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Campaign Chemistry: The best of 2023 – Campaign US

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Campaign Chemistry: The best of 2023 - Campaign US

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The chemistry between Joe Flacco and Amari Cooper is off the charts | Leroy Hoard – WKYC.com

Amari Cooper set the Browns record with 265 receiving yards vs. the Texans. Joe Flacco has created unbelievable chemistry with Cooper in such a short period of time.

Author: wkyc.com

Published: 12:35 PM EST December 26, 2023

Updated: 12:35 PM EST December 26, 2023

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The chemistry between Joe Flacco and Amari Cooper is off the charts | Leroy Hoard - WKYC.com

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AI chemist performs complex experiments based on plain text prompts – Chemical & Engineering News

Dubbed Coscientist, the system uses the language model behind the chatbot ChatGPT. With a prompt such as perform multiple Suzuki reactions, the AI browses the internet to learn about the reactions, scours relevant literature and hardware documentation for information, and in minutes, outlines the procedures necessary to perform these reactions. It then writes a code, which a robot uses to run the experiment.

We are converting bits to atoms, says Gabe Gomes, a chemist and chemical engineer at Carnegie Mellon University, in a press briefing. Taking a natural language prompt, the bits, and converting it into an actual chemical reaction.

Coscientist could successfully perform the complex Nobel Prize-winning palladium-catalyzed cross coupling reaction named after Akira Suzuki with a 50% yield the very first time. It could also accurately plan procedures to synthesize common pharmaceutical compounds such as aspirin and ibuprofen. Gomes says he and his team are fully aware of the potential illicit use of Coscientist and are collaborating with other researchers and policymakers to prevent such misuse.

Tiago Rodrigues, a medicinal chemist at the University of Lisbon, says that Coscientist fills the important gap of communication necessary to meet the long-standing goal of self-driving labs. AI chemists such as Coscientist and ChemCrow, which was recently developed by another research team, could enable the full automation of the design-make-test cycle, he says. This can have tremendous impact in terms of productivity since researchers can dedicate their time to other tasks..

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AI chemist performs complex experiments based on plain text prompts - Chemical & Engineering News

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We don’t hang out for coffee: Tom Hanks Made a Startling Revelation About Meg Ryan That Makes Their Chemistry … – FandomWire

Tom Hanks and Meg Ryan are two actors who, perhaps, have one of the best on-screen chemistry. This aspect of their films has become so distinct that they have worked together a few times. They first starred in the 1990 film, Joe Versus the Volcano,which, though was a flop, audiences could not deny the dynamic these two shared. Following close was 1993s Sleepless in Seattle,which many think of as one of the most beautiful romance films of all time. Finally, the two starred in the 1998 film, Youve Got Mail, which has certainly become one of their most iconic projects of all time.

The authenticity of their relationship with each other in front of a camera has many questioning how exactly they are able to achieve this. During an interview, Hanks revealed how their on-screen chemistry differs from their real life, putting forth an answer to this age-old question.

Also Read: Tom Hanks Was Exhausted After He Was Given an Impossible Job in One of the Best Christmas Movies Ever: The Polar Express

During the Youve Got Mail, Tom Hanks gave a press convince, which has resurfaced thanks to Entertainment Tonight. Here, the actor revealed the true nature of his relationship with Meg Ryan and how the two are with each other when the cameras are turned off. He confessed that they are not as close as many would think. While the statement certainly does not mean that they are unable to tolerate the other, it seems that the two are simply surface-level friends.

Its just a natural thing.he added,I must say,Meg and I are not real close pals, he shockingly remarked. We see each other every now and again. Its like, we dont hang out for coffee.

He elaborated, adding that their dynamic is simply a natural thing and is not a reflection of their real-world connection. He mentioned that, though they do see each other now and then, they are not close enough to hang out with each other at restaurants or have coffee together.

Also Read: You guys are the wrong gender to understand: Tom Hanks Went Off the Rails in One Meg Ryan Movie That Made Him ExtremelyCranky

The closeness, or the lack thereof, of Tom Hanks and Meg Ryans relationship, has seemed to have absolutely no impact on their rapport when they are working on films together. Hanks mentioned exactly this during this interview, adding that though they do not necessarily interact outside of work when they do meet after a long time, they are the same as each other, not having awkwardness weighing down their exchanges.

But when we pick up, we just pick up where we left off and its an effortless thing that I dont think either one of us examines it too much because if we did, itd be a problem. We dont plan. We just do it,

Hanks added that he finds their dynamic to be effortless, one where neither has to think too much about what the other thinks of them and they simply co-exist and enjoy each others company. Knowing this information certainly adds another layer of complexity to the films that feature Hanks and Ryan.

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We don't hang out for coffee: Tom Hanks Made a Startling Revelation About Meg Ryan That Makes Their Chemistry ... - FandomWire

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This GPT-powered robot chemist designs reactions and makes drugs on its own – Nature.com

The autonomous chemical system Coscientist uses an LLM to run robotic laboratory equipment.Credit: Carnegie Mellon University

Chemists have used ChatGPT to design and conduct complex chemical reactions using a robotic laboratory set-up.

The system, called Coscientist, can design, code and carry out several reactions making compounds including paracetamol and aspirin in the wet lab using its robot apparatus. The approach was described in Nature1 on 20 December.

The moment I saw a non-organic intelligence be able to autonomously plan, design and execute a chemical reaction that was invented by humans, that was amazing, says chemist Gabe Gomes at Carnegie Mellon University in Pittsburgh, Pennsylvania, who led the research. It was a holy crap moment.

Fast-paced improvements in artificial intelligence (AI) have seen applications for these tools proliferate throughout science. But for researchers working at the bench or those who arent versed in computer code, AI approaches arent as accessible or so thought Gomes.

When the latest version of the large language model (LLM) behind ChatGPT, called GPT-4, was unveiled in March, Gomes and his team set about making it work for chemists.

The result, Coscientist1, uses the latest powerful LLMs, including GPT-4, to scour the chemical literature and design a reaction pathway to make a molecule when prompted by a human. The LLM reads through instruction manuals on the Internet and decides on the best kit and reagents in its arsenal to make the molecule in real life.

The AI also uses the LLM Claude, developed by the AI firm Anthropic in San Francisco, California, and one called Falcon-40B-Instruct built by the Technology Innovation Institute in Abu Dhabi.

The team prompted the system to plan a synthesis for several known molecules, including the painkillers paracetamol and aspirin, and the organic molecules nitroaniline and phenolphthalein. In the planning stage, Coscientist was able to work out the steps that would give the best reaction yields overall. It made the molecules correctly.

This is a great demonstration of how the literature can be explored using LLMs to help come up with ideas of feasible chemical reactions, says Lee Cronin, a chemist at the University of Glasgow, UK.

The team also tried a more complicated experiment asking Coscientist to execute a reaction called SuzukiMiyaura coupling, which forms carboncarbon bonds and is important in drug discovery. The system aced this test, too.

The group is one of many working on LLM-driven chemistry robots. One such robot, called ChemCrow, was developed at around the same time as Coscientist and can plan and make a range of molecules, including the insecticide DEET2. (Chemist Andrew White at the University of Rochester in New York, who led the team that developed ChemCrow, declined Natures request for comment.)

Tools such as Coscientist are likely to become more commonly used, says Tiago Rodrigues, a pharmaceutical chemist at the University of Lisbon. I can really see a future where automation hardware comes equipped with these AI assistants. Self-driving labs are the future, and AI tools are needed to fully automate the design-make-test cycle, he says.

Routine tasks can now be done by these systems, but Rodrigues adds that most research questions, especially in drug discovery, are still out of reach. Its not just a good understanding of chemistry that is needed, but also biology.

Coscientist can do most of the things that really well-trained chemists can do. And I think about that a lot, says Gomes. His team hasnt made the full code behind its invention freely available, and Gomes says that it is important to think carefully about how and where technologies such as Coscientist and ChemCrow are used, because some applications are likely to be dangerous.

Im not interested in the idea of replacing people and their livelihoods, and their spark and their innovation and their drive, Gomes says.

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This GPT-powered robot chemist designs reactions and makes drugs on its own - Nature.com

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Ancient Mummy-Making Techniques Are Finally Unwrapped – DISCOVER Magazine

Around 2,600 years ago, a small ceramic bowl sat in a subterranean workshop. Carrying hints of cedar and honey, the bowl was used by Egyptian embalmers to blend essential oils and beeswax for the multimonth process that transformed corpses into mummies.

Reciting incantations, removing organs, andapplying substances that made bodies dry, fragrant, and microbe-free, the embalmers employed a multifacetedset of skills.

They knew the ritual practices, but also [a] kind of chemistry, says Maxime Rageot, abiomolecular archaeologist at the University of Tbingen in Germany.

Over the past four years, Rageot and colleagues have gained unprecedented insights into the substances and steps involved inancient Egyptian mummy-making. Their analysis of molecules trapped in pottery, aspublished in a Nature paper from February 2023, revealedthat embalmers sourced ingredients from surprisingly far-flung lands for their specific biomolecular properties.

The Egyptians perfected the practice of mummification over the course of several thousand years, transforming the natural desiccation of bodies into a sophisticated ritual and chemical process between the fifth and first millenniums B.C.E. During the time of the pharaohs, professionals spent up to 70days transforming a tender corpse into a linen-wrapped, afterlife-ready mummy treating it with spells and prayers, as well as substances that mitigated moisture, bacteria, fungi, and stink.

But scholars have long debated how to translate the ingredients named in ancient inscriptions and papyri, meaning that much of the mummy recipe has remained a mystery. And whilesome ingredients have been identified from the molecular analyses of mummies from museums around the world, these methods cannot reveal how specific substances figured into the mummification process whether they were applied to the bandages or the head, for instance, for the purpose of preserving tissues or fending off bacteria.

The possibility of linking substances and steps arrived in 2018, when the late archaeologist Ramadan Hussein invited Rageot to join his excavations at Saqqara, an ancient city about 12 miles south of Cairo. There, Husseins team had uncovered an ancient facility for treating and storing corpses, dated to around 664 to 525 B.C.E. Featuring a workshop more than 40 feet underground, the facility held over 100pottery vessels bearing instructions like to make the odor pleasant, for making beautiful the skin, and head, boil.

Selecting 31 of these pots for closer analysis, Rageot set out to identify their long-lost contents. But because Egypt lacked a specialized laboratory for this kind of work, he and his team brought the pots to a local food chemistry lab, which they converted into one of the countrys only facilities for analyzing ancient biomolecules. Drilling pinches of clay powder from the pots interiors and analyzing the powder in the labs mass spectrometer, they determined which ancient molecules had seeped into the potterys pores.

The successful analyses of the pots revealed embalmers used diverse and exotic materials that could curb moisture, smells, and mummy-munching organisms: Bitumen tar probably from the Dead Sea; pistachio, juniper, and olive oils from the Mediterranean; and tree resins from the tropical forests of Asia and possibly sub-Saharan Africa. To source these items, the embalmers relied on trade that spanned much of their known world.

The diversity of bioproducts which were used, Rageot says, was really impressive.

Now that the Egyptian lab exists, the researchers plan to analyze mummy-making ingredients from more sites. Their hope is to trace how mummification transformed across time and space, applying modern chemical methods to unravel their ancient counterparts.

This story was originally published in our January February 2024 issue.Click hereto subscribe to read more stories like this one.

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Ancient Mummy-Making Techniques Are Finally Unwrapped - DISCOVER Magazine

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