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Although scientists and stock markets have celebrated the approval for emergency use of remdesivir to treat COVID-19, a cure for the disease that has killed nearly 260,000 people remains a long way off and might never arrive.
Hundreds of drugs are being studied around the world, but I dont see a lot of home runs right now, said Dr. Carlos del Rio, a professor of infectious diseases at the Emory University Rollins School of Public Health. I see a lot of strikeouts.
Researchers have launched more than 1,250 studies of COVID-19. Pharmaceutical companies are investing billions to develop effective drugs and vaccines to help end the pandemic.
Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, was cautious when announcing the results of a clinical trial of remdesivir last week, noting it isnt a knockout. Although remdesivir helped hospitalized COVID-19 patients recover more quickly, it hasnt been proved to save lives.
This [drug] is opening the door, Fauci said. As more companies and investors get involved, its going to get better and better.
Researchers have already announced that they will combine remdesivir with an anti-inflammatory drug, baricitinib now used to treat rheumatoid arthritis in the hope of improving results.
But COVID-19 is an elusive enemy.
Doctors treating COVID patients say theyre fighting a war on multiple fronts, battling a virus that batters organs throughout the body, causes killer blood clots and prompts an immune system overreaction called a cytokine storm.
With so many parts of the body under siege at once, scientists say, improving survival rates will require multiple routes of attack and more than one drug. While some of the experimental medications target the virus, others aim to prevent the immune system from inflicting collateral damage.
There are so many pieces of this, and they will all require different therapies, said Dr. Lewis Kaplan, president of the Society of Critical Care Medicine, whose doctors provide intensive care.
High-tech approaches include using stem cells, virus-specific T cells and synthetic antibodies to neutralize the coronavirus.
Scientists are also taking a fresh look at existing medications that might be repurposed to fight COVID-19. These include antivirals for influenza, arthritis drugs, estrogen patches and even antacids. If repurposed drugs are successful, they could reach patients relatively quickly, because doctors are already familiar with their side effects and safety concerns.
Some doctors are skeptical that drugs for heartburn or hot flashes have any chance of treating a killer like COVID-19.
Dr. Steven Nissen, chair of cardiovascular medicine at the Cleveland Clinic, said he fears that hype over unproven products will harm patients, even if it temporarily boosts company stock prices. Patients who demand antacids or antimalarial drugs being studied in COVID-19 could be harmed by side effects, for example. Those who hoard drugs on the hope of protecting themselves from COVID-19 could deprive other patients of medications they need to stay healthy. Some people may refuse to participate in clinical trials because they fear being given a placebo.
This rush to get every imaginable treatment into a study, its not prudent, Nissen said. Its not good medicine. Its an act of desperation.
Other experts say scientists should cast a wide net.
I dont think we want to rule anything out because it sounds out of the ordinary, said Dr. Walid Gellad, director of the Center for Pharmaceutical Policy and Prescribing at the University of Pittsburgh.
Antivirals In The Spotlight
Antivirals such as remdesivir aim to prevent viruses from replicating, said Dr. Peter Hotez, a professor at Baylor College of Medicine in Houston.
That doesnt always work. A small Chinese study of remdesivir, published last month in The Lancet, found no benefit to severely ill COVID-19 patients. Remdesivir had previously failed when tested against Ebola.
Antivirals tend to be most helpful in the early stages of infection, when most of the harm to the patient is caused by the virus itself, rather than the immune system, Hotez said.
Remdesivir is just one of many antivirals being tested against COVID-19.
International researchers are studying the antiviral favipiravir, developed to fight the flu.
The antimalarial drugs chloroquine and hydroxychloroquine which have been heavily touted by President Donald Trump also have antiviral effects. Although the Food and Drug Administration approved forms of those drugs for emergency use against COVID-19, the agency later warned that they could cause dangerous heart rhythm problems.
A study in the New England Journal of Medicine likewise found no benefit in giving two antivirals used to treat HIV a combination of lopinavir and ritonavir, sold as Kaletra in adults hospitalized with severe COVID-19.
Harnessing The Immune System
One of the therapies generating excitement is also one of the oldest: antibody-rich blood from COVID survivors.
The immune system produces antibodies in response to invaders such as viruses and bacteria, allowing the body to recognize and neutralize them. Antibodies also recognize and neutralize the virus the next time that person is exposed.
Doctors hope that patients who develop antibodies against the novel coronavirus will become immune, at least for a few years, although this hasnt been proved.
Scientists developing this convalescent plasma are studying whether COVID-19 survivors can share this immunity with others by donating their plasma, the liquid part of blood that contains antibodies, said Dr. Shmuel Shoham, an associate professor of medicine at the Johns Hopkins University School of Medicine.
In addition to treating people who are already sick, donated plasma could potentially prevent people exposed to the virus such as health care workers from developing symptoms.
Donated antibodies and any immunity they might provide dont last forever, said Dr. William Schaffner, a professor at the Vanderbilt University Medical Center. The body destroys aging antibodies as part of its routine maintenance, he said. In general, half of donated antibodies are eliminated in about three weeks.
The use of convalescent plasma goes back more than a century. It was used during the 1918 flu pandemic and was shown to improve survival during the 2009-10 H1N1 pandemic.
Doctors dont know yet whether convalescent plasma will benefit people with COVID-19.
In general, convalescent plasma is expected to be more effective in preventing illness than in treating it. It may be less likely to help someone in intensive care, Shoham said.
Researchers are also studying the use of prepackaged plasma, called intravenous immunoglobulin, in COVID patients. This product, known as IVIG, is taken from healthy donors in the general population and has long been used to help patients with weakened immune systems fight off infections. Hospitals keep it in stock and some are already using it to treat COVID patients.
Although the antibodies in prepackaged IVIG dont specifically target the coronavirus, researchers hope they will tamp down the immune response.
In a third form of immune therapy, researchers are trying to identify the specific antibodies that are most important for neutralizing the coronavirus, then reproduce them as drugs called monoclonal antibodies. Monoclonal antibodies are already used to treat a variety of conditions, from cancer to rheumatoid arthritis and migraines.
When we give people an antibody, they are immediately at least partially immune to that specific virus, said Dr. James Crowe, director of the Vanderbilt Vaccine Center, who hopes to have antibodies ready for a clinical trial in a few months. Were moving the immune system from one person to another.
Ideally, doctors would develop a very potent monoclonal antibody or a cocktail of antibodies for COVID-19 patients, to ensure the best chance of success, Crowe said. But manufacturing these drugs can be complicated, expensive and time-consuming.
Making two antibodies would be at least twice as complicated as making one, Crowe said. A cocktail might be preferred, but cocktails are harder to move quickly.
Calming The Immune System
In most cases of COVID-19, the immune system neutralizes the coronavirus and patients recover without going to the hospital.
For reasons that doctors dont totally understand, the immune system of some COVID-19 patients becomes hyperactive, attacking not just the virus but the patients own cells. A cytokine storm, in which the immune system floods the body with inflammatory chemicals, can do more damage than the virus itself.
In an effort to calm the immune system, researchers are testing immune-suppressing drugs, including monoclonal antibodies already used to treat autoimmune diseases such as rheumatoid arthritis, said Dr. Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security.
Health care giant Roche is conducting large clinical trials of its drug, Actemra, in the hope of preventing cytokine storms, which can cause organ failure and a life-threatening condition called sepsis. Actemra is designed to lower levels of an inflammatory chemical, interleukin-6, which has been found to be elevated in some COVID-19 patients.
Scientists are also studying similar drugs, anakinra and siltuximab.
Another immune suppressant from Regeneron and Sanofi, called Kevzara, has had disappointing results in clinical trials. The manufacturers plan to continue studying the drug to see if it can help certain types of patients.
Dr. Anar Yukhayev, a New York OB-GYN who was hospitalized with COVID-19 on March 16, agreed to join a clinical trial of Kevzara.
I was having so much trouble breathing that I was desperate for anything to help, said Yukhayev, 31, who was treated at Long Island Jewish Medical Center.
About 36 hours after receiving an infusion, as Yukhayev was being treated in intensive care, his symptoms began to improve. He was able to avoid being put on a ventilator. Doctors didnt tell him if he received Kevzara or a placebo, but his liver enzymes also began to rise, suggesting the organ was under stress. Elevated liver enzymes are a known side effect of Kevzara.
Yukhayev made a full recovery and went back to work full time April 13. He donated his plasma to researchers.
Until vaccines and other preventive medicines are developed, the best way to prevent coronavirus infections is to maintain social distancing, Adalja said.
Social distancing is a blunt tool, he said, but its all that we have.
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Chasing The Elusive Dream Of A COVID Cure - Kaiser Health News
The world is currently suffering because of the coronavirus pandemic. Many people are turning to vitamin supplements to boost their immunity and prevent themselves from catching COVID-19. But there are some things left unsaid about these supplements, including how toxic they can get when taken in excess.
Among the vitamin supplements that are very in demand these days is vitamin E. Since the human body cannot produce it, it must be obtained from the diet and/or supplements. Vitamin E is actually a collective term for a group of fat-soluble compounds that have antioxidant properties.
Apart from its antioxidant properties, vitamin E is also involved in certain bodily functions that promote immunity and carry out metabolic processes. But just because the body is incapable of producing it, that does not mean that we should take this vitamin in large doses.
According to the National Institutes of Health, the Dietary Reference Intakes guide made by the Food and Nutrition Board at the Institute of Medicine of The National Academies only recommends 15 mg of vitamin E per day for people 14 years of age and beyond. The recommended dose for 13 years and below range from 4 mg to 11 mg.
When vitamin E is taken in excess, certain health complications could develop. Too much of this vitamin could lead to blood thinning and fatal bleeding after an injury. A study has even linked vitamin E toxicity to increased hemorrhagic stroke risk.This is a stroke that is caused by bleeding in the brain.
Many people take vitamin E supplements thinking that it could decrease their risk of having certain cancers, improve their overall immune system and enjoy the anti-aging effects that come with the vitamins antioxidant properties.
However, Healthline says there is no need to take vitamin E supplements unless you are deficient of this nurtirent. The vitamin E content that is obtained from the diet is already enough. It is also best to consult with a health care provider or a medical professional first before deciding on purchasing and consuming vitamin E supplements.
A glass filled with various supplements. Pixabay
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Vitamin E Dangers You Should Be Wary Of While In Quarantine - Medical Daily
Medicinal mushrooms are spreading rapidly through the health and wellness world, popping up in protein powders, teas, and supplements at every local health food store.
So, what are medicinal mushrooms? Are they safe? What health benefits are they supposed to have?
First off, medicinal mushrooms are part of ancient, traditional medicine going back thousands of years. These incredible fungi are known for almost every health benefit under the moon including fighting inflammation, boosting energy, decreasing anxiety, preventing cancer, and even getting you a great nights sleep.
Yet, the one thing that most medicinal mushrooms share in common is their ability to support, maintain, and boost the immune system! In these somewhat chaotic and uncertain times, everyone could use a little boost to their immune system.
Plus, due to their growing popularity, medicinal mushrooms are available in a variety of forms including powders, extracts, tinctures, and teas, meaning you can integrate these wonderful natural medicines into your life in any way you feel comfortable.
Medicinal mushrooms have been on the scene for thousands of years.
Edible medicinal mushrooms are part of traditional Chinese medicineand have been used for health promotion and longevity in China and other East Asian countries for centuries. In fact, Ganoderma a very specific medicinal mushroom has been used as an herbal remedyas far back as 2000 years.
So, what makes these fungi so great?
While research is still ongoing regarding the exact mechanism that makes this plant-based medicine tick, structural andpharmacological studies revealed that fungal glycans show multiple physiological and healthy promoting effects including immunomodulation, anti-tumor, anti-aging, anti-oxidation, hypoglycemic, hypolipidemic, anti-radiation, and other effects.
With that said, each mushroom has a unique set of beneficial properties. Knowing the profile of each medicinal mushroom is instrumental when choosing the appropriate single fungi or multiple mushroom mix to tackle your personal health goals!
On that note, what exactly are the most popular medicinal mushrooms? What do they offer? How do you consume them? Where can you find them?
Lots of great questions and Ive got all your answers!
First and foremost, before launching into the world of medicinal mushrooms, its important to outline your own personal health goals. Ask yourself why youre seeking a medicinal aid? Once youve got some goals outlined and clarified, take a deep dive into the following medicinal mushrooms to find the perfect single or mixture!
Familiar to the medicinal practices in Siberia, Russia, Northern European countries, and other parts of Asia, Chaga mushroom has been used for a variety of health benefits and ailments including boosting immunity and improving overall health.
With that said, this mushroom cant really be classified as attractive. Chaga forms into a woody growth, or conk, which looks similar to a clump of burnt charcoal roughly 10-15 inches (25-38 centimeters) in size, yet inside youll discover a soft core with an orange color.
Known as an antioxidant powerhouse, Chaga mushrooms are excellent for fighting free radicals and inflammation. Various studies have shown this mushroom to be effective at combating oxidated stress, linked to skin aging slowing the growth of cancer, and it has also been found to lower low-density lipoprotein LDL, the bad cholesterol. This is why Chaga mushroom is best used to fight the signs of aging, reduce inflammation, and help manage cholesterol.
Unfortunately, there arent any human studies that have determined Chagas safety or appropriate dosage, therefore its up to the consumer to find a reputable supplement company, as well as speak with a medical professional before consuming the product. While Chaga is generally safe, its been known to interact with some common medications, causing potentially harmful effects, such as those taking insulin for diabetes, those taking blood-thinning medications, or those suffering from autoimmune diseases.
If youre looking to get your hands on some of that good old Chaga mushroom, here are a few easy options:this Sayan Siberian Wild Forest Chaga Mushroom Extract Powder Supplement, this Host Defense Chaga Capsules, or this NordicNordic Chaga Mushroom Tea.
When it comes to cordyceps, you have both the soil and insects to thank!
This parasitic fungi grows on the larvae of insects. How does it work? The fungi actually attack their host and replaces its tissue with long, slender stems that grow outside the hosts body. What youre left with are the remains of the insect and fungi which are hand-collected, dried and have been used in Traditional Chinese Medicine for centuries.
Of course, theres not justone typeof cordyceps. In fact, there are over 400 species of Cordyceps discovered, yet two specific varieties have become the focus of health research: Cordyceps sinensisandCordyceps militaris.
While cordyceps have been used for thousands of years to treat a myriad of ailments including fatigue, sickness, kidney disease, and low sex drive modern-day herbal practitioners generally source cordyceps to boost energy, athletic performance, and muscle recovery. Basically, cordyceps are a one-stop-shop for those beginning or uber athletes!
Turns outCordyceps sinesisis particularly difficult to harvest and carries a price tag of more than $9,000 USD per pound, which means that most of these mushrooms are actually synthetically grown. Youll want to look for brands that carry the United States Pharmacopeia (USP) or NSF International (NSF) seal, referring to third-party organizations that weed out impurities and verify ingredients.
More research is needed to verify dosages, yet the most commonly used reference range is between 1,000 [to] 3,000 mg per day which has been associated with side effects and has been found to have certain health benefits.
Cordyceps are best consumed in powder or supplement form. Here are a few vegan-friendly, online options: this Four Sigmatic Cordyceps Mushroom Elixir, this Micro Ingredients Sustainably US Grown Organic Cordyceps Mushroom Powder, or this NOW Foods Cordyceps Supplements.
Lions mane mushrooms go by many traditional names includinghou tou gu and yamabushitakeand have been used far and wide in both culinary and medicinal practices in countries including China, India, Japan, and Korea.In its natural, unadulterated form, the lions mane mushroom is large, white, and shaggy, resembling a lions mane as they grow, hence the Westernized name.As a medicinal aid, lions mane is generally dried and used as an extract in a powder form. When it comes to cooking, this meaty mushroom is a great seafood replacement, oftentimes compared to crab or lobster.
Lions mane is particularly special in that it produces bioprotein nerve growth factor (NFG) and myelin (insulation around nerve fibers), both of which are crucial to brain health. Along with being a wonderful brain-boosting agent, lions mane is linked to increased concentration and memory, better cognition, and even a decreased level of anxiety and irritability (most likely from all those brain-boosting effects!).
While there arent any human studies conducted on lions mane, its generally considered to be a safe food to consume with the guidance of a healthcare professional. With that said, if youre allergic or sensitive to mushrooms you should absolutely avoid lions mane.
Lions mane may look a bit scary in its natural form, yet luckily theres lovely processed forms that make this much more manageable! Try out this Host Defense Lions Mane Capsules, this Four Sigmatic Lions Mane Mushroom Elixir, or this Micro Ingredients Sustainably US Grown Organic Lions Mane Mushroom Powder.
One of the more widely-recognized and popular medicinal mushrooms, reishi also happens to be one of the more affordable and easily accessible!
Also known as Ganoderma lucidum and lingzhi, reishi mushroom is a fungus that grows in various hot and humid locations in Asia. Reishi is a wonderful medicinal agent due to several molecules, includingtriterpenoids, polysaccharides, and peptidoglycans, that may be responsible for its health effects. This medicinal mushroom happens to be one of the varieties safely eaten raw, yet powdered forms are more widely used.
Reishi is well-known for its calming properties all of which are thanks to the compound triterpene, which reishi has its fair share of. This mushroom is known to aid sleep, decrease symptoms of anxiety and depression, and can even increase focus. On top of that, reishi has been known to promote healing.
There are great reasons to get on board with reishi mushroom, yet there are also some safety concerns to consider and go over with your doctor beforehand.
First and foremost, studies have shown that reishi mushroom consumption may cause upset stomach or digestive distress and two case studies, in particular, found significant liver problems after switching to the powdered form of reishi mushroom. This leaves some dangling questions regarding the effect of reishi mushroom on the liver, whether theres something off with the powdered form of reishi or whether it was a specific instance to this study.
With the limited data available, its recommended that those who are pregnant or breastfeeding, have a blood disorder, will be undergoing surgery or have low blood pressure should probably avoid reishi mushroom consumption.
Reishi is super popular in powder form, such as this Micro Ingredients Sustainably US Grown Organic Reishi Mushroom Powder. Yet, if youre a little weary of the powder, you can always try a good old supplement such as this New Chapter Reishi Mushroom Supplement or this BoostCeuticals Reishi Mushroom Capsules.
Shiitake mushrooms happen to be uber popular in fact, they are one of the most popular mushrooms worldwide. Along with offering some great health benefits, shiitake also have a wonderful savory flavor.
Shiitake mushrooms are native to East Asia and are found growing naturally on decaying hardwood trees. Most shiitake mushrooms are sourced from Japan around 83 [percent] in fact yet theyre also grown in the United States, Canada, Singapore, and China. In their natural state, they are tan to dark brown, with caps that grow between 2 and 4 inches (5 and 10 cm). While theyre most popularly consumed raw, you can also find shiitake mushrooms in powder and extract forms.
This particular medicinal mushroom is one of the few that has a full nutrition profile offering fiber, protein, vitamins, riboflavin, niacin, folate, B5, B6, and D and minerals copper, selenium, manganese, and zinc.
Plus, theyre also linked to a myriad of health benefits including boosting heart health, lowering cholesterol, improving blood pressure, increasing circulation, and boosting immunity. Shiitake is particularly nifty for preventing plaque buildup.
Shiitake mushroom is generally recognized as safe to consume, as long as you dont have a food allergy to fungi or mushrooms in particular. For instance, in a few rare cases, people have developed a skin rash from eating or handling raw shiitake, referred to as shiitake dermatitis and is caused by lentinan. On top of that, some observational studies have found that long-term use of the powdered form of shiitake has led to stomach upset and sensitivity to light.
While you can definitely pick up some shiitake at your local grocery store to cook for dinner or even pick up a shiitake-based ingredient such as this Edward & Sons Roads End Organics Gluten-Free Vegan Shiitake Mushroom Gravy Mix, an easier on-the-go option would be either powder or supplements, such as this Gaia Herbs Mushrooms + Herbs Reishi + Turmeric Supplement or this New Chapter Reishi Mushroom Supplement.
Personally, this one has the best of the names, yet dont let this silly title dissuade you from its serious health benefits!
Turkey Tail also goes by Trametes versicolor and versicolor,yet gets its more friendly name due to its striking colors. This is yet another super popular medicinal aid, having been used to treat various conditions for centuries. One of the most recognized qualities of turkey tail is its immune-boosting powers!
Turkey tail contains a compound called polysaccharide-K (PSK) that stimulates the immune system. This compound is also an effective cancer-fighting agent and has been found to improve the immune system of people receiving chemotherapy. This mushroom also contains high amounts of antioxidants, lending to its cancer-preventing and immune-boosting properties.
While turkey tail is considered safe, some people have experienced digestive symptoms like gas, bloating, and dark stools when taking turkey tail mushroom. On top of that, another potential side effect of consuming turkey tail mushroom is the darkening of the fingernails. Very strange, but its a documented side effect!
As is the same with any other medicinal mushroom, always speak with your healthcare provider before beginning consumption!
Get some that wonderful immune boosting turkey tail in your life with this Turkey Tail Sustainably US Grown Organic Turkey Tail Mushroom Powder, this Double Wood Turkey Tail Mushroom Supplement, or this Wild Foods Turkey Tail Mushroom Extract Powder.
Golden Chaga Latte/One Green Planet
Alright, so youve selected youre favorite medicinal mushroom or mix of medicinal mushrooms! and now you want to get down and dirty with infusing your body with all of their goodness. While its super easy to simply add a spoonful to a flavorful smoothie or shake, its also just as easy to create a medicinal mushroom-based meal. Whether you want to use the whole mushroom such as shiitake or lions mane or want to stick with the non-cook powder, theres options out there for everyone!
Comforting Shiitake and Kale Congee/One Green Planet
Shiitake is one of the most popular and easiest of the medicinal mushrooms to use in plant-based recipes. Its one of the more affordable options and is generally available at your local grocery store. Plus, there are lots of ways to get this wonderful medicinal mushroom into your cooking! This Comforting Shiitake and Kale Congee recipe by Annie Oliviero is exactly that, comforting. Warm, savory, and super-nutritious, this recipe is not only filled with medicinal agents to help lower cholesterol, boost heart health, regulate blood pressure, and increase circulation, you also get a dose of detoxing and healing garlic and ginger to boost that immunity.
Chocolate Reishi Latte/One Green Planet
Next to the popularity of shiitake mushrooms, reishi is climbing the ranks in the Western world! This may be due to higher rates of anxiety and depression in these modern times or it could also be attributed to more awareness of self-care and wellness. No matter the reason, reishi is definitely a hot commodity! When it comes to cooking with reishi mushroom, try your hand at the powdered version such as in this Chocolate Reishi Latte recipe by Maria and Alyssa Tosoni. Along with a teaspoon of reishi powder to help with sleep, anxiety, depression, and focus this recipe calls for detoxing raw cacao powder and inflammation-fighting cinnamon, creating a concoction to calm and heal!
No-Bake Chaga Maca Cookie Bites/One Green Planet
As mentioned, Chaga is known as one of the best medicinal mushrooms to help fight premature aging, reduce inflammation, and even helps to lower bad LDL cholesterol. Its also a great ingredient to cook with! While you may think youre stuck with hot beverages, shakes, and smoothies when it comes to using mushroom powder, you can actually include a teaspoon here and there in any of your favorite super flavorful recipes. This No-Bake Chaga Maca Cookie Bites recipe by Crystal Bonnet creates a wonderful treat thats great to have on hand! Not only does it source those medicinal powers from a teaspoon of Chaga mushroom powder, but its also rich in healing and anti-inflammatory maca powder and cacao powder (and nibs!).
Reducing your meat intake and eating more plant-based foods is known to help withchronic inflammation,heart health,mental wellbeing,fitness goals,nutritional needs,allergies,gut healthandmore!Dairy consumption also has been linked to many health problems, includingacne,hormonal imbalance,cancer,prostate cancerand has manyside effects.
For those of you interested in eating more plant-based, we highly recommend downloading theFood Monster App with over 15,000 delicious recipes it is the largest plant-based recipe resource to help reduce your environmental footprint, save animals and get healthy! And, while you are at it, we encourage you to also learn about the environmentalandhealth benefitsof aplant-based diet.
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Voyageur Secures Exclusive Rights To One Of The Worlds Rarest Pharmaceutical Minerals, Creating A New Era In Carbon Based Drug Development -…
CALGARY, Alberta, May 11, 2020 (GLOBE NEWSWIRE) -- Voyageur Pharmaceuticals Ltd. (TSX.V:VM) (USA:VYYRF) (the Company or Voyageur) is pleased to announce it has signed an LOI with an established international mining company (the Counterparty) that has developed a low cost method to extract the natural occurring carbon molecule, C-60 to C-90, from large natural-occurring fullerene resources.
The technology to extract C-60 from natural fullerene deposits is ground-breaking and a first in this industry. Voyageur will be the first company to be able to mass produce C-60 at a low cost, allowing for multiple drug products to be developed, states Brent Willis, CEO of Voyageur Pharmaceuticals.
The barriers for C-60 based drugs has now been broken, which opens up the industry to develop new effective drugs and health care products on an economic scale, continues Brent Willis.
The API, C-60, is a natural, highly effective super antioxidant, like more common antioxidants (Vitamin C, Vitamin A and Selenium). It scavenges toxic free radicals but it stands out as a notable anti-aging innovation because it selectively scavenges the reactive oxygen species that do the most damage to humans as opposed to just working by osmosis like a normal antioxidant. The anti-aging properties are exciting, as studies in animals have shown the potential to significantly extend life span and to slow the aging process.
Voyageur has begun work on its first C-60 product, C-60X, an immune system booster, natural health product, for daily consumption. Voyageur is creating a C-60 R&D Therapeutics division that will be focused on developing natural health products and drugs. For early cash flow, Voyageur will utilize our Calgary-based manufacturing partners for natural health product sales.
Highlights of C-60 Medical Applications
"Thedifficulty inprocessingof fullerenes has presented a major problem in the search for medicinal applications. This is the breakthrough thatour partner hasrecentlyovercome. The patent-pending technology that can recover economic & high volumes of C-60 from natural fullerene mineral ores is a game changer. This opens the door for Voyageur to become the only company to have the capability to develop and mass produce C-60 based drugs and natural health products at a low cost & high volume, says Brent Willis.
Voyageur plans to develop low cost C-60 radiographic contrast drugs, which encapsulate iodine, gadolinium, and other potential molecules. By utilizing C-60, we may be able to enhance the performance and create the safest radiographic contrast media in the marketplace. Studies have shown that MRI C-60 gadolinium contrast media has a gain of a 500-fold sensitivity on intravital MR Contrast Agents.
Essentially, a carbon-60 molecule is comprised of 60 carbon atoms which are arranged in a unique shape that can be thought of as a 'carbon cage' (like a soccer ball). This sphere makes it possible to be a carrier of other molecules creating a protective shield, allowing C-60 to be an excellent drug delivery vehicle in radiology and healthcare.
This drug delivery system is quite unique to the pharmaceutical industry and our company is proud to begin the innovative steps to develop unique new delivery systems, states Brent Willis.
It has long been known that effective delivery systems are of paramount importance in promoting drug efficacy. This is not only a major milestone for our Company, but potentially a major breakthrough for the entire healthcare industry, continues Willis.The significance of the technological breakthrough, to extract natural fullerene from rock, may well pave the way for a low-cost evolution in the carbon-based health care market. Voyageur is the first company to begin to break down the barrier to market. The C-60 therapeutics division will enhance our Companys ability to become more competitive in the radiographic contrast market and become a leader in the C-60 drug & natural health sector. Fullerene is a gateway for Voyageur to become a leader in a new and exciting carbon medicine field. We will continue to build our From The Earth To The Bottle strategy, to become a fully-integrated competitive force in the API mineral based pharmaceutical industry.
The signed LOI for supply exclusivity will allow Voyageur to produce low cost & high-volume natural carbon-60 API for the pharmaceutical industry. This would allow Voyageur to be fully integrated in the C-60 market and become the only low-cost producer of fullerene based health care products. Voyageur is adding C-60 to its portfolio of active pharmaceutical ingredients (API) minerals for use in the radiographic contrast media markets. There are multiple applications for Fullerene based nano medicines in the healthcare industry, which Voyageur will further research and develop.
Due to confidentiality and pending patents, Voyageur cannot disclose at this time, the identity of the Counterparty.
Voyageur Pharmaceuticals Ltd. is Canadian public company listed on the TSX Venture Exchange under the trading symbol VM. Voyageur is focused on the development of barite, iodine, and fullerene Active Pharmaceutical Ingredient (API) minerals. The near-term focus is developing barium, iodine radio-contrast products and fullerene-based pharmaceutical products.
Voyageurs goal is to initially generate the positive cash flow from operations using third party GMP pharmaceutical manufacturers. Ultimately, Voyageur has plans to build all the required infrastructure to become 100% self-sufficient with all manufacturing.
Voyageur owns a 100% interest in three barium sulfate (barite) projects including two properties suitable in grade for the industrial barite marketplace, including interests in a high-grade iodine, lithium & bromine brine project located in Utah, USA.
Voyageur is moving forward with its business plan of becoming the only fully integrated company in the radio-contrast medical field, by controlling all primary input costs under the motto of:
"From the Earth to the Bottle"
For Further Media Information or to set up an interview, please contact:
Neither the TSXV nor its Regulation Services Provider (as that term is defined in the policies of the TSXV) accepts responsibility for the adequacy or accuracy of this news release.
Cautionary Note Regarding Forward-Looking Statements
This news release contains certain statements or disclosures relating to the Company that are based on the expectations of its management as well as assumptions made by and information currently available to the Company which may constitute forward-looking statements or information ("forward-looking statements") under applicable securities laws. All such statements and disclosures, other than those of historical fact, which address activities, events, outcomes, results, or developments that the Companyanticipates may or will occur in the future (in whole or in part) should be considered forward-looking statement and undue reliance should not be placed on any such statements. In some cases, forward-looking statements can be identified by the use of the words "will", "intends", believes, expects, forecasts, "anticipates", "plans" and similar expressions.
In particular, but without limiting the foregoing, this news release contains forward-looking statements pertaining to the following, the certainty of the disclosed LOI being made into a formal binding agreement; the ability of Voyageur to integrate fullerene into marketable pharmaceutical and healthcare markets; the feasibility and expectation of the Company to bring into production those mining assets it has an interest in; the experience of management and directors of Voyageur and its pharmaceutical manufacturingpartners to execute on its business plan and that of its joint venture company; the economics and risks associated with its business plan; future operations and strategies for development, sales and distribution of mineral and pharmaceutical product;; the Companys ability to successfully penetrate either domestic or foreign pharmaceutical markets; the amount, quality and cost of supply of active pharmaceutical ingredients for potential pharmaceutical products; the ability for Voyageur to meet its joint venture obligations; anticipated registrations with Health Canada or similar foreign bodies for various pharmaceutical products the Company plans to develop, produce and sell; and the ability of the Company to attract investment capital to fund operations and capital expenditures.
The forward-looking statements contained in this news release are made as of the date hereof and the Company undertakes no obligations to update publicly or revise any forward-looking statements, whether as a result of new information, future events or otherwise, unless so required by applicable securities laws.
https://www.ncbi.nlm.nih.gov/pubmed/23785493/ https://phys.org/news/2019-09-fullerene-compounds-virus-infections-hiv.html, https://c60-france.com/media_upload/C60-Fullerene-nano-particles-Inhibit-HIV-Replication.pdf https://www.sesres.com/carbon-60-c60-powder/#buy_c60 https://www.sciencedirect.com/science/article/pii/S0142961212003237https://www.hindawi.com/journals/jnm/2015/565638/https://en.wikipedia.org/wiki/Fullerene https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880842/ https://www.sciencedirect.com/science/article/pii/S0142961212003237 Mitsubishi https://www.azonano.com/article.aspx?ArticleID=47 https://pubs.acs.org/doi/full/10.1021/es801869m https://phys.org/news/2020-03-scientists-water-soluble-fullerene-compounds-medicine.html https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676811/https://pubs.acs.org/doi/10.1021/acsanm.9b01698
Why might I get symptoms while wearing a face mask?
The ideal mask will allow for the easy flow of air (breathable) but will prevent the spread of droplets through it (impermeable).
If your mask does not allow air to flow through it, this could have negative effects on your health and well-being.
Typically, when we are worried or anxious, adrenaline causes us to take faster and shallower breaths. This leads to lower levels of carbon dioxide in the blood which in turn can cause dizziness, fatigue, headaches, chest pain, breathlessness, numbness and tingling, a feeling of disorientation or confusion, and increased emotionality.
If your mask is adequately breathable, it is more likely that symptoms experienced are related to your own breathing rather than the mask itself.
Medical grade masks are specifically designed to offer high level protection (impermeability) and adequateoxygenation (breathability) while undertaking highly skilled and high-risk tasks. While the public does not require medical grade masks, manufactured and home-made masks should offer the same level of breathability and reasonable impermeability.
A recent study done in Illinois demonstrated that a mask made with double layered T-shirt material (cotton or cotton/polyester blends) balances the best breathability with a 98% impermeability to droplet spread which performs equally to medical masks.
The only difference is that household materials will retain droplets rather than repel them, so it is important to hot wash (or dispose of) them after each use.
Breathing through the nose provides the benefit of the air being moistened and filtered. Nasal breathing also produces Nitric Oxide which kills viruses and bacteria.
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How To Make Your Face Mask Your Breathing Friend And Filter - Longevity LIVE
Including healing adaptogens in your health regime is important for your longevity. Most simply put, they help push your body into recovery mode so that its able to restore itself before the next rush of fight or flight response. Adaptogens are extracted from non-toxic plants Turmeric, ashwagandha, rhodiola, cordyceps, and ginseng which help regulate the bodys stress response.
Over years of evolution, our bodies have learned to protect us from stressors by fighting or going into flight. The body does this to clear your mind, boost your energy and improve your focus. Its a survival instinct to keep us intact when we try to escape the situation. Basically so you dont die. However, we no longer have to face beasts, dangerous sabre-toothed tigers or cavemen. Back then humans only experienced these threatening situations now and then. Nowadays were faced with continuous, chronic stress from work, traffic, family, and finances. This is seriously bad for the body and keeps us in fight or flight for longer than its meant to be.
Sitting with prolonged chronic stress can seriously damage your health, mood, and quality of life over time. It ages you. Especially during COVID-19, when times are very unsettling. Fortunately, nature has a solution where healing adaptogens bring us the right kind of nutrition. These plant compounds can help us get out of the fight or flight state so that our bodies and minds can recover and restore themselves.
Its true that stress is a killer because it ages you. The more anxious our minds are the less were able to focus and perform. Thats why we need to ingest healing adaptogens regularly to stay younger for longer.
The word adaptogen originates from 1950s. They were first used as medicinal herbs all the way back in 3000 B.C., in Ancient Chinese and Ayurveda practices. Russian toxicologist Nikolay Lazarev, defined healing adaptogens as plants that increase the state of non-specific resistance when applied to stress. This means they can help protect the body against a range of stressors.
Moreover, healing adaptogens are herbs and plants with special properties that are naturally occurring in nature and can help the body resist emotional or physical stressors. They help heal stress, fatigue and work by targeting the bodys three stages of stress:
Now you can imagine being in a prolonged state of stress will inevitably result in pure exhaustion or burn out. You might be familiar with some healing adaptogens including turmeric, goji berries, maca root and various types of mushrooms. There is a very long list so there are loads to try!
Note that adaptogens are extracted from non-toxic plants which help regulate the bodys stress response. They can come from herbs, mushrooms, and roots. Most of which have been used for centuries in Ayurvedic and Chinese medicine. Scientists believe that these plant compounds work by acting on the hypothalamic-pituitary-adrenal (HPA) axis. This involves the interaction between the brain and adrenal glands. Otherwise called the Sympathoadrenal System. This is thepart of the nervous system that helps control the bodys stress response.
Health researchers articles state that healing adaptogens might help boost focus and endurance during tiring situations. This is particularly important for those times when you would normally feel very fatigued and weak which might decrease performance. Healing adaptogens may also help the body resist stress-induced impairments of the neuroendocrine and immune systems.
Some research suggests that healing adaptogens might even benefit those with age-related disorders and cardiovascular problems. This means that elderly people may be able to maintain their health status on a normal level, improve their quality of life and even increase longevity. Doctors also believe that adaptogens could help support standard therapies used to aid patients fighting a range of health issues.
There are many reasons why we should all be using these plant compounds to live better, longer lives. Not only do they help fight daily stressors, but they also promote a more calm and stress-free mental state. If you are less stressed you will have a much stronger immune system which is what we all need during this pandemic. Healing adaptogens also come in a variety of forms like fermented adaptogen powders to help the body address the effects of stress in a natural way.
Theyre said to improve cognitive function and mood, increase energy levels, assist with stress management, and help mental fatigue. We know they help with stress. However, they allow the body to maintain the resistance phase of general adaptation syndrome for longer. This means you will be able to avoid hitting the exhaustion phase. This means youre bulletproof when facing stress or both mental and physical stress. Whenever your heart rate goes up and the adrenaline pumps, a lot of cortisol is released. You might feel more alert and energized so youre able to protect yourself from whatever is threatening you.
But then the body needs to resist, you know straight after a presentation, intense workout or stressful exam. The body needs time to recover from the trauma of the event. More importantly, it has to restore your normal blood pressure and cortisol levels. You will be fine if the stress subsides because your body will return itself to its pre-stress state. However, if stress lingers long term and you remain on alert, your body will try to adapt to this condition.
This is not good. Your body startsrecognizing it as the new normal. Therefore you start learning to live with stress. This is acceptable, to a degree, but if your body continues at this level between alarm and resistance for a while, without time for proper recovery, stress will overtake the body and youll enter Stage 3 of GASexhaustion.
Yes, this is the part where you might feel like you just cant continue. This is the point where youve hit exhaustion and start to feel extremely anxious and tired, moody and maybe even sick. High-stress levels make you more likely to get sick which means you need rest otherwise youll see a serious decline in health and performance.
Luckily, healing adaptogens help keep you in the resistance phase of GAS longer. This means your body has time to recharge itself before any major damage is done. Scientists believe that adaptogens have a stimulatory effect, revving up the recovery process that supports healthy stress hormone levels.
It is very important to know what works best for your body. Everyone responds to healing adaptogens differently. Your friend might be using a particular compound, but It might not have the same effect on you. Thats why if you choose to experiment with adaptogensBe sure to so try them one at a time to determine the exact effect each has on you.
There are a range of benefits by taking a daily adaptogen supplement. Particularly if you want to regulate cortisol levels and improve athletic performance. You get capsules, tablets, tinctures and powders which can be mixed with water or sprinkled on food.
Most healing adaptogens are considered safe, but if youre unsure, it may be best to consult your doctor before adding them to your diet. Especially if youre taking chronic medication. Certain herbal supplements can cause mild allergic reactions or some digestive discomfort.
Experts explain that adaptogens are great at regulating the stress response. However, they may not be for everyone. Just like anything else out there. It needs to be if youve got an autoimmune disorder or youre taking an immunosuppressant. Moreover, adaptogens can cause the immune system to become more active. This is brilliant news for generally healthy people. However, it can cause complications for those whose immune systems already arent working properly.
Every adaptogen is unique in what it can do. They all have benefits but you need to know what each could help you with.
This herb is fantastic at managing due to its curcumin content. Studies state that curcumin aids in regulating inflammatory responses, which helps exercise recovery and muscle soreness. This is great for athletes who want to increase their performance. Better yet, turmeric may be an ideal supplement for just about anyone.
Note that curcumin alone is not very helpful, due to its poor bioavailability. To increase its absorption and effectiveness, always include black pepper, piperine.This increases bioavailability by 2000%. Why? Because pepper inhibits enzymes that break down curcumin in the body. Curcumin is also fat-soluble so combining it with lipids will help absorption even more.
This is a traditional herb that originates in India and could be one of the most powerful and diverse adaptogens. Healing adaptogens like this once can help enhance your health and performance. Studies have discovered that supplementing with ashwagandha can also improve your resistance to stress. This is powerful because your quality of life will be much higher. Moreover, people (about 30%) who were severely stressed also saw a significant reduction in cortisol levels when using ashwagandha.
Not only does this supplement get you out of flight or fight mode, but it also helps your aerobic endurance and strength performance. Amazingly, you might even notice an increase in the development of muscle mass. Researchers believe that healing adaptogens like this one could even help reaction time and performance on cognitive and psychomotor tasks.
If youve never heard of this one, dont stress, neither have many others.
This adaptogen grows as a flowering plant found in the arctic regions. Apparently, it can help improve stress, fatigue, athletic performance and energy levels. Researchers have learned that taking rhodiola for only four weeks can help reduce the symptoms of stressful life situations.
Another study showed it helped boost participants time to exhaustion by 24 seconds during endurance exercise. Wowee!
Used traditionally in Chinese medicine, this is a hybrid fungus that can be used for many reasons. Researchers say that its mainly used today as a performance-boosting supplement. Cordyceps are rich in adenosine, which is a component of ATP. This is the energy source the body uses for all its movements. Therefore, experts believe that cordyceps can help ATP production, which might promote endurance performance.
Other alternative medical studies show that supplementing with cordyceps may help boost metabolic thresholds. This is a marker of aerobic performance in older people. In addition, studies found that cordyceps militaries, which is a synthetic form of Cordyceps. It is also part of a mushroom blend and can aid performance with respect to time to exhaustion during exercise, and VO2 max.
The secret is pairing these with other healing adaptogens like ashwagandha, rhodiola, and astragalus. This will help to promote daily energy and exercise performance. If youre passionate about exercise, then youve got even more reason to take more healing adaptogens especially pre-workout. This will help support you from the beginning of the workout through to the recovery phase. You wont feel as exhausted and will be able to recover a little more quickly, not only during the workout but also for the next session.
Another powerful plant thats particularly famous in Chinese medicine. Healing adaptogens like this one are brilliant at fighting inflammatory responses and helping to boost immunity and cognitive function. This is mainly because of the compounds ginsenosides and gintonin.
Korean studies take ginseng or a placebo a week prior to exercise and four days afterwards. Seventy-two hours after the workout, the ginseng users had significantly lowered markers of muscle damage. Other studies have demonstrated a boost in cellular health when women took ginseng for 12 weeks.
Researchers also state that Ginseng can help keep you feeling calm. You will also be able to concentrate and focus better on tasks within only eight days of usage.
So if youre feeling particularly stressed or anxious right now during the pandemic, then you might want to give Ginseng and other healing adaptogens a try.
We need to learn to manage stress better. When this happens, it can cause a cascade of other problemsmentally, physically and emotionally. Heres what to do.
The Total Guide to Adaptogenic Supplements and Herbs. Omnit. https://www.onnit.com/academy/adaptogens/
Cordyceps Sinensis 101: Why Is This Supplement So Popular? Omnit. https://www.onnit.com/academy/cordyceps-sinensis/
Examining the effects of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. NCBI. https://www.ncbi.nlm.nih.gov/pubmed/26609282
Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. NCBI. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687242/
What Are Adaptogens? Herbs and Plants That Help Reduce Stress and Anxiety. The Beet. https://thebeet.com/what-are-adaptogens-herbs-and-plants-that-can-help-reduce-stress-and-anxiety/