normal part of modern science and medicine Getty Images

That same year, scientists from Alcor, a company associated with Timeship, found that when microscopic worms were deep-frozen and thawed, they not only survived but could remember associations they had learnt before they were frozen.

For Valentine and the cryonics community, these studies are proof that if the most advanced scientific techniques are used, then human organs, brains, and even memories and personalities could survive being frozen.

However, cryonics is unique in that it is utterly reliant on technology that does not exist yet. Even if so-called patients are frozen perfectly after death, they are simply guessing that scientists will one day be able to reanimate them and cure their illnesses and will want to.

Prof Brian Grout, chairman of the Society for Low-Temperature Biology, says that cryonics has become more credible in recent years, and that it would be wrong to dismiss the idea of whole-body freezing.

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But he does have one big problem with the central idea of the Timeship mission: the preservation of dead bodies.

The biggest difficulty is not whether it is possible to recover a whole person from ultra-low temperatures there is a reasonable chance that will happen in the future. It is the fact that they will be dead. If they were dead when they were frozen, they will still very much be dead when you thaw them out.

Timeship wouldn't tell us what these glacial pods would be used for Timeship

Freezing people alive could mean they can be placed in suspended animation for, say, long-term space flights, says Grout.

Technology that may be able to cure what are now incurable illnesses is also not hard to imagine, he says, but overcoming death is another matter.

The technology they will need is not cryotechnology, its reversing death. Thats a pretty big leap for me.

Valentine refuses to be drawn into a debate on whether Timeship would accept living patients if the authorities allowed such a thing, saying that it is a matter for the medical and legal professions.

But he and others believe that various technologies such as gene editing and nanotechnology could one day change how we perceive death, and reverse it.

Other futurists believe that it may one day be possible to upload our minds onto a computer, freeing humanity from the restraints of a physical form entirely.

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Banking on these future technologies may seem like a pretty big gamble, especially when the costs of cryonic preservation start at around $30,000. Yet for people whose lives are cut short by illness, a miraculous breakthrough may literally be the only hope they have.

An example is the 14-year-old British girl known as JS who made global headlines in 2016 after writing, before she died of cancer, that she wanted to be frozen. A judge ruled that her wishes must be respected, and her body was sent to the US to be frozen.

She wrote: Im only 14 years old and I dont want to die, but I know I am going to. I think being cryopreserved gives me a chance to be cured and woken up, even in hundreds of years time.

What the world will look like in hundreds of years time is anyones guess, but there are many logistical challenges for anyone is woken from the dead.

For a start, all your money, friends and family would be long gone, and youd probably struggle to find work in whatever hyper-advanced society has managed to resurrect you.

And there are bigger questions about how the planet would cope with a human population living far longer than it does now.

We are not going to have to worry about all that right now, says Valentine, frustrated by questions he sees as pointless hypothesising. The world may have changed in ways we cant even imagine! We could be inhabiting other planets or have modified ourselves to live in other environments.

Futurist body modification Getty Images

Its certainly hard to dismiss these ideas completely, given the remarkable progress our species has made in just the last few decades. And Valentine is confident that a change of mindset is just round the corner.

If scientists one day freeze a rabbit and bring it back to life, then the idea will spread so fast. People will start to think: why am I being buried in the ground? Why am I being cremated? Ill get frozen, and then one day, who knows. There could be many of these places around the world. This might become the norm.

Valentine himself is not currently signed up to be frozen at the Timeship he says it would distract from his architectural mission and could look like he was designing some kind of monument for myself. But his excitement and enthusiasm for this ambitious project is clear.

Will the travellers in the Timeship find themselves alive and well in the future, freed from the limitations of todays medical science? Or is it an expensive folly, doomed to result in several thousand bodies denied a proper burial?

Theres really only one way to find out and it involves a very long, very cold wait.

1Upload your consciousness to a computer

Getty Images

Some believe that we may one day be able to recreate every detail of our brains on powerful computers, enabling our thoughts and experiences to live on without physical bodies. However, neuroscientists still struggle to simulate the workings of the most primitive animal brains, so it remains a distant prospect.

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2Hibernate

Hibernation, like this dormouse is enjoying, could be one solution for inter-planetary space flight Getty Images

Doctors sometimes lower the body temperature of patients dying from severe injuries to buy more time while they perform emergency surgery.

Lowering the bodys temperature from 37C to around 10C slows down all biological processes, resulting in a kind of induced hibernation.

A similar technique has been proposed as a way of putting long-distance astronauts into a deep sleep.

3Build a new body for yourself

Vampirism has literary roots in disease, manifesting as a malignant way of cheating death iStock

After research in mice showed that the blood of young animals helped old animals memory, endurance and tissue repair, trials have begun to see if blood transfusions from young people can reduce or reverse ageing in older humans, too.

Scientists hope to identify the blood-borne chemical components of ageing.

4Travel through time

If time machines ever get invented, chances are they won't look like this Getty Images

If it was possible for a person to travel at very close to the speed of light, then time would slow down for them relative to everyone else.

This means that when they return to Earth, thousands of years may have flown by. However, unlike in Back To The Future, there would be no way back to the past.

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Introduction to Cryonics – Alcor

Cryonics is an effort to save lives by using temperatures so cold that a person beyond help by todays medicine can be preserved for decades or centuries until a future medical technology can restore that person to full health.

Cryonics sounds like science fiction, but is based on modern science. Its an experiment in the most literal sense of the word. The question you have to ask yourself is this: would you rather be in the experimental group, or the control group?

Cryonics is justified by three facts that are not well known:

1) Life can be stopped and restarted if its basic structure is preserved.

Human embryos are routinely preserved for years at temperatures that completely stop the chemistry of life. Adult humans have survived cooling to temperatures that stop the heart, brain, and all other organs from functioning for up to an hour. These and many other lessons of biology teach us that life is a particular structure of matter. Life can be stopped and restarted if cell structure and chemistry are preserved sufficiently well.

2) Vitrification (not freezing) can preserve biological structure very well.

Adding high concentrations of chemicals called cryoprotectants to cells permits tissue to be cooled to very low temperatures with little or no ice formation. The state of no ice formation at temperatures below -120C is called vitrification. It is now possible to physically vitrify organs as large as the human brain, achieving excellent structural preservation without freezing.

3) Methods for repairing structure at the molecular level can now be foreseen.

The emerging science of nanotechnology will eventually lead to devices capable of extensive tissue repair and regeneration, including repair of individual cells one molecule at a time. This future nanomedicine could theoretically recover any preserved person in which the basic brain structures encoding memory and personality remain inferable, which typically occurs well after spontaneous function has been lost.

So

Then cryonics should work, even though it cannot be demonstrated to work today. That is the scientific justification for cryonics. It is a justification that grows stronger with every new advance in preservation technology.

Death occurs when the chemistry of life becomes so disorganized that normal operation cannot be restored. (Death is not when life turns off. People can and have survived being turned off.) How much chemical disorder can be survived depends on medical technology. A hundred years ago, cardiac arrest was irreversible. People were called dead when their heart stopped beating. Today death is believed to occur 4 to 6 minutes after the heart stops beating because after several minutes it is difficult to resuscitate the brain. However, with new experimental treatments, more than 10 minutes of warm cardiac arrest can now be survived without brain injury. Future technologies for molecular repair may extend the frontiers of resuscitation beyond 60 minutes or more, making todays beliefs about when death occurs obsolete.

Ultimately, real death occurs when cell structure and chemistry become so disorganized that no technology could restore the original state. This is called the information-theoretic criterion for death. Any other definition of death is arbitrary and subject to continual revision as technology changes. That is certainly the case for death pronounced on the basis of absent vital signs today, which is not real death at all.

The object of cryonics is to prevent death by preserving sufficient cell structure and chemistry so that recovery (including recovery of memory and personality) remains possible by foreseeable technology. If indeed cryonics patients are recoverable in the future, then clearly they were never really dead in the first place. Todays physicians will simply have been wrong about when death occurs, as they have been so many times in the past. The argument that cryonics cannot work because cryonics patients are dead is a circular argument.

More than one hundred people have been cryopreserved since the first case in 1967. More than one thousand people have made legal and financial arrangements for cryonics with one of several organizations, usually by means of affordable life insurance. Alcor is the largest organization, and distinguished among cryonics organizations by its advanced technology and advocacy of a medical approach to cryonics.

Alcor procedures ideally begin within moments of cardiac arrest. Blood circulation and breathing are artificially restored, and a series of medications are administered to protect the brain from lack of oxygen. Rapid cooling also begins, which further protects the brain. The goal is to keep the brain alive by present-day criteria for as long as possible into the procedure. It is not always possible to respond so rapidly and aggressively, but that is Alcors ideal, and it has been achieved in many cases.

In 2001 Alcor adapted published breakthroughs in the field of organ preservation to achieve what we believe is ice-free preservation (vitrification) of the human brain. This is a method of stabilizing the physical basis of the human mind for practically unlimited periods of time. The procedure involves partly replacing water in cells with a mixture of chemicals that prevent ice formation. Kidneys have fully recovered after exposure to the same chemicals in published studies.

Alcors future goals include expanding ice-free cryopreservation (vitrification) beyond the brain to include the entire human body, and reducing the biochemical alterations of the process to move closer to demonstrable reversibility. Based on the remarkable progress being made in conventional organ banking research, we believe that demonstrably reversible preservation of the human brain is a medical objective that could be achieved in the natural lifetime of most people living today.

To learn more, please read our list of Frequently Asked Questions and the many other articles in the Alcor Library.

Figure 1: Pre-1992 freezing damage in brain tissue after treatment with 3 molar glycerol. This light micrograph prepared by freeze substitution in the frozen state shows extensive ice crystal damage. This is the kind of damage that many commentators assume is common in cryonics patients. Their assumption is outdated and incorrect.

Figure 2: Pre-1992 freezing damage in brain tissue after treatment with 4 molar glycerol. This electron micrograph prepared after thawing shows tears surrounding a capillary, and a naked cell nucleus with no cell membrane (dark rounded object). There seems to be less damage in frozen-thawed tissue than in tissue imaged in the frozen state.

Figure 3: 1992-2001 freezing damage in brain tissue after treatment with 7.5 molar glycerol. This electron micrograph prepared after thawing shows tears surrounding a capillary, but otherwise good structural preservation. With this protocol, ice damage occurs at intervals throughout the brain, but with most of the volume remaining ice-free.

Figure 4: Today brain tissue preserved with a modern vitrification solution shows virtually no freezing damage. Whole neurons are visible with intact membranes and well defined structure. This is the excellent brain preservation which Alcor can now achieve in human patients. Most experts who complain about damage caused by cryonics procedures are unaware that such preservation is now possible.

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Need Some Podcasts To Listen To In 2023? Five Exciting New Podcasts To Keep Your Ears Happy In The New Year. – Forbes

Need Some Podcasts To Listen To In 2023? Five Exciting New Podcasts To Keep Your Ears Happy In The New Year.  Forbes

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The week in audio: Capitals Jingle Bell Ball; The Most Streamed Christmas No 1s; Lights Out; Frozen Head and more – The Guardian

The week in audio: Capitals Jingle Bell Ball; The Most Streamed Christmas No 1s; Lights Out; Frozen Head and more  The Guardian

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The week in audio: Capitals Jingle Bell Ball; The Most Streamed Christmas No 1s; Lights Out; Frozen Head and more - The Guardian

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Death – Wikipedia

Irreversible cessation of all biological functions that sustain organisms

Death is the irreversible cessation of all biological functions that sustain an organism.[1] For organisms with a brain, death can also be defined as the irreversible cessation of functioning of the whole brain, including brainstem, and[2][3] brain death is sometimes used as a legal definition of death.[4] The remains of a former organism normally begin to decompose shortly after death. Death is an inevitable process that eventually occurs in almost all organisms.

Death is generally applied to whole organisms; the similar process seen in individual components of an organism, such as cells or tissues, is necrosis. Something that is not considered an organism, such as a virus, can be physically destroyed but is not said to die. As of the early 21st century, over 150,000 humans die each day, with ageing being by far the most common cause of death.[citation needed]

Many cultures and religions have the idea of an afterlife, and also may hold the idea of judgement of good and bad deeds in one's life (heaven, hell, karma).

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The concept of death is a key to human understanding of the phenomenon.[5] There are many scientific approaches and various interpretations of the concept. Additionally, the advent of life-sustaining therapy and the numerous criteria for defining death from both a medical and legal standpoint, have made it difficult to create a single unifying definition.

One of the challenges in defining death is in distinguishing it from life. As a point in time, death would seem to refer to the moment at which life ends. Determining when death has occurred is difficult, as cessation of life functions is often not simultaneous across organ systems.[6] Such determination, therefore, requires drawing precise conceptual boundaries between life and death. This is difficult, due to there being little consensus on how to define life.

It is possible to define life in terms of consciousness. When consciousness ceases, an organism can be said to have died. One of the flaws in this approach is that there are many organisms that are alive but probably not conscious (for example, single-celled organisms). Another problem is in defining consciousness, which has many different definitions given by modern scientists, psychologists and philosophers. Additionally, many religious traditions, including Abrahamic and Dharmic traditions, hold that death does not (or may not) entail the end of consciousness. In certain cultures, death is more of a process than a single event. It implies a slow shift from one spiritual state to another.[7]

Other definitions for death focus on the character of cessation of organismic functioning and a human death which refers to irreversible loss of personhood. More specifically, death occurs when a living entity experiences irreversible cessation of all functioning.[8] As it pertains to human life, death is an irreversible process where someone loses their existence as a person.[8]

Historically, attempts to define the exact moment of a human's death have been subjective, or imprecise. Death was once defined as the cessation of heartbeat (cardiac arrest) and of breathing, but the development of CPR and prompt defibrillation have rendered that definition inadequate because breathing and heartbeat can sometimes be restarted. This type of death where circulatory and respiratory arrest happens is known as the circulatory definition of death (DCDD). Proponents of the DCDD believe that this definition is reasonable because a person with permanent loss of circulatory and respiratory function should be considered dead.[9] Critics of this definition state that while cessation of these functions may be permanent, it does not mean the situation is irreversible, because if CPR was applied, the person could be revived.[9] Thus, the arguments for and against the DCDD boil down to a matter of defining the actual words "permanent" and "irreversible," which further complicates the challenge of defining death. Furthermore, events which were causally linked to death in the past no longer kill in all circumstances; without a functioning heart or lungs, life can sometimes be sustained with a combination of life support devices, organ transplants and artificial pacemakers.

Today, where a definition of the moment of death is required, doctors and coroners usually turn to "brain death" or "biological death" to define a person as being dead; people are considered dead when the electrical activity in their brain ceases. It is presumed that an end of electrical activity indicates the end of consciousness. Suspension of consciousness must be permanent, and not transient, as occurs during certain sleep stages, and especially a coma. In the case of sleep, EEGs can easily tell the difference.

The category of "brain death" is seen as problematic by some scholars. For instance, Dr. Franklin Miller, senior faculty member at the Department of Bioethics, National Institutes of Health, notes: "By the late 1990s... the equation of brain death with death of the human being was increasingly challenged by scholars, based on evidence regarding the array of biological functioning displayed by patients correctly diagnosed as having this condition who were maintained on mechanical ventilation for substantial periods of time. These patients maintained the ability to sustain circulation and respiration, control temperature, excrete wastes, heal wounds, fight infections and, most dramatically, to gestate fetuses (in the case of pregnant "brain-dead" women)."[10]

While "brain death" is viewed as problematic by some scholars, there are certainly proponents of it that believe this definition of death is the most reasonable for distinguishing life from death. The reasoning behind the support for this definition is that brain death has a set of criteria that is reliable and reproducible.[11] Also, the brain is crucial in determining our identity or who we are as human beings. The distinction should be made that "brain death" cannot be equated with one who is in a vegetative state or coma, in that the former situation describes a state that is beyond recovery.[11]

Those people maintaining that only the neo-cortex of the brain is necessary for consciousness sometimes argue that only electrical activity should be considered when defining death. Eventually it is possible that the criterion for death will be the permanent and irreversible loss of cognitive function, as evidenced by the death of the cerebral cortex. All hope of recovering human thought and personality is then gone given current and foreseeable medical technology. At present, in most places the more conservative definition of death irreversible cessation of electrical activity in the whole brain, as opposed to just in the neo-cortex has been adopted (for example the Uniform Determination Of Death Act in the United States). In 2005, the Terri Schiavo case brought the question of brain death and artificial sustenance to the front of American politics.

Even by whole-brain criteria, the determination of brain death can be complicated. EEGs can detect spurious electrical impulses, while certain drugs, hypoglycemia, hypoxia, or hypothermia can suppress or even stop brain activity on a temporary basis. Because of this, hospitals have protocols for determining brain death involving EEGs at widely separated intervals under defined conditions.

In the past, adoption of this whole-brain definition was a conclusion of the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research in 1980.[12] They concluded that this approach to defining death sufficed in reaching a uniform definition nationwide. A multitude of reasons were presented to support this definition including: uniformity of standards in law for establishing death; consumption of a family's fiscal resources for artificial life support; and legal establishment for equating brain death with death in order to proceed with organ donation.[13]

Aside from the issue of support of or dispute against brain death, there is another inherent problem in this categorical definition: the variability of its application in medical practice. In 1995, the American Academy of Neurology (AAN), established a set of criteria that became the medical standard for diagnosing neurologic death. At that time, three clinical features had to be satisfied in order to determine "irreversible cessation" of the total brain including: coma with clear etiology, cessation of breathing, and lack of brainstem reflexes.[14] This set of criteria was then updated again most recently in 2010, but substantial discrepancies still remain across hospitals and medical specialties.[14]

The problem of defining death is especially imperative as it pertains to the dead donor rule, which could be understood as one of the following interpretations of the rule: there must be an official declaration of death in a person before starting organ procurement or that organ procurement cannot result in death of the donor.[9] A great deal of controversy has surrounded the definition of death and the dead donor rule. Advocates of the rule believe the rule is legitimate in protecting organ donors while also countering against any moral or legal objection to organ procurement. Critics, on the other hand, believe that the rule does not uphold the best interests of the donors and that the rule does not effectively promote organ donation.[9]

Signs of death or strong indications that a warm-blooded animal is no longer alive are:

The stages that follow after death are:

The death of a person has legal consequences that may vary between different jurisdictions.A death certificate is issued in most jurisdictions, either by a doctor, or by an administrative office upon presentation of a doctor's declaration of death.

There are many anecdotal references to people being declared dead by physicians and then "coming back to life", sometimes days later in their own coffin, or when embalming procedures are about to begin. From the mid-18th century onwards, there was an upsurge in the public's fear of being mistakenly buried alive,[15] and much debate about the uncertainty of the signs of death. Various suggestions were made to test for signs of life before burial, ranging from pouring vinegar and pepper into the corpse's mouth to applying red hot pokers to the feet or into the rectum.[16] Writing in 1895, the physician J.C. Ouseley claimed that as many as 2,700 people were buried prematurely each year in England and Wales, although others estimated the figure to be closer to 800.[17]

In cases of electric shock, cardiopulmonary resuscitation (CPR) for an hour or longer can allow stunned nerves to recover, allowing an apparently dead person to survive. People found unconscious under icy water may survive if their faces are kept continuously cold until they arrive at an emergency room.[18] This "diving response", in which metabolic activity and oxygen requirements are minimal, is something humans share with cetaceans called the mammalian diving reflex.[18]

As medical technologies advance, ideas about when death occurs may have to be re-evaluated in light of the ability to restore a person to vitality after longer periods of apparent death (as happened when CPR and defibrillation showed that cessation of heartbeat is inadequate as a decisive indicator of death). The lack of electrical brain activity may not be enough to consider someone scientifically dead. Therefore, the concept of information-theoretic death[19] has been suggested as a better means of defining when true death occurs, though the concept has few practical applications outside the field of cryonics.

There have been some scientific attempts to bring dead organisms back to life, but with limited success.[20]

The leading cause of human death in developing countries is infectious disease. The leading causes in developed countries are atherosclerosis (heart disease and stroke), cancer, and other diseases related to obesity and aging. By an extremely wide margin, the largest unifying cause of death in the developed world is biological aging,[21] leading to various complications known as aging-associated diseases. These conditions cause loss of homeostasis, leading to cardiac arrest, causing loss of oxygen and nutrient supply, causing irreversible deterioration of the brain and other tissues. Of the roughly 150,000 people who die each day across the globe, about two thirds die of age-related causes.[21] In industrialized nations, the proportion is much higher, approaching 90%.[21] With improved medical capability, dying has become a condition to be managed. Home deaths, once commonplace, are now rare in the developed world.

In developing nations, inferior sanitary conditions and lack of access to modern medical technology makes death from infectious diseases more common than in developed countries. One such disease is tuberculosis, a bacterial disease which killed 1.8M people in 2015.[23] Malaria causes about 400900M cases of fever and 13M deaths annually.[24] AIDS death toll in Africa may reach 90100M by 2025.[25][26]

According to Jean Ziegler (United Nations Special Reporter on the Right to Food, 2000 Mar 2008), mortality due to malnutrition accounted for 58% of the total mortality rate in 2006. Ziegler says worldwide approximately 62M people died from all causes and of those deaths more than 36M died of hunger or diseases due to deficiencies in micronutrients.[27]

Tobacco smoking killed 100million people worldwide in the 20th century and could kill 1billion people around the world in the 21st century, a World Health Organization report warned.[22]

Many leading developed world causes of death can be postponed by diet and physical activity, but the accelerating incidence of disease with age still imposes limits on human longevity. The evolutionary cause of aging is, at best, only just beginning to be understood. It has been suggested that direct intervention in the aging process may now be the most effective intervention against major causes of death.[28]

Selye proposed a unified non-specific approach to many causes of death. He demonstrated that stress decreases adaptability of an organism and proposed to describe the adaptability as a special resource, adaptation energy. The animal dies when this resource is exhausted.[29] Selye assumed that the adaptability is a finite supply, presented at birth. Later on, Goldstone proposed the concept of a production or income of adaptation energy which may be stored (up to a limit), as a capital reserve of adaptation.[30] In recent works, adaptation energy is considered as an internal coordinate on the "dominant path" in the model of adaptation. It is demonstrated that oscillations of well-being appear when the reserve of adaptability is almost exhausted.[31]

In 2012, suicide overtook car crashes for leading causes of human injury deaths in the U.S., followed by poisoning, falls, and murder.[32] Causes of death are different in different parts of the world. In high-income and middle income countries nearly half up to more than two thirds of all people live beyond the age of 70 and predominantly die of chronic diseases. In low-income countries, where less than one in five of all people reach the age of 70, and more than a third of all deaths are among children under 15, people predominantly die of infectious diseases.[33]

An autopsy, also known as a postmortem examination or an obduction, is a medical procedure that consists of a thorough examination of a human corpse to determine the cause and manner of a person's death and to evaluate any disease or injury that may be present. It is usually performed by a specialized medical doctor called a pathologist.

Autopsies are either performed for legal or medical purposes. A forensic autopsy is carried out when the cause of death may be a criminal matter, while a clinical or academic autopsy is performed to find the medical cause of death and is used in cases of unknown or uncertain death, or for research purposes. Autopsies can be further classified into cases where external examination suffices, and those where the body is dissected and an internal examination is conducted. Permission from next of kin may be required for internal autopsy in some cases. Once an internal autopsy is complete the body is generally reconstituted by sewing it back together. Autopsy is important in a medical environment and may shed light on mistakes and help improve practices.

A necropsy, which is not always a medical procedure, was a term previously used to describe an unregulated postmortem examination. In modern times, this term is more commonly associated with the corpses of animals.

Senescence refers to a scenario when a living being is able to survive all calamities, but eventually dies due to causes relating to old age. Animal and plant cells normally reproduce and function during the whole period of natural existence, but the aging process derives from deterioration of cellular activity and ruination of regular functioning. Aptitude of cells for gradual deterioration and mortality means that cells are naturally sentenced to stable and long-term loss of living capacities, even despite continuing metabolic reactions and viability. In the United Kingdom, for example, nine out of ten of all the deaths that occur on a daily basis relates to senescence, while around the world it accounts for two-thirds of 150,000 deaths that take place daily.[34][full citation needed]

Almost all animals who survive external hazards to their biological functioning eventually die from biological aging, known in life sciences as "senescence". Some organisms experience negligible senescence, even exhibiting biological immortality. These include the jellyfish Turritopsis dohrnii,[35] the hydra, and the planarian. Unnatural causes of death include suicide and predation. From all causes, roughly 150,000 people die around the world each day.[21] Of these, two thirds die directly or indirectly due to senescence, but in industrialized countries such as the United States, the United Kingdom, and Germany the rate approaches 90% (i.e., nearly nine out of ten of all deaths are related to senescence).[21]

Physiological death is now seen as a process, more than an event: conditions once considered indicative of death are now reversible.[36] Where in the process a dividing line is drawn between life and death depends on factors beyond the presence or absence of vital signs. In general, clinical death is neither necessary nor sufficient for a determination of legal death. A patient with working heart and lungs determined to be brain dead can be pronounced legally dead without clinical death occurring.

Cryonics (from Greek 'kryos-' meaning 'icy cold') is the low-temperature preservation of animals and humans who cannot be sustained by contemporary medicine, with the hope that healing and resuscitation may be possible in the future.[37][38]

Cryopreservation of people or large animals is not reversible with current technology. The stated rationale for cryonics is that people who are considered dead by current legal or medical definitions may not necessarily be dead according to the more stringent information-theoretic definition of death.[19][39]

Some scientific literature is claimed to support the feasibility of cryonics.[40] Medical science and cryobiologists generally regards cryonics with skepticism.[41]

"One of medicine's new frontiers: treating the dead", recognizes that cells that have been without oxygen for more than five minutes die,[42] not from lack of oxygen, but rather when their oxygen supply is resumed. Therefore, practitioners of this approach, e.g., at the Resuscitation Science institute at the University of Pennsylvania, "aim to reduce oxygen uptake, slow metabolism and adjust the blood chemistry for gradual and safe reperfusion."[43] Moreover, there is an organ perfusion system under development that can restore, i.e. on the cellular level, multiple vital (pig) organs one hour after death (during which the body had prolonged warm ischaemia),[44][45] and a similar method/system, reported in 2019, for partially reviving (pig) brains hours after death.[44][46] It showed that "the process of cell death is a gradual, stepwise process and that some of those processes can be either postponed, preserved or even reversed".[47] Such methods or systems could be developed further to be used to preserve donor organs or for revival in medical emergencies by buying "more time for doctors to treat people whose bodies were starved of oxygen, such as those who died from drowning or heart attacks".[44]

Life extension refers to an increase in maximum or average lifespan, especially in humans, by slowing down or reversing the processes of aging through anti-aging measures. Despite the fact that aging is by far the most common cause of death worldwide, it is socially mostly ignored as such and seen as "necessary" and "inevitable" anyway, which is why little money is spent on research into anti-aging therapies, a phenomenon known as the pro-aging trance.[21]

Average lifespan is determined by vulnerability to accidents and age or lifestyle-related afflictions such as cancer, or cardiovascular disease. Extension of average lifespan can be achieved by good diet, exercise and avoidance of hazards such as smoking. Maximum lifespan is also determined by the rate of aging for a species inherent in its genes. Currently, the only widely recognized method of extending maximum lifespan is calorie restriction. Theoretically, extension of maximum lifespan can be achieved by reducing the rate of aging damage, by periodic replacement of damaged tissues, or by molecular repair or rejuvenation of deteriorated cells and tissues.

A United States poll found that religious people and irreligious people, as well as men and women and people of different economic classes have similar rates of support for life extension, while Africans and Hispanics have higher rates of support than white people.[48] 38 percent of the polled said they would desire to have their aging process cured.

Researchers of life extension are a subclass of biogerontologists known as "biomedical gerontologists". They try to understand the nature of aging and they develop treatments to reverse aging processes or to at least slow them down, for the improvement of health and the maintenance of youthful vigor at every stage of life. Those who take advantage of life extension findings and seek to apply them upon themselves are called "life extensionists" or "longevists". The primary life extension strategy currently is to apply available anti-aging methods in the hope of living long enough to benefit from a complete cure to aging once it is developed.

Before about 1930, most people in Western countries died in their own homes, surrounded by family, and comforted by clergy, neighbors, and doctors making house calls.[51] By the mid-20th century, half of all Americans died in a hospital.[52] By the start of the 21st century, only about 2025% of people in developed countries died outside of a medical institution.[52][53][54] The shift away from dying at home towards dying in a professional medical environment has been termed the "Invisible Death".[52] This shift occurred gradually over the years, until most deaths now occur outside the home.[55]

Death studies is a field within psychology.[56] Many people are afraid of dying. Discussing, thinking about, or planning for their own deaths causes them discomfort. This fear may cause them to put off financial planning, preparing a will and testament, or requesting help from a hospice organization.

Different people have different responses to the idea of their own deaths. Philosopher Galen Strawson writes that the death that many people wish for is an instant, painless, unexperienced annihilation.[57] In this unlikely scenario, the person dies without realizing it and without being able to fear it. One moment the person is walking, eating, or sleeping, and the next moment, the person is dead. Strawson reasons that this type of death would not take anything away from the person, as he believes that a person cannot have a legitimate claim to ownership in the future.[57][58]

In society, the nature of death and humanity's awareness of its own mortality has for millennia been a concern of the world's religious traditions and of philosophical inquiry. This includes belief in resurrection or an afterlife (associated with Abrahamic religions), reincarnation or rebirth (associated with Dharmic religions), or that consciousness permanently ceases to exist, known as eternal oblivion (associated with Secular humanism).[59]

Commemoration ceremonies after death may include various mourning, funeral practices and ceremonies of honouring the deceased. The physical remains of a person, commonly known as a corpse or body, are usually interred whole or cremated, though among the world's cultures there are a variety of other methods of mortuary disposal. In the English language, blessings directed towards a dead person include rest in peace (originally the Latin requiescat in pace), or its initialism RIP.

Death is the center of many traditions and organizations; customs relating to death are a feature of every culture around the world. Much of this revolves around the care of the dead, as well as the afterlife and the disposal of bodies upon the onset of death. The disposal of human corpses does, in general, begin with the last offices before significant time has passed, and ritualistic ceremonies often occur, most commonly interment or cremation. This is not a unified practice; in Tibet, for instance, the body is given a sky burial and left on a mountain top. Proper preparation for death and techniques and ceremonies for producing the ability to transfer one's spiritual attainments into another body (reincarnation) are subjects of detailed study in Tibet.[60] Mummification or embalming is also prevalent in some cultures, to retard the rate of decay.

Legal aspects of death are also part of many cultures, particularly the settlement of the deceased estate and the issues of inheritance and in some countries, inheritance taxation.

Capital punishment is also a culturally divisive aspect of death. In most jurisdictions where capital punishment is carried out today, the death penalty is reserved for premeditated murder, espionage, treason, or as part of military justice. In some countries, sexual crimes, such as adultery and sodomy, carry the death penalty, as do religious crimes such as apostasy, the formal renunciation of one's religion. In many retentionist countries, drug trafficking is also a capital offense. In China, human trafficking and serious cases of corruption are also punished by the death penalty. In militaries around the world courts-martial have imposed death sentences for offenses such as cowardice, desertion, insubordination, and mutiny.[61]

Death in warfare and in suicide attack also have cultural links, and the ideas of dulce et decorum est pro patria mori, mutiny punishable by death, grieving relatives of dead soldiers and death notification are embedded in many cultures. Recently in the western world, with the increase in terrorism following the September 11 attacks, but also further back in time with suicide bombings, kamikaze missions in World War II and suicide missions in a host of other conflicts in history, death for a cause by way of suicide attack, and martyrdom have had significant cultural impacts.

Suicide in general, and particularly euthanasia, are also points of cultural debate. Both acts are understood very differently in different cultures. In Japan, for example, ending a life with honor by seppuku was considered a desirable death, whereas according to traditional Christian and Islamic cultures, suicide is viewed as a sin. Death is personified in many cultures, with such symbolic representations as the Grim Reaper, Azrael, the Hindu god Yama and Father Time.

In Brazil, a human death is counted officially when it is registered by existing family members at a cartrio, a government-authorized registry. Before being able to file for an official death, the deceased must have been registered for an official birth at the cartrio. Though a Public Registry Law guarantees all Brazilian citizens the right to register deaths, regardless of their financial means, of their family members (often children), the Brazilian government has not taken away the burden, the hidden costs and fees, of filing for a death. For many impoverished families, the indirect costs and burden of filing for a death lead to a more appealing, unofficial, local, cultural burial, which in turn raises the debate about inaccurate mortality rates.[63]

Talking about death and witnessing it is a difficult issue with most cultures. Western societies may like to treat the dead with the utmost material respect, with an official embalmer and associated rites. Eastern societies (like India) may be more open to accepting it as a fait accompli, with a funeral procession of the dead body ending in an open-air burning-to-ashes of the same.

Much interest and debate surround the question of what happens to one's consciousness as one's body dies. The belief in the permanent loss of consciousness after death is often called eternal oblivion. Belief that the stream of consciousness is preserved after physical death is described by the term afterlife. Neither are likely to ever be confirmed without the ponderer having to actually die.

After death, the remains of a former organism become part of the biogeochemical cycle, during which animals may be consumed by a predator or a scavenger.[64] Organic material may then be further decomposed by detritivores, organisms which recycle detritus, returning it to the environment for reuse in the food chain, where these chemicals may eventually end up being consumed and assimilated into the cells of an organism. Examples of detritivores include earthworms, woodlice and dung beetles.

Microorganisms also play a vital role, raising the temperature of the decomposing matter as they break it down into yet simpler molecules. Not all materials need to be fully decomposed. Coal, a fossil fuel formed over vast tracts of time in swamp ecosystems, is one example.

Contemporary evolutionary theory sees death as an important part of the process of natural selection.[65] It is considered that organisms less adapted to their environment are more likely to die having produced fewer offspring, thereby reducing their contribution to the gene pool. Their genes are thus eventually bred out of a population, leading at worst to extinction and, more positively, making the process possible, referred to as speciation. Frequency of reproduction plays an equally important role in determining species survival: an organism that dies young but leaves numerous offspring displays, according to Darwinian criteria, much greater fitness than a long-lived organism leaving only one.

Extinction is the cessation of existence of a species or group of taxa, reducing biodiversity. The moment of extinction is generally considered to be the death of the last individual of that species (although the capacity to breed and recover may have been lost before this point). Because a species' potential range may be very large, determining this moment is difficult, and is usually done retrospectively. This difficulty leads to phenomena such as Lazarus taxa, where species presumed extinct abruptly "reappear" (typically in the fossil record) after a period of apparent absence. New species arise through the process of speciation, an aspect of evolution. New varieties of organisms arise and thrive when they are able to find and exploit an ecological niche and species become extinct when they are no longer able to survive in changing conditions or against superior competition.

Inquiry into the evolution of aging aims to explain why so many living things and the vast majority of animals weaken and die with age (exceptions include Hydra and the jellyfish Turritopsis dohrnii, which research shows to be biologically immortal). The evolutionary origin of senescence remains one of the fundamental puzzles of biology. Gerontology specializes in the science of human aging processes.

Organisms showing only asexual reproduction (e.g. bacteria, some protists, like the euglenoids and many amoebozoans) and unicellular organisms with sexual reproduction (colonial or not, like the volvocine algae Pandorina and Chlamydomonas) are "immortal" at some extent, dying only due to external hazards, like being eaten or meeting with a fatal accident. In multicellular organisms (and also in multinucleate ciliates),[67] with a Weismannist development, that is, with a division of labor between mortal somatic (body) cells and "immortal" germ (reproductive) cells, death becomes an essential part of life, at least for the somatic line.[68]

The Volvox algae are among the simplest organisms to exhibit that division of labor between two completely different cell types, and as a consequence include death of somatic line as a regular, genetically regulated part of its life history.[68][69]

In Buddhist doctrine and practice, death plays an important role. Awareness of death was what motivated Prince Siddhartha to strive to find the "deathless" and finally to attain enlightenment. In Buddhist doctrine, death functions as a reminder of the value of having been born as a human being. Being reborn as a human being is considered the only state in which one can attain enlightenment. Therefore, death helps remind oneself that one should not take life for granted. The belief in rebirth among Buddhists does not necessarily remove death anxiety, since all existence in the cycle of rebirth is considered filled with suffering, and being reborn many times does not necessarily mean that one progresses.[70]

Death is part of several key Buddhist tenets, such as the Four Noble Truths and dependent origination.[70]

While there are different sects of Christianity with different branches of belief; the overarching ideology on death grows from the knowledge of afterlife. Meaning after death the individual will undergo a separation from mortality to immortality; their soul leaves the body entering a realm of spirits. Following this separation of body and spirit (i.e. death) resurrection will occur.[71] Representing the same transformation Jesus Christ embodied after his body was placed in the tomb for three days. Like Him, each person's body will be resurrected reuniting the spirit and body in a perfect form.[72] This process allows the individuals soul to withstand death and transform into life after death.

In Hindu texts, death is described as the individual eternal spiritual jiva-atma (soul or conscious self) exiting the current temporary material body. The soul exits this body when the body can no longer sustain the conscious self (life), which may be due to mental or physical reasons, or more accurately, the inability to act on one's kama (material desires). During conception, the soul enters a compatible new body based on the remaining merits and demerits of one's karma (good/bad material activities based on dharma) and the state of one's mind (impressions or last thoughts) at the time of death.

Usually the process of reincarnation (soul's transmigration) makes one forget all memories of one's previous life. Because nothing really dies and the temporary material body is always changing, both in this life and the next, death means forgetfulness of one's previous experiences (previous material identity).

Material existence is described as being full of miseries arising from birth, disease, old age, death, mind, weather, etc. To conquer samsara (the cycle of death and rebirth) and become eligible for one of the different types of moksha (liberation), one has to first conquer kama (material desires) and become self-realized. The human form of life is most suitable for this spiritual journey, especially with the help of sadhu (self-realized saintly persons), sastra (revealed spiritual scriptures), and guru (self-realized spiritual masters), given all three are in agreement.

There are a variety of beliefs about the afterlife within Judaism, but none of them contradict the preference of life over death. This is partially because death puts a cessation to the possibility of fulfilling any commandments.[citation needed]

The word "death" comes from Old English da, which in turn comes from Proto-Germanic *dauuz (reconstructed by etymological analysis). This comes from the Proto-Indo-European stem *dheu- meaning the "process, act, condition of dying".[73]

The concept and symptoms of death, and varying degrees of delicacy used in discussion in public forums, have generated numerous scientific, legal, and socially acceptable terms or euphemisms. When a person has died, it is also said they have "passed away", "passed on", "expired", or "gone", among other socially accepted, religiously specific, slang, and irreverent terms.

As a formal reference to a dead person, it has become common practice to use the participle form of "decease", as in "the deceased"; another noun form is "decedent".

Bereft of life, the dead person is a "corpse", "cadaver", "body", "set of remains" or, when all flesh is gone, a "skeleton". The terms "carrion" and "carcass" are also used, usually for dead non-human animals. The ashes left after a cremation are lately called "cremains".

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