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Category Archives: Anti-Aging Medicine
The Drug That Could One Day Help People and Dogs Live Longer – Discover Magazine
This story appeared in the July/August 2020 issue as "A Dog's Life."Subscribe to Discovermagazine for more stories like this.
Matt Kaeberleins search for the secret to a long life began, in part, with 560 unique strains of bakers yeast.
He noticed that some of the strains with the greatest longevity tended to divide in slow motion. And he found that this slowdown, which takes place in the molecular mechanisms controlling cell division, could be tinkered with artificially by feeding the yeast a drug called rapamycin.
As he began publishing his results in 2006, other researchers were finding that the drug most commonly used to prevent rejection of organ transplants in humans had a similar anti-aging effect in worms and flies. Several years later, a landmark paper in Nature showed that rapamycin could increase the lifespan of middle-aged mice by 9 to 14 percent.
Veterinarian Kate Creevy (with Poet and Bandana) is one of the co-leaders of the Dog Aging Project. To participate, dogs visit the clinic regularly for checkups. (Credit: Texas A&M University College of Veterinary Medicine & Biomedical Sciences)
By then a professor of pathology at the University of Washington medical school,Kaeberlein found these results both tantalizing and frustrating. There would appear to be molecular processes that are shared in the aging process cross lots of different organisms, he says. That means, in theory, a chemical like rapamycin should therefore also prolong the lives of people. But itd be hard to confirm: Humans live such a long time that it would take at least a generation to find out. What he required was a test subject that approximated humans biologically, but with a much shorter lifespan.
An intriguing solution came up in 2011 in a conversation with biologist Daniel Promislow, who would soon become a new colleague and, like Kaeberlein, was a dog owner. Considering that canines have an average life expectancy of about a decade, everyday exposure to a human living environment and natural susceptibility to many of the same frailties as humans from heart disease to cancer Promislow, who was already working toward starting aging studies in dogs, commented that pooches might just be a pathologists best friend. And pathologists could return the favor by helping to extend pets lifespans, a treat for anyonewho has a dog.
Veterinarian Kate Creevy and Rudy during a regular checkup. (Credit: Amber J. Keyser)
Kaeberlein decided to join in. Launching the Dog Aging Project late last year, with $23 million in funding from the National Institute on Aging, he, Promislow and their colleagues got 80,000 responses to their call for canine volunteers.
By then, their ambitions had expanded considerably. For most of his career, Promislow had wondered why larger dogs live shorter lives. It got me interested in thinking about dogs as a model for aging, he says. Looking at the relationship between dog size and lifespan might be a way to find genes associated with diseases of aging and longevity.
To address this question, Promislow plans to observe dogs over their lifetimes. For the next decade, hell collect genetic profiles, owner surveys and data from veterinary checkups.
According to Kate Creevy, a Texas A&M University veterinarian who co-leads the Dog Aging Project with Promislow and Kaeberlein, one of the biggest challenges will be to establish criteria to measure canine aging objectively, because nobody until now has set out to practice canine gerontology. We need something more specific than for me to walk into an exam room and say, Gosh, your dog looks really good, says Creevy.
Creevy and her colleagues are developing metrics that will encompass both physical and mental health, positioning them to investigate the genetics and environments of fast and slow agers, and to see whether similar systemic breakdowns make different breeds of dog susceptible to different diseases.
Daniel Promislow with Frisbee. (Credit: Tammi Kaeberlein)
Kaeberleins contribution to the Dog Aging Project directly complements the longitudinal study headed by Promislow and Creevy. His working hypothesis is that rapamycin targets pathways that contribute to a variety of aging-related diseases, he explains. If rapamycin delays the onset of cancer in golden retrievers and heart disease in Doberman pinschers, he says hell have evidence that there is a molecular biology of aging common to all canines and possibly other mammals.
He has reason to be optimistic. He recently conducted a 10-week study on a couple of dozen middle-aged dogs, testing for side effects of rapamycin. In that brief period, he saw evidence of more youthful heart activity and more affectionate behavior, which might be interpretable as improved cognition.
In an upcoming study, Kaeberlein will give rapamycin or a placebo to 500 middle-aged dogs for three years. Given their maturity, a couple of hundred will probably die in that period. By comparing the lifespan of dogs on the drug with those chowing on placebos, Kaeberlein will be able to determine whether his treatment really works.
He acknowledges the personal disappointments ahead for some participants, but believes the distress will be outweighed by the potential of prolonged life for dogs and humans alike. To a dog person like Kaeberlein, these extra years are a lot more enticing than spending some additional quality time with some long-lived bakers yeast.
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Parsley, Sage, Rosemary and Thyme – News – Utica Observer Dispatch
Whether or not you are going to Scarborough Fair, it might be a good idea to bring home some parsley, sage, rosemary and thyme.
Parsley - multi-vitamin in a leaf
Both the Greeks and Romans gave parsley to their racehorses to make them strong and fast. It is essentially an herbal multivitamin. In The Good Herb (1995), Judith Benn Hurley noted that parsley is essentially a multivitamin in an herb:
A cup of minced fresh parsley (about four ounces) contains more beta carotene than a large carrot, almost twice as much Vitamin C as an orange, more calcium than a cup of milk and 20 times as much iron as one serving of liver.
Other modern uses of parsley are for treatment of kidney stones, as a diuretic, UTI and high blood pressure. National Geographic Guide to Medicinal Herbs (2010).
Rosemary for remembrance
Rosemary has long been credited with having positive effects on the mind. Scholars in ancient Greece tucked fresh rosemary sprigs in their hair while studying, according to The Good Herb.
Science has shown that rosemary is an antispasmodic, anti-depressive and antimicrobial. Rosemary contains a compound called rosmaricine that seems to relieve headaches much the way aspirin does but without irritating the stomach. It has been shown to improve memory and has demonstrable evidence of inhibiting the growth of cancer in lab animals. Desk Reference to Natural Medicine, National Geographic Society (2006).
Sage for salvation
The herbs genus name salvia means salvation or to be saved. Throughout history, there has been a belief in the herbs spiritual powers.
North American Indians would use smudge sticks of sage to purify rooms and to clear negativity. Ancient Arabic and Chinese herbalists believed that drinking sage tea enhanced mental and spiritual clarity. Germanys Commission E, a scientific panel that regulates herbal medicine, states that sage has antibacterial, antifungal, antiviral and astringent properties.
It has research supporting its treatment of cold sores, herpes, and Alzheimer. Desk Reference to Natural Medicine, National Geographic Society (2006).
Thyme for courage
Throughout the ages, thyme has been associated with courage. Greek soldiers allegedly rubbed it on their chest before battle. Romans put it in their baths to impart vigor, courage and strength. Courtly ladies embroidered thyme sprigs on the scarfs they gave to their knights. Desk Reference to Natural Medicine, National Geographic Society (2006).
Although thyme can be toxic in high doses, it is rich in a volatile oil called thymol which is a powerful and proven antiseptic, antibiotic and antifungal. From the 15th through the 17th centuries, thyme was used to combat the plagues that swept through Europe and as recently as World War I the essential oil was used as a battlefield antiseptic.
In the 1990s, Scottish researchers found lab animals fed with thyme oil aged more slowly than those who did not receive it. Desk Reference to Natural Medicine, National Geographic Society, (2006).
Herbalist Susun Weed opines that thyme tea gives courage to the heart and slows the aging process. Her recipe for thyme tea is one teaspoon of dried thyme (or one handful of fresh). Fill the teapot with boiling water and the thyme and steep for two to three minutes. Add one teaspoon of honey per cup. Enjoy.
Victoria Quesada is a nature-study enthusiast from Hamilton.
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Botulinum Toxin Market Trends and Dynamic 2025 Cole Reports – Cole of Duty
Global Botulinum Toxin Market: Snapshot
Botulinum toxin, known to the mankind as one of the most poisonous biological substances, is a neurotoxin produced by theClostridium botulinum bacteria.Clostridium botulinum, the gram-positive, anaerobic, spore-forming bacteria commonly found in water, soil, on plants, and the intestinal tracts of animals can be elaborated into eight exotoxins, all interfering with the process of neural transmission and causing muscle paralysis.
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From the earliest recorded uses of the toxin for the management ofstrabismus in humans to being approved for the treatment of a number of spasticity-related conditions, it has now started witnessing demand across nearly all important sub-specialties of the medicine sector. It was approved by the FDA in 2002 for the cosmetic application of decreasing glabeller forehead frown lines temporarily.
Ever since, botulinum toxins continue to play a key role in the management of a wide range of medical conditions, especially hemifacial spasm, focal dystonias and strabismus, several spastic movement disorders, hyperhidrosis, hypersalivation, headaches, and certain chronic diseases that only partially respond to medical treatments. The set of potential new indications treatable by botulinum toxins is expanding at a rapid pace.
Cosmetological applications, one of the most popular and profitable applications of botulinum toxins, include correction of creases, fine lines, and wrinkles over the face, neck, chin, and chest.Dermatological applicationsof the toxin, including hyperhidrosis, are also gaining increased popularity, chiefly as botulinum toxin injections are often well tolerated and lead to few side effects.
Global Botulinum Toxin Market: Overview
The international botulinum toxin (BNT) market is gigantically advantaged by the soaring number of applications for different purposes. A recent study has revealed that BNT can be used for benefitting patients with shoulder disorders such as those who undergo rotator cuff surgery. BNT in the form of onabotulinum toxin A (OnabotA) is licensed in several countries such as Korea to help with neurogenic detrusor overactivity (NDO) induced urinary incontinence attributable to multiple sclerosis or spinal cord injury.
The world BNT market could be segregated as per two key classifications, i.e. product type and end use. Maintaining a promising share in the global market, botulinum toxin type A (BNTA) is envisioned to be a faster growing product with applications in both aesthetic and therapeutic fronts.
The report on the global BNT market has been compiled after taking comprehensive efforts to gather vital insights for procuring future growth prospects, opportunities to rise against the odds, and data related to the current and future competitive scenario.
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Global Botulinum Toxin Market: Trends and Opportunities
The aesthetic classification by type of end use is prognosticated to make a positive difference in the overall BNT market with a record share registered in 2015. BNT finds application in the treatment of glabellar lines, crows feet, and frown lines. As a result, it has received a significant demand in terms of primary cosmetic application for controlling aging signs and enhancing facial appearance.
Since BNT is a neurotoxin, the lackluster in the adoption of neurotoxins could raise questions on the demand in the global BNT market. The market growth could be further hindered with substandard reimbursement coverage on few products and extortionate treatment procedures. Moreover, shortness of breath and allergic reactions are some of the side effects witnessed on the part of neurotoxins.
However, a substantial number of BNT applications is expected to birth in the near future on account of large investments in research and development projects. The demand for BNT is anticipated to augment even more with the increase in demand for non-invasive and minimally invasive treatments. Vendors can also keep their hopes alive during any turmoil in the market with the escalation of geriatric population.
The therapeutic use of BNT is predicted to see a constant rise owing to the growing application of botulinum toxin B (BNTB) in the treatment of cervical dystonia and Xeomin and Dysport products for hyperhidrosis and blepharospasm.
Global Botulinum Toxin Market: Regional Outlook
Asia Pacific is analyzed to possess the potential to rise as a reliable geographical segment to bet the bottom dollar on. The demand in the Asia Pacific BNT market is envisaged to aggravate as players ride on the growing aged population and their need for anti-aging products. Besides augmenting disposable income, vendors in the Asia Pacific region could heavily benefit from the hot social awareness about commercial anti-aging products in countries such as Japan, China, and India.
Having won the crown of dominant growth in 2015, North America is expected to raise the growth bar once again on the back of the elevating BNT demand for improving external appearances and other aesthetic reasons.
Global Botulinum Toxin Market: Companies Mentioned
Considering their influence in the world BNT market on the basis of commercial availability and brand identity, companies such as Merz Pharma GmbH and Co. KgaA, Ipsen Group, Allergan, Inc., US Worldmeds, LLC, and Medytox, Inc. are predicted to top the list of best global players. These players are foreseen to take advantage of the colossal adoption of BNT on account of tangible benefits such as speedy healing of wounds, shorter stay in the hospital, and small incision.
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Oxytocin: Benefits & How To Boost The Love Hormone – Longevity LIVE
You may know it as the love hormone, but theres more to oxytocin than the feel-good emotions it creates when you give someone a long and warm hug.
Oxytocin is an endorphin that helps to regulate social interaction, playing a pivotal role in bonding. Now while it is commonly referred to as the love hormone, it is anything but a love potion. The brain chemical wont make you instantly fall in love with someone. Rather, it will boost feelings of love, care as well as trust towards someone you already care for. That said, strengthening your social circles isnt all that oxytocin is good for.
According to research, oxytocin can help to improve relationships by enforcing sociable behavior. In fact, one study found that the love hormone not only helps to increase trust and generosity, but it also reduces the fear of betrayal. Additionally, an earlier studyfound that oxytocin helped topromote fidelity within monogamous relationships.
Oxytocin may be the boost that your sex life needs. According to German researchers, after being treated with oxytocin, female partners not only experienced improved sexual response but their male partners also experienced an improvement in their erectile function.
Neuroinflammation refers to inflammation of nervous tissue, most notably of the neurons in the developing brain.
That said, a recent studypublished in the Frontiers in Neurology journal suggests that oxytocin may play a role in the protection of the fetal and infant brain, particularly during gestation, birth trauma, as well as early growth.
While there have yet to be any human trials, oxytocin is currently being investigated for its potential role in drug addiction treatment. A 2017 study found that the love hormone helped reduce addictive behavior in animals.
During childbirth, oxytocin not only strengthens labor contractions but it also facilitates the production of prostaglandins, which are chemicals that help cause the cervix to dilate and contractions to occur. The brain chemical also helps to control bleeding after childbirth.
When a mother breastfeeds her newborn, the act stimulates the release of oxytocin and this helps to foster a strong loving and caring bond between mother and child.
Oxytocin may be the secret to anti-aging.
According to a study published in the Nature Communications journal, high levels of oxytocin may help to protect againstaccelerated signs of aging and it may even encourage better regeneration of aged tissue stem cells.
In a sense, yes. Oxytocin helps to strengthen the bond you have with those closest to you. Now while this is a good thing, it can also make you more overprotective and willing to do anything for them including lie or bend ethical rules. In fact, one study found thatthosewho received oxytocin were twice as likely to lie than usual.
Additionally, too much oxytocin can also make you less trustworthy of people outside your inner circle, and in the w10 orst cases, it can fuel prejudice, envy, aggression, as well as xenophobia (1).
According to research, autism, schizophrenia, depression, as well as anxiety disorders can each cause an oxytocin deficiency.
Additionally, high-stress levels can also cause a deficiency. Studies have found that as levels of the stress hormone cortisol go up, oxytocin levels go down. (2)
According to research, vitamin D helps to activate the brain hormones serotonin and oxytocin.
Now ideally, you should get your vitamin Dnaturally from the sunbut it can be hard to do so, especially in a pandemic. That said, you can either take avitamin D supplementor opt for vitamin D rich foods such as salmon and fortified vitamin D foods.
Vitamin C helps to stimulate the production of oxytocin. Now not only should you increase your vitamin C intaketo raise your oxytocin levels, but it can also help to strengthenyour immune system which we all need to do right now.
In addition to supplements, vitamin C can also be found in citrus fruits, tomatoes, cauliflower, Brussels sprouts, broccoli, as well as cabbage.
Magnesiumis a vital mineral thats involved in over300 biochemical reactions in your body, which includes increasing the action of oxytocin.
Up your magnesiumlevels by increasing your intake of spinach, chard, pumpkin seeds, almonds, avocado, dark chocolate, as well as bananas.
Chamomile is a great calming tea, so much so that it helps to increase oxytocin levels all while lowering levels of cortisol(3).
Now, this may be a little hard to do with the social distancing regulations. However, if youre on lockdown with your family, and theyve each been tested, then theres no reason as to why you cant give them a long hug.
In addition to increasing your oxytocin levels, a10-second hug every day can also help to boost your immune systemand improve heart health.
Daily meditation is great for your health and mood. That said, loving-kindness meditation (also known as metta) has been found to increase your love-hormone levels as well as increase your sense of connection as well as strengthen your relationships with others.
Animals are our best friends and if you have any pets, playing with them can help to lower your blood pressure as well as increase your oxytocin levels.
In fact, one studyfound that oxytocin levels increased in both humans and dogs after just five minutes of petting.
Music is incredibly healing and it can do wonders for your oxytocin levels.
For instance, one study found that after listening to music for 30 minutes a day after open-heart surgery, patients had significantly higher levels of oxytocin compared to those who were simply told to rest in bed.
And its not just listening to the music that can help as singing along can also increase oxytocin levels. Its no wonder mothers are always singing lullabies to their newborns.
A little hard to do with the COVID-19 regulations, but thats nothing the magic of technology cant fix.
Calling, texting or checking in with your friends and family using various apps can help toincrease oxytocin levels.In fact, researchhas found thatyour brain releases more oxytocin during social contact and social bonding, and this can help to speed up healing from disease.
If you want to do some good, as well as boost your own oxytocin, then volunteering is a great way to go.
A study published in the Hormones and Behavior journal found that volunteering not only reduces your stress levels but it also increases oxytocin levels.
With the state of the world, there are plenty of ways you can do good from the comfort of your own home. Be it signing petitions in relation to social justice or donating to COVID-19 relief funds theres plenty of good you can do.
There are at least 20 different types of endorphins and each has a different function.That said, there are plenty of ways one cannaturally boost their levels of endorphins.
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Elder Abuse in the Midst of a Pandemic – We Are The Mighty
Senior exploitation happens more often than you might think, and there's no better time to focus on it than June for World Elder Abuse Month. With the aging baby boomer population comes a higher concentration of wealth in the hands of seniors. On top of that, with the COVID-19 pandemic still ongoing, this population may be even more susceptible to different types of healthcare and charity scams.
Across the industry, elder financial exploitation cases are on the rise year over year, and USAA is noting similar trends impacting our membership. According to the Association of Certified Anti-Money Laundering Specialists, elder financial exploitation costs seniors in the U.S. up to $36.5 billion each year. Additionally, one in five people ages 65 or older report being a victim of financial exploitation or abuse.
Industry data also shows that exploitation is often the most underreported of incidents to law enforcement or Adult Protective Services.[1] That's why we're urging members to be on the lookout, both for themselves and their loved ones, for this type of financial exploitation.
Sometimes the perpetrators can take us completely by surprise. Nine out of ten perpetrators who commit elder abuse are family members or other trusted individuals, like a romantic partner. They are usually people we would know and trust with our elderly relatives. When elderly or other kinds of vulnerable adults put their trust in the wrong person, it can lead to major financial upheaval in their lives. People like caregivers, new "friends" or even a close family member can sometimes perpetrate these scams.
Common warning signs or "red flags" to help you identify potential elder financial exploitation include:
Although difficult to prevent when it involves someone you may know, love or trust, there are certain actions individuals can take to prevent elder abuse. Here are some tips from the Justice Department[2]:
If you or someone you know might be the victim of this type of exploitation, there are things you can do to help. If the case is life-threatening contact 911. For financial exploitation, contact the Fraud Department at each of the financial institutions you hold an account (at USAA, you can reach us at 1-800-531-8722), and report to your local adult protective agency or area agency on aging. You can also contact your local law enforcement office.
[1]"Countering the Financial Exploitation of Elders and Other Vulnerable Populations," presentation by the Association of Certified Anti-Money Laundering Specialists (Accessed 06/04/2020)
[2] "Stop Elder Financial Abuse," presentation by the Department of Justice (Accessed 06/02/2020)
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Salt cave and infrared sauna therapy opening in Casper this summer – Oil City News
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CASPER, Wyo Casper residents looking to address a range of health issues with alternative medicine will soon be able to try halothearpy (salt cave) and infrared (IR) light therapy. According to co-owner Cassandra Baker, Balanced Healing Salt and Sauna is expected to open by August in a business suite on South Beech Street.
According to Baker, the halotherapy booth filtrates fine particles of Himalayan salt into the air. A study in the Journal of Medicine and Life found that halotherapy triggered anti-allergic mechanisms in patients with chronic respiratory symptoms, decreasing inflammatory processes.
Dr. Norman Edelman, Senior Scientific Advisor to the American Lung Association, said, When fine salt particles are inhaled, they will fall on the airway linings and draw water into the airway, thinning the mucus and making it easier to raise, thus making people feel better.
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Baker purchased the infrared light booth from a company called Sunlighten. The mPulse model uses near-, mid-, and far-range infrared light frequencies in various combinations to penetrate tissues at varying depths. Baker said there would be programs to address detoxification, skin rejuvenation, weight loss, anti-aging, pain relief, and cardiovascular health.
A study by the University of Eastern Finland evaluated the effect of sauna on the risk of hypertension in 1,621 middle-aged men over an average 22 year span. They found a 24% decrease in hypertension among men with a sauna frequency of 2-3 times a week, and a decrease of 46% among men who had a sauna 4-7 times a week.
Baker said both therapies will likely be augmented with aromatherapy.
HaloBaker and co-owner Tina Nations (who will handle the halothearpy side of the business) met at Theraexpressions Meditation LLC,. Both had spoken to the yoga studios owner, Candace Lopez, about their interest in opening spas with the respective technologies. Lopez suggested Baker and Nations combine forces.
Baker said everything aligned when the business space below Theraexpressions opened up And then we were off to the races, Baker said. She signed the lease June 1.
She said infrared sauna sessions run 30-40 minutes and the booth can accommodate 2 people. Baker said initial price points for the salt cave will be $20 for 20 minutes, and 30-40 minute sessions in the infrared sauna will run $30. She is also looking at options for membership and referral pricing.
Other studies have shown benefits in collagen production, white blood cell count, and production of pain relieving anti-inflammatory compounds like cortisol.
Baker, associate director of Wyoming Food for Thought, began her studies of alternative medicine 8 years ago to address skin issues and mood imbalances. She said she wasnt getting the answers she was looking for from her traditional doctors. I started eating healthier, I cut out a lot of sugar I started trying to be more active and avoiding putting processed food into my body, and I started feeling better.
Baker said alternative medicine has taken a while to catch up in the community at large, but that the COVID-19 pandemic has gotten people more interested in natural remedies.
She said the therapies could be useful for immunocompromised or wheelchair-bound individuals who arent able to use gyms or participate in more active forms of wellness.
Baker is also seeking accreditation in Ayruvedic medicine, an Eastern modality that addresses health characteristics of individuals based on 3 distinct body-types.
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