Category Archives: Anti-Aging Medicine

it is a Power, Profit, Control Pandemic.

The economic collapse is a result of precisely engineered governmental policies though those policies appear to be in the publics best interest.

COVID-19 meets the technical definition of apandemic, and the World Health Organization (WHO) declare it so. However, the death toll is nowhere near that of real pandemics that would legitimately justify the extraordinary measures being deployed by the US and some other 1st world government.

The Spanish flu in Y 1918 infected 500-M people worldwide, killing between 20 and 50-M. The Bubonic plague killed 50-M people, wiping out 60% of the European population. Those are what people think of when they hear the word pandemic.

COVID-19 presently affects a ultra-tiny fraction of the global population about 1.4-M cases out of a global population of 7.78-B, and even with a death toll of 81,000 worldwide, COVID-19 has had a miniscule impact, having killed a only 0.00001% of the population.

Death is inevitable, but any given individuals risk of dying from the epidemics ofdiabetes,heart diseaseorcancer, for example, is greater than their risk of dying from COVID-19 coronavirus.

Death seems to be acceptable from poor lifestyle-induced disease and environmental toxicity.

The Big Q: Why is it preferable and acceptable than death from an infectious disease?

Also, dying from a preventable medical mistake is a far greater risk, as thatkills up to 440,000 Americans every year.

The Big Q2+: Where is the panic about that? Is not the notion that conventional medicine kills 440,000 people a year terrifying? And 20% elderly patients are also injured by medical care. Where are the calls to protect our aging loved ones from this threat?

Were health policies more aligned with truth, we would not have these chronic disease epidemics and far fewer people would die from preventable medical mistakes.

More people must learn lead healthy lives, the need to be properly informed and take to heart what is harmful and what is healthy.

What I have learned over these past 5 wks is that when it comes to COVID-19, there are simple strategies with which people can address infection that does not require collapsing the global economy, creating unheard of unemployment and isolating everyone from human contact for wks on end. You can find many articles detailing such strategies in our coronavirus archive here

One size does not fit all situations and this knowledge has not been applied in this pandemic. What has been wrongly applied here is that everyone is being treated as though they are high risk for severe infection and death and therefore need to take identical precautions.

The Big Q3: What is happening here?

The Big A3: Shiva Ayyadurai, PhD in systems biology from MIT tell us: We have not said, Hey, lets shut down the economy to address the fact that we have skyrocketing obesity taking place, skyrocketing diabetes. So, the level of contradiction, the level of hypocrisy should wake up everyone to understand that there is another agenda.

There is another agenda afoot. I repeat what my mentor said: When things do not add up, take a step back and ask, what is the other agenda? And the only thing in a common-sense way that reveals itself to me is power, profit and control. Power, Profit and Control.

I believe that fear mongering is being used to suppress dissent, to crash the economy and to issue medical mandates, as does Dr.Ayyadurai. If you look broadly, there were massive uprisings, anti establishment uprisings in different countries. Well, they are all gone now. We do not even hear anything about them, Dr. Ayyadurai says.

He also believes this fearmongering and social isolation mandates will be used as a way to acclimatize people to accept state wants or what a few people deem is good for everyone.

A group of enlightened people tried that in the 1800s and failed, have they come alive and at it again?

That, I think, is the milieu being set up, he says. Theres another agenda,Dr. Ayyadurai says. Thats what I see, because it does not make any rational sense to crash the world economy over COVID-19. And to everyday working people, it does not make sense either. They are trying to sort this out.

In Summary: The 3-pronged agenda is; Power, Profit and Control. To counteract that threat, we need academic freedom and the freedom to discourse and debate. From that freedom, truth, and from truth, we are able to understand health, not only physical health but also in the broadest sense the health of our systems, our infrastructure and environment. With health, we gain the strength to fight for more freedom.

Freedom to manage The Fourth Industrial Revolution, and part of that management is to decentralize healthcare.

Have a healthy weekend, Keep the Faith!

control, coronavirus, COVID-19, death, disease, economy, freedom, health, lifestyle, pandemic, power, revolution, risk, Shiva Ayyadurai, strength, systems, truth, WHO, world

Paul A. Ebeling, polymath, excels in diverse fields of knowledge. Pattern Recognition Analyst in Equities, Commodities and Foreign Exchange and author of The Red Roadmasters Technical Report on the US Major Market Indices, a highly regarded, weekly financial market letter, he is also a philosopher, issuing insights on a wide range of subjects to a following of over 250,000 cohorts. An international audience of opinion makers, business leaders, and global organizations recognizes Ebeling as an expert.

Here is the original post:
COVID-19 is Not Really a Pandemic as Pandemics Go - Live Trading News

Burnout and tiredness

Tired, stressed, feeling on the edge of burnout? Youre not the only one. Burnout has become so common in society today. It is due to the modern ever-running lifestyle that the majority of us live in.

Why do you feel tired? Indeed, during burn out the adrenal glands become depleted. They are not secreting adequate hormones to function properly (Sarah Powell). Thats why, if not treated, you can find yourself in long term effects. These are such as insomnia, depression, weight gain, and lowered immunity.

Well, the mechanism of adrenal fatigue and burnout is understood. What you can do about it?

There is a simple & natural cure that you might neglect. A good herbal tea!

The benefits of herbal teas to our well-being have been long known. Many studies reclaimed these. Herbal teas can help to lower cortisol levels. Increase the production of mood-enhancing hormones like GABA (gamma-aminobutyric acid), and dopamine. Thereby helping you to feel calmer and less anxious (Adrenal Fatigue Coach).

A word of caution: Herbal tea cannot replace a medical cure. Yet it can definitely bring natural calming effects and relaxation. It helps you unwind from a busy and tiring day.

Well, you can find quite readily available herbal teas on most supermarkets and food stores. They are also available online. Its quite easy to find. However, a good herbal tea purchase needs some considerations.

Herbal teas are not medicine. They thus arent regulated by theFDAand other regulators. So a trustworthy source is always a common sense. Have a tea infuser? Whole leaf teas are good in this case.Like to grow your own herbs? That would be for sure an enjoyable way to have a secure source of tea.

Although some herbal teas are highly safe to drink, some might interact with other treatments. Consider your pregnancy or known medical conditions/allergies. Talk with your doctor before taking a new type of herbs. Its always a good idea. Also,most herbal teas are safe to consume in regular but small amounts. But it is important not to go overboardat once.

The final consideration is, of course, which herbs to choose for your tea.

Need help dealing with burnout, anxiety, and insomnia? My best choices for herbal teas would be rooibos, caffeine-reduced green tea, chamomile, ginger, and licorice. Drink these calming teas. Breath their soothing scent. Practice relaxation techniques such as meditation and yoga. They can help you wind down in stressful periods.

Rooibos tea is made from a plant called Aspalathus linearis. It grows only in South Africa. The red rooibos tea that we usually see is the fermented tea. Its considered the best herbal tea in the world. It is caffeine-free, full of antioxidants and extremely safe to drink. It has a lot of beneficial substances such asaspalathin and nothofagin. They provide extraordinary health benefits. These include calming, skin and anti-aging benefits. Rooibos tea alsoblends perfectly with many other ingredients.

The only thing to be aware of is that green tea can have caffeine. This can prevent sleep if you drink in the evening.Therefore, my choice would be for a low percentage of caffeine green tea. And drink them in the morning!

Chamomile tea one of the most popular calming teas. It is easily accessible. A famous bedtime tea, for its relaxation effect and sleep improvement.Researchersfound that chamomile use showed a significant decrease in anxiety symptoms. Indeed, chamomile tea contains apigeninan antioxidant that directly targets neurotransmitters and brain receptors to induce relaxation (Very Well Mind). A pilot study (published in BMC Complementary and Alternative Medicine in 2011) also showed its effect on insomnia reduction.

Im Asian. Thats how ginger has been part of my childhood, in all of our family cooking recipes. Ginger has long since been used throughout Asia and the wider world. (Attention, ginger tea is different from ginseng tea, another plant)Researchshowed a positive health impact of ginger.Ginger tea has calming properties that may help lower your stress and tension. This is thought to be due to a combination of the strong aroma and healing properties. Therefore, in a burnout state, ginger can help reduce the feeling of stress and depression.

Whether to choose it or not? You will need to taste it. Ginger tea has a slightly bitter and invigorating flavor which is not the case of a gentle chamomille or rooibos teas. Also, as ginger benefit during pregnancy is controversial, dont hesitate to consult your doctor.

Finally, we cant forget Licorice tea!David Hoffman, Englands premier herbalist, recommended it for the adrenal cortex (what produces the stress hormone cortisol). So you know, its beneficial for stress reduction.A 2013studyfound that licorice extract may also increase the effects of anti-anxiety medications. A word of caution: If you are taking medications to treat anxiety, always talk to your doctor before trying a new herbal supplement or remedy.

In burnout, untreated stress and fatigue can lead to long term effects. These are such as insomnia, depression, weight gain, and lowered immunity. A simple & natural cure that you might neglect is a good herbal tea. Among those, rooibos, chamomile, green tea, ginger, and licorice are the most popular teas. They are great for relaxation, stress and fatigue relief.

I used to buy those very nice teas as gifts to friends and family during special occasions. Since my burnout, I decided that I merited them as well. I take care and love myself as I do to my beloved one. And I have to say, these royal herbal teas brought me sweet comforting moments. Try them and find out which one you prefer.

Read more

Visit link:
5 best herbal teas for burnout - Thrive Global

In the largest study to date of proteins related to Alzheimers disease, a team of researchers has identified disease-specific proteins and biological processes that could be developed into both new treatment targets and fluid biomarkers. The findings suggest that sets of proteins that regulate glucose metabolism, together with proteins related to a protective role of astrocytes and microglia the brains support cells are strongly associated with Alzheimers pathology and cognitive impairment.

The study, part of the Accelerating Medicines Partnership for Alzheimers Disease (AMP-AD), involved measuring the levels and analyzing the expression patterns of more than 3,000 proteins in a large number of brain and cerebrospinal fluid samples collected at multiple research centers across the United States. This research was funded by the National Institutes of Healths National Institute on Aging (NIA) and published April 13 in Nature Medicine.

This is an example of how the collaborative, open science platform of AMP-AD is creating a pipeline of discovery for new approaches to diagnosis, treatment and prevention of Alzheimers disease, said NIA Director Richard J. Hodes, M.D. This study exemplifies how research can be accelerated when multiple research groups share their biological samples and data resources.

The research team, led by Erik C.B. Johnson, M.D., Ph.D, Nicholas T. Seyfried, Ph.D., and Allan Levey, M.D., Ph.D., all at the Emory School of Medicine, Atlanta, analyzed patterns of protein expression in more than 2,000 human brain and nearly 400 cerebrospinal fluid samples from both healthy people and those with Alzheimers disease. The papers authors, which included Madhav Thambisetty, M.D., Ph.D., investigator and chief of the Clinical and Translational Neuroscience Section in the NIAs Laboratory of Behavioral Neuroscience, identified groups (or modules) of proteins that reflect biological processes in the brain.

The researchers then analyzed how the protein modules relate to various pathologic and clinical features of Alzheimers and other neurodegenerative disorders. They saw changes in proteins related to glucose metabolism and an anti-inflammatory response in glial cells in brain samples from both people with Alzheimers as well as in samples from individuals with documented brain pathology who were cognitively normal. This suggests, the researchers noted, that the anti-inflammatory processes designed to protect nerve cells may have been activated in response to the disease.

The researchers also set out to reproduce the findings in cerebrospinal fluid. The team found that, just like with brain tissue, the proteins involved in the way cells extract energy from glucose are increased in the spinal fluid from people with Alzheimers. Many of these proteins were also elevated in people with preclinical Alzheimers, i.e., individuals with brain pathology but without symptoms of cognitive decline. Importantly, the glucose metabolism/glial protein module was populated with proteins known to be genetic risk factors for Alzheimers, suggesting that the biological processes reflected by these protein families are involved in the actual disease process.

Weve been studying the possible links between abnormalities in the way the brain metabolizes glucose and Alzheimers-related changes for a while now, Thambisetty said. The latest analysis suggests that these proteins may also have potential as fluid biomarkers to detect the presence of early disease.

In a previous study, Thambisetty and colleagues, in collaboration with the Emory researchers, found a connection between abnormalities in how the brain breaks down glucose and the amount of the signature amyloid plaques and tangles in the brain, as well as the onset of symptoms such as problems with memory.

This large, comparative proteomic study points to massive changes across many biological processes in Alzheimers and offers new insights into the role of brain energy metabolism and neuroinflammation in the disease process, said Suzana Petanceska, Ph.D., program director at NIA overseeing the AMP-AD Target Discovery Program. The data and analyses from this study has already been made available to the research community and can be used as a rich source of new targets for the treatment and prevention of Alzheimers or serve as the foundation for developing fluid biomarkers.

Brain tissue samples came from autopsy of participants in Alzheimers disease research centers and several epidemiologic studies across the country, including the Baltimore Longitudinal Study of Aging (BLSA), Religious Orders Study (ROS) and Memory and Aging Project (MAP), and Adult Changes in Thought (ACT) initiatives. The brain collections also contained samples from individuals with six other neurodegenerative disorders as well as samples representing normal aging, which enabled the discovery of molecular signatures specific for Alzheimers. Cerebrospinal fluid samples were collected from study participants at the Emory Goizueta Alzheimers Disease Research Center. These and other datasets are available to the research community through the AD Knowledge Portal, the data repository for the AMP-AD Target Discovery Program, and other NIA supported team-science projects operating under open science principles.

This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research.

The research in this study is funded by NIH grants R01AG053960, R01AG057911, R01AG061800, RF1AG057471, RF1AG057470, R01AG061800, R01AG057911, R01AG057339, U01AG061357, P50AG025688, RF1AG057470, RF1AG051633, P30AG10161, R01AG15819, R01AG17917, U01AG61356, R01AG056533, K08NS099474, U01AG046170, RF1AG054014, RF1AG057440, R01AG057907, U01AG052411, P30AG10124, U01AG046161, R01AG050631, R01AG053960, R01AG057339, U01AG061357, P50AG005146, U24NS072026, and P30AG19610.

Reference: Johnson ECB et al. Large-scale proteomic analysis of Alzheimers disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nature Medicine. 2020 Apr 13. doi:10.1038/s41591-020-0815-6

About the National Institute on Aging (NIA): NIA leads the U.S. federal government effort to conduct and support research on aging and the health and well-being of older people. Learn more about age-related cognitive change and neurodegenerative diseases via NIAs Alzheimer's and related Dementias Education and Referral (ADEAR) Center website. For information about a broad range of aging topics, visit the main NIA website and stay connected.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit the NIH website.

NIH...Turning Discovery Into Health

###

More:
Large-scale analysis links glucose metabolism proteins in the brain to Alzheimer's disease biology - National Institute on Aging

Global Botulinum Toxin Market: Snapshot

Botulinum toxin, known to the mankind as one of the most poisonous biological substances, is a neurotoxin produced by theClostridium botulinum bacteria.Clostridium botulinum, the gram-positive, anaerobic, spore-forming bacteria commonly found in water, soil, on plants, and the intestinal tracts of animals can be elaborated into eight exotoxins, all interfering with the process of neural transmission and causing muscle paralysis.

From the earliest recorded uses of the toxin for the management ofstrabismus in humans to being approved for the treatment of a number of spasticity-related conditions, it has now started witnessing demand across nearly all important sub-specialties of the medicine sector. It was approved by the FDA in 2002 for the cosmetic application of decreasing glabeller forehead frown lines temporarily.

Get Sample Copy of the Report @https://www.tmrresearch.com/sample/sample?flag=B&rep_id=1196

Ever since, botulinum toxins continue to play a key role in the management of a wide range of medical conditions, especially hemifacial spasm, focal dystonias and strabismus, several spastic movement disorders, hyperhidrosis, hypersalivation, headaches, and certain chronic diseases that only partially respond to medical treatments. The set of potential new indications treatable by botulinum toxins is expanding at a rapid pace.

Cosmetological applications, one of the most popular and profitable applications of botulinum toxins, include correction of creases, fine lines, and wrinkles over the face, neck, chin, and chest. Dermatological applications of the toxin, including hyperhidrosis, are also gaining increased popularity, chiefly as botulinum toxin injections are often well tolerated and lead to few side effects.

Global Botulinum Toxin Market: Overview

The international botulinum toxin (BNT) market is gigantically advantaged by the soaring number of applications for different purposes. A recent study has revealed that BNT can be used for benefitting patients with shoulder disorders such as those who undergo rotator cuff surgery. BNT in the form of onabotulinum toxin A (OnabotA) is licensed in several countries such as Korea to help with neurogenic detrusor overactivity (NDO) induced urinary incontinence attributable to multiple sclerosis or spinal cord injury.

The world BNT market could be segregated as per two key classifications, i.e. product type and end use. Maintaining a promising share in the global market, botulinum toxin type A (BNTA) is envisioned to be a faster growing product with applications in both aesthetic and therapeutic fronts.

The report on the global BNT market has been compiled after taking comprehensive efforts to gather vital insights for procuring future growth prospects, opportunities to rise against the odds, and data related to the current and future competitive scenario.

Request TOC of the Report @https://www.tmrresearch.com/sample/sample?flag=T&rep_id=1196

Global Botulinum Toxin Market: Trends and Opportunities

The aesthetic classification by type of end use is prognosticated to make a positive difference in the overall BNT market with a record share registered in 2015. BNT finds application in the treatment of glabellar lines, crows feet, and frown lines. As a result, it has received a significant demand in terms of primary cosmetic application for controlling aging signs and enhancing facial appearance.

Since BNT is a neurotoxin, the lackluster in the adoption of neurotoxins could raise questions on the demand in the global BNT market. The market growth could be further hindered with substandard reimbursement coverage on few products and extortionate treatment procedures. Moreover, shortness of breath and allergic reactions are some of the side effects witnessed on the part of neurotoxins.

However, a substantial number of BNT applications is expected to birth in the near future on account of large investments in research and development projects. The demand for BNT is anticipated to augment even more with the increase in demand for non-invasive and minimally invasive treatments. Vendors can also keep their hopes alive during any turmoil in the market with the escalation of geriatric population.

The therapeutic use of BNT is predicted to see a constant rise owing to the growing application of botulinum toxin B (BNTB) in the treatment of cervical dystonia and Xeomin and Dysport products for hyperhidrosis and blepharospasm.

Global Botulinum Toxin Market: Regional Outlook

Asia Pacific is analyzed to possess the potential to rise as a reliable geographical segment to bet the bottom dollar on. The demand in the Asia Pacific BNT market is envisaged to aggravate as players ride on the growing aged population and their need for anti-aging products. Besides augmenting disposable income, vendors in the Asia Pacific region could heavily benefit from the hot social awareness about commercial anti-aging products in countries such as Japan, China, and India.

Having won the crown of dominant growth in 2015, North America is expected to raise the growth bar once again on the back of the elevating BNT demand for improving external appearances and other aesthetic reasons.

Read Comprehensive Overview of Report @https://www.tmrresearch.com/botulinum-toxin-market

Global Botulinum Toxin Market: Companies Mentioned

Considering their influence in the world BNT market on the basis of commercial availability and brand identity, companies such as Merz Pharma GmbH and Co. KgaA, Ipsen Group, Allergan, Inc., US Worldmeds, LLC, and Medytox, Inc. are predicted to top the list of best global players. These players are foreseen to take advantage of the colossal adoption of BNT on account of tangible benefits such as speedy healing of wounds, shorter stay in the hospital, and small incision.

Highlights of the report:

About TMR Research:

TMR Research is a premier provider of customized market research and consulting services to business entities keen on succeeding in todays supercharged economic climate. Armed with an experienced, dedicated, and dynamic team of analysts, we are redefining the way our clients conduct business by providing them with authoritative and trusted research studies in tune with the latest methodologies and market trends.

View original post here:
Botulinum Toxin Market Expansion Projected to Gain an Uptick During 2025 - Science In Me

Eliminating senescent cells has emerged as a promising anti-aging therapy in the medical field in the past few years. With Alpine Rose Active[1], Mibelle Biochemistry is pioneering the novel senolytics concept in the cosmetics field.

When fibroblasts responsible for the production of collagen either age or encounter too many harmful oxidative stresses (such as UV light and pollution), they become senescent. Senescent cells are also called zombie cells because they no longer divide, but are also far from being dead. These cells continue to secrete signalling molecules that promote inflammation and can influence surrounding cells into also becoming senescent. In younger tissue, senescent cells are usually cleared by the immune system. In aged skin and skin that has been exposed to consistent stress, senescent cells accumulate. The resulting chronic inflammation exacerbates the aging process by promoting collagen degradation, which leads to a lack of skin elasticity.

Alpine Rose Active eliminates senescent skin cells, reduces redness and increases skin elasticity, rejuvenates the deep layers of the skin and protects skin proteins from oxidative stress (Photo: Mibelle Biochemistry)

Studies in medicine have shown that so-called senolytic molecules can eliminate these "old" cells and prevent disease. In order to adapt this concept in the cosmetic field, Mibelle called on the Alpine rose (Rhododendron ferrugineum), one of the most typical and prominent Swiss alpine plants.

Alpine Rose Active was shown to specifically clean-up misdirected, age-promoting senescent cells and in clinical studies to significantly reduce skin redness, increase skin elasticity and protect from UVA induced photo-aging, explains the Swiss-based expert in botanical actives.

To assess the properties of this new active ingredient, Mibelle Biochemistry carried out an in vitro study and two clinical studies.

In vitro, a treatment with 1% Alpine Rose Active significantly reduced the number of senescent fibroblasts in a mixture of senescent and healthy fibroblasts, while not affecting the number of healthy cells.

In vivo, the application of a cream with 2% Alpine Rose Active twice daily on volunteers showed that redness was significantly reduced after 14 days by 8.4%, while skin elasticity significantly increased after 28 days by 16.1% compared to placebo.

In a second in vivo study, using a cream with 2% Alpine Rose Active allowed to completely prevent the oxidation of skin proteins after UVA-irradiation compared to placebo.

Alpine Rose Active is a purified extract of organic alpine rose leaves. This robust and hardy plant grows in the high Alpine regions of Switzerland and is carefully harvested by sustainable wildcrafting. The extract is COSMOS approved and organically certified by EcoCert.

Read the original here:
Mibelle calls on the Alpine rose to fight cellular senescence - Premium beauty

News Release

Monday, April 13, 2020

In the largest study to date of proteins related to Alzheimers disease, a team of researchers has identified disease-specific proteins and biological processes that could be developed into both new treatment targets and fluid biomarkers. The findings suggest that sets of proteins that regulate glucose metabolism, together with proteins related to a protective role of astrocytes and microglia the brains support cells are strongly associated with Alzheimers pathology and cognitive impairment.

The study, part of the Accelerating Medicines Partnership for Alzheimers Disease (AMP-AD), involved measuring the levels and analyzing the expression patterns of more than 3,000 proteins in a large number of brain and cerebrospinal fluid samples collected at multiple research centers across the United States. This research was funded by the National Institutes of Healths National Institute on Aging (NIA) and published April 13 in Nature Medicine.

This is an example of how the collaborative, open science platform of AMP-AD is creating a pipeline of discovery for new approaches to diagnosis, treatment and prevention of Alzheimers disease, said NIA Director Richard J. Hodes, M.D. This study exemplifies how research can be accelerated when multiple research groups share their biological samples and data resources.

The research team, led by Erik C.B. Johnson, M.D., Ph.D, Nicholas T. Seyfried, Ph.D., and Allan Levey, M.D., Ph.D., all at the Emory School of Medicine, Atlanta, analyzed patterns of protein expression in more than 2,000 human brain and nearly 400 cerebrospinal fluid samples from both healthy people and those with Alzheimers disease. The papers authors, which included Madhav Thambisetty, M.D., Ph.D., investigator and chief of the Clinical and Translational Neuroscience Section in the NIAs Laboratory of Behavioral Neuroscience, identified groups (or modules) of proteins that reflect biological processes in the brain.

The researchers then analyzed how the protein modules relate to various pathologic and clinical features of Alzheimers and other neurodegenerative disorders. They saw changes in proteins related to glucose metabolism and an anti-inflammatory response in glial cells in brain samples from both people with Alzheimers as well as in samples from individuals with documented brain pathology who were cognitively normal. This suggests, the researchers noted, that the anti-inflammatory processes designed to protect nerve cells may have been activated in response to the disease.

The researchers also set out to reproduce the findings in cerebrospinal fluid. The team found that, just like with brain tissue, the proteins involved in the way cells extract energy from glucose are increased in the spinal fluid from people with Alzheimers. Many of these proteins were also elevated in people with preclinical Alzheimers, i.e., individuals with brain pathology but without symptoms of cognitive decline. Importantly, the glucose metabolism/glial protein module was populated with proteins known to be genetic risk factors for Alzheimers, suggesting that the biological processes reflected by these protein families are involved in the actual disease process.

Weve been studying the possible links between abnormalities in the way the brain metabolizes glucose and Alzheimers-related changes for a while now, Thambisetty said. The latest analysis suggests that these proteins may also have potential as fluid biomarkers to detect the presence of early disease.

In a previous study, Thambisetty and colleagues, in collaboration with the Emory researchers, found a connection between abnormalities in how the brain breaks down glucose and the amount of the signature amyloid plaques and tangles in the brain, as well as the onset of symptoms such as problems with memory.

This large, comparative proteomic study points to massive changes across many biological processes in Alzheimers and offers new insights into the role of brain energy metabolism and neuroinflammation in the disease process, said Suzana Petanceska, Ph.D., program director at NIA overseeing the AMP-AD Target Discovery Program. The data and analyses from this study has already been made available to the research community and can be used as a rich source of new targets for the treatment and prevention of Alzheimers or serve as the foundation for developing fluid biomarkers.

Brain tissue samples came from autopsy of participants in Alzheimers disease research centers and several epidemiologic studies across the country, including the Baltimore Longitudinal Study of Aging (BLSA), Religious Orders Study (ROS) and Memory and Aging Project (MAP), and Adult Changes in Thought (ACT) initiatives. The brain collections also contained samples from individuals with six other neurodegenerative disorders as well as samples representing normal aging, which enabled the discovery of molecular signatures specific for Alzheimers. Cerebrospinal fluid samples were collected from study participants at the Emory Goizueta Alzheimers Disease Research Center. These and other datasets are available to the research community through the AD Knowledge Portal, the data repository for the AMP-AD Target Discovery Program, and other NIA supported team-science projects operating under open science principles.

This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research.

The research in this study is funded by NIH grants R01AG053960, R01AG057911, R01AG061800, RF1AG057471, RF1AG057470, R01AG061800, R01AG057911, R01AG057339, U01AG061357, P50AG025688, RF1AG057470, RF1AG051633, P30AG10161, R01AG15819, R01AG17917, U01AG61356, R01AG056533, K08NS099474, U01AG046170, RF1AG054014, RF1AG057440, R01AG057907, U01AG052411, P30AG10124, U01AG046161, R01AG050631, R01AG053960, R01AG057339, U01AG061357, P50AG005146, U24NS072026, and P30AG19610.

About the National Institute on Aging (NIA): NIA leads the U.S. federal government effort to conduct and support research on aging and the health and well-being of older people. Learn more about age-related cognitive change and neurodegenerative diseases via NIAs Alzheimer's and related Dementias Education and Referral (ADEAR) Center website. For information about a broad range of aging topics, visit the main NIA website and stay connected.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

###

Read the rest here:
Large-scale analysis links glucose metabolism proteins in the brain to Alzheimer's disease biology - National Institutes of Health