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Category Archives: Anti-Aging Medicine

Gene experts claim they identified human genes that can protect against Covid-19 – CNBC

COVID-19 Coronavirus molecule, March 24, 2020.

CDC | API | Gamma-Rapho via Getty Images

A team of CRISPR scientists at the New York Genome Center, New York University and Icahn School of Medicine at Mount Sinai say they have identified the genes that can protect human cells against Covid-19, a disease that has infected over 40 million and led to 1 million deaths worldwide. The discovery comes after an eight-month screen of all 20,000 genes in the human genome led by Dr. Neville Sanjana at the New York Genome Center. Leading virologist at Mount Sinai, Dr. Benjamin tenOever, developed a series of human lung cell models for the coronavirus screening to better understand immune responses to the disease and co-authored the study.

Their study, published online last month by Cell, will appear in the scientific peer-reviewed journal's Jan. 7 print issue.

The goal was two-fold: to identify the genes that make human cells more resistant to SARS-CoV-2 virus; and test existing drugs on the market that may help stop the spread of the disease.

The breakthrough comes at a time when drug makers such as Pfizer, Oxford-AstraZeneca and Moderna are fast-forwarding vaccine and therapeutics to treat Covid-19. On Friday, Pfizer and BioNTech requested emergency authorization from the FDA for their Covid vaccine that contains genetic material called messenger RNA, which scientists expect provokes the immune system to fight the virus.

In order to better understand the complex relationships between host and virus genetic dependencies, the team used a broad range of analytical and experimental methods to validate their results. This integrative approach included genome editing, single-cell sequencing, confocal imaging and computational analyses of gene expression and proteomic datasets.

After intensive research the scientists and doctors claim they have found 30 genes that block the virus from infecting human cells including RAB7A, a gene that seems to regulate the ACE-2 receptor that the virus binds to and uses to enter the cell. The spike protein's first contact with a human cell is through ACE-2 receptor.

"Our findings confirmed what scientists believe to be true about ACE-2 receptor's role in infection; it holds the key to unlocking the virus," said Dr. tenOever. "It also revealed the virus needs a toolbox of components to infect human cells. Everything must be in alignment for the virus to enter human cells."

The team discovered that the top-ranked genes those whose loss reduces viral infection substantially clustered into a handful of protein complexes, including vacuolar ATPases, Retromer, Commander, Arp2/3, and PI3K. Many of these protein complexes are involved in trafficking proteins to and from the cell membrane.

"We were very pleased to see multiple genes within the same family as top-ranked hits in our genome-wide screen. This gave us a high degree of confidence that these protein families were crucial to the virus lifecycle, either for getting into human cells or successful viral replication," said Dr. Zharko Daniloski, a postdoctoral fellow in the Sanjana Lab and co-first author of the study.

Using proteomic data, they found that several of the top-ranked host genes directly interact with the virus's own proteins, highlighting their central role in the viral lifecycle. The team also analyzed common host genes required for other viral pathogens, such as Zika or H1N1 pandemic influenza.

The research team also identified drugs that are currently on the market for different diseases that they claim block the entry of Covid-19 into human cells by increasing cellular cholesterol. In particular, they found three drugs currently on the market were more than 100-fold more effective in stopping viral entry in human lung cells:

The other five drugs that were tested called PIK-111, Compound 19, SAR 405, Autophinib, ALLN -- are used in research but are not yet branded and used in clinical trials for existing diseases.

Our findings confirmed what scientists believe to be true about ACE-2 receptor's role in infection; it holds the key to unlocking the virus.

Their findings offer insight into novel therapies that may be effective in treating Covid-19 and reveal the underlying molecular targets of those therapies.

The bioengineers in New York were working on other projects with gene-editing technology from CRISPR but quickly pivoted to studying the coronavirus when it swept through the metropolitan area last March. "Seeing the tragic impact of Covid-19 here in New York and across the world, we felt that we could use the high-throughput CRISPR gene editing tools that we have applied to other diseases to understand what are the key human genes required by the SARS-CoV-2 virus," said Dr. Sanjana.

Dr. Neville Sanjana and his team at the New York Genome Center used CRISPR to identify the genes that can protect human cells against Covid-19.

New York Genome Center

As he explained, "current treatments for SARS-CoV-2 infection currently go after the virus itself, but this study offers a better understanding of how host genes influence viral entry and will enable new avenues for therapeutic discovery."

Previously, Dr. Sanjana has applied genome-wide CRISPR screens to identify the genetic drivers of diverse diseases, including drug resistance in melanoma, immunotherapy failure, lung cancer metastasis, innate immunity, inborn metabolic disorders and muscular dystrophy.

"The hope is that the data from this study which pinpoints required genes for SARS-CoV-2 infection could in the future work be combined with human genome sequencing data to identify individuals that might be either more susceptible or more resistant to COVID-19," Dr. Sanjana said.

The New York team is not the first to use CRISPR gene editing techniques to fight Covid-19. Other bioengineering groups at MIT and Stanford have been using CRISPR to develop ways to fight the SARS-CoV-2 and develop diagnostic tools for Covid-19.

The potential for using CRISPR to eliminate viruses has already generated some enthusiasm in the research community. Last year, for example, Excision BioTherapeuticslicenseda technology from Temple University that uses CRISPR, combined with antiretroviral therapy, to eliminate HIV, the virus that causes AIDS.

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Botulinum Toxin Market Estimated to Experience a Hike in Growth by 2025 – The Daily Philadelphian

Global Botulinum Toxin Market: Snapshot

Botulinum toxin, known to the mankind as one of the most poisonous biological substances, is a neurotoxin produced by theClostridium botulinum bacteria.Clostridium botulinum, the gram-positive, anaerobic, spore-forming bacteria commonly found in water, soil, on plants, and the intestinal tracts of animals can be elaborated into eight exotoxins, all interfering with the process of neural transmission and causing muscle paralysis.

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From the earliest recorded uses of the toxin for the management ofstrabismus in humans to being approved for the treatment of a number of spasticity-related conditions, it has now started witnessing demand across nearly all important sub-specialties of the medicine sector. It was approved by the FDA in 2002 for the cosmetic application of decreasing glabeller forehead frown lines temporarily.

Ever since, botulinum toxins continue to play a key role in the management of a wide range of medical conditions, especially hemifacial spasm, focal dystonias and strabismus, several spastic movement disorders, hyperhidrosis, hypersalivation, headaches, and certain chronic diseases that only partially respond to medical treatments. The set of potential new indications treatable by botulinum toxins is expanding at a rapid pace.

Cosmetological applications, one of the most popular and profitable applications of botulinum toxins, include correction of creases, fine lines, and wrinkles over the face, neck, chin, and chest.Dermatological applicationsof the toxin, including hyperhidrosis, are also gaining increased popularity, chiefly as botulinum toxin injections are often well tolerated and lead to few side effects.

Global Botulinum Toxin Market: Overview

The international botulinum toxin (BNT) market is gigantically advantaged by the soaring number of applications for different purposes. A recent study has revealed that BNT can be used for benefitting patients with shoulder disorders such as those who undergo rotator cuff surgery. BNT in the form of onabotulinum toxin A (OnabotA) is licensed in several countries such as Korea to help with neurogenic detrusor overactivity (NDO) induced urinary incontinence attributable to multiple sclerosis or spinal cord injury.

The world BNT market could be segregated as per two key classifications, i.e. product type and end use. Maintaining a promising share in the global market, botulinum toxin type A (BNTA) is envisioned to be a faster growing product with applications in both aesthetic and therapeutic fronts.

The report on the global BNT market has been compiled after taking comprehensive efforts to gather vital insights for procuring future growth prospects, opportunities to rise against the odds, and data related to the current and future competitive scenario.

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Global Botulinum Toxin Market: Trends and Opportunities

The aesthetic classification by type of end use is prognosticated to make a positive difference in the overall BNT market with a record share registered in 2015. BNT finds application in the treatment of glabellar lines, crows feet, and frown lines. As a result, it has received a significant demand in terms of primary cosmetic application for controlling aging signs and enhancing facial appearance.

Since BNT is a neurotoxin, the lackluster in the adoption of neurotoxins could raise questions on the demand in the global BNT market. The market growth could be further hindered with substandard reimbursement coverage on few products and extortionate treatment procedures. Moreover, shortness of breath and allergic reactions are some of the side effects witnessed on the part of neurotoxins.

However, a substantial number of BNT applications is expected to birth in the near future on account of large investments in research and development projects. The demand for BNT is anticipated to augment even more with the increase in demand for non-invasive and minimally invasive treatments. Vendors can also keep their hopes alive during any turmoil in the market with the escalation of geriatric population.

The therapeutic use of BNT is predicted to see a constant rise owing to the growing application of botulinum toxin B (BNTB) in the treatment of cervical dystonia and Xeomin and Dysport products for hyperhidrosis and blepharospasm.

Global Botulinum Toxin Market: Regional Outlook

Asia Pacific is analyzed to possess the potential to rise as a reliable geographical segment to bet the bottom dollar on. The demand in the Asia Pacific BNT market is envisaged to aggravate as players ride on the growing aged population and their need for anti-aging products. Besides augmenting disposable income, vendors in the Asia Pacific region could heavily benefit from the hot social awareness about commercial anti-aging products in countries such as Japan, China, and India.

Having won the crown of dominant growth in 2015, North America is expected to raise the growth bar once again on the back of the elevating BNT demand for improving external appearances and other aesthetic reasons.

Global Botulinum Toxin Market: Companies Mentioned

Considering their influence in the world BNT market on the basis of commercial availability and brand identity, companies such as Merz Pharma GmbH and Co. KgaA, Ipsen Group, Allergan, Inc., US Worldmeds, LLC, and Medytox, Inc. are predicted to top the list of best global players. These players are foreseen to take advantage of the colossal adoption of BNT on account of tangible benefits such as speedy healing of wounds, shorter stay in the hospital, and small incision.

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TMR Research is a premier provider of customized market research and consulting services to busi-ness entities keen on succeeding in todays supercharged economic climate. Armed with an experi-enced, dedicated, and dynamic team of analysts, we are redefining the way our clients conduct business by providing them with authoritative and trusted research studies in tune with the latest methodologies and market trends.

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Botulinum Toxin Market Estimated to Experience a Hike in Growth by 2025 - The Daily Philadelphian

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Five anti-aging foods — and some that age – Richmond Register

You don't need that expensive face cream to look younger, just focus on your diet to help preserve your youthful appearance.

Here are some of the best anti-aging foods and a few to limit when it comes to maintaining a healthy, good looking body.

Best anti-aging foods

n Cheese

Ever wondered why some restaurants offer cheese as a post-meal desert? One reason is because a little cheddar can counteract the acid left behind after a meal. Not only that, calcium helps build strong teeth. So nibbling on cheese after dinner can bring some bling to your pearly whites.

n Tomatoes

These healthy fruits are loaded with lycopene, an antioxidant with natural sunscreen properties. Tomato paste is a good source of lycopene, so adding it to your pasta sauce or as a pizza topping can make a difference to your skin.

n Salmon

A superfood when it comes to your body, the essential omega-3 fats are great for healthy and nourished skin too. Salmon contains anti-oxidants such as selenium and vitamin E that protect against free radicals that can have damaging and aging effects on the skin. Nuts, seeds and avocados are also fantastic for a healthy complexion.

n Watermelon

Even though watermelon is 93 percent water, it's still packed with vitamins and anti-oxidants to help ward off premature aging. Watermelon also contains vitamin A that is linked to helping treat acne, according to a 2015 study in Medical Archives.

n Olive Oil

The monounsaturated fat and anti-oxidants found in olive oil provide numerous health benefits, including heart function, improved memory, reduced inflammation and many others, according to a paper published in the March 2018 issue of the International Journal of Molecular Science. Not only that, olive oil helps keep skin moisturized and protected from damage.

Worst anti-aging foods

n Sugar

Sweets aren't just bad for your teeth, they age your skin too. Collagen production naturally decreases as you get older, but consuming excess sugar speeds up the process.

A study in the Clinics in Dermatology journal highlighted just how sugar is thought to be harmful to your skin. Glucose and fructose, the sugar molecules, link the amino acids in the collagen and elastin that support the skin, producing advanced glycation end products (AGEs).

These AGEs accelerate the process. Research has also found a link between eating a high-glycemic diet (sugar foods) and acne, although the research doesn't show causation

n Salt

Clearly a flavor enhancer, salt is a favorite ingredient in lots of dishes. But too much salt (more than 2,300 milligrams a day) not only increases blood pressure, it can be bad for your skin too.

In a 2019 study published in the journal Science Translational Medicine, skin lesions on people with eczema were found to have elevated levels of sodium chloride (salt), although causation could not be proved.

n Alcohol

Drinking more than the recommended daily amount of alcohol (one drink for women, two drinks for men) can cause dehydration, making your skin look dry and withered. Excess alcohol can also cause inflammation, leading to a myriad of problems such as acne, breakouts, and disrupted sleep.

Poor sleep quality then leads to dark circles under the eyes, wrinkles and sagging skin.

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

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Five anti-aging foods -- and some that age - Richmond Register

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Ra Medical Systems to Feature the Pharos Optimized Excimer Laser at the Virtual New Frontiers in Cosmetic Medicine & Medical Dermatology Symposium…

CARLSBAD, Calif.--(BUSINESS WIRE)--Ra Medical Systems, Inc. (NYSE: RMED), a medical device company focused on commercializing excimer laser systems to treat vascular and dermatological diseases, announces it will feature the Pharos excimer laser at the New Frontiers in Cosmetic Medicine & Medical Dermatology Symposium 2020 Virtual Meeting being held November 21, 2020.

We are delighted to showcase our Pharos excimer laser at this conference, said Will McGuire, Ra Medical Systems CEO. Pharos provides topical treatment of common skin disorders including psoriasis, vitiligo, atopic dermatitis and leukoderma and is a lower cost and safe alternative to immunosuppressive agents. During the pandemic, Pharos may play a particularly valuable role for patients who may be otherwise immunocompromised.

About the New Frontiers in Cosmetic Medicine & Medical Dermatology Conference

New Frontiers in Cosmetic Medicine Symposium will deal with the latest developments in cosmetic dermatology, cosmetic medicine, and anti-aging medicine. It is designed for an audience of physicians, physician assistants, nurses and nurse practitioners who work under the direct supervision of dermatologists, facial plastic surgeons, oculoplastic surgeons, and plastic surgeons, and commonly assist with cosmetic surgery and medicine. More information is available at https://www.cosmeticfrontiers.com/.

About Ra Medical Systems

Ra Medical Systems commercializes excimer lasers and catheters for the treatment of vascular and dermatological diseases. In May 2017 the DABRA excimer laser system received FDA 510(k) clearance in the U.S. for crossing chronic total occlusions, or CTOs, in patients with symptomatic infrainguinal lower extremity vascular disease with an intended use for ablating a channel in occlusive peripheral vascular disease. The Pharos excimer laser system is FDA-cleared and is used as a tool in the treatment of psoriasis, vitiligo, atopic dermatitis and leukoderma. DABRA and Pharos are both based on Ra Medicals core excimer laser technology platform and deploy similar mechanisms of action. Ra Medical manufactures DABRA and Pharos excimer lasers and catheters in a 32,000-square-foot facility located in Carlsbad, Calif. The vertically integrated facility is ISO 13485 certified and is licensed by the State of California to manufacture sterile, single-use catheters in controlled environments.

Cautionary Note Regarding Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements generally relate to future events or Ra Medicals future financial or operating performance. In some cases, you can identify forward-looking statements because they contain words such as may, will, should, expects, plans, anticipates, could, intends, target, projects, contemplates, believes, estimates, predicts, potential or continue or the negative of these words or other similar terms or expressions that concern Ra Medicals future expectations, strategy, plans or intentions. Forward-looking statements in this press release include, but are not limited to, statements regarding the timing and potential outcome of the DABRA atherectomy clinical study. Ra Medicals expectations and beliefs regarding these matters may not materialize, and actual results in future periods are subject to risks and uncertainties that could cause actual results to differ materially from those projected or implied by such forward-looking statements. The potential risks and uncertainties which contribute to the uncertain nature of these statements include, among others, challenges inherent in developing, manufacturing, launching, marketing, and selling new products; risks associated with acceptance of DABRA and Pharos and procedures performed using such devices by physicians, payors, and other third parties; development and acceptance of new products or product enhancements; clinical and statistical verification of the benefits achieved via the use of Ra Medicals products; the results from our clinical trials, which may not support intended indications or may require Ra Medical to conduct additional clinical trials or modify ongoing clinical trials; challenges related to commencement, patient enrollment, completion, and analysis of clinical trials; Ra Medicals ability to manage operating expenses; Ra Medicals ability to effectively manage inventory; Ra Medicals ability to recruit and retain management and key personnel; Ra Medicals need to comply with complex and evolving laws and regulations; intense and increasing competition and consolidation in Ra Medicals industry; the impact of rapid technological change; costs and adverse results in any ongoing or future legal proceedings; adverse outcome of regulatory inspections; and the other risks and uncertainties described in Ra Medicals news releases and filings with the Securities and Exchange Commission. Information on these and additional risks, uncertainties, and other information affecting Ra Medicals business and operating results is contained in Ra Medicals Annual Report on Form 10-K for the year ended December 31, 2020 and in its other filings with the Securities and Exchange Commission. The forward-looking statements in this press release are based on information available to Ra Medical as of the date hereof, and Ra Medical disclaims any obligation to update any forward-looking statements, except as required by law.

Ra Medical investors and others should note that we announce material information to the public about the company through a variety of means, including our website (www.ramed.com), our investor relations website (https://ir.ramed.com/), press releases, SEC filings, and public conference calls in order to achieve broad, non-exclusionary distribution of information to the public and to comply with our disclosure obligations under Regulation FD. We encourage our investors and others to monitor and review the information we make public in these locations as such information could be deemed to be material information. Please note that this list may be updated from time to time.

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CT team developing COVID drug to reverse aging … really – CT Insider

The older you are, the more likely your COVID-19 infection will be more severe, and even fatal. Of the nearly 5,000 COVID-related deaths in Connecticut to date, 81 percent are people over 70 years old.

But what if you could turn back the clock? A team of researchers at UConn are working on ways to literally reverse the effects of aging, as a way to mitigate the severity of a COVID infection.

The goal here is not to erase aging, but rather were testing interventions that are designed to slow the rate of biological aging, and therefore help prevent severe COVID, according to George Kuchel, director of UConns Center on Aging and chief of geriatric medicine at UConn Health.

One drug in particular, called compound RTB101, can theoretically not only slow aging but boost the immune response, helping the body and any potential vaccines do their jobs better.

Thats important because, as Kuchel said, these vaccines dont work as well on older adults.

Even if the vaccine turns out to be as effective, as the initial studies suggest, theres a very strong likelihood that its going to be less effective in older adults, he said. These kinds of approaches are going to be important as additional therapies to the vaccine, for the vaccine alone is not going to be sufficient.

Another weakness of any potential vaccine is their specificity. The COVID-19 pandemic may be contained, but the virus could mutate, or another virus might emerge.

At some point, were going to be done with COVID-19, hopefully, Kuchel said. But I think we all agree that there could very well be another COVID, whether its COVID-21, 22, whatever, or another pathogen out there, that we dont even know about yet. And if older adults are more vulnerable to get this and to die from it, then we believe this approach will be helpful irrespective of what the infection is.

The compound known as RTB101 doesnt actually make you younger. Theres a difference, Kuchel explained, between chronological age how many years you have been alive and biological age.

Whereas biological aging is an effort to capture the rate of aging, how fast somebody ages, Kuchel said. As you can imagine, you could have two people who are both 70 years old, and one could have a biological age which would be younger than most 70-year-olds, and another one who has a biological age that would be older than most 70-year-olds.

RTB101 targets the biological pathways that control the aging process, the so-called mTOR pathway, for example.

Early versions of the compound have been studied for decades at Connecticuts Jackson Labs and elsewhere and have been shown to slow aging in mice.

While inhibiting the natural processes that lead to biological aging, the compound also boosts the bodys ability to fight disease.

There are a lot of genes that are involved in our ability to fend off viral infections, Kuchel said. There are these inflammatory molecules called interferon gamma. That whole family of molecules are very important to our ability to fend off infection, particularly viral infections. What this compound does is it boosts those responses. So it down-regulates mTOR and it up regulates the interferon gamma responses.

In a sense, it kind of resets the body to behave the way it would have at a younger age, and to boost immune responses, Kuchel said.

The work on RTB101 is being funded by the National Institutes for Health and the first step which the team at UConn is currently recruiting subjects for is a small-scale feasibility study involving people over the age of 65 who have either been recently diagnosed with a COVID-19 infection or who lives with someone diagnosed with COVID in the last few days.

Were in a very tight timeline, Kuchel said. We need to do this in the next two months.

But dont expect your doctor to prescribe an anti-aging drug any time soon.

After the feasibility study will come a large-scale, multi-site clinical trial. Only then will Kuchel and his team seek FDA approval.

I know that sometimes the progress of science seems maddeningly slow. But unfortunately, its the only way we can show that it works, Kuchel said. In terms of this being available at physicians offices, its not going to be within the next year or two. This is going to take some time.

But, again, this sort of research could be important, Kuchel said, because it is not a therapy to treat or prevent any specific disease.

We believe that will be transformative not only for the current COVID pandemic, but for future pandemics, future infections, which we know are going to happen, he said. We know that future infections will happen, we know that older adults will be more vulnerable. Thats absolutely clear. The only thing we dont know is what the pathogen will be. With this approach, the argument can be made that we dont need to know what that pathogen is because were not targeting the pathogen, were targeting the person.

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CT team developing COVID drug to reverse aging ... really - CT Insider

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Ageing in humans reversed by hyperbaric oxygen therapy: Israel study – The CEO Magazine

Ageing, which happens over time in humans, has been biologically reversed by hyperbaric oxygen therapy, according to new research published in the journal Aging.

Scientists, led by Yafit Hachmo, from the Research and Development Unit, Shamir Medical Center, Tzrifin, Israel, turned back the human clock for 35 adults aged 64 and older by reversing two key areas of the body thought responsible for the frailty and ill-health that comes with growing older. Protective caps at the ends of chromosomes, known as telomeres, shorten, causing DNA to become damaged and cells to stop replicating as people age. At the same time, senescent cells build up in the body, preventing regeneration.

Increasing telomere length and getting rid of senescent cells is the focus of anti-ageing research, with drugs being developed to target those areas, The Telegraph reported.

The 35 patients were repeatedly given pure oxygen in a hyperbaric chamber, which increased the length of their telomeres by 20%, a feat that has never been achieved before.

Scientists said the growth may mean that the telomeres of trial participants were now as long as they had been 25 years earlier.

The therapy also reduced senescent cells by up to 37%, enabling new healthy cells to regrow. Animal studies have shown that removing senescent cells extends remaining life by more than 33%.

Since telomere shortening is considered the Holy Grail of the biology of ageing, many pharmacological and environmental interventions are being extensively explored in the hopes of enabling telomere elongation, said one of the scientists involved in the research, Professor Shai Efrati, Director of the Sagol Center at Shamir Medical Center.

The significant improvement of telomere length shown during and after these unique protocols provides the scientific community with a new foundation of understanding that ageing can indeed be targeted and reversed at the basic cellular-biological level.

Scientists believe ageing itself is responsible for diseases such as Alzheimers, Parkinsons, arthritis, cancer, heart disease and diabetes.

It is known that obesity, smoking, lack of physical activity, vitamin deficiency and inflammation can speed up the shortening of telomeres, demonstrating that they have a major impact on the length of a life.

The 35 participants did not undergo any lifestyle, diet or medication adjustments. Each patient was placed in a hyperbaric chamber for 90 minutes for five days a week over three months while breathing 100% oxygen through a mask.

The pressurised chamber allows more oxygen to be dissolved into the tissues and mimics a state of hypoxia, or oxygen shortage, which is known to have regenerating effects.

Previous trials have shown that eating a healthy diet can preserve telomere length, while high-intensity training for six months has been proven to lengthen telomeres by up to 5%.

The Israeli team has also previously demonstrated that the pressurised oxygen therapy can improve cognitive decline.

Until now, interventions such as lifestyle modifications and intense exercise were shown to have some inhibition effect on the expected telomere length shortening, said Dr Amir Hadanny, Chief Medical Research Officer of the Sagol Center for Hyperbaric Medicine and Research.

However, what is remarkable to note in our study is that, in just three months of therapy, we were able to achieve such significant telomere elongation at rates far beyond any of the current available interventions or lifestyle modifications.

With this pioneering study, we have opened a door for further research on the prolonged cellular impact of the therapy to reverse the ageing process. After dedicating our research to exploring its impact on the areas of brain functionality and age-related cognitive decline, we have now uncovered, for the first time in humans, biological effects at the cellular level in healthy ageing adults.

The researchers pointed out that the study has several limitations and strengths to consider. First, the limited sample size has to be taken into account. Second, the lack of a control group.

However, the study suggests impressive results on telomeres and senescent cell clearance, which werent observed in other interventions, said the research paper.

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