Category Archives: Anti-Aging Medicine

Resveratrol could be the key to numerous future medical treatments.

Resveratrol is a natural polyphenol that has been suggested to benefit a myriad of health conditions: indeed, a search on the worlds largest medical journal library delivers almost 40,000 results for resveratrol. The naturally occurring compound can be found in several foods, including berries, peanuts and wine, and although its widely claimed to benefit diseases from coronavirus to cancer, there is as-yet no hard evidence to prove the benefits of the supplement.

Given the lack of hard data around resveratrol and lack of regulation, many healthcare professionals are reluctant to officially recommend it to patients, yet it remains popular as a supplementary medicine, not least for its most recent fame as a potential anti-coronavirus agent. Science philanthropist James Drake is a life-long believer in the compounds health benefits, and believes it is a valuable natural supplement, both in the fight against disease and to maintain healthy aging.

The Health Benefits of Resveratrol

Resveratrol is thought to have many pharmaceutical properties, including antioxidant, anti-aging, anti-inflammatory, anti-cancer, neuro-protective and more. While there is scant conclusive data on the exact molecular mechanisms and benefits of resveratrol on human health, there are a multitude studies showing benefit to both animals and humans. Studies have postulated a range of mechanisms of action potentially responsible for the reported benefits of resveratrol, including:

The triggering of a range of antioxidant enzymes, ultimatively leading to reduced oxidative stress

Causing overexpression of the enzyme SIRT1, which is involved in the regulation of metabolism in multiple body tissues

Inhibition of enzymes associated with neurological disorders

As a result, resveratrol has been implicated in health conditions including:

Reducing the risk or level of:

Osteoarthritis

Neurodegenerative disease

Cancer

Malaria

Insulin resistance

Respiratory viral infections, including COVID-19

High blood pressure

Cardiovascular disease

Skin inflammation

Hepatitis

Urinary tract infections

Fungal diseases

Improving the condition of:

Inflammatory responses

Blood flow

Circulation

Skin and eye health

The immune system

Weight loss

Here, James Drake explores seven of the major diseases, infections, and conditions that resveratrol has been claimed to relieve or prevent and explores why the chemical compound has so much potential on the medical scene.

Some people who struggle with osteoarthritis value resveratrols anti-inflammatory properties and find that supplements can effectively reduce pain. Though the antioxidant doesnt repair damaged tissue, it is thought that it can help to prevent tissue erosion by inhibiting some cell signalling proteins that are involved in inflammation, therefore reducing articular cartilage breakdown. and serum biomarkers. One recent study found that resveratrol supplements, when taken in combination with meloxicam, can reduce pain and inflammation in patients suffering from knee osteoarthritis.

Several studies have demonstrated that resveratrols antioxidant properties reduce oxidative stress, thereby improving cognitive function, memory, and cerebral blood flow. Oxidative stress is a driver of various neurodegenerative diseases, such as Alzheimers, multiple sclerosis, and Parkinsons. James Drake, who funds a series of research studies into neurodegenerative decline, highlights that developing safe drugs to treat neurological disease is a major challenge for the medical sector, but that resveratrol could play a role in neuroprotection because of its antioxidant properties and low toxicity.

Research shows that resveratrol can have an anti-ageing effect on animals, though we dont yet know for sure whether the effects are the same for humans. To explore this, Alzheimers News Today details recent studies into resveratrols potential effects on dementias. Though there is no current conclusive evidence for resveratrols effectiveness in treating dementia, the chemical compound could become essential to future neurodegenerative treatments as research progresses.

Cancer

Resveratrol has long been highlighted for its anti-cancer properties, though there are still few evidence-based human studies to support this. Animal research suggests that the chemical compound may stop cancer cells from multiplying, enhance the effectiveness of chemotherapy, and reduce the side effects of radiation. Research suggests that resveratrol could also suppress cell proliferation in human tumour cells and have further therapeutic effects on cancer patients. In particular, a study from the MD Anderson Cancer Center concludes that resveratrol can break down cancer cells in various ways to treat cervical neoplasia.

Malaria

Various studies, including research from The National Institutes of Health, show that resveratrol can help to fight malaria. As a result, scientists are developing candidate vaccinations that they hope will combat the illness, which kills over one-million people around the world every year. The National Institutes of Health shows that resveratrol can significantly reduce malarias ability to adhere to blood vessels in cells. When combined with antimalarial chemotherapy, resveratrol could be key to treating the disease.

Diabetes and Metabolic Disorders

Both anecdotal and evidence-based studies have linked resveratrol with improving metabolic conditions and diabetes. For example, one such clinical trial published in 2016 investigated the effect of resveratrol on insulin resistance, glucose and lipid metabolism in non-alcoholic fatty liver disease. The study found that resveratrol supplementation may benefit patients with the disease, after seeing a marked decrease in cholesterol, glucose and other factors, and an improvement in inclusion resistance. Another study from 2017 examined the effect of resveratrol on artery stiffness in people with diabetes, finding that resveratrol supplementation correlated with a reduction in aortic stiffness in patients with particularly stiff aortas. This effect is attributed to the compounds role in activating the SIRT1 protein, and therefore slowing the effects of aging.

Respiratory Viral Infections

Many studies into the effectiveness of resveratrol focus on its antioxidant, anti-inflammatory, and anti-microbial benefits. However, a recent review from the Department of Public Health and Infectious Diseases at the University of Rome has highlighted resveratrols promising antiviral activity against viruses that cause respiratory infections. The study concludes that resveratrol could be key to preventing and treating respiratory syncytial virus, influenza virus, and SARS-CoV-2.

COVID-19

Amongst these respiratory viral infections, COVID-19 is the newest global threat. Over the last year, scientists and medical professionals have been grappling to develop effective coronavirus treatments. However, back in 2017, BioMed Central published a study that analysed resveratrols antiviral performance and its ability to protect against MERS-CoV, a viral pathogen that caused the MERS epidemic (and which is similar to the COVID-19-causing virus, SARS-CoV-2). The research team found that resveratrol significantly inhibits the virus and prolonged cellular survival, concluding that the natural polyphenol is a potent anti-MERS agent in vitro. Given the similarities between the viruses, its possible that resveratrol could offer some protection against SARS-CoV-2. Indeed, several research studies are already ongoing in this area.

Taking Resveratrol Supplements

The possible health benefits of resveratrol are seemingly endless, with new studies being published every week on its links with improving a multitude of conditions and diseases. However, it should be noted that resveratrol is as yet unregulated and is not prescribed by medical professional. A large amount of the existing information on resveratrol is based on animal or in vitro studies, rather than evidence-based human trials, so we do not yet know the exact benefits of the supplement, nor whether it causes any significant side effects in humans.

That being said, resveratrol is naturally abundant in food stuffs including berries, peanuts, grapes, and by extension red wine. However, the level of resveratrol in these foods is so low that we cannot absorb a therapeutic dose through dietary sources alone. James Drake has taken resveratrol supplements for many years without any known side effects. He highlights that the human body only absorbs around 10% of a supplement, which is why he takes 250 mg capsules. You can buy resveratrol from most reputable health food shops.

About James Drake

James Drake is a science-focused philanthropist who has founded multiple non-profit organisations, including The Drake Foundation and the Drake Calleja Trust. The Drake Foundation funds essential studies into the connection between repetitive head injuries obtained in sports and neurodegenerative decline. Its hoped that these studies will help to inform safe sporting protocols when it comes to head injuries and accelerate vital knowledge share in the medical space. Since its launch in 2014, The Drake Foundation has invested over 2 million into sports-related concussions research.

Meanwhile, Future Science Group (FSG) is a progressive scientific publisher, curating trusted online, print and in-person resources to serve the scientific and medical communities. Although FSGs foundation is in cutting-edge, peer-reviewed scientific journals, the Group has expanded over the years to publish digital/virtual hubs and run events, as well as creative services and publishing solutions.

When James isnt focusing his philanthropic ventures on scientific missions, his other passion lies in the arts. Among his philanthropic projects in music and art is the Drake Calleja Trust, which funds scholarships for talented young classical musicians as they aim to further their musical careers and studies.

Learn more about James Drake at http://www.jamesdrake.com. Alternatively, get in touch by emailing james@jamesdrake.com or connecting on Twitter at @jamesjpdrake.

This article does not necessarily reflect the opinions of the editors or management of EconoTimes

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From COVID-19 To Cancer: James Drake Discusses the Potential Health Benefits of Resveratrol - EconoTimes

In early March, in a conference call with researchers in China, hematologist Alfred Lee, George Goshua, and others at the Yale School of Medicine were forewarned about an unusual finding in COVID-19 patients in advanced stages of the disease. Doctors were observing ischemic digits, or black fingers and toes. To Lee and Goshua, this sounded like a microvascular thrombosis, minute blood clots in small blood vessels. A few weeks later, the Yale physicians were confronted with their first COVID-19 death, ostensibly due to a major blood clot in the patients lung, which prompted them to set up a panel of clotting tests for COVID-19 patients.

What came back was something Lee had never seen before: levels of the von Willebrand factor (VWF), a protein involved in blood clotting, were through the roof; they had surpassed the upper limit of detection of the laboratory assay the group was using. Because VWF is released from endothelial cells that line blood vessels, Lees natural inference was that the endothelium was somehow damaged and releasing enormous amounts of VWF that was then contributing to blood clots.

The Yale team then ran a series of screens for other markers of endothelial damage on 68 COVID-19 patients, and the results published in The Lancet Haematology in June show that proteins such as soluble P-selectin were also elevated in critically ill COVID-19 patients compared with healthy controls. One of the markers, soluble thrombomodulin, even correlated with how long patients stayed in the hospital and whether they died. From these data, the investigators deduced that endothelial injury is linked to disease severity in COVID-19 and that strategies geared toward palliating this damage could improve disease outcomes.

Its impossible to say which came firstthe coronavirus infection or the endothelial damage, which is a known feature of diabetes, hypertension, and other diseases, notes Miriam Merad, an immunologist at the Icahn School of Medicine at Mount Sinai in New York who was not involved in the study. Conditions such as diabetes, hypertension, obesity, and agingcomorbidities present among Lees COVID-19 patientscould have also played a part in the vascular damage, she adds. Still, I think studying the vasculature is very important [in COVID-19], she tells The Scientist.

Goshua comments that to be able to see an endothelial cell signal despite having only one blood sample per patient was something quite profound. In fact, researchers have come to view the vasculature as the tissue most vulnerable to damage from SARS-CoV-2 infection, Thomas Lscher, a cardiologist at Imperial College London who has been studying the endothelium for more than three decades, tells The Scientist.The concept that the endothelium is the main target of this virus is really very important. Endothelial cells in the lungs play a central role in orchestrating damage to this organ, which is the chief target of the SARS-CoV-2.

The endothelium comprises a single layer of cells that forms the interior lining of blood vessels throughout the body. The tissue physically insulates blood elements from the highly thrombogenic, or clot-promoting, subendothelial connective tissue. In addition, under normal conditions, blood cells flow past without getting stuck because of the balance between the pro- and anti-clotting properties of the endothelium.

The endothelium is like Teflon. Nothing sticks to it, Harvard Medical Schools Denisa Wagner tells The Scientist. But just as a Teflon pan becomes sticky when scratched, a host of factorsincluding viral infection and encounters with agents of inflammationmakes it sticky. Such insults trigger endothelial release of VWF, which tethers plateletscells involved in clottingto the vessel wall, while the elevation of P-selectin causes leukocytes or immune cells to stick to the endothelium as well. This sets in motion a cascade of events that drives clot formation and inflammationtwo defining features of severe SARS-CoV-2 infection.

Pathology and autopsy studies have found particles of SARS-CoV-2 inside endothelial cells, and a growing body of evidence suggests that the endothelium plays a key role in the disease. In the early days of the pandemic, doctors discovered that damage to the endothelial lining in the lungs was associated with the fluid leakage and acute respiratory distress syndrome. Following this, researchers linked blood clots in the lungs and elsewhere to endothelial injury, and studies found viral particles in endothelial cells in organs other than the lungs, such as the kidneys. Thus, damage to the endothelium and the ensuing clotting and inflammation emerged as potential drivers of the strokes, cardiac injury, kidney disease, and other features of the disease.

Researchers have come to view the vasculature as the tissue most vulnerable to damage from SARS-CoV-2 infection.

The protean manifestations of COVID-19 strongly implicate activation and dysfunction of the endothelium as a unifying consequence of infection, which can help us frame our thinking about the disease [mechanism], says Peter Libby, a cardiovascular specialist at Harvard Medical School who has been studying the endothelium for nearly 40 years. He adds that this hypothesis helps [us] understand why this disease so perniciously affects so many different organ systems.

This hypothesis has been primarily based on clinical observations. Lees finding of high VWF levels and another study from Western Universitys Douglas Fraser offer the best mechanistic evidence. Fraser and his colleagues tracked endothelial markers in 10 ICU patients with COVID-19, 10 ICU patients who were hospitalized for other reasons, and 10 healthy controls. The team found results similar to Lees investigation, such as raised plasma VWF and soluble P-selectin levels. In addition, Fraser and his colleagues noted telltale signs of damage to the glycocalyx, a moss-like molecular coating that envelops the endothelium, in COVID-19 patients.

Aaron Petrey, an immunologist and glycobiologist at the University of Utah School of Medicine, says that glycocalyx degradation and shedding is a theme in sepsiswhich can occur in COVID-19so its unclear if this is a unique feature of COVID-19.

Wagner, who has studied the endothelium for close to 40 years, tells The Scientist that both studies are a very good beginning to studying the endothelium in COVID-19. She says the finding that VWF is majorly increased is particularly noteworthy. That, I think, is super important to the increased tendency for clotting seen in COVID-19 patients.

Fraser, who published the results in August, says keeping close watch on endothelial cell markers and glycocalyx degradation could aid doctors in treating COVID-19 patients, alerting them to when its time to deploy medical interventions such as ventilators. Libby adds that these endothelial indicators also give doctors tools to assess which patients are likely to develop a blood clot and therefore should be treated with appropriate medications, such as blood thinners.

A few other reports from France, Germany, and China that have looked at various markers of endothelial and glycocalyx damage, both in vitro and in vivo, link endothelial damage to the severity of disease. All these studies bear witness to the endothelial cell dysfunction of COVID-19.

Lscher, who was not involved in any of these studies, says these interrogations of the endothelium are stimulating, but they are not solving the problem yet. Whats the first step that initiates this cascade of events? Thats the real questionthat hasnt been solved yet.

A motley of studies are looking at ways to restore endothelial integrity in COVID-19 patients using various agents, including P-selectin blockers. Targeting the complement cascadean inflammatory pathway that causes endothelial dysfunctionis another approach in clinical testing, with one exploratory Phase 2 trial recently attesting to the safety and tolerability of anti-complement therapy and reporting early efficacy signals.

Breaking up strings of VWF is yet another tactic that might work, says Wagner. As endothelial cells release abundant amounts of VWF, the molecules can self-associate and clog small blood vessels, but an enzyme present in plasma called ADAMTS13 chops up clusters of VWF. In COVID-19, ADAMTS13 levels plummet and, along with extremely high VWF levels, portends severe disease. Its a recipe for trouble, says Wagner. I believe that supplying ADAMTS13 to COVID-19 patients with high VWF would significantly reduce thrombosis and organ damage. Currently, recombinant ADAMTS13 is being trialled in thrombotic thrombocytopenic purpura, a condition where ADAMTS13 deficiency leads to excess VWF and minute clots form in small blood vessels, but so far is not being tested in COVID-19 patients.

Christian Con Yost, a pediatrician at the University of Utah School of Medicine, tells The Scientist that breaking down these large VWF aggregates might also tame the downstream inflammation and accumulation of platelets and leukocytes. Lee agrees that the VWF/ADAMTS13 axis is worth further investigation. Were looking at this very closely, he says.

Targeting these pathways in isolation may ameliorate disease severity but is unlikely to completely attenuate disease progression.

Jamie OSullivan, Royal College of Surgeons in Ireland

Lscher, Libby, and other endothelial experts assert that targeting the two primary pathways to which the endothelium is intricately linkedhyperinflammation and clottingwould be the most beneficial. Reflecting on the current status of these two types of therapies, Libby says that the clinical research field is still in the era of non-randomized observational data and that outcomes of randomized placebo-controlled trials are desperately needed.

Its interesting to try this but Im not sure that [it] will be sufficient to change the course of the disease, Lscher says of these diverse approaches to address endothelial mayhem. This is not a very specific infection. There are many pathways. Thats the dilemma.

Jamie OSullivan, a vascular biologist at the Royal College of Surgeons in Ireland, explains to The Scientistin an email: Targeting these pathways in isolation may ameliorate disease severity but is unlikely to completely attenuate disease progression.

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The Specter of Endothelial Injury in COVID-19 - The Scientist

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The latest beauty secrets to look your best this winter - KGUN

Data Bridge Market Research has recently added a concise research on the Global Medical Aesthetics Market to depict valuable insights related to significant market trends driving the industry. Global Medical Aesthetics Market report gives most appropriate and specific information to the decision makers in the industry which saves their time and result in excellent output. Market analysis and market segmentation has been conducted in terms of markets, geographic scope, years considered for the study, currency and pricing, research methodology, primary interviews with key opinion leaders, DBMR market position grid, DBMR market challenge matrix, secondary sources, and assumptions. This market information of xyz report not only aids businesses in taking sound and proficient decisions but also helps decide the advertising, promotion, marketing and sales strategy more gainfully.

Global medical aesthetics market is projected to register a healthy CAGR of 12.1% in the forecast period of 2019 to 2026.

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Aesthetics devices are an innovative advancement, providing a solution to patients which deal with the ingenuity of creating beauty. The medical aesthetics devices is a growing market owing to its benefits such as maintaining the youthful appearance, pain free and non-invasive beauty treatments, maintenance free skin that remains smooth and hairless without the need for shaving, waxing or unpleasant hair treatments, improving the cosmetic appearance, and technological advancement in medical aesthetics devices.

The market is showing a substantial growth in the emerging countries as these countries are adapting to the trends of urbanization. Brazil, South Africa, Thailand and many others have improved in the past one decade. People are opting different aesthetics surgeries to maintain themselves, which give them better results without any stressful physical efforts. Medical Aesthetics is one of the most trending concepts of the 21stCentury which will show a substantial increase in the future as there is a great technological advancement and innovation in the field by the companies dealing with these devices making them safer and even less invasive leading to more population opting for these procedures.

Competitive Analysis: Global Medical Aesthetics Market

Some of the major players operating in the global medical aesthetics market are Allergan, Bausch Health Companies Inc., Lumenis, Shanghai Fosun Pharmaceutical Group Co. Ltd., Cynosure, Syneron Medical Ltd, Aerolase Corp., A.R.C. Laser Gmbh, Asclepion Laser Technologies Gmbh, Btl, Cutera, Eclipse, Lutronic, Mentor Worldwide Llc, Merz Pharma, Quanta System, Sciton Inc., Sharplight Technologies Inc, Syneron Medical Ltd., Venus Concept.

Segmentation: Global Medical Aesthetics Market

Global medical aesthetics market is segmented into 4 notable segments such as product type, type of care, accessories and end user

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Allergan

The company was founded in 2013 and headquartered at Dublin, Ireland. The company is focused on developing, manufacturing and commercializing branded device, biologic, pharmaceutical, surgical and regenerative medicine products for patients throughout the world. The main business segments are US Specialized Therapeutics, US General Medicine, International. The revenue of the company in healthcare sector 2018 was USD 16,550.8 Million. The company has global presence in North America, Asia Pacific, South America, Europe and Middle East & Africa.

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Bausch Health Companies Inc.

The company was founded in 1959 and headquartered at Quebec, Canada. The company is engaged in manufacturing and marketing a broad range of branded and generic pharmaceuticals, over-the-counter (OTC) products and medical devices. The main business segments are Bausch + Lomb/International, Branded Rx, U.S. Diversified Products. The revenue of the company in healthcare sector 2018 was USD 8,174.8 Million. The company has global presence in North America, Europe, the Middle East, Africa, Asia Pacific and Latin America.

Luimenis

The company was founded in 1991; headquarter in Yokeneam, Israel. The company is engaged in the field of minimally-invasive clinical solutions for the Surgical, Ophthalmology and Aesthetic markets, and expert in developing and commercializing innovative energy-based technologies, including Laser, Intense Pulsed Light (IPL) and Radio-Frequency (RF). The company has global presence in North America, South America, Europe, Asia, Africa and Australia.

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Global Medical Aesthetics Market 2020 Indepth Study Including COVID 19 Update with of Top Key Players Profile of industry - Aerospace Journal

MarketQuest.biz has recently announced a new report entitled Global Medical Wellness Market 2020 by Company, Type and Application, Forecast to 2025 offers an overview of the market by giving market data with characteristics and market chain with analysis and developments and increase. The report delivers a comprehensive analysis of the global market which presents the critical analysis of the current state of the global Medical Wellness industry, demand for the product, environment for investment, and existing competition. Point by point data about the market players who are holding a fundamental position in the market concerning the business, revenue, open market development, and the temporary courses of action are listed in the market. It covers segments such as competitor segment, product type segment, end use/application segment, and geography segment.

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Developments and future opportunities estimated to emerge in the global Medical Wellness industry are looked into in this portion of the study. The report also throws light on the competitive landscape, underlining the corporate strategies that the prominent players across various geographies have employed to get ahead in this industry. The research focuses on business consulting, industry chain research, and consumer research to help customers provide non-linear revenue models within this market.

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Global Medical Wellness Market Import Export Scenario, Application, Growing Trends and Forecast 2020-2025 - The Think Curiouser

After a 20-year career in the corporate world, Selam Kelati was ready for a change. A native of Ethiopia, she grew up in a culture where plants and herbs were part of everyday life and utilized in an array of food, medicines, and cosmetics. So, when she decided to build a business of her own, she constructed the frame around her knowledge of natural remedies and homeopathic plants.

Launching a startup in the competitive U.S. cosmetics-and-skincare sector was no small endeavor. The industry is dominated by powerful multinational brands. But with estimated revenues of $645 million in 2019, the CBD segment of the market still offers plenty of room for startups. Kelati, along with business partner Jennifer Culpepper, seized the opportunity and created I+I Botanicals. (The name is pronounced I and I.)

The company takes an eco-conscious, holistic approach that upholds the traditions and ethics Kelati learned at an early age. Our core message is good for the earth, good for the soul and, of course, good for the body, she said. I and I comes from the Rastafarians, who use the words to mean you and I are the same. The message is that the love you give to yourself, try to give it to another.

Kelati was born and raised in Ethiopia with eight siblings and an extended family that passed down recipes for plant-based foods and medicine. Her grandmother was known in her village as an herbal medicine expert who had a deep knowledge of plants in the region and used them to create concoctions for health, beauty, and wellness.

People would come from near and far to get some kind of something that she would mix for medical purposes, so this was in our house and our family, Kelati explained. Anything to do with herbs or medicine or cooking was just a natural thing in our household. You sit with your grandmother and your aunties and your mom and you learn, but you dont even understand you are learning at that age, because its part of your life, right? So thats where my passion for natural ingredients comes from, and its something Ive carried with me throughout my life.

The prickly pear cactus grows abundantly in Ethiopia and is utilized in a number of different ways, from making jams to feeding livestock. Pressing the seeds creates an oil that is beneficial for skin and hair, Kelati said, and it also has anti-aging and anti-inflammatory properties. Another ingredient widely used in her native region is moringa oil. The substance is created by processing the seeds and leaves of the moringa tree, which has been dubbed the miracle tree due to its bountiful medicinal and nutritional attributes. Kelatis older sister owns a moringa farm in Ethiopia, and that is where I+I sources its oil.

Moringa oil mimics the natural oil we create in our body, so it does help with your hair shine and keeping it healthy and not breaking, Kelati said. And for the skin as well. Its nutrient-dense, which helps reduce the appearance of wrinkles.

Kelati has been experimenting with her own natural plant remedies for most of her life and enjoys sharing her creations with friends and family to gather feedback about what works and what does not. Soon after she heard about CBDs anti-inflammatory, antioxidant, and skin-soothing properties, she immersed herself in research. She went to trade shows and networked with operators in the industry. During her investigation, one product, in particular, stood out to her. It was an under-eye cream that [my business partner] Jennifer shared with me, and I remember seeing the puffiness under my eye being reduced within three or four days of using it, she said. That made me a believer.

I told Jennifer I wanted to have my own beauty line based on natural ingredients, because this is what I know and have been taught since childhood, she continued. Theres some kind of magic we can create using CBD. So, Jennifer and I brainstormed and I+I was born in the process.

There are a lot of people who dont understand that its not just about working hard. Its also about having a starting point.

As working mothers, Kelati and Culpepper understand the unique pressures women face on a daily basis, juggling roles from caregiver to breadwinner and trying to squeeze in time for themselves when and where they can. As such, one of their goals is to give women an easy way to incorporate CBD products into their daily routines and enjoy a relaxing moment or two amid the hustle and bustle.

The global CBD skincare market is expected to reach $1.7 billion by 2025, according to a report by Grand View Research Inc. North America, which accounted for more than 40 percent of the market in 2018, will lead the way, Grand View projected. For brands like I+I, which has a relatively small footprint at this point, establishing a presence in the lucrative space early is crucial. The effort starts with creating unique, compelling products that will stand out from the crowd.

The process Kelati uses to formulate new products is a combination of her homespun plant knowledge and ad hoc testing, with some modern science and technology to clinch the deal. [Jennifer and I] experiment with [a new formulation] ourselves to see how it feels, to get the texture and viscosity we want and the result we want to get, she said. Then we have chemists that we work with, and they produce the product at their facilities.

I+Is original CBD products include moisturizing Dry Oil Body Mist (jojoba oil, moringa oil, and a blend of citrus essential oils), hydrating Face Serum (prickly pear seed oil and hyaluronic acid), and relaxing Bath Tea Blend (essential oils). One of the most popular products, Kelati said, is Coffee Body Scrub, a foaming exfoliator that contains a combination of seven plant extracts, CBD, and fair-trade Ethiopian coffee. This is something we actually use back home after we finish drinking coffee, Kelati said. Using the leftovers, you can scrub it around your feet to make them smooth.

Other ingredients in traditional Ethiopian health and beauty regimens happen to be on-trend in Western markets right now. Called adaptogens, the materials comprise nontoxic plants and plant derivatives that are believed to help the body resist stress. Scientific research and validation for adaptogens is scarce, but adaptogenic concoctions have been used for centuries in Chinese, African, and other cultures. I realized when I looked at the list of ingredients that I knew growing up, they are actually considered adaptogens, although we didnt call them that, Kelati said. So we decided it makes sense to follow up and create products using those ingredients.

The importance of sourcing products from sustainable, eco-conscious farmers and manufacturers cannot be overstated, she said. All the CBD and most other essential ingredients in I+I products are sourced in the U.S., but Kelati also maintains several key partnerships back home. The coffee and moringa oil come from Ethiopia, and the prickly pear seed oil comes from Eritrea, she revealed. So, the main ingredients that represent the product are coming from somewhere we actually source ourselves.

I+I primarily operates in the beauty segment, but Kelati wants to grow the business into other verticals and develop products that appeal to a wider audience. One thing we are working on is beard oil so we can give something to the guys, she said.

As legalization has swept across the U.S., social equity has become one of the hottest of the hot-button issues in the cannabis and hemp industries. People of color and their advocates are fighting for a bigger stake in a space that is overwhelmingly controlled by White investors and operators. Despite legislation and other efforts designed to promote ownership and participation by Black, Indigenous, and people of color (BIPOC) stakeholders, very little progress has been made thus far.

As a Black female entrepreneur, Kelati understands the challenges. She is all too familiar with the discrimination and other issues people of color face as they try to build brands from the ground up with scarce access to investment or business loans. But none of this has tempered her enthusiasm, and Kelati is eager to build I+Is momentum across the country in 2021, one mist and scrub at a time.

Being a Black woman, I did recognize at an early stage that were going to have a lot of challenges, Kelati said. People are going to have doubts about everything we say. But I do see theres a lack of mentorship and representation, and when we go to trade shows, we dont see a lot of buyers who are minorities. So, its justI have to prepare myself more than my colleagues or my competition [must], because I just want to make sure I am representing myself fully so I can capture the audience.

On a more optimistic note, she said Black women are one of the fastest growing groups in business, and in the beauty industry she believes the situation is becoming more favorable for BIPOC and women. She cited the 15-percent pledge as one example of the changing tides. In June, Sephoraa French multinational chain of personal care and beauty storesannounced its U.S. unit would pledge to grow the share of Black businesses it helps empower to at least 15 percent. The company created an advisory group that includes brands owned by people of color to help make changes. Sephora currently works with about 300 brands in the U.S., where it has more than 400 retail storefronts plus kiosks in J.C. Penney stores.

Sephoras initiative has created a sort of trickle-down effect. Weve seen the result of that movement in that we now have partnerships with maybe six to seven different retailers that weve been trying to get our product into, so Ive seen the change in the beauty industry with the 15-percent pledge, Kelati said.

One of the most critical factors for young businesses is raising capital, and Kelati said that has been a difficult hurdle to surmount. When it comes to attracting investors, or even getting grants or any kind of loan, its not that easy for women of color, she said. Weve been trying to get investors to be attracted to our message and product, but it has been very, very challenging. Definitely, if there is more mentorship and representation, those can make a big difference.

Kelati also noted most Black business owners are new to the business world and dont have the same level of experience, capital, or the connections enjoyed by many White business owners. Everybody does not start from the same beginning, and Black business owners dont have that foundation. We start everything from scratch, she said. So, to expect to go the same speed as the competition who actually have a good jumpstart, its really not fair. When you go networking, you dont see someone who looks like you or someone who understands your struggle. There are a lot of people who dont understand that its not just about working hard. Its also about having a starting point. The experience is not the same.

Kelati has seen some signs over the past year that give her hope for a brighter future for BIPOC-owned businesses. In the meantime, I+I is doing its part to highlight a proud legacy with roots in East Africa being carried forward by modern-day female entrepreneurs.

To be honest, it makes me comfortable now to say that, yes we have a Black woman business owner, and we always promote ourselves as a woman-owned business and my face is out there, she said, explaining that even in the cosmetics industry, women-owned businesses face a steep climb. It just makes us more comfortable now because we feel like the [equity] movement [in cannabis] is genuine, and people are trying to make a difference and inviting diversity into this industry.

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After a 20-year career in the corporate world, Selam Kelati was ready for a change. A native of Ethiopia, she - mg Magazine