Category Archives: Anti-Aging Medicine

The growing importance of hormonal health is becoming an integral component of modern medicine especially as the focus shifts toward maintaining and boosting immunocompetence in the population. Many plausible benefits of hormonal factors on autoimmunity have received growing attention in recent years from the scientific community. Research has been conducted investigating the relationship between immune system function and sex hormones testosterone and estrogen.

Importantly, the immune systems of men and women are known to function differently with 80% of autoimmune diseases occurring in women who tend to show stronger immune responses than their male counterparts. Stronger immune responses in women produce faster pathogen clearance and improved vaccine responsiveness while also contributing to their increased susceptibility to inflammatory and autoimmune diseases.

Results from previous experimental studies have revealed that testosterone can have a medium-sized immunosuppressive effect on immune function, however, the impact of estrogen can vary depending on the immune marker measured. Such differences in immune function and responses have contributed to health- and life-span disparities between sexes yet the role of hormones in immune system aging remains to be understood.

Immune Differences and Dimorphism

The differences in immunocompetency between male and female patients are associated with varying testosterone and estrogen levels major regulators of the immune system. Differences in gene expression between the sexes contribute to the concept of immune dimorphism though they are limited to one or a few types of immune cells. Furthermore, genomic differences between sexes have been found to become more prominent after the age of 65 with men having a higher innate and pro-inflammatory activity along with lower adaptive activity.

Female and males have different energy and nutrient requirements largely based on interactions between external factors and sex hormones; interactions between hormones and a patients environment, including cigarette smoke and viral infections, can lead to variable responses in both genders. While enhanced immunity has been reported in female patients, making them less susceptible to viral infections, their hyper immune response can predispose them to immune-pathogenic effects. In addition, sex hormones can control the immune response via circadian rhythms and their ability to regulate T-cell mediated inflammation.

Microbial Composition

Emerging evidence also indicates that sex hormones can impact the guts microbial composition and thus, impact immunocompetency. Studies have shown that diet-based effects on the microbiome are more prominent in men than in women implicating that dietary interventions may have an influence on sex-based immune responses.

The gut microbiota landscape can impact the systemic levels of testosterone, changing metabolic profiles which may heighten the risk for chronic disease including diabetes. However, current knowledge of the mechanism by which microbiome-derived sex steroids impact immunity remains limited.

Previous research has shown that hormonal contraceptives can increase bacterial species, highlighting sex-hormone-dependent differences and their effects on systemic immune responses. However, the gut microbial composition can be influenced by a variety of factors outside of hormonal levels, such as genetics and dietary habits.

The mechanism underlying sex hormone expression and immunocompetency continues to be investigated; this may result in the improvement of future designs for targeted therapeutics that mitigate sex hormone-inflammatory activity or autoimmune diseases. Clinicians interested in expanding their knowledge on the role of hormones in immune function and longevity are invited to attend the cutting-edge, interactive online Role of Hormones in Immunocompetency and Longevity workshop taking place on February 20, 2021.

Read the original here:
The Role of Hormones in Immunocompetence - Anti Aging News

Researchers from the University of Tsukuba find that spontaneous eye blink activity explains the link between physical activity and cognitive function

Although exercise is known to enhance cognitive function and improve mental health, the neurological mechanisms of this link are unknown. Now, researchers from Japan have found evidence of the missing link between aerobic fitness and cognitive function.

In a study published in Medicine & Science in Sports & Exercise, researchers from the University of Tsukuba revealed that spontaneous eye blink rate (sEBR), which reflects activity of the dopamine system, could be used to understand the connection between cognitive function and aerobic fitness.

The dopaminergic system is known to be involved in physical activity and exercise, and previous researchers have proposed that exercise-induced changes in cognitive function might be mediated by activity in the dopaminergic system. However, a marker of activity in this system was needed to test this hypothesis, something the researchers at the University of Tsukuba aimed to address.

"The dopaminergic system is associated with both executive function and motivated behavior, including physical activity," says first author of the study Ryuta Kuwamizu. "We used sEBR as a non-invasive measure of dopaminergic system function to test whether it could be the missing link between aerobic fitness and cognitive function."

To do this, the researchers asked healthy participants to undergo a measure of sEBR, a test of cognitive function, and an aerobic fitness test. They also measured brain activity during the cognitive task using functional near-infrared spectroscopy.

"As expected, we found significant correlations between aerobic fitness, cognitive function, and sEBR," explains Professor Hideaki Soya, senior author. "When we examined these relationships further, we found that the connection between higher aerobic fitness and enhanced cognitive function was mediated in part by dopaminergic regulation."

Furthermore, activity in the left dorsolateral prefrontal cortex (l-DLPFC) during the cognitive task was the same or lower in participants with higher sEBR compared with lower sEBR, even though those with higher sEBR appeared to have greater executive function, and thus higher neural efficiency.

"Although previous studies have indicated that aerobic fitness and cognitive function are correlated, this is the first to provide a neuromodulatory basis for this connection in humans. Our data indicate that dopamine has an essential role in linking aerobic fitness and cognition," says first author Kuwamizu.

Given that neural efficiency in the l-DLPFC is a known characteristic of the dopaminergic system that has been observed in individuals with higher fitness and executive function, it is possible that neural efficiency in this region partially mediates the association between aerobic fitness and executive function. Furthermore, physical inactivity may be related to dopaminergic dysfunction. This information provides new directions for research regarding how fitness affects the brain, which may lead to improved exercise regimens. For instance, exercise that specifically focuses on improving dopaminergic function may particularly boost motivation, mood, and mental function.

We revealed that spontaneous eye blink rate significantly mediated the association between higher aerobic fitness and greater cognitive function. indicates standardized regression coefficient, which represents the degree of association between variables.

More:
Blink! The Link between Aerobic Fitness and Cognition - Anti Aging News

Breadcrumb Trail Links

The scientists are searching for drugs and diet supplements that could tweak human biology to better withstand the ravages of time

Author of the article:

Publishing date:

Its one of the curiosities of the COVID-19 pandemic.

In much of Africa, amidst widespread poverty and with a limited health-care infrastructure, the pandemic has actually taken less of a death toll than in rich countries like Canada.

The reasons for that seeming contradiction are not yet totally clear, but Colin Farrelly points to one likely explanation: the continents markedly youthful population.

The COVID-19 pandemic is a highly fatal pandemic largely because of population aging, notes Farrelly, a Queens University professor who has a new journal paper on the topic. Our success in delaying death in late life made us vulnerable to COVID-19 mortality.

This advertisement has not loaded yet, but your article continues below.

More intriguingly, and hopefully, Farrelly and others say the pandemic is a compelling reason to double down on a fascinating new domain of medical research. Its goal, rather than finding cures for individual diseases, is to treat the aging process itself.

Old age makes humans vulnerable to a range of killers, now including the novel coronavirus. Finding a way to slow down or reverse the aging process will protect people not just from traditional foes like diabetes and hypertension, but infectious diseases such as COVID-19, the thinking goes.

I think of it as 21st century medicine, as opposed to 20th century medicine, in which there were these silos of people who treat your heart, people who treat your lungs, people who treat your brain, Austad said. (Now) theyve started talking to each other.

Targeting aging, argues Farrelly, ought to be the major public health goal of the 21st century.

Nobody has run away from aging by dieting and exercising ... To change the paradigm, we need to look at pharmaceuticals

What anti-aging scientists are pursuing is not the lifestyle fixes long proven to lessen disease risk, like regular exercise and a healthy diet. Instead, theyre searching for drugs and dietary supplements that could actually tweak human biology to better withstand the ravages of time.

This advertisement has not loaded yet, but your article continues below.

The key seems to be that the animal somehow avoids the clumping together of protein on the shell-opening tissue, a factor for humans not just in muscle ailments, but neurological diseases like Parkinsons and Alzheimers, too, Austad said.

Meanwhile, experts like him stress there are already relatively cheap and safe drugs prescribed for other uses that have great potential as anti-aging agents. They include rapamycin, used now to combat organ rejection in transplant patients, and metformin, a diabetes medicine.

This advertisement has not loaded yet, but your article continues below.

Underlying the research are some cold, hard facts about human biology. Evolution, it seems, has ensured humans live healthily long enough to reproduce and look after their offspring until they become independent.

That translates into an average biological warranty period of about 70 years, the time before which the body begins to undermine itself, increasing the risk of disease and frailty, says Farrelly. So as weve learned to at least manage diseases of old-age and get people to live longer, the result is often years of illness and disability at the end of life, he said.

But thats not to say that growing old and weak in the way we expect is written in stone.

Theres no law of physics or law of the universe that says that aging has to occur, said Austad. Living organisms are almost definable by their ability to repair themselves Aging is the ultimate failure of repair. (But) that doesnt mean its not possible to intervene in the system.

Such intervention would not necessarily extend lifespans, but ideally make the later years healthier and more productive, a major advance in itself.

That would change the nature of human existence incredibly, said Austad. If you had another 10 to 20 years of healthy life to look forward to, that might influence almost everything you did when you went to school, when you had kids, how many careers you had.

This advertisement has not loaded yet, but your article continues below.

After it was discovered in the soil of Easter Island in the 1960s, Canadian researchers at Ayerst Pharmaceuticals found it had fungal-fighting properties. It eventually was approved as an anti-rejection drug. What has been learned about it since suggests its one of the very brilliant molecules that nature made, said Zhavoronkov, founder of Hong Kong-based companies Insilico and Deep Longevity.

It should be administered under a doctors supervision and tailored to individual recipients, he said, but the time is now.

This advertisement has not loaded yet, but your article continues below.

Theres no law of physics or law of the universe that says that aging has to occur

The trillions of dollars governments have spent on the fallout from COVID-19 with its disproportionate burden on the elderly drives home the point, he argues.

So how soon before a drug arrives that brings, not immortality exactly, but a longer healthspan?

Austad believes it s coming within 10 years. Zhavoronkov is also optimistic, saying the last decade has seen remarkable progress, more discoveries in aging medicine than in the entire human history.

It feels personal to Farrelly, a political-studies professor who monitors geriatric science. His mother died in the midst of the pandemic after years of battling cancer, unable to see family in the last three months of her life because of COVID protocols. But hes hopeful.

I believe it will happen in my kids lifetime, said Farrelly. They wont age like my mother did.

Sign up to receive the daily top stories from the National Post, a division of Postmedia Network Inc.

A welcome email is on its way. If you don't see it please check your junk folder.

The next issue of Posted Newsletter will soon be in your inbox.

We encountered an issue signing you up. Please try again

Postmedia is committed to maintaining a lively but civil forum for discussion and encourage all readers to share their views on our articles. Comments may take up to an hour for moderation before appearing on the site. We ask you to keep your comments relevant and respectful. We have enabled email notificationsyou will now receive an email if you receive a reply to your comment, there is an update to a comment thread you follow or if a user you follow comments. Visit our Community Guidelines for more information and details on how to adjust your email settings.

Read this article:
COVID-19 the new disease of growing old, hastening the work of anti-aging scientists - National Post

While 2020 may have felt like the longest year, unfortunately, there is one aspect of the pandemic that may have been accelerated aging skin.

According to board-certified dermatologist Rajani Katta, MD, FAAD, clinical assistant professor at the Baylor College of Medicine, a combination of factors brought on by the pandemic are contributing to growing complaints of accelerated skin aging.

Some of this has to do with perception and what I call Zoom face. Between the poor lighting, harsh shadows and strange angles in which were seeing ourselves on camera, its the equivalent of looking at our face for hours in an unflattering mirror, said Dr. Katta. In addition to more video calls, the pandemic has ushered in many sleepless nights and increased stress levels, which we know can contribute to premature skin aging.

Dr. Katta is also seeing more patients who are experimenting with at-home treatments like peels and masks that can cause redness, irritation and flaking skin, which can make your skin appear older. Some patients who are experiencing skin irritation from wearing a face mask have had to stop using effective anti-aging products altogether during the pandemic. Finally, lifestyle changes that include less exercise and more unhealthy eating have contributed to accelerated skin aging.

Dr. Katta is available to discuss additional insights on how the pandemic is impacting peoples skin and offers these tips to her patients.

Five tips for combating aging skin during the pandemic:

###

More Information

11 ways to reduce premature skin aging

Anti-aging skin care

Age spots and dark marks

Skin care in your 40s and 50s

How to maintain younger-looking skin

How to treat wrinkles

How to treat scars and stretch marks

Read more from the original source:
Board-Certified Dermatologist and Baylor Professor: Has the Pandemic Accelerated Aging Skin? - Newswise

Longer life-expectancy is a cumulative effect of a healthy lifestyle and favorable environmental conditions. A trend of continuously increasing life expectancy has been a witness since a decade, primarily because of advances in medical sciences and treatment of chronic life-threatening diseases, availability of clean water and environment and other factors. This trend is projected to further show even more exponential growth graph owing to the anti-aging medicines, stem cell therapeutics, genetic screening and interventions, and high-tech biomedicines. American Academy of Anti-Aging Medicine claimed that anti-aging medicines can add up to 10-20 years to the life expectancy of a human. Today, a combination of calorie-restricted diet, regular exercise, and anti-aging medicines are claimed to slow the process of senescence and aging. Various medicines used against the treatment of acute or chronic diseases can be considered as anti-aging medicines, however, to define anti-aging medicine market we have considered only the drugs that are directly prescribed and used for delaying the effects of aging.

To remain ahead of your competitors, request for a sample[emailprotected]https://www.persistencemarketresearch.com/samples/26233

The constantly growing demand to look young in old individuals and to remain young and youthful in young people drive the anti-aging market. The influence of aesthetics from the fashion and television industry propel the demand to retain the features and energy of younger age in old people. Additionally, the increasing number of anti-aging medicine manufacturers in the decade contribute to higher availability of the anti-aging medicine resulting in expansion of the global anti-aging medicine market. However, skeptical approach to anti-aging medicine as being an external stimulator of cell-cycles is a restraint to the expansion of anti-aging medicine market.

The global Anti-aging medicine market is segmented on basis of product type, age group, distribution channel, and region:

To receive Methodology request here @https://www.persistencemarketresearch.com/methodology/26233

The rising demand for beauty consciousness amongst people and the desire to stay young is the primary factor fueling the growth of anti-aging medicines in the market. The acclaimed benefits of the products and affordability along with regional presence compel the demand for anti-aging medicine in the global market. Hormonal replacement therapy segment in product type is expected to account maximum market share in the terms of revenue in the global anti-aging medicine market. However, antioxidant therapy segment in product type is expected to grow with the highest CAGR over the forecast years owing to the rising awareness about the plethora of benefits of antioxidants in anti-aging among the public. On the basis of the route of administration, the global anti-aging medicine market is segmented as oral, injectable and topical, out of which oral segment is expected to generate maximum revenue share over the forecast period. As per the distribution channel, the global anti-aging medicine market is segmented as hospital pharmacies, retail pharmacies, e-commerce, and drug stores. The e-commerce segment in the distribution channel is estimated to grow with the highest CAGR over the forecast time.

Regionally, the global anti-aging medicine market is segmented into five key regions viz. North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. North America anti-aging medicine market is projected to account for the largest market share in the terms of revenue in the global anti-aging medicine market owing to the higher healthcare expenditure and presence of numerous manufacturers. Europe is expected to hold the second largest share in the global anti-aging medicine market during the forecast period because of the growing geriatric population and higher spending on healthcare products and supplements. MEA anti-aging medicine market is expected to witness sluggish growth over the forecast time owing to the limited presence of manufacturers and lower healthcare expenditure. Asia Pacific is projected to grow with the highest CAGR over the forecast years in the global anti-aging medicine market due to higher demand from end users and regional penetration of the key players in the region.

To receive extensive list of important regions, Request Table of Content here @https://www.persistencemarketresearch.com/toc/26233

Some of the players operating in the global anti-aging medicine market are

About Us

Persistence Market Research is a U.S.-based full-service market intelligence firm specializing in syndicated research, custom research and consulting services. Persistence Market Research boasts market research expertise across the Healthcare, Chemicals and Materials, Technology and Media, Energy and Mining, Food and Beverages, Semiconductor and Electronics, Consumer Goods, and Shipping and Transportation industries. The company draws on its multi-disciplinary capabilities and high pedigree team of analysts to share data that precisely corresponds to clients business needs.

Persistence Market Research stands committed to bringing more accuracy and speed to clients business decisions. From ready-to-purchase market research reports to customized research solutions, its engagement models are highly flexible without compromising on its deep-seated research values.

Contact Us:

Sourabh KJ

305 Broadway

7th Floor

New York City, NY 10007

United States

U.S.A Canada Toll-Free: 800-961-0353

Email: [emailprotected]

https://neighborwebsj.com/

View post:
The Anti Aging Medicine Market to witness livewire performance between 2020 and 2030 NeighborWebSJ - NeighborWebSJ

MIAMI, Feb. 8, 2021 /PRNewswire/ -- Ponce Therapeutics, Inc. ("Ponce"), a company leveraging the growing scientific knowledge surrounding the aging process to develop anti-aging technologies, has now become operational with the launching of its first R & D program, targeting aging-associated skin disorders. The Company has secured laboratory space in Houston, TX, and has hired its first scientists for executing their R & D plan targeting the elimination of p16-expressing cells in the skin. The cell proliferation inhibitor, p16, is highly expressed in both senescent cells and in in situ carcinoma (Bowen's Disease), which will be the focus of Ponce's efforts for first product approval.

Rapha Capital Management, LLC (https://www.raphacap.com), an investment management firm located in Miami, Florida, through Rapha Capital Investment XIII, LLC ("RCI XIII") (an entity managed by Rapha Capital), led Ponce's recently closed Convertible Note financing. The $1,500,000 financing will be used to transition Ponce into an operational company and begin execution of Ponce's R & D plan. With the close of the Convertible Note financing, Kevin Slawin, founder and President of Rapha Capital Management, added the title of Executive Chairman, to his CEO role at Ponce.

Rapha Capital is an investment management firm focused on making strategic investments in early stage, non-public biotechnology companies, through special purpose joint venture entities which it manages. Rapha Capital was founded by its President, Kevin Slawin, M.D., a successful and experienced oncologic and robotic surgeon. After leaving practice, Dr. Slawin has been serving as a biotech consultant, investor, and founder, focusing on disruptive technologies in oncology, T cells and immunotherapy, and other breakthrough healthcare technologies. He is the founder of Bellicum Pharmaceuticals, Inc.("Bellicum"), a publicly traded company listed on NASDAQ, leading Bellicum to a successful $161 million IPO in December, 2014. He also plays a guiding role in several of the investments managed by Rapha Capital in certain companies, serving as a board member at 3DBio Therapeutics, Inc. (https://3dbiocorp.com/), FIZE Medical, Inc. (www.fizemedical.com), and Demeetra AgBio, Inc. (www.demeetra.com).

Kevin Slawin, MD is the founder of Ponce, and will serve as the Chairman and CEO. David Spencer, PhD. is the founding Chief Technology Officer. Ponce Therapeutics, Inc. reunites the team that founded Bellicum Pharmaceuticals and took it public in 2014 with a $55 million crossover Series C and a $161 million IPO. The team is retooling their original cell control technology with state-of-the-art advances towards their new goal of creating anti-aging products with a solid underlying scientific basis that actually work.

"The science of aging has continued to mature and can now provide a scientific basis for technologies to reverse the aging process in humans. Proof of concept data in animal models demonstrates that removal of senescent cells from organs improves their function and imbues them with a more youthful profile. Targeting p16-expressing cells for apoptotic elimination is one approach to removing senescent cells from the body and is also a valid approach to targeting Bowen's disease of the skin, which also expresses high levels of p16, profile," said Dr. Slawin. "I'm excited to begin work in the anti-aging space, which I believe will quickly rival oncology in both value and interest" he added. "Given our greater than two-decade animal model and clinical experience with regulated cell signaling and cell survival, along with recent advances in non-viral gene delivery platforms, we are now poised to leverage an increasingly detailed, mechanistic understanding of aging to arrest or even reverse it," added Dr. Spencer.

About Rapha Capital Management, LLC Rapha Capital Management, LLC is an investment management firm located in Miami, Florida, focusing on strategic investments in early stage, non-public biotechnology companies. Rapha Capital was founded by its President, Kevin Slawin, MD, a successful and experienced oncologic and robotic surgeon, biotech consultant, investor, and founder focusing on technologies in oncology, T cells and immunotherapy, as well as other breakthrough healthcare technologies. He is the founder of Bellicum Pharmaceuticals, Inc. (NASDAQ: BLCM). He is co-Inventor of the FDA,-approved "prostate health index (phi)" test licensed and marketed by Beckman Coulter and utilized around the world. He has published extensively in top medical and scientific journals including theJournal of the American Medical Association (JAMA), Journal of the National Cancer Institute (JNCI), and the New England Journal of Medicine (NEJM). He has also been routinely listed in America's Top Doctors for Cancer (Castle Connolly Medical) and The Best Doctors in America (Woodward/White). In 2003, he was awarded the F. Brantley Scott, Jr., Award for Innovation and Creativity in Urology.

About Ponce Therapeutics, Inc.Ponce Therapeutics "Anti-aging Technologies Based on Real Science and Developed by Real Scientists" - Ponce Therapeutics is leveraging the growing scientific knowledge surrounding the process of aging to develop its first state-of-the-art biotechnology platform to restore the youthful balance of aged or "senescent" and young cells in the skin, targeting the p16-expressing senescent cells for elimination. This provides a "reboot" of one's genetic program to turn the clock on one's skin back to its youthful exuberance. Targeting p16 will also potentially allow targeting of Bowen's disease as the regulatory pathway for approval. While initially focused on skin, Ponce is planning to develop a wide-ranging portfolio of anti-aging products based on the best science in the nascent anti-aging field. Ponceis headquartered in Miami, Florida with research facilities located in Houston, TX. For more information, visitwww.poncethera.comor email info@poncethera.com.

For more information about Ponce Therapeutics, Inc., email info@poncethera.com or visit https://www.poncethera.com

For more information about Rapha Capital Management, email info@raphacapital.comor visit https://www.raphacap.com

View original content to download multimedia:http://www.prnewswire.com/news-releases/ponce-therapeutics-inc-commences-first-r--d-program-in-anti-aging-products-for-skin-301221629.html

SOURCE Rapha Capital Management, LLC and Ponce Therapeutics, Inc.

See the original post here:
Ponce Therapeutics Inc. Commences First R & D Program in Anti-Aging Products for Skin - BioSpace